If you made any changes in Pure these will be visible here soon.

Research Output 1997 2019

1997

Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance

Kantharidis, P., El-Osta, A., DeSilva, M., Wall, D. M. P., Hu, X. F., Slater, A., Nadalin, G., Parkin, J. D. & Zalcberg, J. R., Nov 1997, In : Clinical Cancer Research. 3, 11, p. 2025-2032 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia

Wall, D. M. P., El-Osta, S., Tzelepis, D., Bertoncello, I., Kantharidis, P., Chou, S. T., Zalcberg, J. R. & Parkin, J. D., 1997, In : British Journal of Haematology. 96, 4, p. 697-707 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequential extraction of DNA and DNA-binding proteins from low cell numbers

El-Osta, S., Kantharidis, P. & Zalcberg, J. R., Apr 1997, In : BioTechniques. 22, 4, p. 645-648 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Absolute quantitation of MDR1 transcripts using heterologous DNA standards - Validation of the competitive RT-PCR (CRT-PCR) approach

El-Osta, A., Kantharidis, P. & Zalcberg, J., 1999, In : BioTechniques. 26, 6, p. 1114-1124 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

DNA methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease

El-Osta, A. & Wolffe, A. P., 7 Dec 2000, In : Gene Expression. 9, 1-2, p. 63-75 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines

Zalcberg, J., Hu, X. F., Slater, A., Parisot, J., El-Osta, S., Kantharidis, P., Chou, S. T. & Parkin, J. D., 2000, In : Prostate Cancer and Prostatic Diseases. 3, 2, p. 66-75 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of MDR1 gene expression: Emerging concepts

Kantharidis, P., El-Osta, S., De Silva, M., Lee, G., Hu, X. F. & Zalcberg, J., Apr 2000, In : Drug Resistance Updates. 3, 2, p. 99-108 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2001

Analysis of chromatin-immunopurified MeCP2-associated fragments

El-Osta, A. & Wolffe, A. P., 7 Dec 2001, In : Biochemical and Biophysical Research Communications. 289, 3, p. 733-737 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

FMR1 silencing and the signals to chromatin: A unified model of transcriptional regulation

El-Osta, A., 1 Jan 2002, In : Biochemical and Biophysical Research Communications. 295, 3, p. 575-581 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling methyl-CpG specific determinants on transcriptionally silent chromatin

El-Osta, A., Baker, E. K. & Wolffe, A. P., 15 Jul 2002, In : Molecular Biology Reports. 28, 4, p. 209-215 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

DNMT cooperativity - The developing links between methylation, chromatin structure and cancer

El-Osta, A., 1 Nov 2003, In : BioEssays. 25, 11, p. 1071-1084 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

On the use of DNA methylation inhibitors and the reversal of transcriptional silencing [4] (multiple letters)

El-Osta, A., Lübbert, M., Wijermans, P. W., Licht, T. & Jones, P. A., 15 Feb 2003, In : Blood. 101, 4, p. 1656-1658 3 p.

Research output: Contribution to journalLetterOtherpeer-review

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer

Baker, E. K. & El-Osta, A., 1 Nov 2003, In : Experimental Cell Research. 290, 2, p. 177-194 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2004

Coordination of epigenetic events

El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2135-2136 2 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Double-strand breaks: Signaling pathways and repair mechanisms

Karagiannis, T. C. & El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2137-2147 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic changes activate widespread signals in response to double-strand breaks

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 7, p. 617-623 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL)

Harikrishnan, K. N., Bassal, S., Tikellis, C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 10, p. 989-994 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional links between transcription, DNA repair and apoptosis

Berardi, P., Russell, M., El-Osta, A. & Riabowol, K., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2173-2180 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

MDR1, chemotherapy and chromatin remodeling

Baker, E. K. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 819-824 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Radio- and chemo-sensitization of human erythroleukemic K562 cells by the histone deacetylase inhibitor Trichostatin A

Karagiannis, T. C., Smith, A. J. & El'Osta, A., 1 Sep 2004, In : Medicine, Science and the Law. 7, 3, p. 184-191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

siRNAs: Mechanism of RNA interference, in vivo and potential clinical applications

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 11

Research output: Contribution to journalReview ArticleResearchpeer-review

The rise and fall of genomic methylation in cancer

El-Osta, A., 1 Jan 2004, In : Leukemia. 18, 2, p. 233-237 5 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Understanding the consequences of epigenetic mechanisms and their effect on transcription in health and disease

El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 816-818 3 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2005

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

Harikrishnan, K. N., Chow, M. Z., Baker, E. K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J. M., Jones, P. L., Sif, S. & El-Osta, A., 2005, In : Nature Genetics. 37, 3, p. 254-264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages

Escher, G., Hoang, A., Georges, S., Tchoua, U., El-Osta, A., Krozowski, Z. & Sviridov, D., 1 Feb 2005, In : Journal of Lipid Research. 46, 2, p. 356-365 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA damage detection and repair, and the involvement of epigenetic states

Bassal, S. & El-Osta, A., 21 Feb 2005, In : Human Mutation. 25, 2, p. 101-109 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

Baker, E. K., Johnstone, R. W., Zalcberg, J. R. & El-Osta, A., 1 Dec 2005, In : Oncogene. 24, 54, p. 8061-8075 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy

Forbes, J. M., Thorpe, S. R., Thallas-Bonke, V., Pete, J., Thomas, M. C., Deemer, E. R., Bassal, S., El-Osta, A., Long, D. M., Panagiotopoulos, S., Jerums, G., Osicka, T. M. & Cooper, M. E., 12 Dec 2005, In : Journal of the American Society of Nephrology. 16, 8, p. 2363-2372 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Review on epigenetics in cancer gene therapy: Series I

El-Osta, A., 1 Aug 2005, In : Cancer Gene Therapy. 12, 8, p. 663-664 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

RNA interference and potential therapeutic applications of short interfering RNAs

Karagiannis, T. C. & El-Osta, A., 1 Oct 2005, In : Cancer Gene Therapy. 12, 10, p. 787-795 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The histone deacetylase inhibitor, trichostatin A, enhances radiation sensitivity and accumulation of γH2A.X

Karagiannis, T. C., Harikrishnan, K. N. & El-Osta, A., 1 Jan 2005, In : Cancer Biology and Therapy. 4, 7, p. 787-793 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer

Karagiannis, T. C. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 121-126 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Harikrishnan et al. reply [3]

Harikrishnan, K. N., Pal, S., Yarski, M., Baker, E. K., Chow, M. Z., De Silva, M. G., Okabe, J., Wang, L., Jones, P. L., Sif, S. & El-Osta, A., 4 Sep 2006, In : Nature Genetics. 38, 9, p. 964-967 4 p.

Research output: Contribution to journalLetterOtherpeer-review

Mechanisms of abnormal gene expression in tumor cells.

El-Osta, A., 1 Jan 2006, In : EXS. 96, p. 351-361 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Modulation of cellular radiation responses by histone deacetylase inhibitors

Karagiannis, T. C. & El-Osta, A., 29 Jun 2006, In : Oncogene. 25, 28, p. 3885-3893 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The epigenetic modifier, valproic acid, enhances radiation sensitivity

Karagiannis, T. C., Kn, H. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 131-137 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The neuronal noradrenaline transporter, anxiety and cardiovascular disease

Esler, M. D., Alvarenga, M., Pier, C., Richards, J. C., El-Osta, A., Barton, D. A., Haikerwal, D., Kaye, D., Schlaich, M., Guo, L., Jennings, G., Socratous, F. & Lambert, G. W., 2006, In : Journal of Psychopharmacology. 20, 4, p. 60 - 66 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation

Karagiannis, T. C. & El-Osta, A., 1 Feb 2006, In : Cell Cycle. 5, 3, p. 288-295 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2007

Chromatin modifications and DNA double-strand breaks: The current state of play

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 2, p. 195-200 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments

Karagiannis, T. C., Kn, H. & El-Osta, A., 7 Jun 2007, In : Oncogene. 26, 27, p. 3963-3971 9 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA double-strand breaks repair pathways in the framework of chromatin

Karagiannis, T. C. & El-Osta, A., 1 Dec 2007, New Research on DNA Repair. Nova Science Publishers, p. 295-324 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 1, p. 61-65 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2008

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments

Harikrishnan, K. N., Karagiannis, T. C., Chow, M. Z. & El-Osta, A., 15 Feb 2008, In : Cell Cycle. 7, 4, p. 468-476 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic regulation and fetal programming

Gicquel, C., El-Osta, A. & Le Bouc, Y., 1 Feb 2008, In : Best Practice and Research in Clinical Endocrinology and Metabolism. 22, 1, p. 1-16 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Erratum: Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia ((2008) 205:10 (2409-2417))

El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G., Cooper, M. E. & Brownlee, M., 27 Oct 2008, In : Journal of Experimental Medicine. 205, 11, p. 2683 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder

Esler, M., Eikelis, N., Schlaich, M., Lambert, G., Alvarenga, M., Kaye, D., El-Osta, A., Guo, L., Barton, D., Pier, C., Brenchley, C., Dawood, T., Jennings, G. & Lambert, E., 1 Dec 2008, In : Annals of the New York Academy of Sciences. 1148, p. 338—348 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G., Cooper, M. E. & Brownlee, M., 29 Sep 2008, In : Journal of Experimental Medicine. 205, 10, p. 2409-2417 9 p.

Research output: Contribution to journalArticleResearchpeer-review