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Research Output 1997 2019

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions

Perez, S., Gevor, M., Davidovich, A., Kaspi, A., Yamin, K., Domovich, T., Meirson, T., Matityahu, A., Brody, Y., Stemmer, S. M., El-Osta, A., Haviv, I., Onn, I. & Gal-Tanamy, M., 18 Mar 2019, In : Nucleic Acids Research. 47, 5, p. 2455-2471 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Epigenetics, cardiovascular disease, and cellular reprogramming

Al-Hasani, K., Mathiyalagan, P. & El-Osta, A., 1 Mar 2019, In : Journal of Molecular and Cellular Cardiology. 128, p. 129-133 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Evaluation of genomic methylation indices in juvenile myoclonic epilepsy

El-Osta, A., 1 May 2019, In : Epilepsia. 60, 5, p. e37-e39 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling

Nguyen, M-N., Ziemann, M., Kiriazis, H., Su, Y., Thomas, Z., Lu, Q., Donner, D. G., Zhao, W-B., Rafehi, H., Sadoshima, J., McMullen, J. R., El-Osta, A. & Du, X-J., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H45-H60 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Intergenerational Prevention Of Heart Failure Through Maternal Intake Of High Fibre

Jama, H. A., Shihata, W., Ziemann, M. D., Donner, D. G., Kiriazis, H., Du, X-J., El-Osta, A., Mackay, C. R., Kaye, D. M. & Coelho Marques, F., Feb 2019.

Research output: Contribution to conferenceAbstractOther

2018

Age-related differential structural and transcriptomic responses in the hypertensive heart

Marques, F. Z., Chu, P. Y., Ziemann, M., Kaspi, A., Kiriazis, H., Du, X. J., El-Osta, A. & Kaye, D. M., 9 Jul 2018, In : Frontiers in Physiology. 9, JUL, 13 p., 817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Contemporary Trends Emerging in Epigenomics and Metabolism

El-Osta, A., 10 Oct 2018, In : Antioxidants and Redox Signaling. 29, 11, p. 1019-1022 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

Kaspi, A., Khurana, I., Ziemann, M., Connor, T., Spolding, B., Zimmet, P., Walder, K. & El-Osta, A., 1 Jul 2018, In : Molecular Nutrition and Food Research. 62, 14, 10 p., 1800134.

Research output: Contribution to journalArticleResearchpeer-review

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine

Zimmet, P., Shi, Z., El-Osta, A. & Ji, L., 1 Dec 2018, In : Nature Reviews Endocrinology. 14, 12, p. 738-746 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic Contribution to the Development and Progression of Vascular Diabetic Complications

Rodriguez, H. & El-Osta, A., 10 Oct 2018, In : Antioxidants and Redox Signaling. 29, 11, p. 1074-1091 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena

Costantino, S., Libby, P., Kishore, R., Tardif, J. C., El-Osta, A. & Paneni, F., 14 Dec 2018, In : European Heart Journal. 39, 47, p. 4150-4158 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Epigenetics in diabetic nephropathy, immunity and metabolism

Keating, S. T., van Diepen, J. A., Riksen, N. P. & El-Osta, A., 1 Jan 2018, In : Diabetologia. 61, 1, p. 6-20 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolic karma-the atherogenic legacy of diabetes: The 2017 edwin bierman award lecture

Cooper, M. E., El-Osta, A., Allen, T. J., Watson, A. M. D., Thomas, M. C. & Jandeleit-Dahm, K., 1 May 2018, In : Diabetes. 67, 5, p. 785-790 6 p.

Research output: Contribution to journalArticleOther

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Lipponen, A., El-Osta, A., Kaspi, A., Ziemann, M., Khurana, I., Kn, H., Navarro-Ferrandis, V., Puhakka, N., Paananen, J. & Pitkänen, A., 27 Feb 2018, In : Acta neuropathologica communications. 6, 1, 16 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Valproic acid attenuates hyperglycemia-induced complement and coagulation cascade gene expression

Felisbino, M. B., Ziemann, M., Khurana, I., de Oliveira, C. B. M., Mello, M. L. & El-Osta, A., 2018, (Accepted/In press) bioRxiv.

Research output: Other contributionResearch

2017

Epigenetic programming, early life nutrition and the risk of metabolic disease

Block, T. & El-Osta, A., 1 Nov 2017, In : Atherosclerosis. 266, p. 31-40 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome

Khan, A. W., Corcoran, S. J., Esler, M. & El-Osta, A., 1 Mar 2017, In : Neuroscience and Biobehavioral Reviews. 74, p. 342-355 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Exercise increases GLUT4 promoter histone acetylation in human skeletal muscle

Hargreaves, M., Flores-Opazo, M., Garnham, A., Ziemann, M. D., Kaipananickal, H., Khurana, I., Kaspi, A. D. & El-Osta, A., 2017, p. P1.068.

Research output: Contribution to conferencePosterOtherpeer-review

Open Access

High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

MeCP2 interacts with chromosomal microRNAs in brain

Khan, A. W., Ziemann, M., Rafehi, H., Maxwell, S., Ciccotosto, G. D. & El-Osta, A., 2 Dec 2017, In : Epigenetics. 12, 12, p. 1028-1037 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolism and chromatin dynamics in health and disease

Rodriguez, H., Rafehi, H., Bhave, M. & El-Osta, A., Apr 2017, In : Molecular Aspects of Medicine. 54, p. 1-15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Multi-Cellular Transcriptional Analysis of Mammalian Heart Regeneration

Quaife-Ryan, G. A., Sim, C. B., Ziemann, M., Kaspi, A., Rafehi, H., Ramialison, M., El-Osta, A., Hudson, J. E. & Porrello, E. R., 19 Sep 2017, In : Circulation. 136, 12, p. 1123-1139 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NET silencing by let-7i in postural tachycardia syndrome

Khan, A. W., Ziemann, M., Corcoran, S. J., K N, H., Okabe, J., Rafehi, H., Maxwell, S. S., Esler, M. D. & El-Osta, A., 23 Mar 2017, In : JCI Insight. 2, 6, 11 p., e90183.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacological histone deacetylation distinguishes transcriptional regulators

Rafehi, H., Karagiannis, T. C. & El-Osta, A., 1 May 2017, In : Current Topics in Medicinal Chemistry. 17, 14, p. 1611 - 1622 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Rafehi, H., Kaspi, A., Ziemann, M., Okabe, J., Karagiannis, T. C. & El-Osta, A., 2 Nov 2017, In : Epigenetics. 12, 11, p. 991-1003 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Current perspectives in Set7 mediated stem cell differentiation

Karimnia, N., Rafehi, H., Tuano, N. K., Ziemann, M., K.N., H., Okabe, J. & El-Osta, A., 4 Dec 2016, In : Non-Coding RNA. 2, 4, 8 p., 2040014.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus

Khurana, I., Kaspi, A., Ziemann, M., Block, T., Connor, T., Spolding, B., Cooper, A., Zimmet, P., El-Osta, A. & Walder, K., 1 Jul 2016, In : International Journal of Obesity. 40, 7, p. 1079-1088 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Dietary Fibre Intake and the Gut Microbiota in a Model of Heart Failure

Coelho Marques, F., Nelson, E. M., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M. D., Tan, J., Kuruppu, D. M. S., Rajapakse, N., El-Osta, A., Mackay, C. R. & Kaye, D. M., 11 Nov 2016. 1 p.

Research output: Contribution to conferenceAbstractOther

Epigenetic changes in diabetes and cardiovascular risk

Keating, S. T., Plutzky, J. & El-Osta, A., 27 May 2016, In : Circulation Research. 118, 11, p. 1706-1722 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Etiology matters-Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy

Debski, K. J., Pitkanen, A., Puhakka, N., Bot, A. M., Khurana, I., Harikrishnan, K. N., Ziemann, M., Kaspi, A., El-Osta, A., Lukasiuk, K. & Kobow, K., 9 May 2016, In : Scientific Reports. 6, 14 p., 25668.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Evaluation of microRNA alignment techniques

Ziemann, M., Kaspi, A. & El-Osta, A., 1 Aug 2016, In : Rna-A Publication of the Rna Society. 22, 8, p. 1120-1138 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gene name errors are widespread in the scientific literature

Ziemann, M., Eren, Y. & El-Osta, A., 23 Aug 2016, In : Genome Biology. 17, 1, 177.

Research output: Contribution to journalComment / DebateOtherpeer-review

Genetics and Epigenetics in Cardiac Psychology

Bayles, R. & El-Osta, A., 2016, Handbook of Psychocardiology. Alvarenga, M. E. & Byrne, D. (eds.). Springer, Vol. 2. p. 789-805 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

HDAC inhibition in vascular endothelial cells regulates the expression of ncRNAs

Rafehi, H. & El-Osta, A., 25 May 2016, In : Non-Coding RNA. 2, 2, 10 p., 4.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Improving understanding of chromatin regulatory proteins and potential implications for drug discovery

Rafehi, H., Khan, A. W. & El-Osta, A., 2 Apr 2016, In : Expert Review of Proteomics. 13, 4, p. 435-445 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells

Balcerczyk, A., Rybaczek, D., Wojtala, M., Pirola, L., Okabe, J. & El-Osta, A., 1 Dec 2016, In : Biochemical Pharmacology. 121, p. 18-32 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Feb 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 2, p. 295-307 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells

Tuano, N. K., Okabe, J., Ziemann, M. D., Cooper, M. E. & El-Osta, A., 2016, In : Nucleic Acids Research. 44, 19, p. 9206-9217 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Clinical applicability of methylome sequencing in a pilot study of ischemic stroke individuals

Ziemann, M., Kaipananickal, H., Khurana, I., Kaspi, A., Keating, S. T., De Silva, D. A., Moe, K. T. & El-Osta, A., Jan 2015, In : Methods in Next Generation Sequencing. 2, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Current advances in noncoding RNA relevant to epigenetic mechanisms

Mathiyalagan, P., Khan, W., Du, X-J. & El-Osta, A., Mar 2015, In : Current Molecular Biology Reports. 1, 1, p. 29 - 38 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Current Epigenetic Perspective on Diabetes: Who Regulates the Regulators?

Keating, S. T. & El-Osta, A., 18 Dec 2015, In : Cellular & Molecular Medicine: Open access. 1, p. 1-4 4 p., 7.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Development of novel activin-targeted therapeutics

Chen, J., Walton, K., Al-Musawi, S., Kelly, E. M., Qian, H., La, M., Lu, L., Lovrecz, G. O., Ziemann, M., Lazarus, R., El-Osta, A., Gregorevic, P. & Harrison, C. A., 2015, In : Molecular Therapy. 23, 3, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic changes in the cardiac methylome during postnatal development

Sim, C. B., Ziemann, M., Kaspi, A., Harikrishnan, K. N., Ooi, J., Khurana, I., Chang, L., Hudson, J. E., El-Osta, A. & Porrello, E. R., 1 Apr 2015, In : FASEB Journal. 29, 4, p. 1329-1343 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic-Mediated Reprogramming of Pancreatic Endocrine Cells

Mathiyalagan, P., Keating, S. T., Al-Hasani, K. & El-Osta, A., 1 Jun 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1483-1495 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetics and metabolism

Keating, S. T. & El-Osta, A., 13 Feb 2015, In : Circulation Research. 116, 4, p. 715-736 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Ooi, J., Tuano, N. K., Rafehi, H., Gao, X-M., Ziemann, M., Du, X-J. & El-Osta, A., 2015, In : Epigenetics. 10, 5, p. 418-430 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathological hypertrophy reverses β2-adrenergic receptorinduced angiogenesis in mouse heart

Xu, Q., Jennings, N. L., Sim, K., Chang, L., Gao, X. M., Kiriazis, H., Lee, Y. Y., Nguyen, M-N., Woodcock, E. A., Zhang, Y. Y., Osta, A. E., Dart, A. M. & Du, X. J., 2015, In : Physiological Reports. 3, 3, 16 p., e12340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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