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Personal profile


El-Osta research group: www.med.monash.edu/cecs/diabetes/research/el-osta-group.html

Professor El-Osta is an epigeneticist and his research is recognized at the highest international level and this is clearly demonstrated by his rapid upward trajectory with respect to publications including citations. He has contributed more than 175 articles and publishes research that is highly influential in the field of transcription and chromatin biology. In recognition of his research into epigenetics, he was awarded AMGEN Australian Medical Researcher of the Year in 2006 by the ASMR Australian Society for Medical Research. The inclusion of his prominent research into the Faculty of 1000 Biology and Nature Milestones as well as most read articles in Circulation Research "honor roll" for 2011 exemplify an authoritative position, influence, and international reputation. While frequently invited to write editorials, his research is recognized in editorials and was awarded in the “2013 Anthology” of most significant science in Circulation Research. He was recently elected vice-president of the International Epigenetics Society and serve as guest editor and solicited to contribute authoritative reviews for prominent journals that in 2015/16 include Antioxidants & Redox Signaling, Cellular and Molecular Life Sciences, Molecular Aspects of Medicine and Circulation Research. As well as his promotion to Professor in 2013 and in recognition of excellence in supervision and mentoring, in 2015, he is an adjunct Professor in epigenetics at the Prince of Wales Hospital, Hong Kong as well as visiting lecturer with Kobenhavns Professionshojskole, University College Copenhagen (formerly known as Metropolitan University College and recently merged with University College Capital) in Denmark. His highly original contributions are influential and reflected by prestigious international invitations that include keynote and plenary lectures, which in 2016 include EAS (Austria), EASD (Munich) and IDF-WPR (Taipei). Since 2011, he has received >$6 Million dollars in external research funding, which has become more diversified to include not only NHMRC and Centre of Research Excellence funding but also competitive international sources such as the European Union and FP7 and JDRF. In 2009 he was awarded the prestigious Millennium Type 1 Diabetes Research Award by the Diabetes Australia Research Trust and received the inaugural Juvenile Diabetes Research Foundation & Macquarie Group Foundation in 2009 for diabetes research innovation, in recognition excellence and innovation in medical research. Further evidence of increasing academic achievements by his group includes 7 Ph.D. students graduating and 3 new Ph.D. students with scholarships in the last two years. His reputation for excellence in training, research and technology are considered world class with students obtaining international postdoctoral postings. He is recognized by the NHMRC “honor roll” with prominent international advisory appointments such as ESF, JDRF, and Oxford Global and recently invited to serve on the editorial board for the journals, ncRNA and Epigenetics. As a principal investigator, he leads extensive multidisciplinary collaborative research programs that include leading research sites within the European Union and China.



Professor El-Osta is frequently invited to speak at major international meetings that include keynote and opening lectures and over the past 5 years have presented at local and national meetings on 13 occasions and presented on 63 occasions at international meetings including 12 Plenary/Keynote lectures. International invitations with several keynote and plenary lectures that in 2016 include, Lecture 1st Epigenomics Meeting (Dubrovnik), Plenary lecture 84th European Atherosclerosis Society (Austria), 52nd European Association for the Study of Diabetes (Munich) and Keynote lecture 11th IDF-WPR Congress 2016 & 8th AASD Scientific Meeting (Taipei). Together with Professor Ronald Ma, he is an International Organizer for the Gordon Research Conference, Epigenomics of Diabetes and other Metabolic Diseases, Hong Kong SAR 2018.



Professor El-Osta has extensive mentoring and supervisory roles for new researchers in the field, with his laboratory hosting international and local scholarship awardees, as well as postdoctoral scientists (HFSP, NHMRC-INSERM, and EFSD). He has a reputation for excellence in training, research and technology continue at the highest international level with postdoctoral postings from Finland, Germany, Italy, Poland, France and The Netherlands. He is a primary and associate supervisor to 33 students (20 Ph.D., 4 MSc, 3 Hons) and 6 completed international trainees. World-class academic achievements in my group are demonstrated and on the rise with six Ph.D. students graduating with doctoral awards and three new Ph.D. students with scholarships in the last two years. He has also helped the career of several early research fellows, many who have now established their own independent research groups achieving funding and fellowships in their own right.

Research area keywords

  • Complex Disease
  • Clinical and Molecular Epigenetics
  • Chromatin
  • Diabetes
  • Histones
  • Transcriptional Regulation
  • Computational Epigenomics
  • Epilepsy
  • Neurological Disorders
  • Metabolic disease
  • POTS
  • Orthostatic Intolerance

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2023

Research Output 1997 2019

Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility

Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T-V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, S., Meikle, P., Wilson, S., Forbes, J. M. & 4 others, Cooper, M. E., Ekinci, E., Woodruff, T. M. & Coughlan, M., 17 Oct 2019, (Accepted/In press) In : Diabetes.

Research output: Contribution to journalArticleResearchpeer-review

Digital expression explorer 2: A repository of uniformly processed RNA sequencing data

Ziemann, M., Kaspi, A. & El-Osta, A., 3 Apr 2019, In : GigaScience. 8, 4, 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions

Perez, S., Gevor, M., Davidovich, A., Kaspi, A., Yamin, K., Domovich, T., Meirson, T., Matityahu, A., Brody, Y., Stemmer, S. M., El-Osta, A., Haviv, I., Onn, I. & Gal-Tanamy, M., 18 Mar 2019, In : Nucleic Acids Research. 47, 5, p. 2455-2471 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Epigenetics, cardiovascular disease, and cellular reprogramming

Al-Hasani, K., Mathiyalagan, P. & El-Osta, A., 1 Mar 2019, In : Journal of Molecular and Cellular Cardiology. 128, p. 129-133 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Activities 2008 2019

Cellular and Molecular Life Sciences (Journal)

Sam El-Osta (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial responsibility

Clinical Epigenetics (Journal)

Sam El-Osta (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial responsibility

Circulation Research (Journal)

Sam El-Osta (Editorial board member)
20 Jun 2019

Activity: Publication peer-review and editorial work typesEditorial responsibility

Department of Foreign Affairs and Trade and Council for Australian-Arab Relations

Sam El-Osta (Keynote/plenary speaker)
5 Dec 2018

Activity: Participating in or organising an event typesContribution to workshop, seminar, course

The Sagol Center for Epigenetics of Metabolism and Aging

Sam El-Osta (Invited speaker)
5 Sep 2018

Activity: Participating in or organising an event typesContribution to workshop, seminar, course

Press / Media

Fainting Clue Uncovered

Sam El-Osta


1 item of Media coverage

Press/Media: Article/Feature