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Research Output

2019

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2018

Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism

Deswaerte, V., Nguyen, P., West, A., Browning, A. F., Yu, L., Ruwanpura, S. M., Balic, J., Livis, T., Girard, C., Preaudet, A., Oshima, H., Fung, K. Y., Tye, H., Najdovska, M., Ernst, M., Oshima, M., Gabay, C., Putoczki, T. & Jenkins, B. J., 1 Mar 2018, In : Cancer Research. 78, 5, p. 1293-1307 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Lung Diseases

Ruwanpura, S., Rosli, S. & Tate, M., 1 Jan 2018, Inflammasomes: Clinical and Therapeutic Implications. Cordero, M. D. & Alcocer-Gómez, E. (eds.). Cham, Switzerland: Springer, Vol. 108. p. 61-84 24 p. (Experientia Supplementum; vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Tissue processing for stereological analyses of lung structure in chronic obstructive pulmonary disease

Saad, M. & Ruwanpura, S. M., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). USA: Humana Press, p. 155-162 8 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)
2017

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma

Miller, A., McLeod, L., Alhayyani, S., Szczepny, A., Watkins, D. N., Chen, W., Enriori, P., Ferlin, W., Ruwanpura, S. & Jenkins, B. J., 25 May 2017, In : Oncogene. 36, 21, p. 3059-3066 8 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

King, P. T., Sharma, R., O'Sullivan, K. M., Callaghan, J., Dousha, L., Thomas, B., Ruwanpura, S., Lim, S., Farmer, M. W., Jennings, B. R., Finsterbusch, M., Brooks, G., Selemidis, S., Anderson, G. P., Holdsworth, S. R. & Bardin, P. G., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 12128.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)
5 Citations (Scopus)
2016

IL6 trans-signaling promotes KRAS-driven lung carcinogenesis

Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., Rose-John, S., Ruwanpura, S. & Jenkins, B. J., 15 Feb 2016, In : Cancer Research. 76, 4, p. 866-876 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
42 Citations (Scopus)

Therapeutic targeting of the IL-6 trans-signaling/mechanistic target of rapamycin complex 1 axis in pulmonary emphysema

Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., Alhayyani, S., Tate, M. D., Deswaerte, V., Brooks, G. D., Bozinovski, S., MacDonald, M., Garbers, C., King, P. T., Bardin, P. G., Vlahos, R., Rose-John, S., Anderson, G. P. & Jenkins, B. J., 15 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 12, p. 1494-1505 12 p.

Research output: Contribution to journalArticleResearchpeer-review

File
21 Citations (Scopus)
2015

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis

Miller, A., Brooks, G. D. C., McLeod, L., Ruwanpura, S. M. & Jenkins, B. J., 19 Mar 2015, In : Oncogene. 34, 12, p. 1510 - 1519 10 p.

Research output: Contribution to journalArticleResearchpeer-review

File
8 Citations (Scopus)
2014

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice

Ruwanpura, S. M., McLeod, L., Brooks, G. D. C., Bozinovski, S., Vlahos, R., Longano, A., Bardin, P. G., Anderson, G. & Jenkins, B. J., 2014, In : Respirology. 19, 3, p. 419 - 427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2013

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice

Ruwanpura, S. M., McLeod, L., Lilja, A., Brooks, G. D. C., Dousha, L., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. & Jenkins, B. J., 2013, In : PLoS ONE. 8, 10, 9 p., e78095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2012

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., Longano, A., Bardin, P., Bozinovski, S., Anderson, G. & Jenkins, B., 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 32, 7, p. L627 - L639 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)
2011

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., Ernst, M., Armes, J., Bardin, P., Anderson, G. & Jenkins, B., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 4, p. 720 - 730 11 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2010

Hormonal regulation of male germ cell development

Ruwanpura, S., McLachlan, R. I. & Meachem, S., 2010, In : Journal of Endocrinology. 205, 2, p. 117 - 131 15 p.

Research output: Contribution to journalArticleOther

121 Citations (Scopus)

Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues

Crosbie, J., Anderson, R., Rothkamm, K., Restall, C., Cann, L. M., Ruwanpura, S. M., Meachem, S. J., Yagi, N., Svalbe, I. D., Lewis, R., Williams, B. R. G. & Rogers, P. A. W., 2010, In : International Journal of Radiation Oncology Biology Physics. 77, 3, p. 886 - 894 9 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)
2008
28 Citations (Scopus)

Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men

Ruwanpura, S. M., McLachlan, R. I., Matthiesson, K. L. & Meachem, S. J., 2008, In : Human Reproduction. 23, 2, p. 403 - 411 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
18 Citations (Scopus)
2007
9 Citations (Scopus)
2005

Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation

Meachem, S. J., Ruwanpura, S. M., Ziolkowski, J., Ague, J. M., Skinner, M. K. & Loveland, K. A. L., 2005, In : Journal of Endocrinology. 186, 12, p. 429 - 446 18 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)