Roxanne Toivanen

Miss

20102023
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Research Output 2010 2019

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2018

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 othersHuglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer

Zou, M., Toivanen, R., Mitrofanova, A., Floch, N., Hayati, S., Sun, Y., Le Magnen, C., Chester, D., Mostaghel, E. A., Califano, A., Rubin, M. A., Shen, M. M. & Abate-Shen, C., 1 Jul 2017, In : Cancer Discovery. 7, 7, p. 736-749 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis

Toivanen, R., Mohan, A. & Shen, M. M., 10 May 2016, In : Stem Cell Reports. 6, 5, p. 660-667 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015

Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis

Risbridger, G. P., Taylor, R. A., Clouston, D., Sliwinski, A., Thorne, H. J., Hunter, S. M., Li, J., Mitchell, G. W. E., Murphy, D. G. M., Frydenberg, M., Pook, D. W., Pedersen, J. S., Toivanen, R., Wang, H., Papargiris, M., Lawrence, M. G. & Bolton, D. M., 1 Mar 2015, In : European Urology. 67, 3, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome

Leach, D. A., Need, E. F., Toivanen, R., Trotta, A., Palenthorpe, H. M., Tamblyn, D. J., Kopsaftis, T., England, G. M., Smith, E., Drew, P. A., Pinnock, C. B., Lee, P., Holst, J., Risbridger, G. P., Chopra, S., DeFranco, D. B., Taylor, R. A. & Buchanan, G., 2015, In : Oncotarget. 6, 18, p. 16135 - 16150 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer

Wang, Z. A., Toivanen, R., Bergren, S. K., Chambon, P. & Shen, M. M., 2014, In : Cell Reports. 8, 5, p. 1339-1346 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Single luminal epithelial progenitors can generate prostate organoids in culture

Chua, C. W., Shibata, M., Lei, M., Toivanen, R., Barlow, L. J., Bergren, S. K., Badani, K. K., McKiernan, J. M., Benson, M. C., Hibshoosh, H. & Shen, M. M., 1 Jan 2014, In : Nature Cell Biology. 16, 10, p. 951-961 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors

Toivanen, R., Frydenberg, M., Murphy, D., Pedersen, J. S., Ryan, A., Pook, D. W., Berman, D. M., Taylor, R. A. & Risbridger, G. P., 2013, In : Science Translational Medicine. 5, 187 (Art. No.:187ra71), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A preclinical xenograft model of prostate cancer using human tumors

Lawrence, M. G., Taylor, R. A., Toivanen, R., Pedersen, J. S., Norden, S., Pook, D. W., Frydenberg, M., Australian Prostate Cancer BioResource, Papargiris, M., Niranjan, B., Richards, M. G., Wang, H., Collins, A. T., Maitland, N. J. & Risbridger, G. P., 2013, In : Nature Protocols. 8, 5, p. 836 - 848 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Breaking through a roadblock in prostate cancer research: An update on human model systems

Toivanen, R., Taylor, R. A., Pook, D. W., Ellem, S. J. & Risbridger, G. P., 2012, In : Journal of Steroid Biochemistry and Molecular Biology. 131, 3-5, p. 122 - 131 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status

Taylor, R. A., Toivanen, R., Frydenberg, M., Pedersen, J. S., Harewood, L., Australian Prostate Cancer Bio, U., Collins, A. T., Maitland, N. J. & Risbridger, G. P., 2012, In : Stem Cells. 30, 6, p. 1087 - 1096 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Brief report: A bioassay to identify primary human prostate cancer repopulating cells

Toivanen, R., Berman, D., Wang, H., Pedersen, J. S., Frydenberg, M., Meeker, A., Ellem, S., Risbridger, G. & Taylor, R., 2011, In : Stem Cells. 29, 8, p. 1310 - 1314 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated

McPherson, S. J., Hussain, S., Balanathan, P., Hedwards, S. L., Niranjan, B., Grant, M., Chandrasiri, U. P., Toivanen, R., Wang, Y., Taylor, R. A. & Risbridger, G. P., 2010, In : Proceedings of the National Academy of Sciences. 107, 7, p. 3123 - 3128 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Stem cells in prostate cancer: Treating the root of the problem

Taylor, R. A., Toivanen, R. & Risbridger, G. P., 2010, In : Endocrine-Related Cancer. 17, 4, p. R273 - R285 13 p.

Research output: Contribution to journalArticleResearchpeer-review