20022020
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Research Output 2002 2019

2019

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., Erlichster, M., Witkowski, M. T., Liu, G. J., Chopin, M., Dakic, A., Simankowicz, E., Pomilio, G., Vu, T., Krsmanovic, P., Su, S. & 21 othersTian, L., Baldwin, T. M., Zalcenstein, D. A., DiRago, L., Wang, S., Metcalf, D., Johnstone, R. W., Croker, B. A., Lancaster, G. I., Murphy, A. J., Naik, S. H., Nutt, S. L., Pospisil, V., Schroeder, T., Wall, M., Dawson, M. A., Wei, A. H., de Thé, H., Ritchie, M. E., Zuber, J. & Dickins, R. A., 1 Aug 2019, In : Cell Stem Cell. 25, 2, p. 258-272.e9 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D'Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., Belz, G. T., Naik, S. H., Lew, A. M., Bouillet, P., Herold, M. J., Smyth, G. K., Corcoran, L. M. & Nutt, S. L., 15 Jan 2019, In : Immunity. 50, 1, p. 77-90.e5 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors (Nature (2017) DOI: 10.1038/nature21076)

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 othersRoss, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 28 Jun 2018, In : Nature. 558, 7711, p. E5 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2017

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski, M. T., Hu, Y., Roberts, K. G., Boer, J. M., McKenzie, M. D., Liu, G. J., Le Grice, O. D., Tremblay, C., Ghisi, M., Willson, T. A., Horstmann, M. A., Aifantis, I., Cimmino, L., Frietze, S., den Boer, M. L., Mullighan, C. G., Smyth, G. K. & Dickins, R. A., 6 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 773-791 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of an inducible mouse model to reversibly silence Stat3

Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.

Research output: Contribution to journalArticleResearchpeer-review

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M., Kats, L. & 6 othersGearhart, M. D., Bardwell, V. J., Dickins, R. A., Hannan, R. D., Papenfuss, A. T. & Johnstone, R. W., 6 Mar 2017, In : Nature Communications. 8, 14581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic gatekeeper function of B-lymphoid transcription factors

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 othersRoss, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 23 Feb 2017, In : Nature. 542, 7642, p. 479-483 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., Grillo, I., Bakogianni, S., Ndiaye-Lobry, D., Martín, M. T., Guillamot, M., Banh, R. S., Xu, M., Figueroa, M. E., Dickins, R. A., Abdel-Wahab, O. & 4 othersPark, C. Y., Tsirigos, A., Neel, B. G. & Aifantis, I., 7 Sep 2017, In : Cell. 170, 6, p. 1079 - 1095.e20 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking Par1 into the Par3 locus reveals Par1 expression is not tolerated in mouse platelets

French, S. L., Paramitha, A. C., Moon, M. J., Dickins, R. A. & Hamilton, J. R., 1 Oct 2016, In : PLoS ONE. 11, 10, 14 p., e0165565.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia

Ghisi, M., Kats, L., Masson, F., Li, J., Kratina, T., Vidacs, E., Gilan, O., Doyle, M. A., Newbold, A., Bolden, J. E., Fairfax, K. A., de Graaf, C. A., Firth, M., Zuber, J., Dickins, R. A., Corcoran, L. M., Dawson, M. A., Belz, G. T. & Johnstone, R. W., 11 Jul 2016, In : Cancer Cell. 30, 1, p. 59-74 16 p.

Research output: Contribution to journalArticleResearchpeer-review

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

Pang, S. H. M., Minnich, M., Gangatirkar, P., Zheng, Z., Ebert, A., Song, G., Dickins, R. A., Corcoran, L. M., Mullighan, C. G., Busslinger, M., Huntington, N. D., Nutt, S. L. & Carotta, S., 2016, In : Leukemia. 30, 6, p. 1375-1387 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

Witkowski, M. T., Cimmino, L., Hu, Y., Trimarchi, T., Tagoh, H., McKenzie, M. D., Best, S. A., Tuohey, L., Willson, T. A., Nutt, S. L., Busslinger, M., Aifantis, I., Smyth, G. K. & Dickins, R. A., 2015, In : Leukemia. 29, p. 1301 - 1311 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Sheridan, J. M., Ritchie, M. E., Best, S. A., Jiang, K., Beck, T. J., Vaillant, F., Liu, K., Dickins, R. A., Smyth, G. K., Lindeman, G. J. & Visvader, J., 2015, In : BMC Cancer. 15, 1 (Art. No: 221), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

Lee, E. F., Takiguchi, M., Pettikiriarachchi, A., Evangelista, M., Huang, D. C. S., Dickins, R. A. & Fairlie, W. D., 12 Mar 2015, In : Cell Death and Disease. 6, 3 p., e1679.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

Churchman, M., Low, J., Qu, C., Paietta, E. M., Kasper, L. H., Chang, Y., Payne-Turner, D., Althoff, M. J., Song, G., Chen, S-C., Ma, J., Rusch, M., McGoldrick, D. J., Edmonson, M. N., Gupta, P. C., Wang, Y-D., Caufield, W., Freeman, B. B., Panetta, J. C., Baker, S. D. & 25 othersYang, Y-L., Roberts, K. G., McCastlain, K., Iacobucci, I., Peters, J. L., Centonze Frohlich, V. E., Notta, F., Dobson, S. M., Zandi, S., Dick, J. E., Janke, L. J., Peng, J., Kodali, K. K., Pagala, V. R., Min, J., Mayasundari, A., Williams, R. T., Willman, C. L., Rowe, J. M., Luger, S. M., Dickins, R. A., Guy, R. K., Chen, T., Mullighan, C. G. & Li, L., 2015, In : Cancer Cell. 28, 3, p. 343 - 356 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

Ho, P. W. M., Goradia, A., Russell, M. R., Chalk, A. M., Milley, K. M., Baker, E. K., Danks, J. A., Slavin, J. L., Walia, M. K., Crimeen-Irwin, B., Dickins, R. A., Martin, T. J. & Walkley, C. R., 2015, In : Oncogene. 34, 22, p. 2922 - 2933 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

Merino, D., Best, S. A., Asselin-Labat, M-L., Vaillant, F., Pal, B., Dickins, R. A., Anderson, R. L., Strasser, A., Bouillet, P., Lindeman, G. J. & Visvader, J., 2015, In : Oncogene. 34, 30, p. 3926 - 3934 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The class II PI 3-kinase, PI3KC2{alpha}, links platelet internal membrane structure to shear-dependent adhesive function

Mountford, J. K., Petitjean, C., Kusuma Putra, H. W., McCafferty, J. A., Setiabakti, N. M., Lee, H., Tonnesen, L. L., McFadyen, J. D., Schoenwaelder, S. M., Eckly, A., Gachet, C., Ellis, S. L., Voss, A. K., Dickins, R. A., Hamilton, J. R. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 6535), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

Chen, C., Liu, Y. K., Rappaport, A. R., Kitzing, T., Schultz, N., Zhao, Z., Shroff, A. S., Dickins, R. A., Vakoc, C. R., Bradner, J. E., Stock, W., LeBeau, M. M., Shannon, K. M., Kogan, S. C., Zuber, J. & Lowe, S. W., 2014, In : Cancer Cell. 25, p. 652 - 665 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

Liu, G. J., Cimmino, L., Jude, J. G., Hu, Y., Witkowski, M. T., McKenzie, M. D., Kartal-Kaess, M., Best, S. A., Tuohey, L., Liao, Y., Shi, W., Mullighan, C. G., Farrar, M. A., Nutt, S. L., Smyth, G. K., Zuber, J. & Dickins, R. A., 2014, In : Genes and Development. 28, p. 1337-1350 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ShRNA-seq data analysis with edgeR

Ritchie, M. E., Dai, Z., Sheridan, J. M., Gearing, L. J., Moore, D. L., Su, S., Dickins, R. A. & Blewitt, M. E., 2014, In : F1000Research. 3, 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Stage-specific control of early B cell development by the transcription factor Ikaros

Schwickert, T. A., Tagoh, H., Gultekin, S., Dakic, A., Axelsson, E., Minnich, M., Ebert, A., Werner, B., Roth, M., Cimmino, L., Dickins, R. A., Zuber, J., Jaritz, M. & Busslinger, M., 2014, In : Nature Immunology. 15, p. 283 - 293 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Waibel, M., Solomon, V. S., Knight, D. A., Ralli, R. A., Kim, S-K., Banks, K-M., Vidacs, E., Virely, C., Sia, K. C. S., Bracken, L. S., Collins-Underwood, R., Drenberg, C., Ramsey, L. B., Meyer, S. C., Takiguchi, M., Dickins, R. A., Levine, R., Ghysdael, J., Dawson, M. A., Lock, R. B. & 2 othersMullighan, C. G. & Johnstone, R. W., 2013, In : Cell Reports. 5, p. 1047 - 1059 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Modeling distinct osteosarcoma subtypes in vivo using Cre: Lox and lineage-restricted transgenic shRNA

Mutsaers, A. J., Ng, A. J. M., Baker, E. K., Russell, M. R., Chalk, A. M., Wall, M., Liddicoat, B. J. J., Ho, P. W. M., Slavin, J. L., Goradia, A., Martin, T. J., Purton, L. E., Dickins, R. A. & Walkley, C. R., 2013, In : Bone. 55, p. 166 - 178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

Newbold, A., Matthews, G. M., Bots, M., Cluse, L. A., Clarke, C. J. P., Banks, K-M., Cullinane, C. M., Bolden, J. E., Christiansen, A. J., Dickins, R. A., Miccolo, C., Chiocca, S., Kral, A. M., Ozerova, N. D., Miller, T. A., Methot, J. L., Richon, V. M., Secrist, J. P., Minucci, S. & Johnstone, R. W., 2013, In : Molecular Cancer Therapeutics. 12, p. 2709 - 2721 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Holmfeldt, L., Wei, L., Diaz-Flores, E., Walsh, M. F., Zhang, J., Ding, L., Payne-Turner, D., Churchman, M., Andersson, A., Chen, S-C., McCastlain, K., Becksfort, J., Ma, J., Wu, G., Patel, S. N., Heatley, S. L., Phillips, L. A., Song, G., Easton, J., Parker, M. & 43 othersChen, X., Rusch, M., Boggs, K., Vadodaria, B., Hedlund, E., Drenberg, C., Baker, S. D., Pei, D., Cheng, C., Huether, R., Lu, C., Fulton, R. S., Fulton, L. L., Tabib, Y., Dooling, D. J., Ochoa, K., Minden, M., Lewis, I. D., To, L. B., Marlton, P., Roberts, A. W., Raca, G., Stock, W., Neale, G., Drexler, H. G., Dickins, R. A., Ellison, D. W., Shurtleff, S. A., Pui, C-H., Ribeiro, R. C., Devidas, M., Carroll, A. J., Heerema, N. A., Wood, B., Borowitz, M. J., Gastier-Foster, J. M., Raimondi, S. C., Mardis, E. R., Wilson, R. K., Hunger, S. P., Downing, J. R., Loh, M. L-C. & Mullighan, C. G., 2013, In : Nature Genetics. 45, p. 242 - 252 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Takiguchi, M., Dow, L. E., Prier, J. E., Carmichael, C., Kile, B., Turner, S. J., Lowe, S. W., Huang, D. C. S. & Dickins, R. A., Jan 2013, In : PLoS ONE. 8, 1, 10 p., e54009.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2012

A pipeline for the generation of shRNA transgenic mice

Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J. & Lowe, S. W., 2012, In : Nature Protocols. 7, p. 374 - 393 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A rapid and scalable system for studying gene function in mice using conditional RNA interference

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C., Zuber, J., Dickins, R. A., Kogan, S. C., Shroyer, K. R., Sordella, R., Hannon, G. J. & Lowe, S. W., 2011, In : Cell. 145, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay

Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, C. D., Dickins, R. A., Xu, Q., Hengartner, M. O., Elledge, S. J., Hannon, G. J. & Lowe, S. W., 2011, In : Molecular Cell. 41, p. 733 - 746 14 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression

Xu, Y., Schnorrer, P., Proietto, A. I., Kowalski, G. M., Febbraio, M. A., Acha-Orbea, H., Dickins, R. A. & Villadangos, J. A., 2011, In : Journal of Immunology. 186, p. 3666 - 3673 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M. Q. & Lowe, S. W., 2010, In : Cancer Cell. 17, p. 376 - 387 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Transgenic, inducible RNAi in megakaryocytes and platelets in mice

Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. CS., Kile, B. & Dickins, R. A., 2010, In : Journal of Thrombosis and Haemostasis. 8, 1538-7933, p. 2751 - 2756 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Senescence of activated stellate cells limits liver fibrosis

Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L. & Lowe, S. W., 22 Aug 2008, In : Cell. 134, 4, p. 657-667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

Ha, L., Lchikawa, T., Anver, M. R., Dickins, R. A., Lowe, S. W., Sharpless, N. E., Krimpenfort, P. J. A., DePinho, R. A., Bennett, D. C., Sviderskaya, E. V. & Merlino, G. T., 2007, In : Proceedings of the National Academy of Sciences. 104, p. 10968 - 10973 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen, X., Zender, L., Miething, C., Dickins, R. A., Hernando-Monge, E. M., Krizhanovsky, V., Cordon-Cardo, C. & Lowe, S. W., 2007, In : Nature. 445, p. 656-660 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue-specific and reversible RNA interference in transgenic mice

Dickins, R. A., McJunkin, K., Hernando-Monge, E. M., Premsrirut, P. K., Krizhanovsky, V., Burgess, D. J., Kim, S. Y., Cordon-Cardo, C., Zender, L., Hannon, G. J. & Lowe, S. W., 2007, In : Nature Genetics. 39, p. 914 - 921 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations

Ramiro, A. R., Jankovic, M., Callen, E., Difilippantonio, S., Chen, H-T., McBride, K. M., Eisenreich, T. R., Chen, J., Dickins, R. A., Lowe, S. W., Nussenzweig, A. & Nussenzweig, M. C., 2006, In : Nature. 440, p. 105 - 109 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia

Yin, B., Kogan, S. C., Dickins, R. A., Lowe, S. W. & Largaespada, D. A., 2006, In : Experimental Hematology. 34, p. 631 - 641 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

Dickins, R. A., Hemann, M. T., Zilfou, J. T., Simpson, D. R., Hannon, G. J. & Lowe, S. W., 2005, In : Nature Genetics. 37, p. 1289 - 1295 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation

Quinn, L. M., Dickins, R. A., Coombe, M., Hime, G. R., Bowtell, D. D. L. & Richardson, H. E., 2004, In : Development. 131, p. 1411 - 1423 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Generation and analysis of Siah2 mutant mice

Frew, I. J., Hammond, V. E., Dickins, R. A., Quinn, J. M. W., Walkley, C. R., Sims, N. A., Schnall, R., Della, N. G., Holloway, A. J., Digby, M. R., Janes, P. W., Tarlinton, D. M., Purton, L. E., Gillespie, M. T. & Bowtell, D. D. L., 2003, In : Molecular and Cellular Biology. 23, 24, p. 9150 - 9161 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Normal p53 function in primary cells deficient for Siah genes

Frew, I. J., Dickins, R. A., Cuddihy, A. R., Del Rosario, M., Reinhard, C., O'Connell, M. J. & Bowtell, D. D. L., 2002, In : Molecular and Cellular Biology. 22, p. 8155 - 8164 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice

Dickins, R. A., Frew, I. J., House, C. M., O'Bryan, M. K., Holloway, A. J., Haviv, I., Traficante, N., de Kretser, D. M. & Bowtell, D. D. L., 2002, In : Molecular and Cellular Biology. 22, 7, p. 2294 - 2303 10 p.

Research output: Contribution to journalArticleResearchpeer-review