Projects per year
Personal profile
Biography
Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral fellow in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and transgenic mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Of particular interest is understanding how mutations in hematopoietic transcription factors impose the maturation block common to all acute leukemias, and novel strategies for triggering leukemia differentiation and clearance.
Related Links:
Keywords
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- Tumour suppressor genes
- Transcription factors
- Differentiation therapy
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2009 2020
Overcoming the differentiation block in acute myeloid leukaemia
Dickins, R. & Zuber, J.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/20
Project: Research
NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
Role of ZEB/NuRD interactions in Haematopoiesis and Lymphoid Malignancies
Haigh, J., Dickins, R. & Mecucci, C.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
Tumour suppressive mechanisms of CEBPA and PU.1 in acute myeloid leukaemia
Dickins, R., Ritchie, M. & Zuber, J.
National Health & Medical Research Council (NHMRC)
1/01/14 → 31/12/16
Project: Research
Research Output 2002 2019
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., Erlichster, M., Witkowski, M. T., Liu, G. J., Chopin, M., Dakic, A., Simankowicz, E., Pomilio, G., Vu, T., Krsmanovic, P., Su, S. & 21 others, 1 Aug 2019, In : Cell Stem Cell. 25, 2, p. 258-272.e9 24 p.Research output: Contribution to journal › Article › Research › peer-review
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT
Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D'Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., Belz, G. T., Naik, S. H., Lew, A. M., Bouillet, P., Herold, M. J., Smyth, G. K., Corcoran, L. M. & Nutt, S. L., 15 Jan 2019, In : Immunity. 50, 1, p. 77-90.e5 19 p.Research output: Contribution to journal › Article › Research › peer-review
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors (Nature (2017) DOI: 10.1038/nature21076)
Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 others, 28 Jun 2018, In : Nature. 558, 7711, p. E5 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
Witkowski, M. T., Hu, Y., Roberts, K. G., Boer, J. M., McKenzie, M. D., Liu, G. J., Le Grice, O. D., Tremblay, C., Ghisi, M., Willson, T. A., Horstmann, M. A., Aifantis, I., Cimmino, L., Frietze, S., den Boer, M. L., Mullighan, C. G., Smyth, G. K. & Dickins, R. A., 6 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 773-791 19 p.Research output: Contribution to journal › Article › Research › peer-review
Generation of an inducible mouse model to reversibly silence Stat3
Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.Research output: Contribution to journal › Article › Research › peer-review