20022020
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Personal profile

Biography

Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral fellow in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and transgenic mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Of particular interest is understanding how mutations in hematopoietic transcription factors impose the maturation block common to all acute leukemias, and novel strategies for triggering leukemia differentiation and clearance.

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Keywords

  • Acute myeloid leukaemia
  • Acute lymphoblastic leukaemia
  • Tumour suppressor genes
  • Transcription factors
  • Differentiation therapy

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Projects 2009 2020

Research Output 2002 2019

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D'Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., Belz, G. T., Naik, S. H., Lew, A. M., Bouillet, P., Herold, M. J., Smyth, G. K., Corcoran, L. M. & Nutt, S. L., 15 Jan 2019, In : Immunity. 50, 1, p. 77-90.e5 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors (Nature (2017) DOI: 10.1038/nature21076)

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 othersRoss, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 28 Jun 2018, In : Nature. 558, 7711, p. E5 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski, M. T., Hu, Y., Roberts, K. G., Boer, J. M., McKenzie, M. D., Liu, G. J., Le Grice, O. D., Tremblay, C., Ghisi, M., Willson, T. A., Horstmann, M. A., Aifantis, I., Cimmino, L., Frietze, S., den Boer, M. L., Mullighan, C. G., Smyth, G. K. & Dickins, R. A., 6 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 773-791 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of an inducible mouse model to reversibly silence Stat3

Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.

Research output: Contribution to journalArticleResearchpeer-review

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure, M., Tothill, R. W., Kruse, E., Hawkins, E. D., Shortt, J., Matthews, G. M., Gregory, G. P., Martin, B. P., Kelly, M. J., Todorovski, I., Doyle, M. A., Lupat, R., Li, J., Schroeder, J., Wall, M., Craig, S., Poortinga, G., Cameron, D., Bywater, M., Kats, L. & 6 othersGearhart, M. D., Bardwell, V. J., Dickins, R. A., Hannan, R. D., Papenfuss, A. T. & Johnstone, R. W., 6 Mar 2017, In : Nature Communications. 8, 14581.

Research output: Contribution to journalArticleResearchpeer-review

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