Projects per year
Personal profile
Biography
Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral fellow in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and transgenic mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Of particular interest is understanding how mutations in hematopoietic transcription factors impose the maturation block common to all acute leukemias, and novel strategies for triggering leukemia differentiation and clearance.
Related Links:
Research area keywords
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- Tumour suppressor genes
- Transcription factors
- Differentiation therapy
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Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
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Overcoming the differentiation block in acute myeloid leukaemia
Dickins, R. & Zuber, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
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Role of ZEB/NuRD interactions in Haematopoiesis and Lymphoid Malignancies
Haigh, J., Dickins, R. & Mecucci, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
Research output
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T-ALL can evolve to oncogene independence
Abdulla, H., Vo, A., Shields, B. J., Davies, T. J., Jackson, J. T., Alserihi, R., Viney, E. M., Wong, T., Yan, F., Wong, N. C., Demoen, L., Curtis, D. J., Alexander, W. S., Van Vlierberghe, P., Dickins, R. A. & McCormack, M. P., 22 Jan 2021, (Accepted/In press) In: Leukemia. 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Rerouting DOT1L inhibitors in leukemia
Dickins, R. A., 22 Oct 2020, In: Blood. 136, 17, p. 1900-1901 2 p.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
The EMT Modulator SNAI1 Contributes to AML Pathogenesis via Its Interaction With LSD1
Carmichael, C. L., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., Milne, A. R., Samuel, S., Gillinder, K., Hediyeh-Zadeh, S., Vo, N., Huang, Y., Knezevic, K., McInnes, W. R. L., Shields, B. J., Mitchell, H., Ritchie, M. E., Lammens, T., Lintermans, B., Van Vlierberghe, P. & 17 others, , 20 Aug 2020, In: Blood. 136, 8, p. 957-973 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., Erlichster, M., Witkowski, M. T., Liu, G. J., Chopin, M., Dakic, A., Simankowicz, E., Pomilio, G., Vu, T., Krsmanovic, P., Su, S. & 21 others, , 1 Aug 2019, In: Cell Stem Cell. 25, 2, p. 258-272.e9 24 p.Research output: Contribution to journal › Article › Research › peer-review
17 Citations (Scopus) -
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT
Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D'Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., Belz, G. T., Naik, S. H., Lew, A. M., Bouillet, P., Herold, M. J., Smyth, G. K., Corcoran, L. M. & Nutt, S. L., 15 Jan 2019, In: Immunity. 50, 1, p. 77-90.e5 19 p.Research output: Contribution to journal › Article › Research › peer-review
17 Citations (Scopus)