Projects per year
Personal profile
Biography
Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral scientist in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and in mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML). Of particular interest is understanding how mutations affecting transcription factors impose the maturation block in acute leukemia, and novel approaches to trigger leukemia differentiation and prevent relapse. His lab also studies how myeloid lineage antigen-presenting cells regulate T cell costimulation in autoimmunity and cancer.
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- Tumour suppressor genes
- Transcription factors
- Differentiation therapy
Network
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NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
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Modeling lymphocytic leukaemia and its treatment using RNA interference
Sylvia & Charles Viertel Charitable Foundation
1/01/11 → 31/12/15
Project: Research
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Mechanism of leukemia suppression by the transcription factor Ikaros
1/01/12 → 31/12/14
Project: Research
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Role of ZEB/NuRD interactions in Haematopoiesis and Lymphoid Malignancies
Haigh, J., Dickins, R. & Mecucci, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Investigating tumour maintenance using regulated RNA interference
1/01/09 → 31/12/11
Project: Research
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Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
Van Thillo, Q., De Bie, J., Seneviratne, J. A., Demeyer, S., Omari, S., Balachandran, A., Zhai, V., Tam, W. L., Sweron, B., Geerdens, E., Gielen, O., Provost, S., Segers, H., Boeckx, N., Marshall, G. M., Cheung, B. B., Isobe, K., Kato, I., Takita, J., Amos, T. G. & 10 others, , Dec 2021, In: Nature Communications. 12, 1, 15 p., 4164.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, C. D., Dickins, R. A., Xu, Q., Hengartner, M. O., Elledge, S. J., Hannon, G. J. & Lowe, S. W., 2011, In: Molecular Cell. 41, p. 733 - 746 14 p.Research output: Contribution to journal › Article › Research › peer-review
165 Citations (Scopus) -
IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression
Xu, Y., Schnorrer, P., Proietto, A. I., Kowalski, G. M., Febbraio, M. A., Acha-Orbea, H., Dickins, R. A. & Villadangos, J. A., 2011, In: Journal of Immunology. 186, p. 3666 - 3673 8 p.Research output: Contribution to journal › Article › Research › peer-review
37 Citations (Scopus) -
A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo
Lee, E. F., Takiguchi, M., Pettikiriarachchi, A., Evangelista, M., Huang, D. C. S., Dickins, R. A. & Fairlie, W. D., 12 Mar 2015, In: Cell Death & Disease. 6, 3 p., e1679.Research output: Contribution to journal › Letter › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Transgenic, inducible RNAi in megakaryocytes and platelets in mice
Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. CS., Kile, B. & Dickins, R. A., 2010, In: Journal of Thrombosis and Haemostasis. 8, 1538-7933, p. 2751 - 2756 6 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus)