Projects per year
Personal profile
Biography
Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral scientist in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and in mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML). Of particular interest is understanding how mutations affecting transcription factors impose the maturation block in acute leukemia, and novel approaches to trigger leukemia differentiation and prevent relapse. His lab also studies how myeloid lineage antigen-presenting cells regulate T cell costimulation in autoimmunity and cancer.
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- Tumour suppressor genes
- Transcription factors
- Differentiation therapy
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Overcoming the differentiation block in acute myeloid leukaemia
Dickins, R. & Zuber, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
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Role of ZEB/NuRD interactions in Haematopoiesis and Lymphoid Malignancies
Haigh, J., Dickins, R. & Mecucci, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
Ngo, S., Oxley, E. P., Ghisi, M., Garwood, M. M., McKenzie, M. D., Mitchell, H. L., Kanellakis, P., Susanto, O., Hickey, M. J., Perkins, A. C., Kile, B. T. & Dickins, R. A., Dec 2021, In: Nature Communications. 12, 1, 14 p., 6546.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
Van Thillo, Q., De Bie, J., Seneviratne, J. A., Demeyer, S., Omari, S., Balachandran, A., Zhai, V., Tam, W. L., Sweron, B., Geerdens, E., Gielen, O., Provost, S., Segers, H., Boeckx, N., Marshall, G. M., Cheung, B. B., Isobe, K., Kato, I., Takita, J., Amos, T. G. & 10 others, , Dec 2021, In: Nature Communications. 12, 1, 15 p., 4164.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
T-ALL can evolve to oncogene independence
Abdulla, H., Vo, A., Shields, B. J., Davies, T. J., Jackson, J. T., Alserihi, R., Viney, E. M., Wong, T., Yan, F., Wong, N. C., Demoen, L., Curtis, D. J., Alexander, W. S., Van Vlierberghe, P., Dickins, R. A. & McCormack, M. P., Aug 2021, In: Leukemia. 35, p. 2205–2219 15 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Rerouting DOT1L inhibitors in leukemia
Dickins, R. A., 22 Oct 2020, In: Blood. 136, 17, p. 1900-1901 2 p.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
The EMT Modulator SNAI1 Contributes to AML Pathogenesis via Its Interaction With LSD1
Carmichael, C. L., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., Milne, A. R., Samuel, S., Gillinder, K., Hediyeh-Zadeh, S., Vo, N., Huang, Y., Knezevic, K., McInnes, W. R. L., Shields, B. J., Mitchell, H., Ritchie, M. E., Lammens, T., Lintermans, B., Van Vlierberghe, P. & 17 others, , 20 Aug 2020, In: Blood. 136, 8, p. 957-973 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile13 Citations (Scopus)