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Ross Dickins

Assoc Professor

 https://orcid.org/0000-0003-4112-5304

Accepting PhD Students

20022022
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Personal profile

Biography

Ross is a laboratory head at the Australian Centre for Blood Diseases, a Monash University department at the Alfred Hospital. As a postdoctoral fellow in New York he helped develop RNA interference technology allowing reversible inhibition of endogenous gene expression in cultured cells and transgenic mice. His laboratory now uses these tools to investigate hematopoiesis and leukemia, focusing on genes recurrently mutated in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Of particular interest is understanding how mutations in hematopoietic transcription factors impose the maturation block common to all acute leukemias, and novel strategies for triggering leukemia differentiation and clearance.

Related Links:

Research area keywords

  • Acute myeloid leukaemia
  • Acute lymphoblastic leukaemia
  • Tumour suppressor genes
  • Transcription factors
  • Differentiation therapy

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Projects 2009 2022

Mechanisms of AML differentiation therapy response and relapse

Dickins, R.

1/01/20 → 31/12/22

Project: Research

Overcoming the differentiation block in acute myeloid leukaemia

Dickins, R. & Zuber, J.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/20

Project: Research

NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system

Tarlinton, D., O'Hehir, R., Cooper, M. E., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.

1/12/16 → 31/12/16

Project: Research

Role of ZEB/NuRD interactions in Haematopoiesis and Lymphoid Malignancies

Haigh, J., Dickins, R. & Mecucci, C.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/18

Project: Research

Transcriptional tumour suppression' by Pax5 and Ikaros in B progenitor acute lymphoblastic leukaemia

Dickins, R.

National Health & Medical Research Council (NHMRC)

1/05/15 → 30/04/18

Project: Research

Research Output 2002 2019

3 Citations (Scopus)

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., Erlichster, M., Witkowski, M. T., Liu, G. J., Chopin, M., Dakic, A., Simankowicz, E., Pomilio, G., Vu, T., Krsmanovic, P., Su, S. & 21 others, Tian, L., Baldwin, T. M., Zalcenstein, D. A., DiRago, L., Wang, S., Metcalf, D., Johnstone, R. W., Croker, B. A., Lancaster, G. I., Murphy, A. J., Naik, S. H., Nutt, S. L., Pospisil, V., Schroeder, T., Wall, M., Dawson, M. A., Wei, A. H., de Thé, H., Ritchie, M. E., Zuber, J. & Dickins, R. A., 1 Aug 2019, In : Cell Stem Cell. 25, 2, p. 258-272.e9 24 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D'Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., Belz, G. T., Naik, S. H., Lew, A. M., Bouillet, P., Herold, M. J., Smyth, G. K., Corcoran, L. M. & Nutt, S. L., 15 Jan 2019, In : Immunity. 50, 1, p. 77-90.e5 19 p.

Research output: Contribution to journal › Article › Research › peer-review

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors (Nature (2017) DOI: 10.1038/nature21076)

Chan, L. N., Chen, Z., Braas, D., Lee, J. W., Xiao, G., Geng, H., Cosgun, K. N., Hurtz, C., Shojaee, S., Cazzaniga, V., Schjerven, H., Ernst, T., Hochhaus, A., Kornblau, S. M., Konopleva, M., Pufall, M. A., Cazzaniga, G., Liu, G. J., Milne, T. A., Koeffler, H. P. & 7 others, Ross, T. S., Sánchez-García, I., Borkhardt, A., Yamamoto, K. R., Dickins, R. A., Graeber, T. G. & Müschen, M., 28 Jun 2018, In : Nature. 558, 7711, p. E5 1 p.

Research output: Contribution to journal › Comment / Debate › Other › peer-review

10 Citations (Scopus)

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski, M. T., Hu, Y., Roberts, K. G., Boer, J. M., McKenzie, M. D., Liu, G. J., Le Grice, O. D., Tremblay, C., Ghisi, M., Willson, T. A., Horstmann, M. A., Aifantis, I., Cimmino, L., Frietze, S., den Boer, M. L., Mullighan, C. G., Smyth, G. K. & Dickins, R. A., 6 Mar 2017, In : Journal of Experimental Medicine. 214, 3, p. 773-791 19 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Generation of an inducible mouse model to reversibly silence Stat3

Alorro, M. G., Pierce, T. P., Eissmann, M. F., Dijkstra, C., Dickins, R. A., Ernst, M., Buchert, M. & Masson, F., Apr 2017, In : Genesis. 55, 4, 10 p., e23023.

Research output: Contribution to journal › Article › Research › peer-review