Ron Firestein

Dr

20092024
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Research Output 2009 2018

2018

An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer

Bhakta, S., Crocker, L. M., Chen, Y., Hazen, M., Schutten, M. M., Li, D., Kuijl, C., Ohri, R., Zhong, F., Poon, K. A., Go, M. A. T., Cheng, E., Piskol, R., Firestein, R., Fourie-O'Donohue, A., Kozak, K. R., Raab, H., Hongo, J. A., Sampath, D., Dennis, M. S. & 3 othersScheller, R. H., Polakis, P. & Junutula, J. R., 1 Mar 2018, In : Molecular Cancer Therapeutics. 17, 3, p. 638-649 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

Daemen, A., Liu, B., Song, K., Kwong, M., Gao, M., Hong, R., Nannini, M., Peterson, D., Liederer, B. M., de la Cruz, C., Sangaraju, D., Jaochico, A., Zhao, X., Sandoval, W., Hunsaker, T., Firestein, R., Latham, S., Sampath, D., Evangelista, M. & Hatzivassiliou, G., 4 Sep 2018, In : Cell Metabolism. 28, 3, p. 383-399 27 p.

Research output: Contribution to journalArticleResearchpeer-review

PLK1 has tumor-suppressive potential in APC-Truncated colon cancer cells

Raab, M., Sanhaji, M., Matthess, Y., Hörlin, A., Lorenz, I., Dötsch, C., Habbe, N., Waidmann, O., Kurunci-Csacsko, E., Firestein, R., Becker, S. & Strebhardt, K., 1 Dec 2018, In : Nature Communications. 9, 1, 17 p., 1106.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Preclinical efficacy of an antibody-drug conjugate targeting mesothelin correlates with quantitative89 Zr-ImmunoPET

Van Terwisscha Scheltinga, A. G. T., Ogasawara, A., Pacheco, G., Vanderbilt, A. N., Tinianow, J. N., Gupta, N., Li, D., Firestein, R., Marik, J., Scales, S. J. & Williams, S-P., 1 Jan 2017, In : Molecular Cancer Therapeutics. 16, 1, p. 134-142 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the seeds of small cell lung cancer

Mahara, S. & Firestein, R., 1 Mar 2017, In : Annals of Translational Medicine. 5, 5, 113.

Research output: Contribution to journalArticleOtherpeer-review

2016

CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer

McCleland, M. L., Mesh, K., Lorenzana, E., Chopra, V. S., Segal, E., Watanabe, C., Haley, B., Mayba, O., Yaylaoglu, M., Gnad, F. & Firestein, R., 1 Feb 2016, In : Journal of Clinical Investigation. 126, 2, p. 639-652 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8

Bergeron, P., Koehler, M. F. T., Blackwood, E. M., Bowman, K., Clark, K., Firestein, R., Kiefer, J. R., Maskos, K., McCleland, M. L., Orren, L., Ramaswamy, S., Salphati, L., Schmidt, S., Schneider, E. V., Wu, J. & Beresini, M., 9 Jun 2016, In : A C S Medicinal Chemistry Letters. 7, 6, p. 595-600 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

Koehler, M. F. T., Bergeron, P., Blackwood, E. M., Bowman, K., Clark, K. R., Firestein, R., Kiefer, J. R., Maskos, K., McCleland, M. L., Orren, L., Salphati, L., Schmidt, S., Schneider, E. V., Wu, J. & Beresini, M. H., 10 Mar 2016, In : A C S Medicinal Chemistry Letters. 7, 3, p. 223-228 6 p.

Research output: Contribution to journalArticleResearchpeer-review

ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1

Williams, S-P., Ogasawara, A., Tinianow, J. N., Flores, J. E., Kan, D., Lau, J., Go, M. A., Vanderbilt, A. N., Gill, H. S., Miao, L., Goldsmith, J., Rubinfeld, B., Mao, W., Firestein, R., Yu, S. F., Marik, J. & Van Scheltinga, A. G. T. T., 1 May 2016, In : Oncotarget. 7, 18, p. 25103-25112 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Boudreau, A., Purkey, H. E., Hitz, A., Robarge, K., Peterson, D., Labadie, S., Kwong, M., Hong, R., Gao, M., Del Nagro, C., Pusapati, R., Ma, S., Salphati, L., Pang, J., Zhou, A., Lai, T., Li, Y., Chen, Z., Wei, B., Yen, I. & 1 othersFirestein, R., 1 Oct 2016, In : Nature Chemical Biology. 12, 10, p. 779-786 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Storm, E. E., Durinck, S., De Sousa E. Melo, F., Tremayne, J., Kljavin, N., Tan, C., Ye, X., Chiu, C., Pham, T. S., Hongo, J. A., Bainbridge, T., Firestein, R., Blackwood, E., Metcalfe, C., Stawiski, E. W., Yauch, R. L., Wu, Y. & De Sauvage, F. J., 7 Jan 2016, In : Nature. 529, 7584, p. 97-100 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

An Anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer

Leong, S. R., Liang, W. C., Wu, Y., Crocker, L., Cheng, E., Sampath, D., Ohri, R., Raab, H., Hass, P. E., Pham, T. S., Firestein, R., Li, D., Schutten, M., Stagg, N. J., Ogasawara, A., Koppada, N., Roth, L., Williams, S. P., Lee, B. C., Chalouni, C. & 5 othersPeng, I., Devoss, J., Tremayne, J., Polakis, P. & Polson, A. G., 1 Jun 2015, In : Molecular Pharmaceutics. 12, 6, p. 1717-1729 13 p.

Research output: Contribution to journalArticleResearchpeer-review

An antibody-drug conjugate directed against lymphocyte antigen 6 complex, locus E (LY6E) provides robust tumor killing in a wide range of solid tumor malignancies

Asundi, J., Crocker, L., Tremayne, J., Chang, P., Sakanaka, C., Tanguay, J., Spencer, S., Chalasani, S., Luis, E., Gascoigne, K., Desai, R., Raja, R., Friedman, B. A., Haverty, P. M., Polakis, P. & Firestein, R., 15 Jul 2015, In : Clinical Cancer Research. 21, 14, p. 3252-3262 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Castration-resistant Lgr5+ cells are long-lived stem cells required for prostatic regeneration

Wang, B. E., Wang, X., Long, J. E., Eastham-Anderson, J., Firestein, R. & Junttila, M. R., 12 May 2015, In : Stem Cell Reports. 4, 5, p. 768-779 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesis

McCleland, M. L., Soukup, T. M., Liu, S. D., Esensten, J. H., De Sousa E Melo, F., Yaylaoglu, M., Warming, S., Roose-Girma, M. & Firestein, R., 1 Dec 2015, In : Journal of Pathology. 237, 4, p. 508-519 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Yu, N., Kakunda, M., Pham, V., Lill, J. R., Du, P., Wongchenko, M., Yan, Y., Firestein, R. & Huang, X. D., 2015, In : Molecular and Cellular Biology. 35, 8, p. 1390-1400 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Preclinical development of an anti-NaPi2b (SLC34A2) antibody-drug conjugate as a therapeutic for non-small cell lung and ovarian cancers

Lin, K., Rubinfeld, B., Zhang, C., Firestein, R., Harstad, E., Roth, L., Tsai, S. P., Schutten, M., Xu, K., Hristopoulos, M. & Polakis, P., 15 Nov 2015, In : Clinical Cancer Research. 21, 22, p. 5139-5150 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer

Junttila, M. R., Mao, W., Wang, X., Wang, B. E., Pham, T. S., Flygare, J. A., Yu, S. F., Yee, S., Goldenberg, D. M., Fields, C., Eastham-Anderson, J., Singh, M., Vij, R., Hongo, J. A., Firestein, R., Schutten, M., Flagella, K., Polakis, P. & Polson, A. G., 18 Nov 2015, In : Science Translational Medicine. 7, 314, 11 p., 314ra186.

Research output: Contribution to journalArticleResearchpeer-review

Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer

Ryner, L., Guan, Y., Firestein, R., Xiao, Y., Choi, Y., Rabe, C., Lu, S., Fuentes, E., Huw, L. Y., Lackner, M. R., Fu, L., Amler, L. C., Bais, C. & Wang, Y., 1 Jul 2015, In : Clinical Cancer Research. 21, 13, p. 2941-2951 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

An antimesothelin-monomethyl auristatin E conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models

Scales, S. J., Gupta, N., Pacheco, G., Firestein, R., French, D. M., Koeppen, H., Rangell, L., Barry-Hamilton, V., Luis, E., Chuh, J., Zhang, Z-Y., Ingle, G. S., Fourie-O'Donohue, A., Kozak, K. R., Ross, S., Dennis, M. S. & Spencer, S., 1 Nov 2014, In : Molecular Cancer Therapeutics. 13, 11, p. 2630-2640 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

Adler, A. S., McCleland, M. L., Yee, S., Yaylaoglu, M., Hussain, S., Cosino, E., Quinones, G., Modrusan, Z., Seshagiri, S., Torres, E., Chopra, V. S., Haley, B., Zhang, Z., Blackwood, E. M., Singh, M., Junttila, M. R., Stephan, J. P., Liu, J., Pau, G., Fearon, E. R. & 2 othersJiang, Z. & Firestein, R., 2014, In : Genes and Development. 28, 10, p. 1068-1084 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

Liu, J., McCleland, M., Stawiski, E. W., Gnad, F., Mayba, O., Haverty, P. M., Durinck, S., Chen, Y-J., Klijn, C., Jhunjhunwala, S., Lawrence, M., Liu, H., Wan, Y., Chopra, V. S., Yaylaoglu, M. B., Yuan, W., Ha, C., Gilbert, H. N., Reeder, J., Pau, G. & 10 othersStinson, J., Stern, H. M., Manning, G., Wu, T. D., Neve, R. M., De Sauvage, F. J., Modrusan, Z., Seshagiri, S., Firestein, R. & Zhang, Z., 8 May 2014, In : Nature Communications. 5, 8 p., 3830.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oncogenic ERBB3 Mutations in Human Cancers

Jaiswal, B. S., Kljavin, N. M., Stawiski, E. W., Chan, E., Parikh, C., Durinck, S., Chaudhuri, S., Pujara, K., Guillory, J., Edgar, K. A., Janakiraman, V., Scholz, R. P., Bowman, K., Lorenzo, M., Li, H., Wu, J., Yuan, W., Peters, B. A., Kan, Z., Stinson, J. & 11 othersMak, M., Modrusan, Z., Eigenbrot, C., Firestein, R., Stern, H. M., Rajalingam, K., Schaefer, G., Merchant, M. A., Sliwkowski, M. X., deSauvage, F. J. & Seshagiri, S., 14 Apr 2014, In : Cancer Cell. 25, 4, p. 543-544 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2013

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: Case study of TENB2

Boswell, C. A., Mundo, E. E., Firestein, R., Zhang, C., Mao, W., Gill, H. S., Young, C., Ljumanovic, N., Stainton, S., Ulufatu, S., Fourie-O'Donohue, A., Kozak, K. R., Fuji, R., Polakis, P., Khawli, L. A. & Lin, K., Jan 2013, In : British Journal of Pharmacology. 168, 2, p. 445-457 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth

Lau, T., Chan, E., Callow, M., Waaler, J., Boggs, J., Blake, R. A., Magnuson, S., Sambrone, A., Schutten, M., Firestein, R., Machon, O., Korinek, V., Choo, E., Diaz, D., Merchant, M. A., Polakis, P., Holsworth, D. D., Krauss, S. & Costa, M., 15 May 2013, In : Cancer Research. 73, 10, p. 3132-3144 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas

McCleland, M. L., Adler, A. S., Deming, L., Cosino, E., Lee, L., Blackwood, E. M., Solon, M., Tao, J., Li, L., Shames, D., Jackson, E., Forrest, W. F. & Firestein, R., 15 Feb 2013, In : Clinical Cancer Research. 19, 4, p. 773-784 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oncogenic ERBB3 Mutations in Human Cancers

Jaiswal, B. S., Kljavin, N. M., Stawiski, E. W., Chan, E., Parikh, C., Durinck, S., Chaudhuri, S., Pujara, K., Guillory, J., Edgar, K. A., Janakiraman, V., Scholz, R. P., Bowman, K., Lorenzo, M., Li, H., Wu, J., Yuan, W., Peters, B. A., Kan, Z., Stinson, J. & 11 othersMak, M., Modrusan, Z., Eigenbrot, C., Firestein, R., Stern, H. M., Rajalingam, K., Schaefer, G., Merchant, M. A., Sliwkowski, M. X., deSauvage, F. J. & Seshagiri, S., 13 May 2013, In : Cancer Cell. 23, 5, p. 603-617 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer

McCleland, M. L., Adler, A. S., Shang, Y., Hunsaker, T., Truong, T., Peterson, D., Torres, E., Li, L., Haley, B., Stephan, J. P., Belvin, M., Hatzivassiliou, G., Blackwood, E. M., Corson, L., Evangelista, M., Zha, J. & Firestein, R., 15 Nov 2012, In : Cancer Research. 72, 22, p. 5812-5823 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency

Adler, A. S., McCleland, M. L., Truong, T., Lau, S., Modrusan, Z., Soukup, T. M., Roose-Girma, M., Blackwood, E. M. & Firestein, R., 15 Apr 2012, In : Cancer Research. 72, 8, p. 2129-2139 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma

Chen, Y., Chalouni, C., Tan, C., Clark, R., Venook, R., Ohri, R., Raab, H., Firestein, R., Mallet, W. & Polakis, P., 13 Jul 2012, In : Journal of Biological Chemistry. 287, 29, p. 24082-24091 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma

Asundi, J., Reed, C., Arca, J., McCutcheon, K., Ferrando, R., Clark, S., Luis, E., Tien, J., Firestein, R. & Polakis, P., 1 Mar 2011, In : Clinical Cancer Research. 17, 5, p. 965-975 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

CDK8 expression in 470 colorectal cancers in relation to β-catenin activation, other molecular alterations and patient survival

Firestein, R., Shima, K., Nosho, K., Irahara, N., Baba, Y., Bojarski, E., Giovannucci, E. L., Hahn, W. C., Fuchs, C. S. & Ogino, S., 15 Jun 2010, In : International Journal of Cancer. 126, 12, p. 2863-2873 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CK1ε is required for breast cancers dependent on β-catenin activity

Kim, S. Y., Dunn, I. F., Firestein, R., Gupta, P., Wardwell, L., Repich, K., Schinzel, A. C., Wittner, B., Silver, S. J., Root, D. E., Boehm, J. S., Ramaswamy, S., Lander, E. S. & Hahn, W. C., 1 Feb 2010, In : PLoS ONE. 5, 2, 10 p., e8979.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2009

Integrative genomic approaches to understanding cancer

Hahn, W. C., Dunn, I. F., Kim, S. Y., Schinzel, A. C., Firestein, R., Guney, I. & Boehm, J. S., Jun 2009, In : Biochimica et Biophysica Acta. General Subjects. 1790, 6, p. 478-484 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Revving the throttle on an oncogene: CDK8 takes the driver seat

Firestein, R. & Hahn, W. C., 15 Oct 2009, In : Cancer Research. 69, 20, p. 7899-7901 3 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer

Nosho, K., Shima, K., Irahara, N., Kure, S., Firestein, R., Baba, Y., Toyoda, S., Chen, L., Hazra, A., Giovannucci, E. L., Fuchs, C. S. & Ogino, S., Jul 2009, In : Modern Pathology. 22, 7, p. 922-932 11 p.

Research output: Contribution to journalArticleResearchpeer-review