Projects per year
Personal profile
Biography
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Research interests
HCMV is a β-herpesvirus that infects over 60% of the adult population. HCMV becomes latent after a primary infection, and can periodically re-activate for reasons still unknown. HCMV is a significant cause of morbidity and mortality in immuno-compromised individuals such as organ transplant recipients. However, the largest burden of disease occurs from intrauterine HCMV transmission during pregnancy. This occurs in at least 1% of pregnancies worldwide, and can cause permanent hearing loss, vision impairment, and mental retardation. There is no vaccine currently available, and discovery of new antivirals is urgently required. Importantly, the process by which infectious virus is packaged and released is not well understood, and this presents a novel molecular loci to develop potential antiviral therapeutics.
We use a hybrid multidisciplinary approach integrating virology, molecular biology, microscopy, proteomics, and bioinformatics to study viral pathognesis. Research in the lab is dedicated towards defining:
- Critical host-viral protein interactions
- Viral proteins mediating host organelle remodelling
- Hijacking of host molecular pathways involved in virion egress
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Virology
- Molecular Biology
- Proteomics
- Mass spectrometry
- Host-pathogen interactions
Network
Projects
- 2 Finished
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Sirtuins and Pathogenesis of Human Cytomegalovirus
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 16/12/16
Project: Research
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A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridium sordellii
Vidor, C. J., Hamiot, A., Wisniewski, J., Mathias, R. A., Dupuy, B., Awad, M. & Lyras, D., Feb 2022, In: Toxins. 14, 2, 19 p., 124.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction
Turner, D. L. & Mathias, R. A., 25 Nov 2022, In: Frontiers in Cell and Developmental Biology. 10, 34 p., 1053139.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access -
UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation
Turner, D. L., Templin, R. M., Barugahare, A. A., Russ, B. E., Turner, S. J., Ramm, G. & Mathias, R. A., 1 May 2022, In: International Journal of Molecular Sciences. 23, 10, 21 p., 5773.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
UL49 is an essential subunit of the viral pre-initiation complex that regulates human cytomegalovirus gene transcription
Turner, D. L., Fritzlar, S., Sadeghipour, S., Barugahare, A. A., Russ, B. E., Turner, S. J. & Mathias, R. A., 21 Oct 2022, In: iScience. 25, 10, 17 p., 105168.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The host exosome pathway underpins biogenesis of the human cytomegalovirus virion
Turner, D. L., Korneev, D. V., Purdy, J. G., de Marco, A. & Mathias, R. A., 10 Sep 2020, In: eLife. 9, 29 p., e58288.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile18 Citations (Scopus)