• 23 Innovation Walk, 77 Room 245

    3800 Clayton

    Australia

Accepting PhD Students

20092018
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Research interests

HCMV is a β-herpesvirus that infects over 60% of the adult population. HCMV becomes latent after a primary infection, and can periodically re-activate for reasons still unknown. HCMV is a significant cause of morbidity and mortality in immuno-compromised individuals such as organ transplant recipients. However, the largest burden of disease occurs from intrauterine HCMV transmission during pregnancy. This occurs in at least 1% of pregnancies worldwide, and can cause permanent hearing loss, vision impairment, and mental retardation. There is no vaccine currently available, and discovery of new antivirals is urgently required. Importantly, the process by which infectious virus is packaged and released is not well understood, and this presents a novel molecular loci to develop potential antiviral therapeutics.

We use a hybrid multidisciplinary approach integrating virology, molecular biology, microscopy, proteomics, and bioinformatics to study viral pathognesis. Research in the lab is dedicated towards defining:

  • Critical host-viral protein interactions
  • Viral proteins mediating host organelle remodelling
  • Hijacking of host molecular pathways involved in virion egress

Keywords

  • Virology
  • Molecular Biology
  • Proteomics
  • Mass spectrometry
  • Host-pathogen interactions

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2018

Research Output 2009 2018

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract

Rabi, R., Larcombe, S., Mathias, R., McGowan, S., Awad, M. & Lyras, D., 18 Apr 2018, In : PLoS Pathogens. 14, 4, 25 p., e1007004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Extracellular vesicles: Their role in cancer biology and epithelial-mesenchymal transition

Gopal, S. K., Greening, D. W., Rai, A., Chen, M., Xu, R., Shafiq, A., Mathias, R. A., Zhu, H. J. & Simpson, R. J., 1 Jan 2017, In : Biochemical Journal. 474, 1, p. 21-45 25 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Herpesviruses hijack host exosomes for viral pathogenesis

Sadeghipour, S. & Mathias, R. A., Jun 2017, In : Seminars in Cell and Developmental Biology. 67, p. 91-100 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly

Pastino, A. K., Greco, T. M., Mathias, R., Cristea, I. M. & Schwarzbauer, J. E., May 2017, In : Matrix Biology. 59, p. 39-53 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection

Jean Beltran, P. M., Mathias, R. A. & Cristea, I. M., 26 Oct 2016, In : Cell Systems. 3, 4, p. 361-373 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File