Projects per year
Personal profile
Biography
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Research interests
HCMV is a β-herpesvirus that infects over 60% of the adult population. HCMV becomes latent after a primary infection, and can periodically re-activate for reasons still unknown. HCMV is a significant cause of morbidity and mortality in immuno-compromised individuals such as organ transplant recipients. However, the largest burden of disease occurs from intrauterine HCMV transmission during pregnancy. This occurs in at least 1% of pregnancies worldwide, and can cause permanent hearing loss, vision impairment, and mental retardation. There is no vaccine currently available, and discovery of new antivirals is urgently required. Importantly, the process by which infectious virus is packaged and released is not well understood, and this presents a novel molecular loci to develop potential antiviral therapeutics.
We use a hybrid multidisciplinary approach integrating virology, molecular biology, microscopy, proteomics, and bioinformatics to study viral pathognesis. Research in the lab is dedicated towards defining:
- Critical host-viral protein interactions
- Viral proteins mediating host organelle remodelling
- Hijacking of host molecular pathways involved in virion egress
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Virology
- Molecular Biology
- Proteomics
- Mass spectrometry
- Host-pathogen interactions
Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Blocking Human Cytomegalovirus: Targeting Host Organelle Remodelling and the Viral AssemblyComplex
Mathias, R. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Sirtuins and Pathogenesis of Human Cytomegalovirus
Mathias, R. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 16/12/16
Project: Research
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Bacterial flagella hijack type IV pili proteins to control motility
Liu, X., Tachiyama, S., Zhou, X., Mathias, R. A., Bonny, S. Q., Khan, M. F., Xin, Y., Roujeinikova, A., Liu, J. & Ottemann, K. M., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 4, 7 p., e2317452121.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation
Ashley, C. L., McSharry, B. P., McWilliam, H. E. G., Stanton, R. J., Fielding, C. A., Mathias, R. A., Fairlie, D. P., McCluskey, J., Villadangos, J. A., Rossjohn, J., Abendroth, A. & Slobedman, B., 10 Feb 2023, In: Frontiers in Immunology. 14, 13 p., 1107497.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridium sordellii
Vidor, C. J., Hamiot, A., Wisniewski, J., Mathias, R. A., Dupuy, B., Awad, M. & Lyras, D., Feb 2022, In: Toxins. 14, 2, 19 p., 124.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction
Turner, D. L. & Mathias, R. A., 25 Nov 2022, In: Frontiers in Cell and Developmental Biology. 10, 34 p., 1053139.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access9 Citations (Scopus) -
UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation
Turner, D. L., Templin, R. M., Barugahare, A. A., Russ, B. E., Turner, S. J., Ramm, G. & Mathias, R. A., 1 May 2022, In: International Journal of Molecular Sciences. 23, 10, 21 p., 5773.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)