Projects per year
Personal profile
Biography
My training commenced at the University of Vienna (Austria) where I completed a Masters in Nutrition Science in 2005 and a PhD in Medical Sciences in 2012.
My PhD specialized in endocrinology and metabolism with a particular focus on Diabetes. I conducted my PhD research training at Yale University under the guidance of two world leaders in diabetes/obesity research, Prof. Roden (German Diabetes Center, Germany) and Prof. Shulman (Yale University, USA). In Prof. Shulman's lab, I worked in mitochondrial metabolism and focused on how cells sense energy. I closely worked together with Prof. Shulman's research fellow at this time, A./Prof. Kibbey (Yale University, USA), a pioneer of the 'mitochondrial-GTP (mtGTP) theory' as an energy-sensor and an expert in isotopologue mass spectrometry. I learned to develop novel methodologies to address key research questions. For example, I designed a method to measure mitochondrial substrate flux using mass spectrometry. My research skills do not only include in vivo measurements of complex physiological parameters (e.g. rodent hyperinsulinemic-euglycemic clamps), but also in vitro research in several cell systems and metabolomics using mass spectrometry. My PhD work focused on the role of mitochondrial PEPCK (PEPCK-M) in glucose homeostasis and raised novel aspects about its function, which was highlighted as a key discovery by its inclusion in the Journal of Biological Chemistry Thematic Minireview of PEPCK.
In September 2009 I moved to Australia and joined A./Prof. Watt (Monash University) as a research assistant in the field of lipid metabolism. After I completed my PhD studies in 2012, I joined the lab of Dr Zane Andrews (Monash University, Australia).
Currently, I am a National Health Medical Research Council (NHMRC) Early Career Fellow and investigate neural mechanisms regulating food intake and weight, and how metabolic cues in the brain regulate peripheral tissues in order to maintain energy balance.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medical Sciences, PhD
Award Date: 3 Jul 2012
Science of nutrition, Master of science, University of Vienna
Award Date: 30 Jun 2005
Research area keywords
- Diabetes
- Obesity
- glucose metabolism
- Mitochondria
Network
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Targeting the brain and sympathetic nervous system to improve outcomes in cancer cachexia
Lockie, S., Marks, D., Walton, K., Andrews, Z., Stark, R., Oldfield, B., Sloan, E. & Gregorevic, P.
1/01/22 → 31/12/25
Project: Research
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How does the brain sense low blood glucose and switch on corrective actions?
1/08/19 → 31/07/23
Project: Research
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Is ghrelin signaling in the ventromedial hypothalamus responsible for detecting hypoglycemia?
8/05/17 → 14/05/17
Project: Research
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AAS France-Australia Science Innovation Collaboration (FASIC) Program - Rod Rickards Fellowship Scheme
31/08/15 → 25/09/15
Project: Research
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Itle: An open-source device for measuring food intake and operant behavior in rodent home-cages
Matikainen-Ankney, B. A., Earnest, T., Ali, M., Casey, E., Wang, J. G., Sutton, A. K., Legaria, A. A., Barclay, K. M., Murdaugh, L. B., Norris, M. R., Chang, Y. H., Nguyen, K. P., Lin, E., Reichenbach, A., Clarke, R. E., Stark, R., Conway, S. M., Carvalho, F., Al-Hasani, R., McCall, J. G. & 6 others, , Mar 2021, In: eLife. 10, 18 p., e66173.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
The hunger games: Homeostatic state-dependent fluctuations in disinhibition measured with a novel gamified test battery
Voigt, K., Giddens, E., Stark, R., Frisch, E., Moskovsky, N., Kakoschke, N., Stout, J. C., Bellgrove, M. A., Andrews, Z. B. & Verdejo-Garcia, A., 10 Jun 2021, In: Nutrients. 13, 6, 14 p., 2001.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health
Abulizi, A., Cardone, R. L., Stark, R., Lewandowski, S. L., Zhao, X., Hillion, J., Ma, L., Sehgal, R., Alves, T. C., Thomas, C., Kung, C., Wang, B., Siebel, S., Andrews, Z. B., Mason, G. F., Rinehart, J., Merrins, M. J. & Kibbey, R. G., 3 Nov 2020, In: Cell Metabolism. 32, 5, p. 751-766 16 p.Research output: Contribution to journal › Article › Research › peer-review
14 Citations (Scopus) -
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans
Hornsby, A. K. E., Buntwal, L., Carisi, M. C., Santos, V. V., Johnston, F., Roberts, L. D., Sassi, M., Mequinion, M., Stark, R., Reichenbach, A., Lockie, S. H., Siervo, M., Howell, O., Morgan, A. H., Wells, T., Andrews, Z. B., Burn, D. J. & Davies, J. S., 20 Oct 2020, In: Cell Reports Medicine. 1, 7, p. 1-e9 23 p., 100120.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area
Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., Jul 2019, In: Journal of Neuroendocrinology. 31, 7, 6 p., e12696.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)