Romana Stark

Dr

Accepting PhD Students

20072023
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Personal profile

Biography

 

My training commenced at the University of Vienna (Austria) where I completed a Masters in Nutrition Science in 2005 and a PhD in Medical Sciences in 2012.

My PhD specialized in endocrinology and metabolism with a particular focus on Diabetes. I conducted my PhD research training at Yale University under the guidance of two world leaders in diabetes/obesity research, Prof. Roden (German Diabetes Center, Germany) and Prof. Shulman (Yale University, USA). In Prof. Shulman's lab, I worked in mitochondrial metabolism and focused on how cells sense energy. I closely worked together with Prof. Shulman's research fellow at this time, A./Prof. Kibbey (Yale University, USA), a pioneer of the 'mitochondrial-GTP (mtGTP) theory' as an energy-sensor and an expert in isotopologue mass spectrometry. I learned to develop novel methodologies to address key research questions. For example, I designed a method to measure mitochondrial substrate flux using mass spectrometry. My research skills do not only include in vivo measurements of complex physiological parameters (e.g. rodent hyperinsulinemic-euglycemic clamps), but also in vitro research in several cell systems and metabolomics using mass spectrometry. My PhD work focused on the role of mitochondrial PEPCK (PEPCK-M) in glucose homeostasis and raised novel aspects about its function, which was highlighted as a key discovery by its inclusion in the Journal of Biological Chemistry Thematic Minireview of PEPCK. 

In September 2009 I moved to Australia and joined A./Prof. Watt (Monash University) as a research assistant in the field of lipid metabolism. After I completed my PhD studies in 2012, I joined the lab of Dr Zane Andrews (Monash University, Australia). 

Currently, I am a National Health Medical Research Council (NHMRC) Early Career Fellow and investigate neural mechanisms regulating food intake and weight, and how metabolic cues in the brain regulate peripheral tissues in order to maintain energy balance.

Education/Academic qualification

Medical Sciences, PhD

Science of nutrition, Master of science, University of Vienna

Research area keywords

  • Diabetes
  • Obesity
  • glucose metabolism
  • Mitochondria

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Projects 2015 2023

Research Output 2007 2019

Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area

Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., Jul 2019, In : Journal of Neuroendocrinology. 31, 7, 6 p., e12696.

Research output: Contribution to journalArticleResearchpeer-review

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S. & Andrews, Z. B., 1 Dec 2018, In : FASEB Journal. 32, 12, p. 6923-6933 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice

Reichenbach, A., Mequinion, M., Bayliss, J. A., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Stark, R. & Andrews, Z. B., 1 Jun 2018, In : Endocrinology. 159, 6, p. 2473-2483 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

Lockie, S. H., Stark, R., Mequinion, M., Ch'ng, S., Kong, D., Spanswick, D. C., Lawrence, A. J. & Andrews, Z. B., 1 Nov 2018, In : Endocrinology. 159, 11, p. 3605-3614 10 p.

Research output: Contribution to journalArticleResearchpeer-review