19862011
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Research Output 1986 2011

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2011
7 Citations (Scopus)

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis

Sundaram, K., Dhagat, U., Endo, S., Chung, R., Matsunaga, T., Hara, A. & El-Kabbani, O., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 2, p. 801 - 804 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
15 Citations (Scopus)

Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor

Carbone, V., Giglio, M., Chung, R., Huyton, T., Adams, J., Maccari, R., Ottana, R., Hara, A. & El-Kabbani, O., 2010, In : European Journal of Medicinal Chemistry. 45, 3, p. 1140 - 1145 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
16 Citations (Scopus)

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase

Carbone, V., Zhao, H-T., Chung, R. P-T., Endo, S., Hara, A. & El-Kabbani, O., 2009, In : Bioorganic & Medicinal Chemistry. 17, 3, p. 1244 - 1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14)

Chung, R. P-T., Endo, S., Hara, A. & El-Kabbani, O., 2009, In : Acta Crystallographica. Section F: Structural Biology Communications. 65, Pt 4, p. 395 - 397 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase

Zhao, H-T., Endo, S., Ishikura, S., Chung, R. P-T., Hogg, P. J., Hara, A. & El-Kabbani, O., 2009, In : Cellular and Molecular Life Sciences. 66, 9, p. 1570 - 1579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
11 Citations (Scopus)
9 Citations (Scopus)

Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis

Carbone, V., Endo, S., Sumii, R., Chung, R. P-T., Matsunaga, T., Hara, A. & El-Kabbani, O., 2008, In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 176 - 187 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
24 Citations (Scopus)

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase

Dhagat, U., Carbone, V., Chung, R. P-T., Matsunaga, T., Endo, S., Hara, A. & El-Kabbani, O., 2007, In : Medicinal Chemistry. 3, 6, p. 546 - 550 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme

Dhagat, U., Carbone, V., Chung, R. P-T., Schulze-Briese, C., Endo, S., Hara, A. & El-Kabbani, O., 2007, In : Acta Crystallographica. Section F: Structural Biology Communications. 63, p. 825 - 830 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
47 Citations (Scopus)

Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex

Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R. P-T., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A. & Podjarny, A. D., 2005, In : Journal of Medicinal Chemistry. 48, 18, p. 5659 - 5665 7 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity

El-Kabbani, O., Carbone, V., Darmanin, C., Oka, M., Mitschler, A., Podjarny, A. D., Schulze-Briese, C. & Chung, R. P-T., 2005, In : Journal of Medicinal Chemistry. 48, 17, p. 5536 - 5542 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
86 Citations (Scopus)

Aldose reductase structures: implications for mechanism and inhibition

El-Kabbani, O., Ruiz, F., Darmanin, C. & Chung, R. P-T., 2004, In : Cellular and Molecular Life Sciences. 61, 7-Aug, p. 750 - 762 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis

El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R. P-T., Usami, N. & Hara, A., 2004, In : Proteins: Structure, Function, and Bioinformatics. 55, 3, p. 724 - 732 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Sorbitol Dehydrogenase: Structure, Function and Ligand Design

El-Kabbani, O., Darmanin, C. & Chung, R. P-T., 2004, In : Current Medicinal Chemistry. 11, 4, p. 465 - 476 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
3 Citations (Scopus)

Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase

Darmanin, C., Iwata, T., Carper, D. A., Sparrow, L. G., Chung, R. P-T. & El-Kabbani, O., 2003, In : Acta Crystallographica Section D: Biological Crystallography. D59, p. 558 - 560 3 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme

El-Kabbani, O., Ramsland, P. A., Darmanin, C., Chung, R. P-T. & Podjarny, A. D., 2003, In : Proteins: Structure, Function, and Bioinformatics. 50, 2, p. 230 - 238 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
5 Citations (Scopus)

Crystallization and preliminary crystallographic analysis of human L-xylulose reductase

El-Kabbani, O., Chung, R. P-T., Ishikura, S., Usami, N., Nakagawa, J. & Hara, A., 2002, In : Acta Crystallographica Section D: Biological Crystallography. D58, Part 8, p. 1379 - 1380 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase

El-Kabbani, O., Chung, R. P-T., Ramsland, P. A., Asada, Y., Ishikura, S., Usami, N. & Hara, A., 2002, In : Acta Crystallographica Section D: Biological Crystallography. D58, Part 1, p. 163 - 164 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
24 Citations (Scopus)

Aldose and aldehyde reductases:correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site

El-Kabbani, O., Rogniaux, H., Barth, P., Chung, R. P-T., Fletcher, E. V., Van Dorsselaer, A. & Podjarny, A., 2000, In : Proteins: Structure, Function, and Bioinformatics. p. 407 - 414 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystallization and preliminary x-ray analysis of porcine aldehyde reductase in complex with coenzyme and quercetin

El-Kabbani, O. & Chung, R. P-T., 2000, In : Protein and Peptide Letters. p. 201 - 206 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1997
30 Citations (Scopus)

Purification and characterization of basic proteins with in vitro antifungal activity from seeds of cotton, Gossypium hirsutum

Chung, R. P. T., Neumann, G. M. & Polya, G. M., 27 Aug 1997, In : Plant Science. 127, 1, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
54 Citations (Scopus)

Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine

Riffkin, C. D., Chung, R., Wall, D. M., Zalcberg, J. R., Cowman, A. F., Foley, M. & Tilley, L., 22 Nov 1996, In : Biochemical Pharmacology. 52, 10, p. 1545-1552 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
3 Citations (Scopus)

Radical-Induced Decomposition of Dimethyl-n-(2-cyano-2-propyl)Ketenimine

Chung, R. P. T., Danek, S. K., Quach, C. & Solomon, D. H., 1 Mar 1994, In : Journal of Macromolecular Science, Part A. 31, 3, p. 329-337 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
9 Citations (Scopus)

Copurification and characterisation of poppy seed phosphatase and phosphoprotein phosphatase activities

Chung, R. P. T. & Polya, G. M., 1 Jan 1992, In : Plant Science. 84, 2, p. 153-162 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Purification and characterization of wheat and pine small basic protein substrates for plant calcium-dependent protein kinase

Polya, G. M., Chandra, S., Chung, R., Neumann, G. M. & Höj, P. B., 17 Apr 1992, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1120, 3, p. 273-280 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Recent developments in free-radical polymerization - a mini review

Chung, R. P. T. & Solomon, D. H., 20 Dec 1992, In : Progress in Organic Coatings. 21, 2-3, p. 227-254 28 p.

Research output: Contribution to journalArticleResearchpeer-review

1991
34 Citations (Scopus)

Resolution of a higher plant protein kinase similar to the catalytic subunit of cyclic AMP-dependent protein kinase

Polya, G. M., Chung, R. & Menting, J., 1 Jan 1991, In : Plant Science. 79, 1, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1990
22 Citations (Scopus)

Micellar Catalysis of Organic Reactions. 27. Micellar Bound Meisenheimer Complexes

Broxton, T. J. & Chung, R. P. T., 1 Jan 1990, In : Journal of Organic Chemistry. 55, 12, p. 3886-3890 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1989
9 Citations (Scopus)

Micellar catalysis of organic reactions. 24. Comparison of SNAr reactions in hydroxy‐functionalized micelles and in the presence of cyclodextrins

Broxton, T. J., Christie, J. R. & Chung, R. P. T., 1 Jan 1989, In : Journal of Physical Organic Chemistry. 2, 7, p. 519-530 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1988
48 Citations (Scopus)

Micellar Catalysis of Organic Reactions. 23. Effect of Micellar Orientation of the Substrate on the Magnitude of Micellar Catalysis

Broxton, T. J., Christie, J. R. & Chung, R. P. T., 1 Jan 1988, In : Journal of Organic Chemistry. 53, 13, p. 3081-3084 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1986
13 Citations (Scopus)

Micellar Catalysis of Organic Reactions. 19. Basic Hydrolysis of Carbamates in the Presence of Hydroxy-Functionalized Micelles

Broxton, T. J. & Chung, R. P. T., 1 Jan 1986, In : Journal of Organic Chemistry. 51, 16, p. 3112-3115 4 p.

Research output: Contribution to journalArticleResearchpeer-review