If you made any changes in Pure these will be visible here soon.

Research Output 1969 2019

Filter
Article
2009

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3

Summers, R. J., Bathgate, R. A. D., Wade, J. D., van der Westhuizen, E. T. & Halls, M. L., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 99 - 104 6 p.

Research output: Contribution to journalArticleResearchpeer-review

RXFP1 couples to the Galphai3-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail

Halls, M. L., Papaioannou, M., Wade, J. D., Evans, B. A., Bathgate, R. A. D. & Summers, R. J., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 117 - 120 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2008, In : Brain Research Bulletin. 76, 3, p. 224 - 234 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism

Gibbs, M. E., Bowser, D. N., Hutchinson, D. S., Loiacono, R. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, 12, p. 2831 - 2846 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 2008, In : Pharmacology and Therapeutics. 119, 3, p. 291 - 310 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin family peptide receptors - from orphans to therapeutic targets

van der Westhuizen, E. T., Halls, M. L., Samuel, C. S., Bathgate, R., Unemori, E. N., Sutton, S. W. & Summers, R. J., 2008, In : Drug Discovery Today. 13, 15-16, p. 640 - 651 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, p. 2384 - 2397 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The rush to adrenaline: Drugs in sport acting on the beta-adrenergic system

Davis, E. A., Loiacono, R. & Summers, R. J., 2008, In : British Journal of Pharmacology. 154, 3, p. 584 - 597 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

beta2- and beta3-Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: A mechanism for memory enhancement?

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2007, In : Journal of Neurochemistry. 103, 3, p. 997 - 1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes

Halls, M. L., Bathgate, R. & Summers, R. J., 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 281 - 290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2007, In : Biochemical Society Transactions. 35, Pt 5, p. 1035 - 1037 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes

Moore, X-L., Tan, S-L., Lo, C-Y., Fang, L., Su, Y-D., Gao, X-M., Woodcock, E. A., Summers, R. J., Tregear, G. W., Bathgate, R. & Du, X-J., 2007, In : Endocrinology. 148, 4, p. 1582 - 1589 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin family peptide receptors - Former orphans reunite with their parent ligands to activate multiple signalling pathways

Halls, M. L., van der Westhuizen, E. T., Bathgate, R. & Summers, R. J., 2007, In : British Journal of Pharmacology. 150, 6, p. 677 - 691 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin receptors - new drug targets for multiple disease states

van der Westhuizen, E. T., Summers, R. J., Halls, M. L., Bathgate, R. & Sexton, P., 2007, In : Current Drug Targets. 8, 1, p. 91 - 104 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism

van der Westhuizen, E. T., Werry, T. D., Sexton, P. & Summers, R. J., 2007, In : Molecular Pharmacology. 71, 6, p. 1618 - 1629 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Agonist effects of zinterol at the mouse and human beta3-adrenoceptor

Hutchinson, D. S., Chernogubova, E., Sato, M., Summers, R. J. & Bengtsson, T., 2006, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 373, 2, p. 158 - 168 11 p.

Research output: Contribution to journalArticleResearchpeer-review

International union of pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides

Bathgate, R., Ivell, R., Sanborn, B. M., Sherwood, O. D. & Summers, R. J., 2006, In : Pharmacological Reviews. 58, 1, p. 7 - 31 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells

Nevzorova, J., Evans, B. A., Bengtsson, T. & Summers, R. J., 2006, In : British Journal of Pharmacology. 147, 4, p. 446 - 454 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

Halls, M. L., Bathgate, R. A. D. & Summers, R. J., 2006, In : Molecular Pharmacology. 70, 1, p. 214 - 226 13 p.

Research output: Contribution to journalArticleResearchpeer-review

'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease

Samuel, C. S., Du, X-J., Bathgate, R. A. D. & Summers, R. J., 2006, In : Pharmacology and Therapeutics. 112, 2, p. 529 - 552 24 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Contrasting roles for beta1, beta2 and beta3-adrenoceptors in memory formation in the chick

Gibbs, M. E. & Summers, R. J., 2005, In : Neuroscience. 131, 1, p. 31 - 42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Bengtsson, T., Floren, A., Langel, U., Horinouchi, T., Evans, B. A. & Summers, R. J., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 3, p. 1354 - 1361 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8)

Halls, M. L., Bond, C. P., Sudo, S., Kumagai, J., Ferraro, T., Layfield, S., Bathgate, R. A. D. & Summers, R. J., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 2, p. 677 - 687 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The relaxin gene-knockout mouse: a model of progressive fibrosis

Samuel, C., Zhao, C., Bathgate, R., Du, X-J., Summers, R., Amento, E., Walker, L., McBurnie, M., Zhao, L. & Tregear, G., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 173 - 181 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle

Bond, C. P., Parry, L. J., Samuel, C. S., Gehring, H. M., Lederman, F. L., Rogers, P. A. W. & Summers, R. J., 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 7, p. 3477 - 3485 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin-1-deficient mice develop an age-related progression of renal fibrosis

Samuel, C. S., Zhao, C., Bond, C. P., Hewitson, T. D., Amento, E. P. & Summers, R. J., 2004, In : Kidney International. 65, 6, p. 2054 - 2064 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human 3-adrenoceptors

Popp, B. D., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2004, In : European Journal of Pharmacology. 484, 2-3, p. 323 - 331 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways

Summers, R. J., Broxton, N., Hutchinson, D. S. & Evans, B. A., 2004, In : Clinical and Experimental Pharmacology and Physiology. 31, 11, p. 822 - 827 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

a2-adrenoceptors in the basal ganglia have a role in memory consolidation and reinforcement

Gibbs, M. E. & Summers, R. J., 2003, In : Neuropharmacology. 45, 3, p. 355 - 367 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Physiological or pathological - a role for relaxin in the cardiovascular system?

Samuel, C. S., Parry, L. J. & Summers, R. J., 2003, In : Current Opinion in Pharmacology. 3, 2, p. 152 - 158 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

Samuel, C. S., Zhao, C., Bathgate, R. A. D., Bond, C. P., Burton, M. D., Parry, L. J., Summers, R. J., Tang, M. L. K., Amento, E. P. & Tregear, G. W., 2003, In : FASEB Journal. 17, 1, p. 121 - 123 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Characterization of the -adrenoceptor subtype involved in mediation of glucose transport in L6 cells

Nevzorova, J., Bengtsson, T., Evans, B. A. & Summers, R. J., 2002, In : British Journal of Pharmacology. 137, p. 9 - 18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the β-adrenoceptor subtype involved in mediation of glucose transport in L6 cells

Nevzorova, J., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 137, 1, p. 9-18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of Glucose and 2-Deoxyglucose on Memory Formation in the Chick: Interaction with 3-Adrenoceptor Agonists

Gibbs, M. E. & Summers, R. J., 2002, In : Neuroscience. 114, 1, p. 69 - 79 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene

Bathgate, R., Samuel, C. S., Burazin, T. CD., Layfield, S., Claasz, A. A., Reytomas, I. G., Dawson, N. F., Zhao, C., Bond, C. P., Summers, R. J., Parry, L. J., Wade, J. D. & Tregear, G. W., 2002, In : Journal of Biological Chemistry. 277, p. 1148 - 1157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inotropic Responses to Human Gene 2 (B29) Relaxin in a Rat Model of Mocardial infarction (MI): effect of pertussis Toxin

Kompa, A. R., Samuel, C. S. & Summers, R. J., 2002, In : British Journal of Pharmacology. 137, p. 710 - 718 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): Effect of pertussis toxin

Kompa, A. R., Samuel, C. S. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 137, 5, p. 710-718 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mouse 3a- and 3b- adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 2002, In : British Journal of Pharmacology. 135, p. 1903 - 1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 135, 8, p. 1903-1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin-Like bioactivity of Ovine Insulin 3 (INSL3) Analogues

Claasz, A. A., Bond, C. P., Bathgate, R., Otvos Jnr, L., Dawson, N. F., Summers, R. J., Tregear, G. W. & Wade, J. D., 2002, In : European Journal of Biochemistry. 269, 24, p. 6287 - 6293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of Adrenoceptor Subtypes in Memory Consolidation

Gibbs, M. E. & Summers, R. J., 2002, In : Progress in Neurobiology. 67, 5, p. 345 - 391 47 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria

Tan, Y. Y., Dawson, N. F., Kompa, A. R., Bond, C. P., Claasz, A. A., Wade, J. D., Tregear, G. W. & Summers, R. J., 2002, In : European Journal of Pharmacology. 457, 2-Mar, p. 153 - 160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

b1-Adrenoceptors compensate for b3-adrenoceptors in ileum from b3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2001, In : British Journal of Pharmacology. 132, 2, p. 433 - 442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

b1 - and b3 -adrenoceptor mediated smooth muscle relaxation in hypothyroid rat ileum

Brown, K. J. & Summers, R. J., 2001, In : European Journal of Pharmacology. 415, 2-3, p. 257 - 263 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancement of memory consolidation in chicks by b3-adrenoceptor agonists

Gibbs, M. E. & Summers, R. J., 2001, In : European Journal of Pharmacology. 413, 2-3, p. 235 - 240 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancement of memory consolidation in chicks by β3-adrenoceptor agonists

Gibbs, M. E. & Summers, R. J., 16 Feb 2001, In : European Journal of Pharmacology. 413, 2-3, p. 235-240 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Increase in fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

Heffernan, M. A., Thorburn, A. W., Fam, B., Summers, R. J., Conway-Campbell, B., Waters, M. J. & Ng, F. M., 2001, In : International Journal of Obesity. 25, 10, p. 1442 - 1449 8 p.

Research output: Contribution to journalArticleResearchpeer-review