Research Output per year
Research Output 1969 2019
- 1 - 50 out of 293 results
- Publication Year, Title (descending)
AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis
Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.Research output: Contribution to journal › Article › Research › peer-review
BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization
Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.Research output: Contribution to journal › Article › Research › peer-review
Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists
Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.Research output: Contribution to journal › Article › Research › peer-review
Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research
Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.Research output: Contribution to journal › Article › Research › peer-review
Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity
Diepenhorst, N. A., Leach, K., Keller, A. N., Rueda, P., Cook, A. E., Pierce, T. L., Nowell, C., Pastoureau, P., Sabatini, M., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4095-4108 14 p.Research output: Contribution to journal › Article › Research › peer-review
INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells
Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.Research output: Contribution to journal › Article › Research › peer-review
Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture
Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 249.Research output: Contribution to journal › Article › Research › peer-review
The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake
Merlin, J., Sato, M., Nowell, C., Pakzad, M., Fahey, R., Gao, J., Dehvari, N., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 1 Jan 2018, In : Cellular Signalling. 42, p. 54-66 13 p.Research output: Contribution to journal › Article › Research › peer-review
α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes
Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 27-40 14 p.Research output: Contribution to journal › Article › Research › peer-review
Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor
da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.Research output: Contribution to journal › Article › Research › peer-review
High throughput, quantitative analysis of human osteoclast differentiation and activity
Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.Research output: Contribution to journal › Article › Research › peer-review
Isoform-specific biased agonism of histamine H3 receptor agonists
Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.Research output: Contribution to journal › Article › Research › peer-review
ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.Research output: Contribution to journal › Article › Research › peer-review
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor
Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.Research output: Contribution to journal › Article › Research › peer-review
Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins
Littler, D. R., Ang, S. Y., Moriel, D. G., Kocan, M., Kleifeld, O., Johnson, M. D., Tran, M. T., Paton, A. W., Paton, J. C., Summers, R. J., Schembri, M. A., Rossjohn, J. & Beddoe, T., 8 Sep 2017, In : Journal of Biological Chemistry. 292, 36, p. 15143-15158 16 p.Research output: Contribution to journal › Article › Research › peer-review
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4
Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.Research output: Contribution to journal › Article › Research › peer-review
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, S1, p. S1-S16 16 p.Research output: Contribution to journal › Article › Research › peer-review
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.Research output: Contribution to journal › Article › Research › peer-review
Engineering of a novel simplified human insulin-like peptide 5 agonist
Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.Research output: Contribution to journal › Article › Research › peer-review
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells
Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.Research output: Contribution to journal › Article › Research › peer-review
Murine GPRC6A mediates cellular responses to L-amino acids, but not osteocalcin variants
Rueda, P., Harley, E., Lu, Y., Stewart, G. D., Fabb, S., Diepenhorst, N., Cremers, B., Rouillon, M-H., Wehrle, I., Geant, A., Lamarche, G., Leach, K., Charman, W. N., Christopoulos, A., Summers, R. J., Sexton, P. M. & Langmead, C. J., 1 Jan 2016, In : PLoS ONE. 11, 1, p. 1-19 19 p., e0146846.Research output: Contribution to journal › Article › Research › peer-review
Orthosteric, allosteric and biased signalling at the relaxin-3 receptor RXFP3
Kocan, M., Ang, S. Y. & Summers, R. J., 2016, In : Neurochemical Research. 41, 3, p. 610-619 10 p.Research output: Contribution to journal › Article › Research › peer-review
The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity
Patil, N. A., Bathgate, R. A. D., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R., Grosse, J., Hughes, R. A., Wade, J. D. & Hossain, M. A., 1 Apr 2016, In : Amino Acids. 48, 4, p. 987-992 6 p.Research output: Contribution to journal › Article › Research › peer-review
International union of basic and clinical pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides
Halls, M. L., Bathgate, R. A. D., Sutton, S. W., Dschietzig, T. B. & Summers, R. J., 2015, In : Pharmacological Reviews. 67, 2, p. 389-440 52 p.Research output: Contribution to journal › Article › Research › peer-review
Label-free kinetics: exploiting functional hemi-equilibrium to derive rate constants for muscarinic receptor antagonists
Riddy, D. M., Valant, C., Rueda, P., Charman, W. N., Sexton, P. M., Summers, R. J., Christopoulos, A. & Langmead, C. J., 2015, In : Molecular Pharmacology. 88, 4, p. 779-790 12 p.Research output: Contribution to journal › Article › Research › peer-review
Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins
Sarwar, M., Samuel, C. S., Bathgate, R. A., Stewart, D. R. & Summers, R. J., 2015, In : British Journal of Pharmacology. 172, 4, p. 1005-1019 15 p.Research output: Contribution to journal › Article › Research › peer-review
Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle
Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.Research output: Contribution to journal › Article › Research › peer-review
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
Chow, B. SM., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 2014, In : Kidney International. 86, 1, p. 75 - 85 11 p.Research output: Contribution to journal › Article › Research › peer-review
Signalling profiles of H3 relaxin, H2 relaxin and R3(B?23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)
Kocan, M., Sarwar, M., Hossain, M. A., Wade, J. D. & Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 11, p. 2827 - 2841 15 p.Research output: Contribution to journal › Article › Research › peer-review
Chronic activation of the low affinity site of beta -adrenoceptors stimulates haemodynamics but exacerbated pressure-overload cardiac remodelling
Kiriazis, H., Tugiono, N., Xu, Q., Gao, X-M., Jennings, N., Ming, Z., Su, Y., Klenowski, P., Summers, R. J., Kaumann, A., Molenaar, P. & Du, X-J., 2013, In : British Journal of Pharmacology. 170, 2, p. 352 - 365 14 p.Research output: Contribution to journal › Article › Research › peer-review
Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor
Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.Research output: Contribution to journal › Article › Research › peer-review
Relaxin family peptides and their receptors
Bathgate, R., Halls, M. L., van der Westhuizen, E. T., Callander, G., Kocan, M. & Summers, R. J., 2013, In : Physiological Reviews. 93, 1, p. 405 - 480 76 p.Research output: Contribution to journal › Article › Research › peer-review
Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail
Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.Research output: Contribution to journal › Article › Research › peer-review
Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor
Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.Research output: Contribution to journal › Article › Research › peer-review
alpha{2}-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes
Hutchinson, D. S., Catus, S. L., Merlin, J., Summers, R. J. & Gibbs, M. E., 2011, In : Journal of Neurochemistry. 117, 5, p. 915 - 926 12 p.Research output: Contribution to journal › Article › Research › peer-review
Evolution of beta-blockers: from anti-anginal drugs to ligand-directed signalling
Baker, J. G., Hill, S. J. & Summers, R. J., 2011, In : Trends in Pharmacological Sciences. 32, 4, p. 227 - 234 8 p.Research output: Contribution to journal › Article › Research › peer-review
Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids
Wootten, D., Simms, J., Koole, C., Woodman, O., Summers, R., Christopoulos, A. & Sexton, P., 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 2, p. 540 - 550 11 p.Research output: Contribution to journal › Article › Research › peer-review
Quantification of functional selectivity at the human {alpha}1A-adrenoceptor
Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., 2011, In : Molecular Pharmacology. 79, 2, p. 298 - 307 10 p.Research output: Contribution to journal › Article › Research › peer-review
Role of beta-adrenoceptors in glucose uptake in astrocytes using beta-adrenoceptor knockout mice
Catus, S. L., Gibbs, M. E., Sato, M., Summers, R. J. & Hutchinson, D. S., 2011, In : British Journal of Pharmacology. 162, 8, p. 1700 - 1715 16 p.Research output: Contribution to journal › Article › Research › peer-review
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening
Koole, C., Wootten, D., Simms, J., Valant, C., Sridhar, R., Woodman, O., Miller, L. J., Summers, R., Christopoulos, A. & Sexton, P. M., 2010, In : Molecular Pharmacology. 78, 3, p. 456 - 465 10 p.Research output: Contribution to journal › Article › Research › peer-review
Cardiovascular effects of relaxin: from basic science to clinical therapy
Du, X-J., Bathgate, R. A. D., Samuel, C. S., Dart, A. M. & Summers, R. J., 2010, In : Nature Reviews Cardiology. 7, 1, p. 48 - 58 11 p.Research output: Contribution to journal › Article › Research › peer-review
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3) [S]
van der Westhuizen, E. T., Christopoulos, A., Sexton, P., Wade, J. & Summers, R., 2010, In : Molecular Pharmacology. 77, 5, p. 759 - 772 14 p.Research output: Contribution to journal › Article › Research › peer-review
Ligand-directed signalling at beta-adrenoceptors
Evans, B., Sato, M., Sarwar, M., Hutchinson, D. & Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 1022 - 1038 17 p.Research output: Contribution to journal › Article › Research › peer-review
Memory loss caused by beta-amyloid protein is rescued by a beta3-adrenoceptor agonist
Gibbs, M. E., Maksel, D. M., Gibbs, Z., Hou, X., Summers, R. J. & Small, D. H., 2010, In : Neurobiology of Aging. 31, p. 614 - 624 10 p.Research output: Contribution to journal › Article › Research › peer-review
Molecular pharmacology of G protein-coupled receptors: Editorial
Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 983 - 985 3 p.Research output: Contribution to journal › Article › Research › peer-review
Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors
Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2010, In : Neuroscience. 170, 4, p. 1209 - 1222 14 p.Research output: Contribution to journal › Article › Research › peer-review
The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism
Merlin, J., Evans, B. A., Csikasz, R. I., Bengtsson, T., Summers, R. J. & Hutchinson, D. S., 2010, In : Cellular Signalling. 22, 7, p. 1104 - 1113 10 p.Research output: Contribution to journal › Article › Research › peer-review
Tissue functions mediated by beta3-adrenoceptors-Findings and challenges
Michel, M., Ochodnicky, P. & Summers, R., 2010, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 2, p. 103 - 108 6 p.Research output: Contribution to journal › Article › Research › peer-review
Addition of a carboxy-terminal green fluorescent protein does not alter the binding and signaling properties of relaxin family peptide receptor 3
van der Westhuizen, E. T., Wade, J. D., Sexton, P. M. & Summers, R. J., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 105 - 107 3 p.Research output: Contribution to journal › Article › Research › peer-review
Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick
Gibbs, M. E., Rodricks, C. L., Hutchinson, D. S., Summers, R. J. & Miller, S. L., 2009, In : International Journal of Developmental Neuroscience. 27, p. 27 - 35 8 p.Research output: Contribution to journal › Article › Research › peer-review