Rodney Devenish

Emeritus Prof

1988 …2020
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Personal profile

Biography

Rod Devenish is a Professor in the Department of Biochemistry and Molecular Biology. His current major research interest is the field of autophagy.

Autophagy is a process by which all eukaryotic cells degrade (or turnover) parts of their internal structure including organelles that occurs in a specialized compartment of cells - the vacuole (in yeast) or the lysosome (in mammals). In yeast, autophagy is mainly involved in cellular homeostasis (removal of damaged organelles) and adaptation to starvation, but in multicellular organisms (mammals) it is involved in a variety of additional processes such as programmed cell death and development of different tissue-specific functions. Alterations in the levels of autophagy are linked to a growing number of pathological conditions including neurodegenerative diseases such Parkinson's, myopathies, some forms of cancer, and infection by pathogenic bacteria or viruses.

Current work

Selective autophagy of cellular organelles. The turnover of mitochondria, the nucleus and other organelles by autophagy presumably serves as a means of quality control for organelle function. Mechanistically distinct forms of autophagy have been identified. However, the molecular details and regulation of these processes and how they relate to organelle turnover are only now becoming understood. We are using fluorescent protein technology, together with other biochemical and molecular techniques, in yeast and mammalian cells to monitor turnover. This approach is providing new insights into the pathways and molecular mechanisms by which organelle autophagy occurs.

Host-cell response to bacterial infection. Successful microbial pathogens have evolved strategies to avoid or subvert autophagy thereby ensuring their survival within cells. We are looking at the molecular mechanisms by which the soil bacterium, Burkholderia pseudomallei, achieves the avoidance or subversion of autophagy. In humans, infection leads to Melioidosis, a disease endemic in tropical and subtropical areas, including northern Australia. It is also a significant pathogen in many animals. We are investigating the role played by autophagy in the intracellular life-cycle of B. pseudomallei. Our studies have shown that in response to infection of macrophage-like cell line RAW 264.7, the autophagy marker protein LC3 is actually recruited directly to bacteria-containing phagosomes (a process designated LC3-associated phagocytosis; LAP). However, most of the infecting bacteria escaped from phagosome and do not succumb to autophagy. Current and future studies are directed towards the mechanistic basis of the bacterium's ability to avoid autophagy.

Research area keywords

  • Autophagy
  • Autophagy and Infection
  • Mitophagy
  • Nucleophagy

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Projects 2000 2020

Research Output 1988 2019

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Shin, Y. S., Ryall, J. G., Britto, J. M., Lau, C. L., Devenish, R. J., Nagley, P. & Beart, P. M., Apr 2019, In : Journal of Neurochemistry. 149, 2, p. 269-283 15 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Impaired placental autophagy in placental malaria

Dimasuay, K. G., Gong, L., Rosario, F., McBryde, E., Spelman, T., Glazier, J., Rogerson, S. J., Beeson, J. G., Jansson, T., Devenish, R. J. & Boeuf, P., 10 Nov 2017, In : PLoS ONE. 12, 11, 20 p., e0187291.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Evidence for the recruitment of autophagic vesicles in human brain after stroke

Frugier, T., Taylor, J. M., McLean, C., Bye, N., Beart, P. M., Devenish, R. J. & Crack, P. J., Jun 2016, In : Neurochemistry International. 96, p. 62-68 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., Adhihetty, P. J., Adler, S. G., Agam, G., Agarwal, R., Aghi, M. K., Agnello, M., Agostinis, P., Aguilar, P. V., Aguirre-Ghiso, J. A., Airoldi, E. M. & 30 others, Ait-Si-Ali, S., Akematsu, T., Akporiaye, E., Al-Rubeai, M., Albaiceta, G. M., Albanese, C., Albani, D., Albert, M. L., Aldudo, J., Algul, H., Alirezaei, M., Alloza, I., Almasan, A., Almonte-Becerril, M., Alnemri, E. S., Alonso, C., Altan-Bonnet, N., Altieri, D. C., Alvarez, S., Alvarez-Erviti, L., Alves, S., Amadoro, G., Bryson-Richardson, R. J., Devenish, R. J., Harris, J., Kwok, T., Mijaljica, D., Osellame, L. D., Prescott, M. & Ruparelia, A., 2016, In : Autophagy. 12, 1, p. 1-222 222 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

Lazar Adler, N. R., Allwood, E. M., Deveson Lucas, D., Harrison, P., Watts, S., Dimitropoulos, A., Treerat, P., Alwis, P., Devenish, R. J., Prescott, M., Govan, B., Adler, B., Harper, M. & Boyce, J. D., 4 May 2016, In : BMC Genomics. 17, 17 p., 331.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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