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Article
2018

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, D. J., Yap, F. Y. T., Keshvari, S., Simmons, D. G., Gallo, L. A., Fotheringham, A. K., Zhuang, A., Slattery, R. M., Hasnain, S. Z., Coughlan, M. T., Kantharidis, P. & Forbes, J. M., 2 Jan 2018, In : Islets. 10, 1, p. 10-24 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2016

Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes

Trivedi, P., Graham, K. L., Krishnamurthy, B., Fynch, S., Slattery, R. M., Kay, T. W. H. & Thomas, H. E., 1 Apr 2016, In : Immunology and Cell Biology. 94, 4, p. 334-341 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells

Messina, N., Fulford, T., O'Reilly, L., Loh, W. X., Motyer, J. M., Ellis, D., McLean, C., Naeem, H., Lin, A., Gugasyan, R., Slattery, R. M., Grumont, R. J. & Gerondakis, S., Jun 2016, In : Journal of Autoimmunity. 70, p. 52-62 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2014

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse

Jayasimhan, A., Mansour, K. P. & Slattery, R. M., 2014, In : Clinical Science. 126, 1, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe −/− mice

Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H., Cooper, M. E., Slattery, R. M. & Jandeleit-Dahm, K. A. M., 2014, In : Diabetologia. 57, 3, p. 633 - 642 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

The cross-priming capacity and direct presentation potential of an autoantigen are separable and inversely related properties

Wang, J., Nanjundappa, R. H., Shameli, A., Clemente-Casares, X., Yamanouchi, J., Elliott, J. F., Slattery, R. M., Serra, P. & Santamaria, P., 2014, In : Journal of Immunology. 193, 7, p. 3296 - 3307 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2013

Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells

Tsai, S., Serra, P., Clemente-Casares, X., Yamanouchi, J., Thiessen, S., Slattery, R. M., Elliott, J. F. & Santamaria, P., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 9, p. 3471 - 3476 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor kappa B and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells

Tan, B., Zammit, N. W., Yam, A. O., Slattery, R. M., Walters, S., Malle, E. & Grey, S. T., 2013, In : Diabetologia. 56, 3, p. 520 - 532 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II

Tsai, S., Serra, P., Clemente-Casares, X., Slattery, R. M. & Santamaria, P., 2013, In : Journal of Immunology. 191, 1, p. 70 - 82 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development

Ziegler, A. I., Le Page, M., Maxwell, M. J., Stolp, J., Guo, H., Jayasimhan, A., Hibbs, M., Santamaria, P., Miller, J. F. A. P., Plebanski, M., Silveira, P. A. & Slattery, R. M., 2013, In : Diabetologia. 56, 12, p. 2659 - 2669 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S. M., Ashworth, K. J., Westein, E., Hosseini, E., Salem, H. H., Slattery, R. M., McColl, S. R., Hickey, M. J., Ruggeri, Z. M., Yuan, Y-P. & Jackson, S., 2013, In : Blood. 121, 22, p. 4555 - 4566 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)
2012

Advanced glycation end products as environmental risk factors for the development of type 1 diabetes

Yap, F., Kantharidis, P., Coughlan, M. T., Slattery, R. M. & Forbes, J. M., 2012, In : Current Drug Targets. 13, 4, p. 526 - 540 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

An indirect role for NK cells in a CD4+ T-cell-dependent mouse model of type I diabetes

Angstetra, E., Graham, K., Zhao, Y., Irvin, A. E., Elkerbout, L., Santamaria, P., Slattery, R. M., Kay, T. & Thomas, H., 2012, In : Immunology and Cell Biology. 90, 2, p. 243 - 247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

Graham, K. L., Krishnamurthy, B., Fynch, S., Ayala-Perez, R., Slattery, R. M., Santamaria, P., Thomas, H. E. & Kay, T. W. H., 2012, In : European Journal of Immunology. 42, 7, p. 1717 - 1722 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2011

Advanced glycation end products are direct modulators of beta-cell function

Coughlan, M. T., Yap, F., Tong, D., Andrikopoulos, S., Gasser, A., Thallas-Bonke, V., Webster, D., Miyazaki, J., Kay, T., Slattery, R., Kaye, D., Drew, B., Kingwell, B., Fourlanos, S., Groop, P-H., Harrison, L., Knip, M. & Forbes, J., 2011, In : Diabetes. 60, 10, p. 2523 - 2532 10 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes

Graham, K., Krishnamurthy, B., Fynch, S., Mollah, Z. U. A., Slattery, R. M., Santamaria, P., Kay, T. W. & Thomas, H. E., 2011, In : American Journal of Pathology. 178, 6, p. 2716 - 2725 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

Forbes, J., Soderlund, J., Yap, F., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K., Coughlan, M. T., Forsblom, C., Slattery, R. M., Grey, S., Wessman, M., Yamamoto, H., Bierhaus, A., Cooper, M. & Groop, P., 2011, In : Diabetologia. 54, 5, p. 1032 - 1042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2008

Congenic analysis of the NKT cell control gene Nkt2 Implicates the peroxisomal protein Pxmp4

Fletcher, J. M., Jordan, M. A., Snelgrove, S. L., Slattery, R. M., Dufour, F., Kyparissoudis, K., Besra, G. S., Godfrey, D. I. & Baxter, A., 2008, In : Journal of Immunology. 181, 5, p. 3400 - 3412 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Functional interaction of AIRE with PIAS1 in transcriptional regulation

Ilmarinen, T., Kangas, H., Kytomaa, T., Eskelin, P., Saharinen, J., Seeler, J-S., Tanhuanpaa, K., Chan, F., Slattery, R. M., Alakurtti, K., Palvimo, J. J. & Ulmanen, I., 2008, In : Molecular Immunology. 45, 7, p. 1847 - 1862 16 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2007

Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice

De Jersey, J., Snelgrove, S. L., Palmer, S. E., Teteris, S. A., Mullbacher, A., Miller, J. F. A. P. & Slattery, R. M., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 4, p. 1295 - 1300 5 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2004

MHC class II molecules play a role in the selection of autoreactive class I restricted CD8 T cells that are essential contributors to type I diabetes development in NOD mice

Serreze, D. V., Holl, T. M., Marron, M. P., Graser, R. T., Johnson, E. A., Choisy-Rossi, C., Slattery, R. M., Lieberman, S. M. & Di Lorenzo, T. P., 2004, In : Journal of Immunology. 172, 2, p. 871 - 879 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Beta Cell MHC Class I is a Late Requirement for Diabetes

Hamilton-Williams, E. E., Palmer, S. E., Charlton, B. & Slattery, R. M., 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 11, p. 6688 - 6693 6 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Mechanisms of accelerated immune-mediated diabetes resulting from islet Beta cell expression of a fas ligand transgene

Silva, D. G., Petrovsky, N., Socha, L., Slattery, R. M., Gatenby, P. & Charlton, B., 2003, In : Journal of Immunology. 170, 10, p. 4996 - 5002 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice

Petrovsky, N., Silva, D. G., Socha, L., Slattery, R. M. & Charlton, B., 2002, In : Annals of the New York Academy of Sciences. 958, p. 204 - 208 5 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2001

B lymphocytes not required for progression from insulitis to diabetes in non-obese diabetic mice

Charlton, B., Zhang, M. D. & Slattery, R. M., 2001, In : Immunology and Cell Biology. 79, p. 597 - 601 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Transgenic rescue implicates beta 2 microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

Hamilton-Williams, E. E., Serreze, D. V., Charlton, B., Johnson, E. A., Marron, M. P., Mullbacher, A. & Slattery, R. M., 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11533 - 11538 6 p.

Research output: Contribution to journalArticleResearchpeer-review