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Research Output 2001 2019

2019
2 Citations (Scopus)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A. L., La, H. M., Rossello, F., Anko, M-L., Fuller-Pace, F. V. & Hobbs, R., 1 Dec 2019, In : Nature Communications. 10, 1, 21 p., 2278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions

Tichy, A-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M. & Janovjak, H., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3046-3055 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing

Liao, J., Ng, S. H., Luk, A. C., Suen, H. C., Qian, Y., Lee, A. W. T., Tu, J., Fung, J. C. L., Tang, N. L. S., Feng, B., Chan, W. Y., Fouchet, P., Hobbs, R. M. & Lee, T. L., 27 Mar 2019, In : Development (Cambridge). 146, 6, 15 p., dev174953.

Research output: Contribution to journalArticleResearchpeer-review

2018
5 Citations (Scopus)

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of P13K/Akt signaling

Sinha, D., Kalimutho, M., Bowles, J., Chan, A-L., Merriner, D. J., Bain, A. L., Simmons, J. L., Freire, R., Lopez, J. A., Hobbs, R. M., O'Bryan, M. K. & Khanna, K. K., Sep 2018, In : FASEB Journal. 32, 9, p. 4984-4999 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

La, H. M., Chan, A-L., Legrand, J. M. D., Rossello, F. J., Gangemi, C. G., Papa, A., Cheng, Q., Morand, E. F. & Hobbs, R. M., 1 Sep 2018, In : Development. 145, 18, dev165324.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

RNA processing in the male germline: Mechanisms and implications for fertility

Legrand, J. M. D. & Hobbs, R. M., Jul 2018, In : Seminars in Cell and Developmental Biology. 79, p. 80-91 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2017
10 Citations (Scopus)

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Chan, A. L., La, H. M., Legrand, J. M. D., Mäkelä, J. A., Eichenlaub, M., De Seram, M., Ramialison, M. & Hobbs, R. M., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 956-971 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
14 Citations (Scopus)

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

Hakim, S., Dyson, J. M., Feeney, S. J., Davies, E. M., Sriratana, A., Koenig, M. N., Plotnikova, O., Smyth, I. M., Ricardo, S. D., Hobbs, R. M. & Mitchell, C. A., 2016, In : Human Molecular Genetics. 25, 11, p. 2295-2313 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
9 Citations (Scopus)

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells

Guarnerio, J., Riccardi, L., Taulli, R., Maeda, T., Wang, G., Hobbs, R. M., Song, M. S., Sportoletti, P., Bernardi, R., Bronson, R. T., Castillo-Martin, M., Cordon-Cardo, C., Lunardi, A. & Pandolfi, P. P., 1 Apr 2015, In : Cancer Discovery. 5, 4, p. 396-409 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling

Hobbs, R. M., La, H. M., Makela, J-A., Kobayashi, T., Noda, T. & Pandolfi, P. P., 2015, In : EMBO Reports. 16, 4, p. 467 - 480 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

Liu, X. S., Chandramouly, G., Rass, E., Guan, Y., Wang, G., Hobbs, R. M., Rajendran, A., Xie, A., Shah, J. V., Davis, A. J., Scully, R., Lunardi, A. & Pandolfi, P. P., 8 Oct 2015, In : Nature Communications. 6, 10 p., 8325.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Suppression of CHK1 by ETS family members promotes DNA damage response bypass and tumorigenesis

Lunardi, A., Varmeh, S., Chen, M., Taulli, R., Guarnerio, J., Ala, U., Seitzer, N., Ishikawa, T., Carver, B. S., Hobbs, R. M., Quarantotti, V., Ng, C., Berger, A. H., Nardella, C., Poliseno, L., Montironi, R., Castillo-Martin, M., Cordon-Cardo, C., Signoretti, S. & Pandolfi, P. P., 1 May 2015, In : Cancer Discovery. 5, 5, p. 550-563 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
127 Citations (Scopus)

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

Papa, A., Wan, L., Bonora, M., Salmena, L., Song, M., Hobbs, R. M., Lunardi, A., Webster, K., Ng, C., Newton, R. H., Knoblauch, N. W., Guarnerio, J., Ito, K., Turka, L. A., Beck, A. H., Pinton, P., Bronson, R. T., Wei, W. & Pandolfi, P. P., 2014, In : Cell. 157, 3, p. 595 - 610 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Reprogramming can be a transforming experience

Hobbs, R. M. & Polo, J. M., 2014, In : Cell Stem Cell. 14, 3, p. 269 - 271 3 p.

Research output: Contribution to journalArticleOther

43 Citations (Scopus)

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition

González-Billalabeitia, E., Seitzer, N., Song, S. J., Song, M. S., Patnaik, A., Liu, X. S., Epping, M. T., Papa, A., Hobbs, R. M., Chen, M., Lunardi, A., Ng, C., Webster, K. A., Signoretti, S., Loda, M., Asara, J. M., Nardella, C., Clohessy, J. G., Cantley, L. C. & Pandolfi, P. P., Aug 2014, In : Cancer Discovery. 4, 8, p. 896-904 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013
22 Citations (Scopus)

Glucocorticoid-induced leucine zipper (GILZ) regulates testicular FOXO1 activity and spermatogonial stem cell (SSC) function

Ngo, D., Cheng, Q., O'Connor, A., DeBoer, K. D., Lo, C. Y-W., Beaulieu, E. V., De Seram, M., Hobbs, R. M., O'Bryan, M. K. & Morand, E. F., 2013, In : PLoS ONE. 8, 3, 9 p., e59149.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012
31 Citations (Scopus)

CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice

Ventelä, S., Côme, C., Mäkelä, J. A., Hobbs, R. M., Mannermaa, L., Kallajoki, M., Chan, E. K., Pandolfi, P. P., Toppari, J. & Westermarck, J., 26 Mar 2012, In : PLoS ONE. 7, 3, e33209.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
98 Citations (Scopus)

Functional antagonism between Sall4 and Plzf defines germline progenitors

Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K., Altruda, F., Nishinakamura, R., Chai, L. & Pandolfi, P. P., 2012, In : Cell Stem Cell. 10, 3, p. 284 - 298 15 p.

Research output: Contribution to journalArticleResearchpeer-review

205 Citations (Scopus)

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

Garcia-Cao, I., Song, M. S., Hobbs, R. M., Laurent, G., Giorgi, C., de Boer, V. CJ., Anastasiou, D., Ito, K., Sasaki, A. T., Rameh, L., Carracedo, A., Vander Heiden, M. G., Cantley, L. C., Pinton, P., Haigis, M. C. & Pandolfi, P. P., 2012, In : Cell. 149, 1, p. 49 - 62 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
96 Citations (Scopus)

Development of promyelocytic zinc finger and ThPOK-expressing innate γδ T cells is controlled by strength of TCR signaling and Id3

Alonzo, E. S., Gottschalk, R. A., Das, J., Egawa, T., Hobbs, R. M., Pandolfi, P. P., Pereira, P., Nichols, K. E., Koretzky, G. A., Jordan, M. S. & Sant'Angelo, D. B., 1 Feb 2010, In : Journal of Immunology. 184, 3, p. 1268-1279 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Erratum: Identification of the miR-106b-25 micro RNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation (Science Signaling (2010) 3 (er6))

Poliseno, L., Salmena, L., Riccardi, L., Fornari, A., Song, M. S., Hobbs, R. M., Sportoletti, P., Varmeh, S., Egia, A., Fedele, G., Rameh, L., Loda, M. & Pandolfi, P. P., 25 May 2010, In : Science Signaling. 3, 123

Research output: Contribution to journalComment / DebateOtherpeer-review

40 Citations (Scopus)

Essential role of the p110β subunit of phosphoinositide 3-OH kinase in male fertility

Ciraolo, E., Morello, F., Hobbs, R. M., Wolf, F., Marone, R., Iezzi, M., Lu, X., Mengozzi, G., Altruda, F., Sorba, G., Guan, K., Pandolfi, P. P., Wymann, M. P. & Hirsch, E., 1 Mar 2010, In : Molecular Biology of the Cell. 21, 5, p. 704-711 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro

Fagoonee, S., Hobbs, R. M., De Chiara, L., Cantarella, D., Piro, R. M., Tolosano, E., Medico, E., Provero, P., Pandolfi, P. P., Silengo, L. & Altruda, F., 1 Aug 2010, In : Stem Cells and Development. 19, 8, p. 1183-1194 12 p.

Research output: Contribution to journalArticleResearchpeer-review

319 Citations (Scopus)

Identification of the miR-106b∼25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Poliseno, L., Salmena, L., Riccardi, L., Fornari, A., Song, M. S., Hobbs, R. M., Sportoletti, P., Varmeh, S., Egia, A., Fedele, G., Rameh, L., Loda, M. & Pandolfi, P. P., 13 Apr 2010, In : Science Signaling. 3, 117

Research output: Contribution to journalArticleResearchpeer-review

152 Citations (Scopus)

Plzf regulates germline progenitor self-renewal by opposing mTORC1

Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S. & Pandolfi, P. P., Aug 2010, In : Cell. 142, 3, p. 468-479 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Shape-shifting and tumor suppression by PLZF

Hobbs, R. M. & Pandolfi, P. P., 2010, In : Oncotarget. 1, 1, p. 3-5 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
60 Citations (Scopus)

Differential requirement of mTOR in postmitotic tissues and tumorigenesis

Nardella, C., Carracedo, A., Alimonti, A., Hobbs, R. M., Clohessy, J. G., Chen, Z., Egia, A., Fornari, A., Fiorentino, M., Loda, M., Kozma, S. C., Thomas, G., Cordon-Cardo, C. & Pandolfi, P. P., 27 Jan 2009, In : Science Signaling. 2, 55

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis

Maeda, T., Ito, K., Merghoub, T., Poliseno, L., Hobbs, R. M., Wang, G., Dong, L., Maeda, M., Dore, L. C., Zelent, A., Luzzatto, L., Teruya-Feldstein, J., Weiss, M. J. & Pandolfi, P. P., 20 Oct 2009, In : Developmental Cell. 17, 4, p. 527-540 14 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity

Kreslavsky, T., Savage, A. K., Hobbs, R., Gounari, F., Bronson, R., Pereira, P., Pandolfi, P. P., Bendelac, A. & Von Boehmer, H., 28 Jul 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12453-12458 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
33 Citations (Scopus)

Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation

Costoya, J. A., Hobbs, R. M. & Pandolfi, P. P., 19 Jun 2008, In : Oncogene. 27, 27, p. 3789-3796 8 p.

Research output: Contribution to journalArticleResearchpeer-review

325 Citations (Scopus)

The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

Kovalovsky, D., Uche, O. U., Eladad, S., Hobbs, R. M., Yi, W., Alonzo, E., Chua, K., Eidson, M., Kim, H. J., Im, J. S., Pandolfi, P. P. & Sant'Angelo, D. B., 2008, In : Nature Immunology. 9, 9, p. 1055-1064 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
149 Citations (Scopus)

Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques

Hermann, B. P., Sukhwani, M., Lin, C. C., Sheng, Y., Tomko, J., Rodriguez, M., Shuttleworth, J. J., McFarland, D., Hobbs, R. M., Pandolfi, P. P., Schatten, G. P. & Orwig, K. E., Sep 2007, In : Stem Cells. 25, 9, p. 2330-2338 9 p.

Research output: Contribution to journalArticleResearchpeer-review

326 Citations (Scopus)

Generation of functional multipotent adult stem cells from GPR125 + germline progenitors

Seandel, M., James, D., Shmelkov, S. V., Falciatori, I., Kim, J., Chavala, S., Scherr, D. S., Zhang, F., Torres, R., Gale, N. W., Yancopoulos, G. D., Murphy, A., Valenzuela, D. M., Hobbs, R. M., Pandolfi, P. P. & Rafii, S., 20 Sep 2007, In : Nature. 449, 7160, p. 346-350 5 p.

Research output: Contribution to journalArticleResearchpeer-review

150 Citations (Scopus)

Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF

Maeda, T., Merghoyb, T., Hobbs, R. M., Dong, L., Maeda, M., Zakrzewski, J., Van Den Brink, M. R. M., Zelent, A., Shigematsu, H., Akashi, K., Teruya-Feldstein, J., Cattoretti, G. & Pandolfi, P. P., 11 May 2007, In : Science. 316, 5826, p. 860-866 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

Guidez, F., Parks, S., Wong, H., Jovanovic, J. V., Mays, A., Gilkes, A. F., Mills, K. I., Guillemin, M. C., Hobbs, R. M., Pandolfi, P. P., De Thé, H., Solomon, E. & Grimwade, D., 20 Nov 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18694-18699 6 p.

Research output: Contribution to journalArticleResearchpeer-review

131 Citations (Scopus)

Repression of kit expression by Plzf in germ cells

Filipponi, D., Hobbs, R. M., Ottolenghi, S., Rossi, P., Jannini, E. A., Pandolfi, P. P. & Dolci, S., Oct 2007, In : Molecular and Cellular Biology. 27, 19, p. 6770-6781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
247 Citations (Scopus)

A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein

Schefe, J. H., Menk, M., Reinemund, J., Effertz, K., Hobbs, R. M., Pandolfi, P. P., Ruiz, P., Unger, T. & Funke-Kaiser, H., Dec 2006, In : Circulation Research. 99, 12, p. 1355-1366 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Pokemon represses art in promoting cellular transformation

Hobbs, R. M., Merghoub, T., Guernah, I., Cordon-Cardo, C., Teruya-Feldstein, J. & Zelent, A., Feb 2005, In : Cancer Biology and Therapy. 4, 2

Research output: Contribution to journalComment / DebateResearchpeer-review

249 Citations (Scopus)

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

Maeda, T., Hobbs, R. H., Morghoub, T., Guernah, I., Zelent, A., Cordon-Cardo, C., Teruya-Feldstein, J. & Pandolfi, P. P., 20 Jan 2005, In : Nature. 433, 7023, p. 278-285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

The transcription factor Pokemon: A new key player in cancer pathogenesis

Maeda, T., Hobbs, R. M. & Pandolfi, P. P., 1 Oct 2005, In : Cancer Research. 65, 19, p. 8575-8578 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2004
38 Citations (Scopus)

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis

Piazza, F., Costoya, J. A., Merghoub, T., Hobbs, R. M. & Pandolfi, P. P., Dec 2004, In : Molecular and Cellular Biology. 24, 23, p. 10456-10469 14 p.

Research output: Contribution to journalArticleResearchpeer-review

627 Citations (Scopus)

Essential role of Plzf in maintenance of spermatogonial stem cells

Costoya, J. A., Hobbs, R. M., Barna, M., Cattoretti, G., Manova, K., Sukhwani, M., Orwig, K. E., Wolgemuth, D. J. & Pandolfi, P. P., Jun 2004, In : Nature Genetics. 36, 6, p. 653-659 7 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

Hobbs, R. M., Silva-Vargas, V., Groves, R. & Watt, F. M., 2004, In : Journal of Investigative Dermatology. 123, 3, p. 503-515 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
36 Citations (Scopus)

Regulation of interleukin-1αa expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease

Hobbs, R. M. & Watt, F. M., 30 May 2003, In : Journal of Biological Chemistry. 278, 22, p. 19798-19807 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
130 Citations (Scopus)

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

Haase, I., Hobbs, R. M., Romero, M. R., Broad, S. & Watt, F. M., 2001, In : Journal of Clinical Investigation. 108, 4, p. 527-536 10 p.

Research output: Contribution to journalArticleResearchpeer-review