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In adult testis, there is a population of germline stem cells (spermatogonial stem cells; SSCs) needed for life-long production of spermatozoa and fertility. SSC maintenance is dependent on crosstalk between cell-intrinsic factors and growth factors produced from a stem cell niche. We have identified key transcription factors and growth factor signalling pathways involved in self-renewal and differentiation of SSCs. Through use of mouse models, we aim to define critical pathways regulating SSC function. Projects will focus on characterizing mechanisms of SSC regulation with particular emphasis on components of transcription factor networks and their downstream targets. This work will involve use of mouse models, isolation and in vitro culture of SSCs, flow cytometry and cell/molecular biological techniques. These studies can have particular relevance to the stem cell and fertility fields.


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Research area keywords

  • Stem cells
  • Fertility
  • Cell signalling
  • Transcription factors
  • Differentiation

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IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Meinhardt, A., Loveland, K., Bhushan, S., Ellem, S. J., Hedger, M., O'Bryan, M., O'Donnell, L., Stanton, P., Risbridger, G., Baker, M. A., Hobbs, R., Loveland, B., Exintaris, B., Western, P., McLachlan, R., Whittaker, M., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.


Project: Research

Research Output

Identification of dynamic undifferentiated cell states within the male germline

La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Chan, A. L., La, H. M., Legrand, J. M. D., Mäkelä, J. A., Eichenlaub, M., De Seram, M., Ramialison, M. & Hobbs, R. M., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 956-971 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling

Hobbs, R. M., La, H. M., Makela, J-A., Kobayashi, T., Noda, T. & Pandolfi, P. P., 2015, In : EMBO Reports. 16, 4, p. 467 - 480 14 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Functional antagonism between Sall4 and Plzf defines germline progenitors

Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K., Altruda, F., Nishinakamura, R., Chai, L. & Pandolfi, P. P., 2012, In : Cell Stem Cell. 10, 3, p. 284 - 298 15 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

Plzf regulates germline progenitor self-renewal by opposing mTORC1

Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S. & Pandolfi, P. P., Aug 2010, In : Cell. 142, 3, p. 468-479 12 p.

Research output: Contribution to journalArticleResearchpeer-review

159 Citations (Scopus)