Projects per year
Personal profile
Biography
In adult testis, there is a population of germline stem cells (spermatogonial stem cells; SSCs) needed for life-long production of spermatozoa and fertility. SSC maintenance is dependent on crosstalk between cell-intrinsic factors and growth factors produced from a stem cell niche. We have identified key transcription factors and growth factor signalling pathways involved in self-renewal and differentiation of SSCs. Through use of mouse models, we aim to define critical pathways regulating SSC function. Projects will focus on characterizing mechanisms of SSC regulation with particular emphasis on components of transcription factor networks and their downstream targets. This work will involve use of mouse models, isolation and in vitro culture of SSCs, flow cytometry and cell/molecular biological techniques. These studies can have particular relevance to the stem cell and fertility fields.
Related Links:
Web: https://www.hudson.org.au/research-group/germline-stem-cell-biology/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Stem cells
- Fertility
- Cell signalling
- Transcription factors
- Differentiation
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Characterization of the Germline Regulatory Landscape
Pocock, R. (Primary Chief Investigator (PCI)), Cao, W. (Chief Investigator (CI)), Fan, Q. (Chief Investigator (CI)), Hutt, K. (Associate Investigator (AI)), Gopal, S. (Associate Investigator (AI)), Schittenhelm, R. (Associate Investigator (AI)), Hobbs, R. (Associate Investigator (AI)), Archer, S. (Associate Investigator (AI)) & Coutts, S. (Associate Investigator (AI))
1/01/23 → 31/12/27
Project: Research
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Regulatory roles of the RNA helicase DDX5 in male germline stem cells
Hobbs, R. (Primary Chief Investigator (PCI)) & Anko, M.-L. (Partner Investigator (PI))
12/07/22 → 11/07/25
Project: Research
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CONTROL OF DEVELOPMENTAL SWITCHES BY IMPORTIN 5
Loveland, K. (Primary Chief Investigator (PCI)), Baker, M. A. (Chief Investigator (CI)), Hobbs, R. (Chief Investigator (CI)) & McLaughlin, E. (Chief Investigator (CI))
Australian Research Council (ARC)
12/01/20 → 11/01/23
Project: Research
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Regulatory networks defining stem cell populations in the adult male germline
1/01/19 → 31/12/21
Project: Research
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IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project
Meinhardt, A. (Primary Chief Investigator (PCI)), Loveland, K. (Chief Investigator (CI)), Bhushan, S. (Chief Investigator (CI)), Ellem, S. J. (Chief Investigator (CI)), Hedger, M. (Chief Investigator (CI)), O'Bryan, M. (Chief Investigator (CI)), O'Donnell, L. (Chief Investigator (CI)), Stanton, P. (Chief Investigator (CI)), Risbridger, G. (Chief Investigator (CI)), Baker, M. A. (Associate Investigator (AI)), Hobbs, R. (Associate Investigator (AI)), Loveland, B. E. (Associate Investigator (AI)), Exintaris, B. (Chief Investigator (CI)), Western, P. (Chief Investigator (CI)), McLachlan, R. (Chief Investigator (CI)), Whittaker, M. (Associate Investigator (AI)), Wagenlehner, F. M. E. (Associate Investigator (AI)), Bergmann, M. (Chief Investigator (CI)), Diemer, T. (Chief Investigator (CI)), Fietz, D. (Chief Investigator (CI)), Fijak, M. (Chief Investigator (CI)), Konrad, L. (Chief Investigator (CI)), Linn, T. (Chief Investigator (CI)), Middendorff, R. (Chief Investigator (CI)), Pilatz, A. M. E. (Chief Investigator (CI)), Schagdarsurengin, U. (Chief Investigator (CI)), Schuppe, H. C. (Chief Investigator (CI)), Steger, K. (Chief Investigator (CI)) & Scheiner-Bobis, G. (Chief Investigator (CI))
1/10/17 → 31/03/22
Project: Research
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Identification of dynamic undifferentiated cell states within the male germline
La, H. M., Mäkelä, J.-A., Chan, A.-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In: Nature Communications. 9, 1, 18 p., 2819.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile74 Citations (Scopus) -
Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes
Chan, A. L., La, H. M., Legrand, J. M. D., Mäkelä, J. A., Eichenlaub, M., De Seram, M., Ramialison, M. & Hobbs, R. M., 12 Sept 2017, In: Stem Cell Reports. 9, 3, p. 956-971 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile54 Citations (Scopus) -
Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling
Hobbs, R. M., La, H. M., Makela, J.-A., Kobayashi, T., Noda, T. & Pandolfi, P. P., 2015, In: EMBO Reports. 16, 4, p. 467 - 480 14 p.Research output: Contribution to journal › Article › Research › peer-review
61 Citations (Scopus) -
Functional antagonism between Sall4 and Plzf defines germline progenitors
Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K., Altruda, F., Nishinakamura, R., Chai, L. & Pandolfi, P. P., 2012, In: Cell Stem Cell. 10, 3, p. 284 - 298 15 p.Research output: Contribution to journal › Article › Research › peer-review
166 Citations (Scopus) -
Plzf regulates germline progenitor self-renewal by opposing mTORC1
Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S. & Pandolfi, P. P., Aug 2010, In: Cell. 142, 3, p. 468-479 12 p.Research output: Contribution to journal › Article › Research › peer-review
240 Citations (Scopus)