Robin Hobbs

Senior Research Fellow, Australian Regenerative Medicine Institute
Monash Biomedicine Discovery Institute

https://orcid.org/0000-0002-3853-2614

EmailRobin.Hobbs@monash.edu

Accepting PhD Students

Research output per year

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Personal profile

Biography

In adult testis, there is a population of germline stem cells (spermatogonial stem cells; SSCs) needed for life-long production of spermatozoa and fertility. SSC maintenance is dependent on crosstalk between cell-intrinsic factors and growth factors produced from a stem cell niche. We have identified key transcription factors and growth factor signalling pathways involved in self-renewal and differentiation of SSCs. Through use of mouse models, we aim to define critical pathways regulating SSC function. Projects will focus on characterizing mechanisms of SSC regulation with particular emphasis on components of transcription factor networks and their downstream targets. This work will involve use of mouse models, isolation and in vitro culture of SSCs, flow cytometry and cell/molecular biological techniques. These studies can have particular relevance to the stem cell and fertility fields.

Research area keywords

Stem cells
Fertility
Cell signalling
Transcription factors
Differentiation

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Projects

2 Active
8 Finished

Regulatory networks defining stem cell populations in the adult male germline

Hobbs, R. & Ramialison, M.

1/01/19 → 31/12/21

Project: Research

IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Meinhardt, A., Loveland, K., Bhushan, S., Ellem, S. J., Hedger, M., O'Bryan, M., O'Donnell, L., Stanton, P., Risbridger, G., Baker, M. A., Hobbs, R., Loveland, B., Exintaris, B., Western, P., McLachlan, R., Whittaker, M., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.

1/10/17 → 31/03/22

Project: Research

Fluorescent Fish: Installation of fluorescence microscopes for screening of fluorescent transgenic animals Fish/Aqua Core

Kaslin, J., Currie, P., Lieschke, G., Ramialison, M., Bryson-Richardson, R., Keightley, C., Peleg, A., Abud, H., McGlinn, E., Merson, T., Hobbs, R., Anko, M. & Bird, P.

1/12/16 → 31/12/17

Project: Research

The characterisation of an essential regulator of pre-mRNA splicing required for germ cell function and male fertility

O'Bryan, M., Hobbs, R. & Jamsai, D.

National Health & Medical Research Council (NHMRC)

1/01/15 → 31/12/18

Project: Research

NHMRC Equipment Grant - Water filtration upgrade for cost effective water treatment in FishCore

Kaslin, J., Abud, H., Anko, M., Bryson-Richardson, R., Currie, P., Dworkin, S., Ferrero, R., Hobbs, R., Keightley, C., Lieschke, G., McGlinn, E., Peleg, A. & Ramialison, M.

National Health & Medical Research Council (NHMRC)

5/12/14 → 31/12/15

Project: Research