Projects per year
Personal profile
Biography
In adult testis, there is a population of germline stem cells (spermatogonial stem cells; SSCs) needed for life-long production of spermatozoa and fertility. SSC maintenance is dependent on crosstalk between cell-intrinsic factors and growth factors produced from a stem cell niche. We have identified key transcription factors and growth factor signalling pathways involved in self-renewal and differentiation of SSCs. Through use of mouse models, we aim to define critical pathways regulating SSC function. Projects will focus on characterizing mechanisms of SSC regulation with particular emphasis on components of transcription factor networks and their downstream targets. This work will involve use of mouse models, isolation and in vitro culture of SSCs, flow cytometry and cell/molecular biological techniques. These studies can have particular relevance to the stem cell and fertility fields.
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Keywords
- Stem cells
- Fertility
- Cell signalling
- Transcription factors
- Differentiation
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2011 2022
Regulatory networks defining stem cell populations in the adult male germline
1/01/19 → 31/12/21
Project: Research
IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project
Meinhardt, A., Loveland, K., Bhushan, S., Ellem, S., Hedger, M., O'Bryan, M., O'Donnell, L., Stanton, P., Risbridger, G., Baker, M. A., Hobbs, R., Loveland, B., Exintaris, B., Western, P., McLachlan, R., Whittaker, M., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.
1/10/17 → 31/03/22
Project: Research
Stem Cells Australia
Little, M., Kilpatrick, T., Gardner, D., Hilton, D., Polo, J., Hobbs, R., Bourne, J., Marcelle, C., Rosenthal, N., Stanley, E., Elefanty, A., Barberi, T., Gray, P., Cooper-White, J., Wainwight, B., Wolvetang, E., Nielsen, L., Bartlett, P. F., Wells, C., Harvey, R., Graham, R., Palpant, N., Alexander, W. S., Laslett, A., Nilsson, S., Haylock, D., Grimmond, S., McDonald, V., Abud, H., Currie, P., Haynes, J., Janovjak, H., Martino, M. & Merson, T.
Australian Research Council (ARC), Monash University – Internal University Contribution
1/01/11 → 31/12/19
Project: Research
Fluorescent Fish: Installation of fluorescence microscopes for screening of fluorescent transgenic animals Fish/Aqua Core
Kaslin, J., Currie, P., Lieschke, G., Ramialison, M., Bryson-Richardson, R., Keightley, C., Peleg, A., Abud, H., McGlinn, E., Merson, T., Hobbs, R., Anko, M. & Bird, P.
1/12/16 → 31/12/17
Project: Research
The characterisation of an essential regulator of pre-mRNA splicing required for germ cell function and male fertility
O'Bryan, M., Hobbs, R. & Jamsai, D.
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/18
Project: Research
Research Output 2001 2019
Identification of dynamic undifferentiated cell states within the male germline
La, H. M., Mäkelä, J-A., Chan, A-L., Rossello, F. J., Nefzger, C. M., Legrand, J. M. D., De Seram, M., Polo, J. M. & Hobbs, R. M., 19 Jul 2018, In : Nature Communications. 9, 1, 18 p., 2819.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes
Chan, A. L., La, H. M., Legrand, J. M. D., Mäkelä, J. A., Eichenlaub, M., De Seram, M., Ramialison, M. & Hobbs, R. M., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 956-971 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling
Hobbs, R. M., La, H. M., Makela, J-A., Kobayashi, T., Noda, T. & Pandolfi, P. P., 2015, In : EMBO Reports. 16, 4, p. 467 - 480 14 p.Research output: Contribution to journal › Article › Research › peer-review
Functional antagonism between Sall4 and Plzf defines germline progenitors
Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K., Altruda, F., Nishinakamura, R., Chai, L. & Pandolfi, P. P., 2012, In : Cell Stem Cell. 10, 3, p. 284 - 298 15 p.Research output: Contribution to journal › Article › Research › peer-review
Plzf regulates germline progenitor self-renewal by opposing mTORC1
Hobbs, R. M., Seandel, M., Falciatori, I., Rafii, S. & Pandolfi, P. P., Aug 2010, In : Cell. 142, 3, p. 468-479 12 p.Research output: Contribution to journal › Article › Research › peer-review