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Research Output 1986 2018

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2018

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Morphology and function of the lamb ileum following preterm birth

Flores, T. J., Nguyen, V. B., Widdop, R. E., Sutherland, M. R., Polglase, G. R., Abud, H. E. & Black, M. J., 29 Jan 2018, In : Frontiers in Pediatrics. 6, 11 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 14, p. 3750-3755 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice

Libinaki, R., Vinh, A., Tesanovic-Klajic, S., Widdop, R. & Gaspari, T., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, S1, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Sampson, A. K., Irvine, J. C., Shihata, W. A., Dragoljevic, D., Lumsden, N., Huet, O., Barnes, T., Unger, T., Steckelings, U. M., Jennings, G. L., Widdop, R. E. & Chin-Dusting, J. P. F., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 729-740 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Luder, K., Kulkarni, K., Lee, H. W., Widdop, R. E., Del Borgo, M. P. & Aguilar, M-I., 29 Feb 2016, In : Chemical Communications. 52, 24, p. 4549-4552 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis

Gaspari, T., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W. & Dear, A. E., 2016, In : Diabetes and Vascular Disease Research. 13, 1, p. 56-68 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

beta-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Del Borgo, M. P., Wang, Y., Bosnyak, S., Walters, P. E., Spizzo, I., Perlmutter, P., Hilliard, L. M., Denton, K. M., Aguilar, M-I. M., Widdop, R. E. & Jones, E. S., 2015, In : Clinical Science. 129, 6, p. 505 - 513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In : PLoS ONE. 10, 11, 11 p., e0142087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In : Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Clayton, D. J., Hanchapola, I., Thomas, W. G., Widdop, R. E., Smith, A. I., Perlmutter, P. & Aguilar, M. M. I. . I., 2015, In : Frontiers in Pharmacology. 6, (Art. No: 5), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice

Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E. & Vinh, A., 2014, In : PLoS ONE. 9, 12, 21 p., e114895.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II

Magnani, F., Pappas, C. G., Crook, T., Magafa, V., Cordopatis, P. A., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E. & Tzakos, A. G., 2014, In : ACS Chemical Biology. 9, 7, p. 1420 - 1425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Chow, B. SM., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 2014, In : Kidney International. 86, 1, p. 75 - 85 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease

Samuel, C. S., Bodaragama, H., Chew, J., Widdop, R. E., Royce, S. G. & Hewitson, T. D., 2014, In : Hypertension. 64, 2, p. 315 - 322 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor

Mirabito, K. M., Hilliard, L. M., Kett, M. M., Brown, R. D., Booth, S. C., Widdop, R. E., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 307, 8, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The protective arms of the renin-angiontensin system in stroke

McCarthy, C. A., Facey, L. J. & Widdop, R. E., 2014, In : Current Hypertension Reports. 16, 7 (Art. No: 440), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasoactive role for angiotensin II type 2 receptors in human radial artery

Zulli, A., Hare, D. L., Buxton, B. F. & Widdop, R. E., 2014, In : International Journal of Immunopathology and Pharmacology. 27, 1, p. 79 - 85 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

Tesanovic Kljajic, S., Widdop, R. E., Vinh, A., Welungoda, I. K., Bosnyak, S., Jones, E. S. & Gaspari, T. A., 2013, In : International Journal of Cardiology. 169, 4, p. 281 - 287 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl donors retain their depressor effects in hypertension

Irvine, J. C., Ravi, R. M., Harper, B. K. & Widdop, R. E., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 6, p. 939 - 945 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective arms of the renin-angiotensin-system in neurological disease

Sumners, C., Horiuchi, M., Widdop, R. E., McCarthy, C. A., Unger, T. & Steckelings, U. M., 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 8, p. 580 - 588 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Update on the angiotensin AT(2) receptor

McCarthy, C. A., Widdop, R. E., Denton, K. M. & Jones, E. S., 2013, In : Current Hypertension Reports. 15, 1, p. 25 - 30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

McCarthy, C. A., Vinh, A., Broughton, B. RS., Sobey, C. G., Callaway, J. K. & Widdop, R. E., 2012, In : Hypertension. 60, 6, p. 1531 - 1537 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats

Bosnyak, S., Widdop, R. E., Denton, K. M. & Jones, E. S., 2012, In : International Journal of Hypertension. 2012, Art. No.192567, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo

Lee, S., Brait, V. H., Arumugam, T., Evans, M. A., Kim, H. H. A., Widdop, R. E., Drummond, G. R., Sobey, C. G. & Jones, E. S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 16), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice

Chan, C., Moore, J., Budzyn, K., Guida, E., Diep, H., Vinh, A., Jones, E. S., Widdop, R. E., Armitage, J. A., Sakkal, S., Ricardo, S. D., Sobey, C. G. & Drummond, G. R., 2012, In : Hypertension. 60, 5, p. 1207 - 1212 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II

Brown, R. D., Hilliard, L. M., Head, G. A., Jones, E. S., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 1, p. 129 - 135 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension

Hilliard, L. M., Jones, E. S., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 2, p. 409 - 414 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model

Gaspari, T., Liu, H., Welungoda, I., Hu, Y., Widdop, R., Knudsen, L., Simpson, R. & Dear, A., 2011, In : Diabetes and Vascular Disease Research. 8, 2, p. 117 - 124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function

Jones, E. S., Del Borgo, M. P., Kirsch, J., Clayton, D. J., Bosnyak, S., Welungoda, I. K., Hausler, N., Unabia, S., Perlmutter, P., Thomas, W. G., Aguilar, M. I. & Widdop, R. E., 2011, In : Hypertension. 57, 3, p. 570 - 576 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Beta-amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2)

Clayton, D., Hanchapola, I., Hausler, N., Unabia, S., Lew, R. A., Widdop, R. E., Smith, A. I., Perlmutter, P. & Aguilar, M. -I., 2011, In : Journal of Molecular Recognition. 24, 2, p. 235 - 244 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor

Hilliard, L. M., Nematbakhsh, M., Kett, M. M., Teichman, E., Sampson, A. K., Widdop, R. E., Evans, R. G. & Denton, K. M., 2011, In : Hypertension. 57, 2, p. 275 - 282 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-peptide AT2-receptor agonists

Steckelings, U., Larhed, M., Hallberg, A., Widdop, R., Jones, E., Wallinder, C., Namsolleck, P., Dahlof, B. & Unger, T., 2011, In : Current Opinion in Pharmacology. 11, 2, p. 187 - 192 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors

Bosnyak, S., Jones, E., Christopoulos, A., Aguilar, M., Thomas, W. & Widdop, R., 2011, In : Clinical Science. 121, 7, p. 297 - 303 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model

Libinaki, R., Tesanovic, S., Heal, A., Nikolovski, B., Vinh, A., Widdop, R. E., Gaspari, T. A., Devaraj, S. & Ogru, E., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, 5-6, p. 587 - 592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucocorticoids suppress growth in neonatal cardiomyocytes co-expressing AT2 and AT1 angiotensin receptors

Porrello, E. R., Meeker, W. F., Thomas, W. G., Widdop, R. E. & Delbridge, L. MD., 2010, In : Neonatology. 97, 3, p. 257 - 265 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats

Bosnyak, S., Welungoda, I. K., Hallberg, A., Alterman, M., Widdop, R. E. & Jones, E. S., 2010, In : British Journal of Pharmacology. 159, 3, p. 709 - 716 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The angiotensin AT2 receptor in left ventricular hypertrophy

Steckelings, U. M., Widdop, R. E., Paulis, L. & Unger, T., 2010, In : Journal of Hypertension. 28, Suppl 1, p. S50 - S55 6 p.

Research output: Contribution to journalArticleResearchpeer-review