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Personal profile

Biography

The renin angiotensin system is one of the major hormonal systems regulating the cardiovascular status of the body, with respect to both pharmacodynamic blood pressure regulation and trophic influences on the heart and vasculature. Increased activity of the renin angiotensin system is likely to contribute to a range of cardiovascular diseases including hypertension, heart failure, atherosclerosis and stroke. There are a number of angiotensin receptor subtypes that are activated by endogenous angiotensin peptides as well as by synthetic compounds. The AT1 receptor subtype mediates most of the classical effects of angiotensin II. Blockade of AT1 receptors by sartan-type compounds has proven very successful in the treatment of diseases such as hypertension. However, other non-AT1 receptors have been less well investigated, and this is a major focus of the Integrative Cardiovascular Pharmacology Laboratory.
In particular, the AT2 receptor exerts counterregulatory effects to the AT1 receptor and we are interested in the functional effects of acute and chronic AT2 receptor stimulation per se, on pharmacodynamic status (blood pressure and flow) and on cardiovascular remodelling (heart and blood vessel antihypertrophic and antifibrotic effects etc.) in a range of models of hypertension, atherosclerosis and stroke, as well as aging. In addition, the role of shorter angiotensin peptide fragments (e.g. Ang 1-7, Ang III, Ang IV) under normal and pathological settings are also under investigation.

Research area keywords

  • Angiotensin II
  • cardiovascular disease
  • Hypertension

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Projects

Research Output

Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats

Hilliard Krause, L. M., Kemp, B. A., Tan, A. S. J., Jones, E. S., Del Borgo, M. P., Aguilar, M. I., Denton, K. M., Carey, R. M. & Widdop, R. E., 17 Apr 2020, In : Clinical Science. 134, 7, p. 871-884 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The anti-fibrotic actions of relaxin are mediated through AT2R-associated protein phosphatases via RXFP1-AT2R functional crosstalk in human cardiac myofibroblasts

Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., 16 Apr 2020, (Accepted/In press) In : The FASEB Journal. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Liu, H., Byrne, M., Perlmutter, P., Walker, A., Sama, G. R., Subbiah, J., Ozcelik, B., Widdop, R. E., Gaspari, T. A., Byron, K., Chen, Y-C., Kaye, D. M. & Dear, A. E., 30 Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 687-692 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A Series of Analogues to the AT 2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, R., Lindman, J., Wannberg, J., Sallander, J., Backlund, M., Baraldi, D., Widdop, R., Hallberg, M., Åqvist, J., Gutierrez de Teran, H., Gising, J. & Larhed, M., 1 Jan 2019, In : ChemistryOpen. 8, 1, p. 114-125 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)