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Biography

The renin angiotensin system is one of the major hormonal systems regulating the cardiovascular status of the body, with respect to both pharmacodynamic blood pressure regulation and trophic influences on the heart and vasculature. Increased activity of the renin angiotensin system is likely to contribute to a range of cardiovascular diseases including hypertension, heart failure, atherosclerosis and stroke. There are a number of angiotensin receptor subtypes that are activated by endogenous angiotensin peptides as well as by synthetic compounds. The AT1 receptor subtype mediates most of the classical effects of angiotensin II. Blockade of AT1 receptors by sartan-type compounds has proven very successful in the treatment of diseases such as hypertension. However, other non-AT1 receptors have been less well investigated, and this is a major focus of the Integrative Cardiovascular Pharmacology Laboratory.
In particular, the AT2 receptor exerts counterregulatory effects to the AT1 receptor and we are interested in the functional effects of acute and chronic AT2 receptor stimulation per se, on pharmacodynamic status (blood pressure and flow) and on cardiovascular remodelling (heart and blood vessel antihypertrophic and antifibrotic effects etc.) in a range of models of hypertension, atherosclerosis and stroke, as well as aging. In addition, the role of shorter angiotensin peptide fragments (e.g. Ang 1-7, Ang III, Ang IV) under normal and pathological settings are also under investigation.

Keywords

  • Angiotensin II
  • cardiovascular disease
  • Hypertension

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Projects 2000 2021

Research Output 1986 2018

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Morphology and function of the lamb ileum following preterm birth

Flores, T. J., Nguyen, V. B., Widdop, R. E., Sutherland, M. R., Polglase, G. R., Abud, H. E. & Black, M. J., 29 Jan 2018, In : Frontiers in Pediatrics. 6, 11 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Novel approaches for treating hypertension

Freeman, A. J., Vinh, A. & Widdop, R. E., 27 Jan 2017, In : F1000Research. 6, 7 p., 80.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 14, p. 3750-3755 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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