1989 …2019

Research output per year

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Research Output

2009

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite sarcoptes scabiei

Beckham, S. A., Boyd, S. E., Reynolds, S., Willis, C., Johnstone, M., Mika, A., Simerska, P., Wijeyewickrema, L. C., Smith, A. I., Kemp, D. J., Pike, R. N. & Fischer, K., 2009, In : The Journal of Biological Chemistry. 284, 49, p. 34413 - 34422 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Conformational change in the chromatin remodelling protein MENT

Ong, P. C., Golding, S. J., Pearce, M. C., Irving, J. A., Grigoryev, S. A., Pike, D., Langendorf, C. G., Bashtannyk-Puhalovich, T. A., Bottomley, S. P., Whisstock, J. C., Pike, R. N. & McGowan, S., 2009, In : PLoS ONE. 4, 3 (e4727), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Cooperative effects in the substrate specificity of the complement protease C1s

Boyd, S. E., Kerr, F. K., Albrecht, D. W., Garcia De La Banda, M. J., Ng, N. & Pike, R. N., 2009, In : Biological Chemistry. 390, 5/6, p. 503 - 507 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Corruption of innate immunity by bacterial proteases

Potempa, J. & Pike, R. N., 2009, In : Journal of Innate Immunity. 1, 12, p. 70 - 87 18 p.

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)

Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: A mechanism favouring colonization?

McAlister, A. D., Sroka, A., Fitzpatrick, R. E., Quinsey, N. S., Travis, J., Potempa, J. & Pike, R. N., 2009, In : Journal of Periodontal Research. 44, p. 348 - 353 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

High molecular weight gingipains from porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

Fitzpatrick, R. E., Aprico, A., Wijeyewickrema, L. C., Pagel, C. N., Wong, D. M., Potempa, J., MacKie, E. J. & Pike, R. N., Jan 2009, In : Journal of Innate Immunity. 1, 2, p. 109-117 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Modulation of the proteolytic activity of the complement protease C1s by polyanions: Implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray-Rust, T. A., Kerr, F. K., Thomas, A. R., Wu, T. J-T., Yongqing, T., Ong, P. C., Quinsey, N. S., Whisstock, J. C., Wagenaar-Bos, I. C., Freeman, C. & Pike, R. N., 2009, In : Biochemical Journal. 422, 2, p. 295 - 303 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Scabies mite inactivated serine protease paralogs inhibit the human complement system

Bergstrom, F. C., Reynolds, S., Johnstone, M., Pike, R. N., Buckle, A. M., Kemp, D. J., Fischer, K. & Blom, A. M., 2009, In : Journal of Immunology. 182, 12, p. 7809 - 7817 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Fischer, K., Langendorf, C., Irving, J. A., Reynolds, S., Willis, C., Beckham, S. A., Law, R. H. P., Yang, S., Bashtannyk-Puhalovich, T. A., McGowan, S., Whisstock, J., Pike, R. N., Kemp, D. J. & Buckle, A. M., 2009, In : Journal of Molecular Biology. 390, 4, p. 635 - 645 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Subsite cooperativity in protease specificity

Ng, N. M., Pike, R. N. & Boyd, S. E., 2009, In : Biological Chemistry. 390, 5-6, p. 401 - 407 7 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The effects of exosite occupancy on the substrate specificity of thrombin

Ng, N. M-Y., Quinsey, N. S., Matthews, A. Y., Kaiserman, D., Wijeyewickrema, L. C., Bird, P. I., Thompson, P. E. & Pike, R. N., 2009, In : Archives of Biochemistry and Biophysics. 489, 1-2, p. 48 - 54 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

Fitzpatrick, R. E., Wijeyewickrema, L. C. & Pike, R. N., 2009, In : Future Microbiology. 4, 4, p. 471 - 487 17 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures

Fitzpatrick, R. E., Campbell, P. D., Sivagurunathan, S., Pagel, C. N., Potempa, J., Mackie, E. J. & Pike, R. N., 2009, In : Journal of Periodontal Research. 44, p. 565 - 567 2 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids

Pagel, C. N., Song, S-J., Loh, L. H., Tudor, E. M., Murray-Rust, T. A., Pike, R. N. & Mackie, E. J., 2009, In : Bone. 44, 5, p. 813 - 821 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2008

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

Kerr, F. K., Thomas, A. R., Wijeyewickrema, L. C., Whisstock, J., Boyd, S. E., Kaiserman, D., Matthews, A. Y., Bird, P. I., Thielens, N. M., Rossi, V. & Pike, R. N., 2008, In : Molecular Immunology. 45, p. 670 - 677 7 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Fasciola hepatica and Fasciola gigantica: Cloning and characterisation of 70 kDa heat-shock proteins reveals variation in HSP70 gene expression between parasite species recovered from sheep

Smith, R., Spithill, T. W., Pike, R. N., Meeusen, E. N. T. & Piedrafita, D. M., 2008, In : Experimental Parasitology. 118, p. 536 - 542 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Osteopontin and skeletal muscle myoblasts: Association with muscle regeneration and regulation of myoblast function in vitro

Uaesoontrachoon, K., Yoo, H-J., Tudor, E. M., Pike, R. N., Mackie, E. J. & Pagel, C. N., 2008, In : International Journal of Biochemistry and Cell Biology. 40, 10, p. 2303 - 2314 12 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The initiating proteases of the complement system: controlling the cleavage

Duncan, R. C., Wijeyewickrema, L. C. & Pike, R. N., 2008, In : Biochimie. 90, p. 387 - 395 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2007

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

193 Citations (Scopus)

DNA accelerates the inhibition of human cathepsin V by serpins

Ong, P. C., McGowan, S., Pearce, M. C., Irving, J. A., Kan, W-T., Grigoryev, S. A., Turk, B., Silverman, G. A., Brix, K., Bottomley, S. P., Whisstock, J. & Pike, R. N., 2007, In : The Journal of Biological Chemistry. 282, 51, p. 36980 - 36986 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K. L., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M. C. J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. & Whisstock, J., 2007, In : Nature Structural & Molecular Biology. 14, 4, p. 280 - 286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)

MENT a chromatin-associated serpin from avian blood cells: structure and function

Grigoryev, S. A., Bulynko, Y. A., Pike, R. N. & Whisstock, J., 2007, Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. Silverman, G. A. & Lomas, D. A. (eds.). 1st ed. Singapore: World Scientific Publishing, p. 243 - 259 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Molecular characterization of centerin, a germinal centre cell serpin

Paterson, M. A., Horvath, A. J., Pike, R. N. & Coughlin, P. B., 2007, In : Biochemical Journal. 405, 3, p. 489 - 494 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Regulation of hemostasis by heparin-binding serpins

Church, F. C., Pike, R. N., Tollefsen, D. M., Buckle, A. M., Ciaccia, A. V. & Olson, S. T., 2007, Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. Silverman, G. A. & Lomas, D. A. (eds.). 1st ed. Singapore: World Scientific Publishing, p. 509 - 554 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Serpin Conformations

Pearce, M. C., Pike, R. N., Lesk, A. M. & Bottomley, S. P., 2007, Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. Silverman, G. A. & Lomas, D. A. (eds.). 1st ed. Singapore: World Scientific Publishing, p. 35 - 66 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The effects of thrombomodulin on the substrate specificity of thrombin

Sotiropoulou, G. (ed.), Ng, N., Pampalakis, G. (ed.), Boyd, S. E., Arampatzidou, M. (ed.), Bird, P. I., Thompson, P., Matthews, A. Y., Kaiserman, D. & Pike, R. N., 2007, p. 375 - 375. 1 p.

Research output: Contribution to conferenceAbstract

2006

An overview of the serpin superfamily

Law, R. H. P., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W., Rosado, C. J., Langendorf, C., Pike, R. N., Bird, P. I. & Whisstock, J., 2006, In : Genome Biology. 7, 5, p. 216-1 - 216-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

359 Citations (Scopus)

Approaches to selective peptidic inhibitors of factor Xa

Bromfield, K. M., Quinsey, N. S., Duggan, P. J. & Pike, R. N., 2006, In : Chemical Biology & Drug Design. 68, 1, p. 11 - 19 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Functional responses of bone cells to thrombin

Pagel, C. N., Sivagurunathan, S., Loh, L. H., Tudor, E. M., Pike, R. N. & Mackie, E. J., 2006, In : Biological Chemistry. 387, 8, p. 1037 - 1041 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Guest Editorial Protease Inhibitors

Sommerhoff, C. P., Fritz, H. (ed.), Dunn, B. M. & Pike, R. N., 2006, p. 825 - 825. 1 p.

Research output: Contribution to conferenceAbstract

Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite

Beckham, S. A., Law, R. H-P., Smooker, P. M., Quinsey, N. S., Caffrey, C. R., McKerrow, J. H., Pike, R. N. & Spithill, T. W., 2006, In : Biological Chemistry. 387, 8, p. 1053 - 1061 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

McGowan, S., Buckle, A. M., Irving, J. A., Ong, P. C., Bashtannyk-Puhalovich, T. A., Kan, W-T., Henderson, K., Bulynko, Y. A., Popova, E. Y., Smith, A. I., Bottomley, S. P., Rossjohn, J., Grigoryev, S. A., Pike, R. N. & Whisstock, J. C., 2006, In : The EMBO Journal. 25, 13, p. 3144 - 3155 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)
2005

An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone loss

O'Brien-Simpson, N. M., Pathirana, R. D., Paolini, R. A., Chen, Y-Y., Veith, P. D., Tam, V., Ally, N., Pike, R. N. & Reynolds, E. C., 2005, In : Journal of Immunology. 175, 6, p. 3980 - 3989 10 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

Bacterial peptidases

Potempa, J. & Pike, R. N., 2005, Concepts in Bacterial Virulence. Russell, W., Herwald, H. & Schmidt, A. (eds.). 12 ed. Basel Switzerland: Karger, p. 132 - 180 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans

Pike, R. N., Buckle, A. M., Le Bonniec, B. & Church, F. C., 2005, In : FEBS Journal. 272, 19, p. 4842 - 4851 10 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Elucidation of the substrate specificity of the C1s protease of the classical complement pathway

Kerr, F. K., O'Brien, G., Quinsey, N. S., Whisstock, J., Boyd, S. E., Garcia De La Banda, M. J., Kaiserman, D., Matthews, A. Y., Bird, P. I. & Pike, R. N., 2005, In : The Journal of Biological Chemistry. 280, 47, p. 39510 - 39514 5 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

PoPS: A computational tool for modeling and predicting protease specificity

Boyd, S. E., Pike, R. N., Rudy, G. B., Whisstock, J. & Garcia De La Banda, M. J., 2005, In : Journal of Bioinformatics and Computational Biology. 3, 3, p. 551 - 585 35 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)
8 Citations (Scopus)

Studies on the receptors mediating responses of osteoblasts to thrombin

Song, S. J., Pagel, C. N., Pike, R. N. & Mackie, E. J., 2005, In : International Journal of Biochemistry and Cell Biology. 37, 1, p. 206 - 213 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Substrate specificity of mannose lectin binding associated serine proteinase 3

Quinsey, N. S. & Pike, R. N., 2005, In : FEBS Journal. 272, p. 174 - 174 1 p.

Research output: Contribution to journalLetterOther

The murine orthologue of human antichymotrypsin: a structural paradigm for CLADE A3 serpins

Horvath, A. J., Irving, J. A., Rossjohn, J., Law, R. H. P., Bottomley, S. P., Quinsey, N. S., Pike, R. N., Coughlin, P. B. & Whisstock, J., 2005, In : The Journal of Biological Chemistry. 280, 52, p. 43168 - 43178 11 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

The role of protease-activated receptor-1 in bone healing

Song, S. J., Pagel, C. N., Campbell, T. M., Pike, R. N. & Mackie, E. J., 2005, In : American Journal of Pathology. 166, 3, p. 857 - 868 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
2004

Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation

Smith, R. A., Ransjo, M., Tatarczuch, L., Song, S-J., Pagel, C. N., Morrison, J. R., Pike, R. N. & Mackie, E. J., 2004, In : Journal of Bone and Mineral Research. 19, 3, p. 507 - 516 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Antithrombin: in control of coagulation

Quinsey, N. S., Greedy, A. L., Bottomley, S. P., Whisstock, J. C. & Pike, R. N., 2004, In : International Journal of Biochemistry and Cell Biology. 36, 3, p. 386 - 389 4 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Physical characterization of serpin conformations

Dafforn, T. R., Pike, R. N. & Bottomley, S. P., 2004, In : Methods. 32, 2, p. 150 - 158 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

PoPS: a computational tool for modeling and predicting protease specificity

Boyd, S. E., De La Banda, M. G., Pike, R. N., Whisstock, J. C. & Rudy, G. B., 2004, Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004. IEEE, Institute of Electrical and Electronics Engineers, p. 372-381 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

13 Citations (Scopus)

PoPS: a computational tool for modeling and predicting protease specificity

Boyd, S. E., Garcia De La Banda, M. J., Pike, R. N., Whisstock, J. & Rudy, G. B., 2004, Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference. Markstein, V. (ed.). Los Alamitos USA: IEEE Computer Society, p. 372 - 381 10 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities

Sztukowska, M., Sroka, A., Bugno, M., Banbula, A., Takahashi, Y., Pike, R. N., Genco, C. A., Travis, J. & Potempa, J., 2004, In : Molecular Microbiology. 54, 5, p. 1393 - 1408 16 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2003

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

Ally, N., Whisstock, J. C., Sieprawskalupa, M., Potempa, J., Le Bonniec, B. F., Travis, J. & Pike, R. N., 2003, In : Biochemistry. 42, 40, p. 11693 - 11700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Cloning and expression of the major secreted cathepsin B-Iike protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection

Law, R. H. P., Smooker, P. M., Irving, J. A., Piedrafita, D., Ponting, R., Kennedy, N. J., Whisstock, J. C., Pike, R. N. & Spithill, T. W., 2003, In : Infection and Immunity. 71, 12, p. 6921 - 6932 12 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)