1989 …2019

Research output per year

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Research Output

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

193 Citations (Scopus)

Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation

Smith, R. A., Ransjo, M., Tatarczuch, L., Song, S-J., Pagel, C. N., Morrison, J. R., Pike, R. N. & Mackie, E. J., 2004, In : Journal of Bone and Mineral Research. 19, 3, p. 507 - 516 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: A new trait in microbial pathogenicity

Lourbakos, A., Yuan, Y. P., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 15 Jun 2001, In : Blood. 97, 12, p. 3790-3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

Activation of protease-activated receptors by gingipains from porphyromonas gingivalis leads to platelet aggregation: a new trait in micobial pathogenicity

Lourbakos, A., Yuan, Y., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 2001, In : Blood. 97, 12, p. 3790 - 3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation ofproteinase activated receptor - 2 on human neutrophils by arginine gingpain from Porphyromonas gingivalis

Lourbakos, A., Chinni, C., Mackie, E. J. & Pike, R. N., 1998, p. 51 - 51. 1 p.

Research output: Contribution to conferenceAbstract

Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles

Norbury, L. J., Beckham, S. A., Pike, R. N., Grams, R., Spithill, T. W., Fecondo, J. V. & Smooker, P. M., 2011, In : Biochimie. 93, 3, p. 604 - 611 8 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

A High Yield Method For The Isolation Of Sheep'S Liver Cathepsin L

Pike, R. & Dennison, C., 1 Jan 1989, In : Preparative Biochemistry. 19, 3, p. 231-245 15 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

Beckham, S. A., Piedrafita, D. M., Phillips, C. I., Samarawickrema, N., Law, R. H. P., Smooker, P. M., Quinsey, N. S., Irving, J. A., Greenwood, D. L., Verhelst, S. H. L., Bogyo, M., Turk, B., Coetzer, T. H., Wijeyewickrema, L. C., Spithill, T. W. & Pike, R. N., 2009, In : International Journal of Biochemistry and Cell Biology. 41, 7, p. 1601 - 1612 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Scally, S., Petersen, J., Law, S. C. CHENG., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., McCluskey, J., Toes, R. E., La Gruta, N. L., Purcell, A. W., Reid, H. H., Thomas, R. & Rossjohn, J., 2013, In : Journal of Experimental Medicine. 210, 12, p. 2569 - 2582 14 p.

Research output: Contribution to journalArticleResearchpeer-review

212 Citations (Scopus)

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : The Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference

Norbury, L. J., Hung, A., Beckham, S. A., Pike, R. N., Spithill, T. W., Craik, C. S., Choe, Y., Fecondo, J. V. & Smooker, P. M., 2012, In : Biochimie. 94, 5, p. 1119 - 1127 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis

Nuttall, S. N., Krishnan, U. V., Doughty, L., Nathanielsz, A., Ally, N., Pike, R. N., Hudson, P. J., Kortt, A. A. & Irving, R. A., 2002, In : FEBS Letters. 516, 1-3, p. 80 - 86 7 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus

Streatfeild-James, R. M., Williamson, D., Pike, R. N., Tewksbury, D., Carrell, R. W. & Coughlin, P. B., 1998, In : FEBS Letters. p. 267 - 270 4 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone loss

O'Brien-Simpson, N. M., Pathirana, R. D., Paolini, R. A., Chen, Y-Y., Veith, P. D., Tam, V., Ally, N., Pike, R. N. & Reynolds, E. C., 2005, In : Journal of Immunology. 175, 6, p. 3980 - 3989 10 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

An overview of the serpin superfamily

Law, R. H. P., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W., Rosado, C. J., Langendorf, C., Pike, R. N., Bird, P. I. & Whisstock, J., 2006, In : Genome Biology. 7, 5, p. 216-1 - 216-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

359 Citations (Scopus)

Anti-peptide antibodies to cathepsins B, L and D and type IV collagenase. Specific recognition and inhibition of the enzymes

Coetzer, T. H. T., Elliott, E., Fortgens, P. H., Pike, R. N. & Dennison, C., 15 Feb 1991, In : Journal of Immunological Methods. 136, 2, p. 199-210 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Antithrombin: in control of coagulation

Quinsey, N. S., Greedy, A. L., Bottomley, S. P., Whisstock, J. C. & Pike, R. N., 2004, In : International Journal of Biochemistry and Cell Biology. 36, 3, p. 386 - 389 4 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Antithrombins Wibble and Wobble (T85M/K): Archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation

Beauchamp, N. J., Pike, R. N., Daly, M., Butler, L., Makris, M., Dafforn, T. R., Zhou, A., Fitton, H. L., Preston, F. E., Peake, I. R. & Carrell, R. W., 15 Oct 1998, In : Blood. 92, 8, p. 2696-2706 11 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

A peptide antibody that specifically inhibits cathepsin L

Dennison, C. & Pike, R. N., 1 Dec 1991, In : Advances in Experimental Medicine and Biology. 303, p. 285-288 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Approaches to selective peptidic inhibitors of factor Xa

Bromfield, K. M., Quinsey, N. S., Duggan, P. J. & Pike, R. N., 2006, In : Chemical Biology & Drug Design. 68, 1, p. 11 - 19 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Arginine-specific protease from porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion

Lourbakos, A., Potempa, J., Travis, J., D'Andrea, M. R., Andrade-Gordon, P., Santulli, R. & Pike, R. N., 2001, In : Infection and Immunity. 69, 8, p. 5121 - 5130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

184 Citations (Scopus)

A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica

Smooker, P. M., Whisstock, J. C., Irving, J., Siyaguna, S., Spithill, T. W. & Pike, R. N., 2000, In : Protein Science. p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS

Dunstan, R. A., Heinz, E., Wijeyewickrema, L. C., Pike, R. N., Purcell, A. W., Evans, T. J., Praszkier, J., Robins-Browne, R. M., Strugnell, R. A., Korotkov, K. V. & Lithgow, T. J., 2013, In : PLoS Pathogens. 9, 1 (Art # e1003117), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin

Morty, R. E., Troeberg, L., Pike, R. N., Jones, R., Nickel, P., Lonsdale-Eccles, J. D. & Coetzer, T. H., 1998, In : FEBS Letters. p. 251 - 256 6 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Baboon (Papio ursinus) cathepsin L: purification, characterization and comparison with human and sheep cathepsin L

Coetzer, T. H. T., Dennehy, K. M., Pike, R. N. & Dennison, C., 1 Jan 1995, In : Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 112, 3, p. 429-439 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Bacterial peptidases

Potempa, J. & Pike, R. N., 2005, Concepts in Bacterial Virulence. Russell, W., Herwald, H. & Schmidt, A. (eds.). 12 ed. Basel Switzerland: Karger, p. 132 - 180 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Binding affinity of gingipain proteinase-adhesins to a range of proteins

Ally, N. & Pike, R. N., 1999, p. A4 - A4. 1 p.

Research output: Contribution to conferenceAbstract

Bioinformatic approaches for predicting substrates of proteases

Song, J., Tan, H., Boyd, S. E., Shen, H., Mahmood, K., Webb, G., Akutsu, T., Whisstock, J. & Pike, R., 2011, In : Journal of Bioinformatics and Computational Biology. 9, 1, p. 149 - 178 30 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase

Janusz, M. J., Hare, M., Durham, S. L., Potempa, J., McGraw, W., Pike, R., Travis, J. & Shapiro, S. D., 14 Jun 1999, In : Inflammation Research. 48, 5, p. 280-288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Cathepsin B proteases of flukes: The key to facilitating parasite control?

Smooker, P. M., Jayaraj, R., Pike, R. N. & Spithill, T. W., 2010, In : Trends in Parasitology. 26, 10, p. 506 - 514 9 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Characterisation of the Activity and Stability of Single-chain Cathepsin L and of Proteolytically Active Cathepsin L/Cystatin Complexes

Dennison, C., Pike, R., Coetzer, T. & Kirk, K., 1 Jan 1992, In : Biological Chemistry Hoppe-Seyler. 373, 2, p. 419-426 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Characterization of a recombinant Fasciola Hepatica cathepsin L

Pike, R. N., Smooker, P. M., Irving, J., Whisstock, J. C. & Spithill, T. W., 1998, p. 63 - 63. 1 p.

Research output: Contribution to conferenceAbstract

Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite sarcoptes scabiei

Beckham, S. A., Boyd, S. E., Reynolds, S., Willis, C., Johnstone, M., Mika, A., Simerska, P., Wijeyewickrema, L. C., Smith, A. I., Kemp, D. J., Pike, R. N. & Fischer, K., 2009, In : The Journal of Biological Chemistry. 284, 49, p. 34413 - 34422 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis

Pike, R. N., Potempa, J., Mcgraw, W., Coetzer, T. H. T. & Travis, J., 1 Jan 1996, In : Journal of Bacteriology. 178, 10, p. 2876-2882 7 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

Ally, N., Whisstock, J. C., Sieprawskalupa, M., Potempa, J., Le Bonniec, B. F., Travis, J. & Pike, R. N., 2003, In : Biochemistry. 42, 40, p. 11693 - 11700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Cleavage and activation of preinase-activated receptor-2 on human neutrphil s by gingpain -R from Porphyromonas gingivilis

Lourbakos, A., Chinni, C., Thompson, P. E., Potempa, J., Travis, J., Mackie, E. J. & Pike, R. N., 1998, In : FEBS Letters. p. 45 - 48 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis

Lourbakos, A., Chinni, C., Thompson, P., Potempa, J., Travis, J., MacKie, E. J. & Pike, R. N., 11 Sep 1998, In : FEBS Letters. 435, 1, p. 45-48 4 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

Cleavage of the Human C5a Receptor by Proteinases Derived from Porphyromonas gingivalis: Cleavage of Leukocyte C5a Receptor

Jagels, M. A., Ember, J. A., Travis, J., Potempa, J., Pike, R. & Hugli, T. E., 1 Dec 1996, In : Advances in Experimental Medicine and Biology. 389, p. 155-164 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Cleaved antitrypsin polymers at atomic resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B. F., Parker, M. W. & Bottomley, S. P., 13 Mar 2000, In : Protein Science. 9, 2, p. 417-420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Cleaved antitrypsin polymers at atominc resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B., Parker, M. W. & Bottomley, S. P., 2000, In : Protein Science. p. 417 - 420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloning and expression of the major secreted cathepsin B-Iike protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection

Law, R. H. P., Smooker, P. M., Irving, J. A., Piedrafita, D., Ponting, R., Kennedy, N. J., Whisstock, J. C., Pike, R. N. & Spithill, T. W., 2003, In : Infection and Immunity. 71, 12, p. 6921 - 6932 12 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Conformational change in the chromatin remodelling protein MENT

Ong, P. C., Golding, S. J., Pearce, M. C., Irving, J. A., Grigoryev, S. A., Pike, D., Langendorf, C. G., Bashtannyk-Puhalovich, T. A., Bottomley, S. P., Whisstock, J. C., Pike, R. N. & McGowan, S., 2009, In : PLoS ONE. 4, 3 (e4727), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin

Whisstock, J. C., Pike, R. N., Jin, L., Skinner, R., Pei, X. Y., Carrell, R. W. & Lesk, A. M., 2000, In : Journal of Molecular Biology. p. 1287 - 1305 19 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans

Pike, R. N., Buckle, A. M., Le Bonniec, B. & Church, F. C., 2005, In : FEBS Journal. 272, 19, p. 4842 - 4851 10 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Cooperative effects in the substrate specificity of the complement protease C1s

Boyd, S. E., Kerr, F. K., Albrecht, D. W., Garcia De La Banda, M. J., Ng, N. & Pike, R. N., 2009, In : Biological Chemistry. 390, 5/6, p. 503 - 507 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Corruption of innate immunity by bacterial proteases

Potempa, J. & Pike, R. N., 2009, In : Journal of Innate Immunity. 1, 12, p. 70 - 87 18 p.

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)

Cysteine proteinase inhibitors kill cultured bloodstream forms of "Trypanosoma brucei brucei"

Troeberg, L., Morty, R. E., Pike, R. N., Lonsdale-Eccles, J. D., Palmer, J. T., McKerrow, J. H. & Coetzer, T. H., 1999, In : Experimental Parasitology. p. 349 - 355 7 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis

Imamura, T., Potempa, J., Pike, R. N. & Travis, J., 1 Jan 1995, In : Infection and Immunity. 63, 5, p. 1999-2003 5 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Determination of the P'1, P'2 and P'3 subsite-specificity of factor Xa

Ludeman, J. P., Pike, R. N., Bromfield, K. M., Duggan, P. J., Cianci, J., Le Bonniec, B., Whisstock, J. C. & Bottomley, S. P., 2003, In : International Journal of Biochemistry and Cell Biology. 35, 2, p. 221 - 225 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

Ng, N., Pierce, M. J., Webb, G., Ratnikov, B., Wijeyewickrema, L. C., Duncan, R., Robertson, A. L., Bottomley, S. P., Boyd, S. E. & Pike, R. N., 2011, In : Biochemistry. 50, 48, p. 10499 - 10507 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)