1980 …2024

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2019

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Daglas, M., Draxler, D. F., Ho, H., McCutcheon, F., Galle, A., Au, A. E., Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M. & Medcalf, R. L., 29 Oct 2019, In : Cell Reports. 29, 5, p. 1178-1191.e6 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke

Draxler, D. F., Lee, F., Ho, H., Keragala, C. B., Medcalf, R. L. & Niego, B., 27 Mar 2019, In : Frontiers in Immunology. 10, MAR, 12 p., 591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

Draxler, D. F., Awad, M. M., Hanafi, G., Daglas, M., Ho, H., Keragala, C., Galle, A., Roquilly, A., Lyras, D., Sashindranath, M. & Medcalf, R. L., 1 Dec 2019, In : Journal of Neurotrauma. 36, 23, p. 3297-3308 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Draxler, D. F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Gregory, J., Larsson, P., Keragala, C., Wright, D. K., Tavancheh, E., Au, A. E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M. & Medcalf, R. L., Dec 2019, In : Journal of Thrombosis and Haemostasis. 17, 12, p. 2174-2187 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Tranexamic acid modulates the immune response and reduces postsurgical infection rates

Draxler, D. F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L. M., Forbes, A., Goncalves, I., Tran, H. A., Wallace, S., Plebanski, M., Myles, P. S. & Medcalf, R. L., 28 May 2019, In : Blood Advances. 3, 10, p. 1598-1609 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)
2018

The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Bain, C. R., Draxler, D. F., Taylor, R., Wallace, S., Gouldthorpe, O., Corcoran, T. B., Myles, P. S., L. Medcalf, R. & Bozaoglu, K., Aug 2018, In : Anaesthesia. 73, 8, p. 955-966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2017

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler, D. F., Madondo, M. T., Hanafi, G., Plebanski, M. & Medcalf, R. L., 1 Apr 2017, In : Cytometry Part A. 91, 4, p. 336-350 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan, H., Lisman, T. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 113-114 2 p., 02414.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Fibrinolysis: from blood to the brain

Medcalf, R. L., 1 Nov 2017, In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2089-2098 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
15 Citations (Scopus)

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Plasmin: A Modulator of Immune Function

Draxler, D. F., Sashindranath, M. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 143-153 11 p., 02353.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In : PLoS ONE. 12, 5, 21 p., e0177332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

Fredriksson, L., Lawrence, D. A. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 154-168 15 p., 02355.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2016

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D., Wang, H., Johnston, L., Daglas, M., Ates, R. C., Medcalf, R. L., Taylor, J. M. & Crack, P. J., 1 Jan 2016, In : eNeuro. 3, 1, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

Szabo, R., Samson, A. L., Lawrence, D. A., Medcalf, R. L. & Bugge, T. H., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1618-1628 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In : Biology Open. 6, 11, 12 p., 160098.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

The influence of differentially expressed tissue-type plasminogen activator in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Dahl, L. C. M., Nasa, Z., Chung, J., Niego, B., Tarlac, V., Ho, K. C. H., Galle, A. A., Petratos, S., Alderuccio, F. P. & Medcalf, R. L., 18 Jul 2016, In : PLoS ONE. 11, 7, 22 p., e0158653.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2015

Dendritic cell-mediated phagocytosis but not immune activation is enhanced by plasmin

Borg, R., Samson, A. L., Au, A. E-L., Scholzen, A., Fuchsberger, M., Kong, Y. Y., Freeman, R., Mifsud, N. A., Plebanski, M. & Medcalf, R. L., 2015, In : PLoS ONE. 10, 7 , 19 p., e0131216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Evaluation of gait impairment in mice subjected to craniotomy and traumatic brain injury

Sashindranath, M., Daglas, M. & Medcalf, R. L., 2015, In : Behavioural Brain Research. 286, p. 33 - 38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su, E. J., Fredriksson, L. T., Kanzawa, M., Moore, S., Folestad, E., Stevenson, T. K., Nilsson, I., Sashindranath, M., Schielke, G. P., Warnock, M., Ragsdale, M., Mann, K. M., Lawrence, A-L. E., Medcalf, R. L., Eriksson, U., Murphy, G. G. & Lawrence, D. A., 2015, In : Frontiers in Cellular Neuroscience. 9, (Art. No: 385), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

The dynamics of adult haematopoiesis in the bone and bone marrow environment

Ho, M. S. H., Medcalf, R. L., Livesey, S. A. & Traianedes, K., 2015, In : British Journal of Haematology. 170, 4, p. 472 - 486 15 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The fibrinolytic system-more than fibrinolysis?

Draxler, D. & Medcalf, R. L., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect

Boyd, B. J., Galle, A., Daglas, M., Rosenfeld, J. V. & Medcalf, R., 2015, In : Journal of Drug Targeting. 23, 9, p. 847-853 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
38 Citations (Scopus)

Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

Gardiner, E. E. & Medcalf, R. L., 2014, In : Journal of Thrombosis and Haemostasis. 12, 10, p. 1703 - 1705 3 p.

Research output: Contribution to journalArticleOther

9 Citations (Scopus)

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase

Samson, A. L., Knaupp, A. S., Kass, I., Kleifeld, O., Marijanovic, E. M., Hughes, V. A., Lupton, C. J., Buckle, A. M., Bottomley, S. P. & Medcalf, R. L., 2014, In : Journal of Biological Chemistry. 289, 39, p. 26922 - 26936 15 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Species-specific regulation of t-PA and PAI-1 gene expression in human and rat astrocytes

Tjarnlund Wolf, A., Hultman, K., Blomstrand, F., Nilsson, M., Medcalf, R. L. & Jern, C., 2014, In : Gene Regulation and Systems Biology. 2014, 8, p. 113 - 118 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

Wang, X., Palasubramaniam, J., Gkanatsas, Y., Hohmann, J. D., Westein, E., Kanojia, R., Alt, K., Huang, D., Jia, F., Ahrens, I., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2014, In : Circulation Research. 114, 7, p. 1083 - 1093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

Freeman, R., Niego, B., Croucher, D. R., Pederson, L. O. & Medcalf, R. L., 2014, In : Brain Research. 1565, p. 63 - 73 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2013

Improved method for the preparation of a human cell-based, contact model of the blood-brain barrier

Niego, B. & Medcalf, R. L., 2013, In : Journal of Visualized Experiments. 2013, 81, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2

Schuliga, M., Langenbach, S. Y., Xia, Y., Qin, C., Mok, J., Harris, T., Mackay, G., Medcalf, R. L. & Stewart, A. G., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 49, 5, p. 751 - 758 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait

Cops, E., Sashindranath, M., Daglas, M., Short, K. M., Pereira, C. D. F., Pang, T., Lijnen, R., Smyth, I. M., Hannan, A. J., Samson, A. L. & Medcalf, R. L., 2013, In : Experimental Neurology. 249C, p. 8 - 19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2012

Desmoteplase: Discovery, insights and opportunities for ischaemic stroke

Medcalf, R., 2012, In : British Journal of Pharmacology. 165, 1, p. 75 - 89 15 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

Samson, A. L., Knaupp, A. S., Sashindranath, M., Borg, R. J., Au, A. E-L., Cops, E. J., Saunders, H. M., Cody, S. H., McLean, C. A., Nowell, C., Hughes, V. A., Bottomley, S. P. & Medcalf, R. L., 2012, In : Cell Reports. 2, 4, p. 889 - 901 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Plasminogen activation and thrombolysis for ischemic stroke

Medcalf, R. L. & Davis, S. M., 2012, In : International Journal of Stroke. 7, 5, p. 419 - 425 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

Larsson, P., Ulfhammer, E., Magnusson, M., Bergh, N., Lunke, S., El-Osta, A., Medcalf, R. L., Svensson, P. A., Karlsson, L. & Jern, S., Feb 2012, In : PLoS ONE. 7, 2 , 9 p., e31573.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
27 Citations (Scopus)

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A. L., Cops, E., Beckham, S. A., Galle, A. A., McLean, C. A., Morganti-Kossmann, M. C., Rosenfeld, J. V., Madani, R., Vassalli, J-D., Su, E. J., Lawrence, D. A. & Medcalf, R. L., 2012, In : Brain. 135, 11, p. 3251 - 3264 14 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Tissue plasminogen activator does not alter development of acquired epilepsy

Tan, M-L., Ng, A. Q. P., Pandher, P., Sashindranath, M., Hamilton, J. A., Davis, S. M., O'Brien, T. J., Medcalf, R. L., Yan, B. & Jones, N., 2012, In : Epilepsia. 53, 11, p. 1998 - 2004 7 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain

Wu, F., Wu, J., Nicholson, A., Echeverry, R., Haile, W., Catano, M., An, J., Lee, A., Duong, D., Dammer, E., Seyfried, N. T., Tong, F. C., Votaw, J. R., Medcalf, R. L. & Yepes, M., 2012, In : Journal of Neuroscience. 32, 29, p. 9848 - 9858 11 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

Niego, B., Freeman, R., Puschmann, T., Turnley, A. & Medcalf, R. L., 2012, In : Blood. 119, 20, p. 4752 - 4761 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2011

Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue

Tjarnlund-Wolf, A., Hultman, K., Curtis, M., Faull, R., Medcalf, R. & Jern, C., 2011, In : Thrombosis and Haemostasis. 105, 6, p. 945 - 953 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Sashindranath, M., Samson, A., Downes, C. E., Crack, P., Lawrence, A. J., Li, Q-X., Ng, A. Q. P., Jones, N. C., Farrugia, J., Abdella, E., Vassalli, J-D., Madani, R. & Medcalf, R., 2011, In : Laboratory Investigation. 91, 7, p. 1079 - 1091 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction

Liu, Y., Gao, X-M., Fang, L., Jennings, N., Su, Y., Xu, Q., Samson, A., Kiriazis, H., Wang, X-F., Shan, L., Sturgeon, S., Medcalf, R., Jackson, S., Dart, A. & Du, X-J., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 4, p. 834 - 841 8 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Plasminogen activation-based thrombolysis for ischaemic stroke: The diversity of targets may demand new approaches

Medcalf, R., 2011, In : Current Drug Targets. 12, 12, p. 1772 - 1781 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)