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Research Output

2020

Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH

Moore, H. B., Gando, S., Iba, T., Kim, P. Y., Yeh, C. H., Brohi, K., Hunt, B. J., Levy, J. H., Draxler, D. F., Stanworth, S., Görlinger, K., Neal, M. D., Schreiber, M. A., Barrett, C. D., Medcalf, R. L., Moore, E. E., Mutch, N. J., Thachil, J., Urano, T., Thomas, S. & 3 others, Scărlătescu, E., Walsh, M. & for the Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and Hemostasis, 1 Mar 2020, In : Journal of Thrombosis and Haemostasis. 18, 3, p. 740-747 8 p.

Research output: Contribution to journalArticleOtherpeer-review

Editorial: Fibrinolysis in Immunity

Kolev, K. & Medcalf, R. L., 31 Mar 2020, In : Frontiers in Immunology. 11, 2 p., 582.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Fibrinolysis and the Immune Response in Trauma

Medcalf, R. L., Keragala, C. B. & Draxler, D. F., 1 Mar 2020, In : Seminars in Thrombosis and Hemostasis. 46, 2, p. 176-182 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Fibrinolysis and tranexamic acid: mechanistic principles

Draxler, D. F. & Medcalf, R. L., 1 Apr 2020, In : ANZ Journal of Surgery. 90, 4, p. 410-411 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
1 Citation (Scopus)

The Complexity of Trauma-Induced Coagulopathy

Moore, H. B., Walsh, M., Kwaan, H. C. & Medcalf, R. L., 1 Mar 2020, In : Seminars in Thrombosis and Hemostasis. 46, 2, p. 114-115 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2019

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Daglas, M., Draxler, D. F., Ho, H., McCutcheon, F., Galle, A., Au, A. E., Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M. & Medcalf, R. L., 29 Oct 2019, In : Cell Reports. 29, 5, p. 1178-1191.e6 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications

Moore, H. B., Moore, E. E., Neal, M. D., Sheppard, F. R., Kornblith, L. Z., Draxler, D. F., Walsh, M., Medcalf, R. L., Cohen, M. J., Cotton, B. A., Thomas, S. G., Leeper, C. M., Gaines, B. A. & Sauaia, A., 1 Sep 2019, In : Anesthesia and Analgesia. 129, 3, p. 762-773 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke

Draxler, D. F., Lee, F., Ho, H., Keragala, C. B., Medcalf, R. L. & Niego, B., 27 Mar 2019, In : Frontiers in Immunology. 10, MAR, 12 p., 591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

Draxler, D. F., Awad, M. M., Hanafi, G., Daglas, M., Ho, H., Keragala, C., Galle, A., Roquilly, A., Lyras, D., Sashindranath, M. & Medcalf, R. L., 1 Dec 2019, In : Journal of Neurotrauma. 36, 23, p. 3297-3308 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Draxler, D. F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Gregory, J., Larsson, P., Keragala, C., Wright, D. K., Tavancheh, E., Au, A. E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M. & Medcalf, R. L., Dec 2019, In : Journal of Thrombosis and Haemostasis. 17, 12, p. 2174-2187 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Tranexamic acid modulates the immune response and reduces postsurgical infection rates

Draxler, D. F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L. M., Forbes, A., Goncalves, I., Tran, H. A., Wallace, S., Plebanski, M., Myles, P. S. & Medcalf, R. L., 28 May 2019, In : Blood Advances. 3, 10, p. 1598-1609 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies

Picetti, R., Shakur-Still, H., Medcalf, R. L., Standing, J. F. & Roberts, I., 1 Jan 2019, In : Blood Coagulation and Fibrinolysis. 30, 1, p. 1-10 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2018

Haemostasis and innate immunity – a complementary relationship: A review of the intricate relationship between coagulation and complement pathways

Keragala, C. B., Draxler, D. F., McQuilten, Z. K. & Medcalf, R. L., 1 Mar 2018, In : British Journal of Haematology. 180, 6, p. 782-798 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)

Intravenous administration of t-PA dampens the immune response in a murine model of ischaemic stroke

Draxler, D. F., Lee, F., Ho, H., Medcalf, R. & Niego, B., 3 Sep 2018.

Research output: Contribution to conferenceAbstract

Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion

Medcalf, R. L., Hagemeyer, C. E. & Alt, K., 1 Apr 2018, In : Journal of Thrombosis and Haemostasis. 16, 4, p. 615-617 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)

The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Bain, C. R., Draxler, D. F., Taylor, R., Wallace, S., Gouldthorpe, O., Corcoran, T. B., Myles, P. S., L. Medcalf, R. & Bozaoglu, K., Aug 2018, In : Anaesthesia. 73, 8, p. 955-966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2017

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler, D. F., Madondo, M. T., Hanafi, G., Plebanski, M. & Medcalf, R. L., 1 Apr 2017, In : Cytometry Part A. 91, 4, p. 336-350 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan, H., Lisman, T. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 113-114 2 p., 02414.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Fibrinolysis: from blood to the brain

Medcalf, R. L., 1 Nov 2017, In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2089-2098 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
16 Citations (Scopus)

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Plasmin: A Modulator of Immune Function

Draxler, D. F., Sashindranath, M. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 143-153 11 p., 02353.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In : PLoS ONE. 12, 5, 21 p., e0177332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

Fredriksson, L., Lawrence, D. A. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 154-168 15 p., 02355.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2016

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D., Wang, H., Johnston, L., Daglas, M., Ates, R. C., Medcalf, R. L., Taylor, J. M. & Crack, P. J., 1 Jan 2016, In : eNeuro. 3, 1, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

Anti-fibrinolytics

Draxler, D. F., Medcalf, R. L. & Gruen, R. L., 1 Jan 2016, Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B. & Moore, E. E. (eds.). Springer, p. 403-418 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Editorial: The role of the plasminogen activating system in neurobiology

Medcalf, R. L. & Lawrence, D. A., 4 Oct 2016, In : Frontiers in Cellular Neuroscience. 10, OCT2016, 3 p., 222.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

Szabo, R., Samson, A. L., Lawrence, D. A., Medcalf, R. L. & Bugge, T. H., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1618-1628 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In : Biology Open. 6, 11, 12 p., 160098.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Plasminogen and stroke: more is better

Medcalf, R. L., 1 Sep 2016, In : Journal of Thrombosis and Haemostasis. 14, 9, p. 1819-1821 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The influence of differentially expressed tissue-type plasminogen activator in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Dahl, L. C. M., Nasa, Z., Chung, J., Niego, B., Tarlac, V., Ho, K. C. H., Galle, A. A., Petratos, S., Alderuccio, F. P. & Medcalf, R. L., 18 Jul 2016, In : PLoS ONE. 11, 7, 22 p., e0158653.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2015

Dendritic cell-mediated phagocytosis but not immune activation is enhanced by plasmin

Borg, R., Samson, A. L., Au, A. E-L., Scholzen, A., Fuchsberger, M., Kong, Y. Y., Freeman, R., Mifsud, N. A., Plebanski, M. & Medcalf, R. L., 2015, In : PLoS ONE. 10, 7 , 19 p., e0131216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

Evaluation of gait impairment in mice subjected to craniotomy and traumatic brain injury

Sashindranath, M., Daglas, M. & Medcalf, R. L., 2015, In : Behavioural Brain Research. 286, p. 33 - 38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su, E. J., Fredriksson, L. T., Kanzawa, M., Moore, S., Folestad, E., Stevenson, T. K., Nilsson, I., Sashindranath, M., Schielke, G. P., Warnock, M., Ragsdale, M., Mann, K. M., Lawrence, A-L. E., Medcalf, R. L., Eriksson, U., Murphy, G. G. & Lawrence, D. A., 2015, In : Frontiers in Cellular Neuroscience. 9, (Art. No: 385), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

The dynamics of adult haematopoiesis in the bone and bone marrow environment

Ho, M. S. H., Medcalf, R. L., Livesey, S. A. & Traianedes, K., 2015, In : British Journal of Haematology. 170, 4, p. 472 - 486 15 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The fibrinolytic system-more than fibrinolysis?

Draxler, D. & Medcalf, R. L., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

The traumatic side of fibrinolysis

Medcalf, R. L., 2015, In : Blood. 125, 15, p. 2457 - 2458 2 p.

Research output: Contribution to journalLetterOther

26 Citations (Scopus)

Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect

Boyd, B. J., Galle, A., Daglas, M., Rosenfeld, J. V. & Medcalf, R., 2015, In : Journal of Drug Targeting. 23, 9, p. 847-853 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

What drives "fibrinolysis"?

Medcalf, R. L., 2015, In : Hamostaseologie. 35, 4, p. 303-310 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

Gardiner, E. E. & Medcalf, R. L., 2014, In : Journal of Thrombosis and Haemostasis. 12, 10, p. 1703 - 1705 3 p.

Research output: Contribution to journalArticleOther

9 Citations (Scopus)

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase

Samson, A. L., Knaupp, A. S., Kass, I., Kleifeld, O., Marijanovic, E. M., Hughes, V. A., Lupton, C. J., Buckle, A. M., Bottomley, S. P. & Medcalf, R. L., 2014, In : The Journal of Biological Chemistry. 289, 39, p. 26922 - 26936 15 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?

Niego, B. & Medcalf, R. L., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1283 - 1296 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
55 Citations (Scopus)

Species-specific regulation of t-PA and PAI-1 gene expression in human and rat astrocytes

Tjarnlund Wolf, A., Hultman, K., Blomstrand, F., Nilsson, M., Medcalf, R. L. & Jern, C., 2014, In : Gene Regulation and Systems Biology. 2014, 8, p. 113 - 118 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)