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Personal profile

Biography

Dr Robert De Matteo works in the Respiratory Development and Programming Group located in the Department of Anatomy and Developmental Biology in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow.

Our research group focuses on better outcomes for preterm infants. Some of the areas we are investigating include;

  • the male disadvantage
  • treatments that may provide protection against fetal brain injury
  • the influence of high oxygen concentrations on the developing lung


My current roles also include Honours convenor in the Department of Anatomy and Developmental Biology. I am also part of the executive committee of the Fetal and Neonatal Workshop of Australia and New Zealand (FNWANZ). The FNWANZ provides a forum for discussion of new ideas and presentation of experimental and clinical data in fetal and neonatal biology and aims to encourage discussion and establish collaborations between basic scientists and researchers from all disciplines of PSANZ. For more information please visit http://www.med.monash.edu.au/anatomy/workshops/fanworkshop.html

I joined the Respiratory Development and Programming Group in 2006. Research in this group centred on the theme of developmental programming. In particular, how do changes in the developing fetal environment alter the long term structure and function of key organs. Changes in the fetal environment include placental insufficiency or maternal undernutrition (causing fetal growth restriction), premature birth, exposure to inflammatory intra-uterine environment, ventilator-induced lung injury and maternal alcohol ingestion.

My first introduction to the concept of Developmental Programming was during 2004-2005, when I examined if altered fetal renal development, from prenatal glucocorticoid exposure contributed to the higher blood pressure seen in adult sheep, conducted in the Department of Physiology, Monash University.

Prior to 2004, my post-doctoral research was centred on cardiovascular neuroscience, investigating the role of the hypothalamic paraventricular nucleus in cardiovascular and renal regulation in the conscious rabbit.

I completed my PhD in 1997, at the Howard Florey Institute of Experimental Physiology and Medicine investigating the renal and cardiovascular actions of adrenal steroids in the conscious unstressed adult sheep.

Overall I have gained in depth knowledge in the following disciplines; central regulation of blood pressure, role of the sympathetic nervous system in disease states, regulation of renal haemodynamics, integrated renal physiology, endocrinology of the adrenal gland, fetal programming, developmental origins of health and disease, lung development and fetal physiology.

Keywords

  • Fetal Physiology
  • Premature babies
  • Developmental Origins of Health and Disease
  • Neuroprotection
  • Sexual dimorphism

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Projects 2010 2015

Research Output 1997 2018

Impact of preterm birth on the developing myocardium of the neonate

Bensley, J. G., Moore, L., De Matteo, R., Harding, R. & Black, M. J., 1 Apr 2018, In : Pediatric Research. 83, 4, p. 880-888 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Mrocki, M. M., Nguyen, V. B., Lombardo, P., Sutherland, M. R., Bensley, J. G., Nitsos, I., Allison, B. J., Harding, R., De Matteo, R., Schneider, M., Polglase, G. R. & Black, M. J., 1 Dec 2018, In : Journal of Physiology. 596, 23, p. 5965-5975 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Betamethasone-exposed preterm birth does not impair insulin action in adult sheep

De Matteo, R., Hodgson, D. J., Bianco-Miotto, T., Nguyen, V., Owens, J. A., Harding, R., Allison, B. J., Polglase, G., Black, M. J. & Gatford, K. L., 1 Feb 2017, In : Journal of Endocrinology. 232, 2, p. 175-187 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Caffeine for apnea of prematurity: Effects on the developing brain

Atik, A., Harding, R., De Matteo, R., Kondos-Devcic, D., Cheong, J., Doyle, L. W. & Tolcos, M., 1 Jan 2017, In : NeuroToxicology. 58, p. 94-102 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review