Robert Bryson-Richardson

Assoc Professor

Accepting PhD Students

20032021
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Personal profile

Biography

Robert studied Human Genetics at the University of Nottingham before moving to the Medical Research Council's Human Genetics Unit in Edinburgh to complete his PhD and begin his work using the zebrafish model system. He completed his PhD in 2003 and continued his research at the Victor Chang Cardiac Research Institute in Sydney and the Australian Regenerative Medicine Institute at Monash University. He joined the school as a lecturer and researcher in 2010.

 

Research interests

Robert's research focuses on the genetics and cell biology of muscle development and disease. His team uses zebrafish, which grow very rapidly and are transparent when young, to study these processes. Generating zebrafish models of muscle disease allows them to investigate how muscle function is disrupted improving our understanding of both normal muscle development and of the causes of muscle disease. Additionally these fish can be used to test therapies and to identify effective drugs treatments.

Other projects in the laboratory include the examination of genetic and environmental signals controlling the changing shape of the developing heart as it grows from a simple tube to a multi-chambered pump. This again improves our understanding of how the heart forms and also the processes that can be disrupted in congenital heart disease.

 

Lab Website: www.bryson-richardsonlab.org

Supervision interests

PhD projects are available investigating the genetic basis of neuromuscular disease and the underling biology leading to pathology. 

I am also seeking a motivated student interested in developing cryo-EM techniques for large samples. 

 

Keywords

  • myopathy
  • muscle
  • 3D and 4D imaging
  • zebrafish

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Projects 2011 2021

Novel genes in skeletal muscle disease

Forest, A., Ravenscroft, G., Bryson-Richardson, R., Laing, N. G. & Carninci, P.

1/01/1831/12/20

Project: Research

Identifying disease genes for neurogenetic disorders using next generation sequencing

Laing, N., Clarke, N., MacArthur, D., Nowak, K., Ravenscroft, G., Allcock, R. & Bryson-Richardson, R.

National Health & Medical Research Council (NHMRC)

1/01/1531/12/19

Project: Research

Research Output 2003 2019

Linking life-history theory and metabolic theory explains the offspring size-temperature relationship

Pettersen, A. K., White, C. R., Bryson-Richardson, R. J. & Marshall, D., 7 Jan 2019, In : Ecology Letters. 22, 3, p. 518-526 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Advances in the Understanding of Skeletal Myopathies from Zebrafish Models

Baxter, E. C. & Bryson-Richardson, R. J., 11 Oct 2018, Zebrafish, Medaka, and Other Small Fishes: New Model Animals in Biology, Medicine, and Beyond. Hirata, H. & Iida, A. (eds.). Singapore: Springer, p. 151-183 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Does the cost of development scale allometrically with offspring size?

Pettersen, A. K., White, C. R., Bryson-Richardson, R. J. & Marshall, D. J., 1 Mar 2018, In : Functional Ecology. 32, 3, p. 762-772 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

Sztal, T. E., McKaige, E. A., Williams, C., Ruparelia, A. A. & Bryson-Richardson, R. J., 1 Feb 2018, In : PLoS Genetics. 14, 2, 15 p., e1007212.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy

Messineo, A., Gineste, C., Sztal, T. E., McNamara, E., Vilmen, C., Ogier, A., Hahne, D., Bendahan, D., Laing, N., Bryson-Richardson, R. J., Gondin, J. & Nowak, K. J., 31 Jul 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 11490.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File