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2019

Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms

Weller, C. D., Gardiner, E. E., Arthur, J. F., Southey, M. & Andrews, R. K., Jun 2019, In : International Wound Journal. 16, 3, p. 788-792 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Novel stenotic microchannels to study thrombus formation in shear gradients: influence of shear forces and human platelet-related factors

Lui, M., Gardiner, E. E., Arthur, J. F., Pinar, I., Lee, W. M., Ryan, K., Carberry, J. & Andrews, R. K., 18 Jun 2019, In : International Journal of Molecular Sciences. 20, 12, 10 p., 2967.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Platelet protein disulfide isomerase promotes glycoprotein ib&-mediated platelet-neutrophil interactions under thromboinflammatory conditions

Li, J., Kim, K., Jeong, S. Y., Chiu, J., Xiong, B., Petukhov, P. A., Dai, X., Li, X., Andrews, R. K., Du, X., Hogg, P. J. & Cho, J., 5 Mar 2019, In : Circulation. 139, 10, p. 1300-1319 20 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation

Schroder, W. A., Le, T. T., Gardner, J., Andrews, R. K., Gardiner, E. E., Callaway, L. & Suhrbier, A., 4 Jul 2019, In : Platelets. 30, 5, p. 658-663 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
2018

Autoregulation of von Willebrand factor function by a disulfide bond switch

Butera, D., Passam, F., Ju, L., Cook, K. M., Woon, H., Aponte-Santamaría, C., Gardiner, E., Davis, A. K., Murphy, D. A., Bronowska, A., Luken, B. M., Baldauf, C., Jackson, S., Andrews, R., Gräter, F. & Hogg, P. J., 28 Feb 2018, In : Science Advances. 4, 2, 13 p., eaaq1477.

Research output: Contribution to journalArticleResearchpeer-review

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20 Citations (Scopus)

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4–heparin antibodies in heparin-induced thromobocytopenia

Wines, B. D., Tan, C. W., Duncan, E., McRae, S., Baker, R. I., Andrews, R. K., Esparon, S., Gardiner, E. E. & Hogarth, P. M., 1 Dec 2018, In : Journal of Thrombosis and Haemostasis. 16, 12, p. 2520-2525 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Mechanisms of Platelet Dysfunction in Patients with Implantable Devices

Casan, J., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Feb 2018, In : Seminars in Thrombosis and Hemostasis. 44, 1, p. 12-19 8 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

NLRP3 regulates platelet integrin ±IIbβ3 outside-in signaling, hemostasis and arterial thrombosis

Qiao, J., Wu, X., Luo, Q., Wei, G., Xu, M., Wu, Y., Liu, Y., Li, X., Zi, J., Ju, W., Fu, L., Chen, C., Wu, Q., Zhu, S., Qi, K., Li, D., Li, Z., Andrews, R. K., Zeng, L., Gardiner, E. E. & 1 others, Xu, K., 31 Aug 2018, In : Haematologica: the hematology journal. 103, 9, p. 1568-1576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

Montague, S. J., Delierneux, C., Lecut, C., Layios, N., Dinsdale, R. J., Lee, C. S. M., Poulter, N. S., Andrews, R. K., Hampson, P., Wearn, C. M., Maes, N., Bishop, J., Bamford, A., Gardiner, C., Lee, W. M., Iqbal, T., Moiemen, N., Watson, S. P., Oury, C., Harrison, P. & 1 others, Gardiner, E. E., 13 Feb 2018, In : Blood Advances. 2, 3, p. 240-251 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)
2017

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim, K., Li, J., Barazia, A., Tseng, A., Youn, S. W., Abbadessa, G., Yu, Y., Schwartz, B., Andrews, R. K., Gordeuk, V. R. & Cho, J., 2017, In : Haematologica: the hematology journal. 102, 2, p. 246-259 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P. & Jung, S. M., 1 Mar 2017, In : Journal of Thrombosis and Haemostasis. 15, 3, p. 549-564 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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25 Citations (Scopus)

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Trevillyan, J. M., Gardiner, E. E., Andrews, R. K., Maisa, A., Hearps, A. C., Al-Tamimi, M., Crowe, S. M. & Hoy, J. F., 3 Apr 2017, In : Platelets. 28, 3, p. 301-304 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis

Stack, J. R., Madigan, A., Helbert, L., Dunne, E., Gardiner, E. E., Andrews, R. K., Finan, R., Smyth, E., Kenny, D. & McCarthy, G. M., 1 Nov 2017, In : PLoS ONE. 12, 11, 8 p., e0188027.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

The cutting edge of platelets

Andrews, R. K. & Gardiner, E. E., 19 May 2017, In : Platelets. 28, 4, p. 317-318 2 p.

Research output: Contribution to journalArticleOtherpeer-review

2016

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J. M., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., Van Der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 27 Sep 2016, In : Nature Communications. 7, 17 p., 12862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets

Facey, A. D., Pinar, I., Arthur, J. F., Qiao, J. L., Jing, J., Mado, B., Carberry, J. J., Andrews, R. K. & Gardiner, E. E., 2016, In : Biochemistry. 55, 8, p. 1187 - 1194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices

Muthiah, K., Connor, D., Ly, K., Gardiner, E. E., Andrews, R. K., Qiao, J., Rutgers, D., Robson, D., Low, J., Jarvis, S., MacDonald, P. B., Dhital, K., Jansz, P., Joseph, J. E. & Hayward, C. S., 1 Jun 2016, In : Journal of Heart and Lung Transplantation. 35, 6, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

Lukito, P., Wong, A., Jing, J., Arthur, J. F., Marasco, S. F., Murphy, D. A., Bergin, P. J., Shaw, J. A., Collecutt, M. F., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 11, p. 2253-2260 8 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2015

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sanchez Guiu, I. M., Martinez-Martinez, I., Martinez, C., Navarro-Fernandez, J., Garcia-Candel, F., Ferrer-Marin, F., Vicente, V., Watson, S. P., Andrews, R. K., Gardiner, E. E., Lozano, M. L. & Rivera, J., 2015, In : Thrombosis and Haemostasis. 114, 2, p. 313 - 324 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Current state and novel approaches of antiplatelet therapy

Metharom, P., Berndt, M. C., Baker, R. I. & Andrews, R. K., 2015, In : Arteriosclerosis, Thrombosis and Vascular Biology. 35, 6, p. 1327 - 1338 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Effects of abacavir administration on structural and functional markers of platelet activation

Trevillyan, J. M., Arthur, J. F., Jing, J., Andrews, R. K., Gardiner, E. E. & Hoy, J. F., 2015, In : AIDS. 29, 17, p. 2309 - 2313 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Extracorporeal membrane oxygenation-hemostatic complications

Murphy, D. A., Hockings, L. E., Andrews, R. K., Aubron, C., Gardiner, E. E., Pellegrino, V. & Davis, A. K., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 90 - 101 12 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ib? in a patient with Bernard-Soulier syndrome

Qiao, J. L., Davis, A. K., Morel-Kopp, M-C., Ward, C., Gardiner, E. E. & Andrews, R. K., 2015, In : Annals of Hematology. 94, 12, p. 2069 - 2071 3 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar, I., Arthur, J. F., Andrews, R. K., Gardiner, E. E., Ryan, K. & Carberry, J. J., 2015, In : PLoS ONE. 10, 12, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation

Kim, K., Li, J., Tseng, A., Andrews, R. K. & Cho, J., 2015, In : Blood. 126, 16, p. 1952 - 1964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Flierl, U., Nero, T. L., Lim, B., Arthur, J. F., Yao, Y., Jung, S. M., Gitz, E., Pollitt, A. Y., Zaldivia, M. T. K., Jandrot-Perrus, M., Schafer, A., Nieswandt, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 2015, In : The Journal of Experimental Medicine. 212, 2, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

The platelet Fc receptor, FcgammaRIIa

Qiao, J. L., Al-Tamimi, M., Baker, R. I., Andrews, R. K. & Gardiner, E. E., 2015, In : Immunological Reviews. 268, 1, p. 241 - 252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb{alpha}

Carrim, N., Arthur, J. F., Hamilton, J. R., Gardiner, E. E., Andrews, R. K., Moran, N., Berndt, M. & Metharom, P., 2015, In : Redox Biology. 6, p. 640 - 647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Manchev, V. T., Hilpert, M., Berrou, E., Elaib, Z., Aouba, A., Boukour, S., Souquere, S., Pierron, G., Rameau, P., Andrews, R. K., Lanza, F., Bobe, R., Vainchenker, W. P., Rosa, J. P., Bryckaert, M. C., Debili, N., Favier, R. & Raslova, H., 2014, In : Blood. 124, 16, p. 2554 - 2563 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma

Pennings, G., Yong, A., Wong, C., Al-Tamimi, M., Gardiner, E. E., Andrews, R. K. & Kritharides, L., 2014, In : Platelets. 25, 8, p. 639 - 642 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Gitz, E., Pollitt, A. Y., Gitz-Francois, J. J., Alshehri, O., Mori, J., Montague, S., Nash, G. B., Douglas, M. R., Gardiner, E. E., Andrews, R. K., Buckley, C. D., Harrison, P. & Watson, S. P., 2014, In : Blood. 124, 14, p. 2262 - 2270 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

DiagnoSTic assays for heparin-induced thrombocytopenia

Gardiner, E. E., Andrews, R. K. & Cuker, A. C., 2014, In : British Journal of Haematology. 166, 5, p. 631 - 633 3 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Neutrophil extracellular traps (NETs) and the role of platelets in infection

Andrews, R. K., Arthur, J. F. & Gardiner, E. E., 2014, In : Thrombosis and Haemostasis. 112, 4, p. 659 - 665 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Platelet receptor expression and shedding: Glycoprotein Ib-IX-V and glycoprotein VI

Gardiner, E. E. & Andrews, R. K., 2014, In : Transfusion Medicine Reviews. 28, 2, p. 56 - 60 5 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Primary haemostasis: newer insights

Berndt, M. C., Metharom, P. & Andrews, R. K., 2014, In : Haemophilia. 20, S4, p. 15 - 22 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Structure and function of platelet receptors initiating blood clotting

Gardiner, E. E. & Andrews, R. K., 2014, In : Advances in Experimental Medicine and Biology. 844, p. 263 - 275 13 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Targeting GPVI as a novel antithrombotic strategy

Andrews, R. K., Arthur, J. F. & Gardiner, E. E., 2014, In : Journal of Blood Medicine. 2014, 5, p. 59 - 68 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein ibalpha

Kruss, S., Erpenbeck, L., Amschler, K., Mundinger, T. A., Boehm, H., Helms, H. J., Friede, T., Andrews, R. K., Schon, M. & Spatz, J. P., 2013, In : ACS Nano. 7, 11, p. 9984 - 9996 13 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Bernard-Soulier syndrome: an update

Andrews, R. K. & Berndt, M. C., 2013, In : Seminars in Thrombosis and Hemostasis. 39, 6, p. 656 - 662 7 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of type 1 diabetes

Arthur, J. F., Shen, Y., Chen, Y., Qiao, J. L., Ni, R., Lu, Y. R., Andrews, R. K., Gardiner, E. E. & Cheng, J., 2013, In : Journal of Diabetes Research. 2013, Art. ID: 370212, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)

Qiao, J. L., Schoenwaelder, S. M., Mason, K. D., Tran, H. A., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R. K., Roberts, A. W. & Gardiner, E. E., 2013, In : Blood. 121, 8, p. 1479 - 1481 3 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2012

An acquired defect associated with abnormal signaling of the platelet collagen receptor glycoprotein VI

Qiao, J. L., Arthur, J. F., Collecutt, M., Shen, Y., Mu, F-T., Berndt, M. C., Davis, A., Andrews, R. K. & Gardiner, E. E., 2012, In : Acta Haematologica. 128, 4, p. 233 - 241 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Conotoxin engineering: Dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability

Dekan, Z., Wang, C. I. A., Andrews, R. K., Lewis, R. J. & Alewood, P. F., 14 Aug 2012, In : Organic and Biomolecular Chemistry. 10, 30, p. 5791-5794 4 p.

Research output: Contribution to journalArticleOtherpeer-review

10 Citations (Scopus)

Focusing on plasma glycoprotein VI

Al-Tamimi, M., Arthur, J. F., Gardiner, E. E. & Andrews, R. K., 2012, In : Thrombosis and Haemostasis. 107, 4, p. 648 - 655 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways

Arthur, J. F., Qiao, J. L., Shen, Y., Davis, A., Dunne, E., Berndt, M. C., Gardiner, E. E. & Andrews, R. K., 2012, In : Journal of Thrombosis and Haemostasis. 10, 6, p. 1133 - 1141 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction

Gardiner, E. E. & Andrews, R. K., 2012, In : Blood Reviews. 26, 6, p. 255 - 259 5 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Pathologic shear triggers shedding of vascular receptors: A novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

Al-Tamimi, M., Tan, C. W., Qiao, J. L., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J. F., Davis, A., Jing, J., Mu, F-T., Hamilton, J. R., Jackson, S., Ludwig, A., Berndt, M. C., Ward, C., Kritharides, L., Andrews, R. K. & Gardiner, E. E., 2012, In : Blood. 119, 18, p. 4311 - 4320 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Platelet receptor shedding

Gardiner, E., Al-Tamimi, M., Andrews, R. & Berndt, M., 2012, In : Methods in Molecular Biology. 788, p. 321 - 339 19 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)