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Research Output

2019

Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms

Weller, C. D., Gardiner, E. E., Arthur, J. F., Southey, M. & Andrews, R. K., Jun 2019, In : International Wound Journal. 16, 3, p. 788-792 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Novel stenotic microchannels to study thrombus formation in shear gradients: influence of shear forces and human platelet-related factors

Lui, M., Gardiner, E. E., Arthur, J. F., Pinar, I., Lee, W. M., Ryan, K., Carberry, J. & Andrews, R. K., 18 Jun 2019, In : International Journal of Molecular Sciences. 20, 12, 10 p., 2967.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Platelet protein disulfide isomerase promotes glycoprotein ib&-mediated platelet-neutrophil interactions under thromboinflammatory conditions

Li, J., Kim, K., Jeong, S. Y., Chiu, J., Xiong, B., Petukhov, P. A., Dai, X., Li, X., Andrews, R. K., Du, X., Hogg, P. J. & Cho, J., 5 Mar 2019, In : Circulation. 139, 10, p. 1300-1319 20 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Platelet Ubiquitylation - It's Everywhere

Gardiner, E. E. & Andrews, R. K., 1 Jan 2019, In : Thrombosis and Haemostasis. 119, 1, p. 6-8 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation

Schroder, W. A., Le, T. T., Gardner, J., Andrews, R. K., Gardiner, E. E., Callaway, L. & Suhrbier, A., 4 Jul 2019, In : Platelets. 30, 5, p. 658-663 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
2018

Autoregulation of von Willebrand factor function by a disulfide bond switch

Butera, D., Passam, F., Ju, L., Cook, K. M., Woon, H., Aponte-Santamaría, C., Gardiner, E., Davis, A. K., Murphy, D. A., Bronowska, A., Luken, B. M., Baldauf, C., Jackson, S., Andrews, R., Gräter, F. & Hogg, P. J., 28 Feb 2018, In : Science Advances. 4, 2, 13 p., eaaq1477.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

Bone marrow defects and platelet function: A focus on MDS and CLL

Luu, S., Gardiner, E. E. & Andrews, R. K., 1 May 2018, In : Cancers. 10, 5, 10 p., 147.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4–heparin antibodies in heparin-induced thromobocytopenia

Wines, B. D., Tan, C. W., Duncan, E., McRae, S., Baker, R. I., Andrews, R. K., Esparon, S., Gardiner, E. E. & Hogarth, P. M., 1 Dec 2018, In : Journal of Thrombosis and Haemostasis. 16, 12, p. 2520-2525 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

EPHB2 regulates platelet activation

Berndt, M. C. & Andrews, R. K., 8 Nov 2018, In : Blood. 132, 19, p. 2002-2004 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Mechanisms of Platelet Dysfunction in Patients with Implantable Devices

Casan, J., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Feb 2018, In : Seminars in Thrombosis and Hemostasis. 44, 1, p. 12-19 8 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Mechanisms of receptor shedding in platelets

Montague, S. J., Andrews, R. K. & Gardiner, E. E., 13 Dec 2018, In : Blood. 132, 24, p. 2535-2545 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Monitoring the pulse of thrombus formation: Comment on “Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones” by A.V. Belyaev et al.

Andrews, R. K. & Gardiner, E. E., 1 Nov 2018, In : Physics of Life Reviews. 26-27, p. 113-115 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

NLRP3 regulates platelet integrin ±IIbβ3 outside-in signaling, hemostasis and arterial thrombosis

Qiao, J., Wu, X., Luo, Q., Wei, G., Xu, M., Wu, Y., Liu, Y., Li, X., Zi, J., Ju, W., Fu, L., Chen, C., Wu, Q., Zhu, S., Qi, K., Li, D., Li, Z., Andrews, R. K., Zeng, L., Gardiner, E. E. & 1 others, Xu, K., 31 Aug 2018, In : Haematologica: the hematology journal. 103, 9, p. 1568-1576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Regulation of platelet activation and thrombus formation by reactive oxygen species

Qiao, J., Arthur, J. F., Gardiner, E. E., Andrews, R. K., Zeng, L. & Xu, K., 1 Apr 2018, In : Redox Biology. 14, p. 126-130 5 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Open Access
43 Citations (Scopus)

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

Montague, S. J., Delierneux, C., Lecut, C., Layios, N., Dinsdale, R. J., Lee, C. S. M., Poulter, N. S., Andrews, R. K., Hampson, P., Wearn, C. M., Maes, N., Bishop, J., Bamford, A., Gardiner, C., Lee, W. M., Iqbal, T., Moiemen, N., Watson, S. P., Oury, C., Harrison, P. & 1 others, Gardiner, E. E., 13 Feb 2018, In : Blood Advances. 2, 3, p. 240-251 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment

Flierl, U., Nero, T. L., Lim, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 1 Jan 2018, In : Journal of Thrombosis and Haemostasis. 16, 1, p. 181-185 5 p.

Research output: Contribution to journalLetterOtherpeer-review

1 Citation (Scopus)
2017

A brief history of blood platelets: A personal view

Berndt, M. C., Metharom, P. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Gresele, P., Kleiman, N. S., Lopez, J. A. & Page, C. P. (eds.). Cham: Springer, p. 3-10 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim, K., Li, J., Barazia, A., Tseng, A., Youn, S. W., Abbadessa, G., Yu, Y., Schwartz, B., Andrews, R. K., Gordeuk, V. R. & Cho, J., 2017, In : Haematologica: the hematology journal. 102, 2, p. 246-259 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Basic mechanisms of platelet receptor shedding

Andrews, R. K. & Gardiner, E. E., 19 May 2017, In : Platelets. 28, 4, p. 319-324 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

17 Citations (Scopus)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P. & Jung, S. M., 1 Mar 2017, In : Journal of Thrombosis and Haemostasis. 15, 3, p. 549-564 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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25 Citations (Scopus)

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., van der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 30 Aug 2017, In : Nature Communications. 8, 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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1 Citation (Scopus)

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Trevillyan, J. M., Gardiner, E. E., Andrews, R. K., Maisa, A., Hearps, A. C., Al-Tamimi, M., Crowe, S. M. & Hoy, J. F., 3 Apr 2017, In : Platelets. 28, 3, p. 301-304 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Platelet adhesion

Gardiner, E. E. & Andrews, R. K., 8 Mar 2017, Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Cham: Springer, p. 309-319 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

5 Citations (Scopus)

Platelet hyperreactivity in diabetes: Focus on GPVI signaling-are useful drugs already available?

Arthur, J. F., Jandeleit-Dahm, K. & Andrews, R. K., 1 Jan 2017, In : Diabetes. 66, 1, p. 7-13 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis

Stack, J. R., Madigan, A., Helbert, L., Dunne, E., Gardiner, E. E., Andrews, R. K., Finan, R., Smyth, E., Kenny, D. & McCarthy, G. M., 1 Nov 2017, In : PLoS ONE. 12, 11, 8 p., e0188027.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

The cutting edge of platelets

Andrews, R. K. & Gardiner, E. E., 19 May 2017, In : Platelets. 28, 4, p. 317-318 2 p.

Research output: Contribution to journalArticleOtherpeer-review

2016

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J. M., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., Van Der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 27 Sep 2016, In : Nature Communications. 7, 17 p., 12862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

A-disintegrin-and-metalloproteinase (ADAM) 10 activity on resting and activated platelets

Facey, A. D., Pinar, I., Arthur, J. F., Qiao, J. L., Jing, J., Mado, B., Carberry, J. J., Andrews, R. K. & Gardiner, E. E., 2016, In : Biochemistry. 55, 8, p. 1187 - 1194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Liver-mediated shedding of platelet GPVI

Berndt, M. C. & Andrews, R. K., 11 Aug 2016, In : Blood. 128, 6, p. 751-752 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices

Muthiah, K., Connor, D., Ly, K., Gardiner, E. E., Andrews, R. K., Qiao, J., Rutgers, D., Robson, D., Low, J., Jarvis, S., MacDonald, P. B., Dhital, K., Jansz, P., Joseph, J. E. & Hayward, C. S., 1 Jun 2016, In : Journal of Heart and Lung Transplantation. 35, 6, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction

Ong, D. M., Aumann, H. A., Andrews, R. K., Gardiner, E. E., Rodgers, S. & Davis, A. K., 1 Jul 2016, In : Haemophilia. 22, 4, p. e345-e346

Research output: Contribution to journalLetterOtherpeer-review

1 Citation (Scopus)

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

Lukito, P., Wong, A., Jing, J., Arthur, J. F., Marasco, S. F., Murphy, D. A., Bergin, P. J., Shaw, J. A., Collecutt, M. F., Andrews, R. K., Gardiner, E. E. & Davis, A. K., 1 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 11, p. 2253-2260 8 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Metalloproteolytic receptor shedding…platelets “acting their age”

Andrews, R. K. & Gardiner, E. E., 17 Aug 2016, In : Platelets. 27, 6, p. 512-518 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

10 Citations (Scopus)
2015

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sanchez Guiu, I. M., Martinez-Martinez, I., Martinez, C., Navarro-Fernandez, J., Garcia-Candel, F., Ferrer-Marin, F., Vicente, V., Watson, S. P., Andrews, R. K., Gardiner, E. E., Lozano, M. L. & Rivera, J., 2015, In : Thrombosis and Haemostasis. 114, 2, p. 313 - 324 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Current state and novel approaches of antiplatelet therapy

Metharom, P., Berndt, M. C., Baker, R. I. & Andrews, R. K., 2015, In : Arteriosclerosis, Thrombosis and Vascular Biology. 35, 6, p. 1327 - 1338 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Editorial: ADAMs control inflammation from afar

Andrews, R. K. & Gardiner, E. E., 2015, In : Journal of leukocyte biology. 97, 3, p. 437 - 438 2 p.

Research output: Contribution to journalLetterOther

Effects of abacavir administration on structural and functional markers of platelet activation

Trevillyan, J. M., Arthur, J. F., Jing, J., Andrews, R. K., Gardiner, E. E. & Hoy, J. F., 2015, In : AIDS. 29, 17, p. 2309 - 2313 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Extracorporeal membrane oxygenation-hemostatic complications

Murphy, D. A., Hockings, L. E., Andrews, R. K., Aubron, C., Gardiner, E. E., Pellegrino, V. & Davis, A. K., 2015, In : Transfusion Medicine Reviews. 29, 2, p. 90 - 101 12 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ib? in a patient with Bernard-Soulier syndrome

Qiao, J. L., Davis, A. K., Morel-Kopp, M-C., Ward, C., Gardiner, E. E. & Andrews, R. K., 2015, In : Annals of Hematology. 94, 12, p. 2069 - 2071 3 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Methods for understanding shear induced thrombus growth

Pinar, I. P., Arthur, J., Andrews, R., Gardiner, E. E., Ryan, K. & Carberry, J. J., 1 Jan 2015, Ninth International Symposium on Turbulence and Shear Flow Phenomena (TSFP-9). Tavoularis, S. & Marusic, I. (eds.). Melbourne Vic Australia: University of Melbourne, p. 1-5 5 p. (9th International Symposium on Turbulence and Shear Flow Phenomena, TSFP 2015; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar, I., Arthur, J. F., Andrews, R. K., Gardiner, E. E., Ryan, K. & Carberry, J. J., 2015, In : PLoS ONE. 10, 12, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation

Kim, K., Li, J., Tseng, A., Andrews, R. K. & Cho, J., 2015, In : Blood. 126, 16, p. 1952 - 1964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Flierl, U., Nero, T. L., Lim, B., Arthur, J. F., Yao, Y., Jung, S. M., Gitz, E., Pollitt, A. Y., Zaldivia, M. T. K., Jandrot-Perrus, M., Schafer, A., Nieswandt, B., Andrews, R. K., Parker, M. W., Gardiner, E. E. & Peter, K., 2015, In : The Journal of Experimental Medicine. 212, 2, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

The platelet Fc receptor, FcgammaRIIa

Qiao, J. L., Al-Tamimi, M., Baker, R. I., Andrews, R. K. & Gardiner, E. E., 2015, In : Immunological Reviews. 268, 1, p. 241 - 252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb{alpha}

Carrim, N., Arthur, J. F., Hamilton, J. R., Gardiner, E. E., Andrews, R. K., Moran, N., Berndt, M. & Metharom, P., 2015, In : Redox Biology. 6, p. 640 - 647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Manchev, V. T., Hilpert, M., Berrou, E., Elaib, Z., Aouba, A., Boukour, S., Souquere, S., Pierron, G., Rameau, P., Andrews, R. K., Lanza, F., Bobe, R., Vainchenker, W. P., Rosa, J. P., Bryckaert, M. C., Debili, N., Favier, R. & Raslova, H., 2014, In : Blood. 124, 16, p. 2554 - 2563 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma

Pennings, G., Yong, A., Wong, C., Al-Tamimi, M., Gardiner, E. E., Andrews, R. K. & Kritharides, L., 2014, In : Platelets. 25, 8, p. 639 - 642 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Gitz, E., Pollitt, A. Y., Gitz-Francois, J. J., Alshehri, O., Mori, J., Montague, S., Nash, G. B., Douglas, M. R., Gardiner, E. E., Andrews, R. K., Buckley, C. D., Harrison, P. & Watson, S. P., 2014, In : Blood. 124, 14, p. 2262 - 2270 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)