1982 …2020

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Article
2019

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M. S., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 Jan 2019, In : Oncogene. 38, 20, p. 3824-3842 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

AbuHammad, S., Cullinane, C., Martin, C., Bacolas, Z., Ward, T., Chen, H., Slater, A., Ardley, K., Kirby, L., Chan, K. T., Brajanovski, N., Smith, L. K., Rao, A. D., Lelliott, E. J., Kleinschmidt, M., Vergara, I. A., Papenfuss, A. T., Lau, P., Ghosh, P., Haupt, S. & 12 others, Haupt, Y., Sanij, E., Poortinga, G., Pearson, R. B., Falk, H., Curtis, D. J., Stupple, P., Devlin, M., Street, I., Davies, M. A., McArthur, G. A. & Sheppard, K. E., 3 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17990-18000 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2018

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 others, Lin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Martin, C. A., Cullinane, C., Kirby, L., Abuhammad, S., Lelliott, E. J., Waldeck, K., Young, R. J., Brajanovski, N., Cameron, D. P., Walker, R., Sanij, E., Poortinga, G., Hannan, R. D., Pearson, R. B., Hicks, R. J., McArthur, G. A. & Sheppard, K. E., 15 May 2018, In : International Journal of Cancer. 142, 10, p. 2139-2152 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 others, Huglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Udugama, M., Sanij, E., Voon, H. P. J., Son, J., Hii, L., Henson, J. D., Chan, F. L., Chang, F. T. M., Liu, Y., Pearson, R. B., Kalitsis, P., Mann, J. R., Collas, P., Hannan, R. D. & Wong, L. H., 1 May 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4737-4742 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In : Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2017

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

Trigos, A. S., Pearson, R. B., Papenfuss, A. T. & Goode, D. L., 13 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 24, p. 6406-6411 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Hung, S., Lesmana, A., Peck, A., Lee, R., Tchoubrieva, E., Hannan, K. M., Lin, J., Sheppard, K. E., Jastrzebski, K., Quinn, L. M., Rothblum, L. I., Pearson, R. B., Hannan, R. D. & Sanij, E., 15 May 2017, In : Gene. 612, p. 36-48 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N., Cameron, D. P., Hannan, K. M., Nguyen, N. Y. N., Fong, C. Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C. M., Diesch, J., Devlin, J. R., George, A. J., Sanij, E., Quin, J. E., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D. J., Harrison, S. J., Rozario, J. D. & 10 others, Powell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 25 May 2017, In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2016

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Kang, J., Kusnadi, E. P., Ogden, A. J., Hicks, R. J., Bammert, L., Kutay, U., Hung, S., Sanij, E., Hannan, R. D., Hannan, K. M. & Pearson, R. B., 2016, In : Oncotarget. 7, 31, p. 48887-48904 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Devlin, J. R., Hannan, K. M., Hein, N., Cullinane, C. M., Kusnadi, E. P., Ng, P. Y., George, A. J., Shortt, J., Bywater, M. J., Poortinga, G., Sanij, E., Kang, J., Drygin, D. J., O'Brien, S. E., Johnstone, R. W., McArthur, G. A., Hannan, R. D. & Pearson, R. B., 2016, In : Cancer Discovery. 6, 1, p. 59-70 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
49 Citations (Scopus)

Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence

Chan, K. T., Paavolainen, L., Hannan, K. M., George, A. J., Hannan, R. D., Simpson, K. J., Horvath, P. & Pearson, R. B., 1 Sep 2016, In : Assay and Drug Development Technologies. 14, 7, p. 416-428 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Quin, J. E., Chan, K. T., Devlin, J. R., Cameron, D. P., Diesch, J., Cullinane, C. M., Ahern, J., Khot, A. S., Hein, N., George, A. J., Hannan, K. M., Poortinga, G., Sheppard, K. E., Khanna, K. K., Johnstone, R. W., Drygin, D. J., McArthur, G. A., Pearson, R. B., Sanij, E. & Hannan, R. D., 2016, In : Oncotarget. 7, 31, p. 49800-49818 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

Rebello, R. J., Kusnadi, E., Cameron, D. P., Pearson, H. B., Lesmana, A., Devlin, J. R., Drygin, D., Clark, A. K., Porter, L., Pedersen, J., Sandhu, S., Risbridger, G. P., Pearson, R. B., Hannan, R. D. & Furic, L., 15 Nov 2016, In : Clinical Cancer Research. 22, 22, p. 5539-5552 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)
2015

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Sanij, E., Diesch, J., Lesmana, A., Poortinga, G., Hein, N., Lidgerwood, G., Cameron, D. P., Ellul, J., Goodall, G. J., Wong, L. H., Dhillon, A. S., Hamdane, N., Rothblum, L. I., Pearson, R. B., Haviv, I., Moss, T. & Hannan, R. D., 2015, In : Genome Research. 25, 2, p. 201 - 212 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A. C., Verrills, N., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. & Dhillon, A. S., 2015, In : Oncogene. 34, 10, p. 1333-1339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B. & Kang, J., 2015, In : Gene. 556, 1, p. 27 - 34 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Mitchell, N. C., Tchoubrieva, E. B., Chahal, A., Woods, S. J., Lee, A., Lin, J., Parsons, L., Jastrzebski, K., Poortinga, G., Hannan, K. M., Pearson, R. B., Hannan, R. D. & Quinn, L. M., 2015, In : Cellular Signalling. 27, 10, p. 2045 - 2053 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Woods, S. J., Hannan, K. M., Pearson, R. B. & Hannan, R. D., 2015, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1849, 7, p. 821 - 829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Ramsdale, R., Jorissen, R. N., Li, F. Z., Al-Obaidi, S., Ward, T., Sheppard, K. E., Bukczynska, P. E., Young, R. J., Boyle, S. E., Shackleton, M., Bollag, G., Long, G. V., Tulchinsky, E., Rizos, H., Pearson, R. B., McArthur, G. A., Dhillon, A. S. & Ferrao, P. T., 18 Aug 2015, In : Science Signaling. 8, 390, 13 p., ra82.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
2014

Targeting the nucleolus for cancer intervention

Quin, J. E., Devlin, J. R., Cameron, D., Hannan, K. M., Pearson, R. B. & Hannan, R. D., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 6, p. 802 - 816 15 p.

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

Diesch, J., Sanij, E., Gilan, O., Love, C., Tran, H., Fleming, N. I., Ellul, J., Amalia, M., Haviv, I., Pearson, R. B., Tulchinsky, E., Mariadason, J. M., Sieber, O. M., Hannan, R. D. & Dhillon, A. S., 2014, In : PLoS ONE. 9, 3, 11 p., e88950.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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45 Citations (Scopus)
2013

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B., Guthridge, M. A., Pearson, R. B. & Ekert, P. G., 2013, In : Cell Death and Differentiation. 20, 10, p. 1341 - 1349 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

AKT-independent PI3-K signaling in cancer - Emerging role for SGK3

Bruhn, M. A., Pearson, R. B., Hannan, R. D. & Sheppard, K. E., 2013, In : Cancer Management and Research. 5, 1, p. 281 - 292 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
56 Citations (Scopus)

AKT signalling is required for ribosomal RNA synthesis and progression of E-mu-Myc B-cell lymphoma in vivo

Devlin, J. R., Hannan, K. M., Ng, P. Y., Bywater, M., Shortt, J., Cullinane, C. M., McArthur, G., Johnstone, R. W., Hannan, R. D. & Pearson, R. B., 2013, In : FEBS Journal. 280, 21, p. 5307 - 5316 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis

Boglev, Y., Badrock, A. P., Trotter, A., Du, Q., Richardson, E. J., Parslow, A., Markmiller, S. J., Hall, N. E., de Jong-Curtain, T. A., Ng, A. Y., Verkade, H., Ober, E. A., Field, H. A., Shin, D., Shin, C., Hannan, K. M., Hannan, R. D., Pearson, R. B., Kim, S-H., Ess, K. C. & 3 others, Lieschke, G., Stainier, D. Y. R. & Heath, J. K., 2013, In : PLoS Genetics. 9, 2 (Art # e1003279), p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
42 Citations (Scopus)

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Shortt, J., Martin, B. P., Newbold, A., Hannan, K. M., Devlin, J. R., Baker, A., Ralli, R. A., Cullinane, C. M., Schmitt, C. A., Reimann, M., Hall, M. N., Wall, M., Hannan, R. D., Pearson, R. B., McArthur, G. A. & Johnstone, R. W., 2013, In : Blood. 121, 15, p. 2964 - 2974 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Dysregulation of RNA polymerase I transcription during disease

Hannan, K. M., Sanij, E., Rothblum, L. I., Hannan, R. D. & Pearson, R. B., 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 3-4, p. 342 - 360 19 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Bywater, M., Pearson, R. B., McArthur, G. A. & Hannan, R. D., 2013, In : Nature Reviews Cancer. 13, 5, p. 299 - 314 16 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer

Davis, S. J., Sheppard, K. E., Pearson, R. B., Campbell, I. G., Gorringe, K. L. & Simpson, K. J., 15 Mar 2013, In : Clinical Cancer Research. 19, 6, p. 1411-1421 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
38 Citations (Scopus)

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Funnell, A. P. W., Mak, K. S., Twine, N. A., Pelka, G. J., Norton, L. J., Radziewic, T., Power, M., Wilkins, M. R., Bell-Anderson, K. S., Fraser, S. T., Perkins, A. C., Tam, P., Pearson, R. C. M. & Crossley, M., Aug 2013, In : Molecular and Cellular Biology. 33, 15, p. 2976-2987 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Sheppard, K. E., Cullinane, C. M., Hannan, K. M., Wall, M., Chan, J. C., Barber, F., Foo, J., Cameron, D., Neilsen, A., Ng, P., Ellul, J., Kleinschmidt, M., Kinross, K. M., Bowtell, D. D. L., Christensen, J. G., Hicks, R., Johnstone, R. W., McArthur, G. A., Hannan, R. D., Phillips, W. A. & 1 others, Pearson, R. B., 2013, In : European Journal of Cancer. 49, 18, p. 3936 - 3944 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

The mTORC1 inhibitor everolimus prevents and treats Emu-Myc lymphoma by restoring oncogene-induced senescence

Wall, M., Poortinga, G., Stanley, K. L., Lindemann, R. K., Bots, M., Chan, C. J. C., Bywater, M., Kinross, K. M., Astle, M. V., Waldeck, K. L., Hannan, K. M., Shortt, J., Smyth, M. J., Lowe, S. W., Hannan, R. D., Pearson, R. B., Johnstone, R. W. & McArthur, G. A., 2013, In : Cancer Discovery. 3, 1, p. 82 - 95 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
48 Citations (Scopus)
2012

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Astle, M., Hannan, K., Ng, P., Lee, R., George, A., Hsu, A., Haupt, Y., Hannan, R. & Pearson, R., 2012, In : Oncogene. 31, 15, p. 1949 - 1962 14 p.

Research output: Contribution to journalArticleResearchpeer-review

118 Citations (Scopus)

An activating {Pik3ca} mutation coupled with {Pten} loss is sufficient to initiate ovarian tumorigenesis in mice

Kinross, K. M., Montgomery, K. G., Kleinschmidt, M., Waring, P., Ivetac, I., Tikoo, A., Saad, M., Hare, L. M., Roh, V., Mantamadiotis, T., Sheppard, K. E., Ryland, G. L., Campbell, I. G., Gorringe, K. L., Christensen, J. G., Cullinane, C. M., Hicks, R. J., Pearson, R. B., Johnstone, R. W., McArthur, G. A. & 1 others, Phillips, W., 2012, In : Journal of Clinical Investigation. 122, 2, p. 553 - 557 5 p.

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)
Open Access
7 Citations (Scopus)

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

Bywater, M. J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C. M., Wall, M., Cluse, L. A., Drygin, D., Anderes, K., Huser, N., Proffitt, C., Bliesath, J., Haddach, M., Schwaebe, M. K., Ryckman, D. M., Rice, W. G., Schmitt, C., Lowe, S. W., Johnstone, R. W. & 3 others, Pearson, R. B., McArthur, G. A. & Hannan, R. D., 2012, In : Cancer Cell. 22, 1, p. 51 - 65 15 p.

Research output: Contribution to journalArticleResearchpeer-review

279 Citations (Scopus)

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

Cowin, P. A., George, J., Fereday, S., Loehrer, E., Van Loo, P., Cullinane, C. M., Etemadmoghadam, D., Ftouni, S., Galletta, L., Anglesio, M. S., Hendley, J., Bowes, L., Sheppard, K. E., Christie, E. L., Pearson, R. B., Harnett, P. R., Heinzelmann-Schwarz, V., Friedlander, M., McNally, O. M., Quinn, M. & 3 others, Campbell, P., DeFazio, A. & Bowtell, D. D. L., 15 Aug 2012, In : Cancer Research. 72, 16, p. 4060-4073 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

Targeting cancer with PI3K pathway inhibitors: Who to aim at?

Kinross, K. M., Sheppard, K. E., Pearson, R. B. & Phillips, W. A., 1 Aug 2012, In : Translational Cancer Research. 1, 2, p. 119-121 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Targeting PI3 kinase/AKT/mTOR signaling in cancer

Sheppard, K. E., Kinross, K. M., Solomon, B., Pearson, R. B. & Phillips, W. A., 2012, In : Critical Reviews in Oncogenesis. 17, 1, p. 69 - 95 27 p.

Research output: Contribution to journalArticleResearchpeer-review

171 Citations (Scopus)

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo

Funnell, A. P. W., Norton, L. J., Mak, K. S., Burdach, J., Artuz, C. M., Twine, N. A., Wilkins, M. R., Power, C. A., Hung, T-T., Perdomo, J., Koh, P., Bell-Anderson, K. S., Orkin, S. H., Fraser, S. T., Perkins, A. C., Pearson, R. C. M. & Crossley, M., Aug 2012, In : Molecular and Cellular Biology. 32, 16, p. 3281-3292 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)
2011

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

Chan, J., Hannan, K. M., Riddell, K., Ng, P. Y., Peck, A., Lee, R. S., Hung, S., Astle, M. V., Bywater, M., Wall, M., Poortinga, G., Jastrzebski, K., Sheppard, K. E., Hemmings, B. A., Hall, M. N., Johnstone, R. W., McArthur, G. A., Hannan, R. D. & Pearson, R. B., 2011, In : Science Signaling. 4, 188 (Art. No: ra56), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Jastrzebski, K., Hannan, K. M., House, C. M., Hung, S. S-C., Pearson, R. & Hannan, R., 2011, In : Cellular Signalling. 23, 8, p. 1338 - 1347 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

Helland, Å., Anglesio, M. S., George, J., Cowin, P. A., Johnstone, C. N., House, C. M., Sheppard, K. E., Etemadmoghadam, D., Melnyk, N., Rustgi, A. K., Phillips, W. A., Johnsen, H., Holm, R., Kristensen, G. B., Birrer, M. J., Pearson, R. B., Børresen-Dale, A. L., Huntsman, D. G., DeFazio, A., Creighton, C. J. & 2 others, Smyth, G. K. & Bowtell, D. D. L., 2011, In : PLoS ONE. 6, 4, e18064.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
122 Citations (Scopus)

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy

Smith, N. J., Chan, H-W., Qian, H., Bourne, A. M., Hannan, K. M., Warner, F. J., Ritchie, R. H., Pearson, R. B., Hannan, R. D. & Thomas, W. G., May 2011, In : Hypertension. 57, 5, p. 973-980 8 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone

Lin, J. I., Mitchell, N. C., Kalcina, M., Tchoubrieva, E. B., Stewart, M. J., Marygold, S. J., Walker, C. D., Thomas, G., Leevers, S. J., Pearson, R. B., Quinn, L. M. & Hannan, R. D., 2011, In : PLoS Genetics. 7, 12 (Art. No: e1002408), p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

Veldhuis, N. A., Kuiper, M. J., Dobson, R. C. J., Pearson, R. B. & Camakaris, J., Jun 2011, In : BioMetals. 24, 3, p. 477-487 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Relative expression levels rather than specific activity plays the major role in determining in vivo AKT isoform substrate specificity

Lee, R. S., House, C. M., Cristiano, B., Hannan, R., Pearson, R. B. & Hannan, K., 2011, In : Enzyme Research. 2011, 720985, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Signaling to the ribosome in cancer - It is more than just mTORC1

Hannan, K. M., Sanij, E., Hein, N., Hannan, R. D. & Pearson, R. B., 2011, In : IUBMB Life. 63, 2, p. 79 - 85 7 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)