1982 …2019
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Research Output 1982 2019

2019

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, K., Wen, V. W., Middlemiss, S. M. C., Osborne, B., Forgham, H., Jung, M. S., Karsa, M., Clifton, M., Bongers, A., Gao, J., Mayoh, C., Raoufi-Rad, N., Kusnadi, E. P., Hannan, K. M., Scott, D. A., Kwek, A., Liu, B., Flemming, C., Chudakova, D. A., Pandher, R. & 17 others, Failes, T. W., Lim, J., Angeli, A., Osterman, A. L., Imamura, T., Kees, U. R., Supuran, C. T., Pearson, R. B., Hannan, R. D., Davis, T. P., McCarroll, J., Kavallaris, M., Turner, N., Gudkov, A. V., Haber, M., Norris, M. D. & Henderson, M. J., 22 Jan 2019, In : Oncogene. 38, 20, p. 3824-3842 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Cystathionine β -Synthase in Physiology and Cancer

Zhu, H., Blake, S., Chan, K. T., Pearson, R. B. & Kang, J., 28 Jun 2018, In : BioMed Research International. 2018, 11 p., 3205125.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

How the evolution of multicellularity set the stage for cancer

Trigos, A. S., Pearson, R. B., Papenfuss, A. T. & Goode, D. L., 16 Jan 2018, In : British Journal of Cancer. 118, 2, p. 145-152 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 others, Lin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Martin, C. A., Cullinane, C., Kirby, L., Abuhammad, S., Lelliott, E. J., Waldeck, K., Young, R. J., Brajanovski, N., Cameron, D. P., Walker, R., Sanij, E., Poortinga, G., Hannan, R. D., Pearson, R. B., Hicks, R. J., McArthur, G. A. & Sheppard, K. E., 15 May 2018, In : International Journal of Cancer. 142, 10, p. 2139-2152 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 others, Huglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Udugama, M., Sanij, E., Voon, H. P. J., Son, J., Hii, L., Henson, J. D., Chan, F. L., Chang, F. T. M., Liu, Y., Pearson, R. B., Kalitsis, P., Mann, J. R., Collas, P., Hannan, R. D. & Wong, L. H., 1 May 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4737-4742 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In : Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

Trigos, A. S., Pearson, R. B., Papenfuss, A. T. & Goode, D. L., 13 Jun 2017, In : Proceedings of the National Academy of Sciences. 114, 24, p. 6406-6411 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Hung, S., Lesmana, A., Peck, A., Lee, R., Tchoubrieva, E., Hannan, K. M., Lin, J. I., Sheppard, K. E., Jastrzebski, K., Quinn, L. M., Rothblum, L. I., Pearson, R. B., Hannan, R. D. & Sanij, E., 15 May 2017, In : Gene. 612, p. 36-48 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N., Cameron, D. P., Hannan, K. M., Nguyen, N. Y. N., Fong, C. Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C. M., Diesch, J., Devlin, J. R., George, A. J., Sanij, E., Quin, J. E., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D. J., Harrison, S. J., Rozario, J. D. & 10 others, Powell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 25 May 2017, In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective targeting of Cyclin E1-amplified high-grade serous ovarian cancer by Cyclin-dependent kinase 2 and AKT inhibition

Au-Yeung, G. H., Lang, F., Azar, W. J., Mitchell, C., Jarman, K. E., Lackovic, K., Aziz, D., Cullinane, C. M., Pearson, R. B., Mileshkin, L., Rischin, D., Karst, A. M., Drapkin, R., Etemadmoghadam, D. & Bowtell, D. D. L., 1 Apr 2017, In : Clinical Cancer Research. 23, 7, p. 1862-1874 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer

Yan, S., Frank, D., Son, J., Hannan, K. M., Hannan, R. D., Chan, K. T., Pearson, R. B. & Sanij, E., 20 Jan 2017, In : International Journal of Molecular Sciences. 18, 1, 17 p., 210.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Therapeutic approaches targeting MYC-Driven prostate cancer

Rebello, R. J., Pearson, R. B., Hannan, R. D. & Furic, L., 16 Feb 2017, In : Genes. 8, 2, 16 p., 71.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Kang, J., Kusnadi, E. P., Ogden, A. J., Hicks, R. J., Bammert, L., Kutay, U., Hung, S., Sanij, E., Hannan, R. D., Hannan, K. M. & Pearson, R. B., 2016, In : Oncotarget. 7, 31, p. 48887-48904 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Devlin, J. R., Hannan, K. M., Hein, N., Cullinane, C. M., Kusnadi, E. P., Ng, P. Y., George, A. J., Shortt, J., Bywater, M. J., Poortinga, G., Sanij, E., Kang, J., Drygin, D. J., O'Brien, S. E., Johnstone, R. W., McArthur, G. A., Hannan, R. D. & Pearson, R. B., 2016, In : Cancer Discovery. 6, 1, p. 59-70 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Combining high-content imaging and phenotypic classification analysis of senescence-associated beta-galactosidase staining to identify regulators of oncogene-induced senescence

Chan, K. T., Paavolainen, L., Hannan, K. M., George, A. J., Hannan, R. D., Simpson, K. J., Horvath, P. & Pearson, R. B., 1 Sep 2016, In : Assay and Drug Development Technologies. 14, 7, p. 416-428 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Quin, J. E., Chan, K. T., Devlin, J. R., Cameron, D. P., Diesch, J., Cullinane, C. M., Ahern, J., Khot, A. S., Hein, N., George, A. J., Hannan, K. M., Poortinga, G., Sheppard, K. E., Khanna, K. K., Johnstone, R. W., Drygin, D. J., McArthur, G. A., Pearson, R. B., Sanij, E. & Hannan, R. D., 2016, In : Oncotarget. 7, 31, p. 49800-49818 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

Rebello, R. J., Kusnadi, E., Cameron, D. P., Pearson, H. B., Lesmana, A., Devlin, J. R., Drygin, D., Clark, A. K., Porter, L., Pedersen, J., Sandhu, S., Risbridger, G. P., Pearson, R. B., Hannan, R. D. & Furic, L., 15 Nov 2016, In : Clinical Cancer Research. 22, 22, p. 5539-5552 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Sanij, E., Diesch, J., Lesmana, A., Poortinga, G., Hein, N., Lidgerwood, G., Cameron, D. P., Ellul, J., Goodall, G. J., Wong, L. H., Dhillon, A. S., Hamdane, N., Rothblum, L. I., Pearson, R. B., Haviv, I., Moss, T. & Hannan, R. D., 2015, In : Genome Research. 25, 2, p. 201 - 212 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Enhanced GAB2 expression is associated with improved survival in high-grade serous ovarian cancer and sensitivity to PI3K inhibition

Davis, S. J., Sheppard, K. E., Anglesio, M. S., George, J., Traficante, N., Fereday, S., Intermaggio, M. P., Menon, U. N., Gentry-Maharaj, A., Lubinski, J., Gronwald, J., Pearce, C. L., Pike, M. C., Wu, A. H., Kommoss, S., Pfisterer, J., Bois, A. D., Hilpert, F., Ramus, S. J., Bowtell, D. D. L. & 5 others, Huntsman, D. G., Pearson, R. B., Simpson, K. J., Campbell, I. G. & Gorringe, K. L., 1 Jun 2015, In : Molecular Cancer Therapeutics. 14, 6, p. 1495-1503 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A. C., Verrills, N. M., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. & Dhillon, A. S., 5 Mar 2015, In : Oncogene. 34, 10, p. 1340 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A. C., Verrills, N., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. & Dhillon, A. S., 2015, In : Oncogene. 34, 10, p. 1333-1339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of rDNA transcription in response to growth factors, nutrients and energy

Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B. & Kang, J., 2015, In : Gene. 556, 1, p. 27 - 34 8 p.

Research output: Contribution to journalArticleResearchpeer-review

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Mitchell, N. C., Tchoubrieva, E. B., Chahal, A., Woods, S. J., Lee, A., Lin, J., Parsons, L., Jastrzebski, K., Poortinga, G., Hannan, K. M., Pearson, R. B., Hannan, R. D. & Quinn, L. M., 2015, In : Cellular Signalling. 27, 10, p. 2045 - 2053 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Woods, S. J., Hannan, K. M., Pearson, R. B. & Hannan, R. D., 2015, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1849, 7, p. 821 - 829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Ramsdale, R., Jorissen, R. N., Li, F. Z., Al-Obaidi, S., Ward, T., Sheppard, K. E., Bukczynska, P. E., Young, R. J., Boyle, S. E., Shackleton, M., Bollag, G., Long, G. V., Tulchinsky, E., Rizos, H., Pearson, R. B., McArthur, G. A., Dhillon, A. S. & Ferrao, P. T., 18 Aug 2015, In : Science Signaling. 8, 390, p. ra82

Research output: Contribution to journalArticleResearchpeer-review

Unexpected role of CDK4 in a G2/M checkpoint

Sheppard, K. E., Pearson, R. B. & Hannan, R. D., 2015, In : Cell Cycle. 14, 9, p. 1351-1352 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2014

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Young, R. J., Waldeck, K., Martin, C., Foo, J. H., Cameron, D. P., Kirby, L., Do, H., Mitchell, C., Cullinane, C. M., Liu, W., Fox, S. B., Dutton-Regester, K., Hayward, N. K., Jene, N., Dobrovic, A., Pearson, R. B., Christensen, J. G., Randolph, S., McArthur, G. A. & Sheppard, K. E., 2014, In : Pigment Cell and Melanoma Research. 27, 4, p. 590-600 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

Parmenter, T. J., Kleinschmidt, M., Kinross, K. M., Bond, S. T., Li, J., Kaadige, M. R., Rao, A., Sheppard, K. E., Hugo, W., Pupo, G. M., Pearson, R. B., McGee, S. L., Long, G. V., Scolyer, R. A., Rizos, H., Bagnall, R. S., Cullinane, C. M., Ayer, D. E., Ribas, A., Johnstone, R. W. & 2 others, Hicks, R. J. & McArthur, G. A., 2014, In : Cancer Discovery. 4, 4, p. 423-433 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Targeting the nucleolus for cancer intervention

Quin, J. E., Devlin, J. R., Cameron, D., Hannan, K. M., Pearson, R. B. & Hannan, R. D., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 6, p. 802 - 816 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

Diesch, J., Sanij, E., Gilan, O., Love, C., Tran, H., Fleming, N. I., Ellul, J., Amalia, M., Haviv, I., Pearson, R. B., Tulchinsky, E., Mariadason, J. M., Sieber, O. M., Hannan, R. D. & Dhillon, A. S., 2014, In : PLoS ONE. 9, 3, 11 p., e88950.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B., Guthridge, M. A., Pearson, R. B. & Ekert, P. G., 2013, In : Cell Death and Differentiation. 20, 10, p. 1341 - 1349 9 p.

Research output: Contribution to journalArticleResearchpeer-review

AKT-independent PI3-K signaling in cancer - Emerging role for SGK3

Bruhn, M. A., Pearson, R. B., Hannan, R. D. & Sheppard, K. E., 2013, In : Cancer Management and Research. 5, 1, p. 281 - 292 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

AKT signalling is required for ribosomal RNA synthesis and progression of E-mu-Myc B-cell lymphoma in vivo

Devlin, J. R., Hannan, K. M., Ng, P. Y., Bywater, M., Shortt, J., Cullinane, C. M., McArthur, G., Johnstone, R. W., Hannan, R. D. & Pearson, R. B., 2013, In : FEBS Journal. 280, 21, p. 5307 - 5316 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis

Boglev, Y., Badrock, A. P., Trotter, A., Du, Q., Richardson, E. J., Parslow, A., Markmiller, S. J., Hall, N. E., de Jong-Curtain, T. A., Ng, A. Y., Verkade, H., Ober, E. A., Field, H. A., Shin, D., Shin, C., Hannan, K. M., Hannan, R. D., Pearson, R. B., Kim, S-H., Ess, K. C. & 3 others, Lieschke, G., Stainier, D. Y. R. & Heath, J. K., 2013, In : PLoS Genetics. 9, 2 (Art # e1003279), p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Shortt, J., Martin, B. P., Newbold, A., Hannan, K. M., Devlin, J. R., Baker, A., Ralli, R. A., Cullinane, C. M., Schmitt, C. A., Reimann, M., Hall, M. N., Wall, M., Hannan, R. D., Pearson, R. B., McArthur, G. A. & Johnstone, R. W., 2013, In : Blood. 121, 15, p. 2964 - 2974 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dysregulation of RNA polymerase I transcription during disease

Hannan, K. M., Sanij, E., Rothblum, L. I., Hannan, R. D. & Pearson, R. B., 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 3-4, p. 342 - 360 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Bywater, M., Pearson, R. B., McArthur, G. A. & Hannan, R. D., 2013, In : Nature Reviews Cancer. 13, 5, p. 299 - 314 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer

Davis, S. J., Sheppard, K. E., Pearson, R. B., Campbell, I. G., Gorringe, K. L. & Simpson, K. J., 15 Mar 2013, In : Clinical Cancer Research. 19, 6, p. 1411-1421 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Funnell, A. P. W., Mak, K. S., Twine, N. A., Pelka, G. J., Norton, L. J., Radziewic, T., Power, M., Wilkins, M. R., Bell-Anderson, K. S., Fraser, S. T., Perkins, A. C., Tam, P., Pearson, R. C. M. & Crossley, M., Aug 2013, In : Molecular and Cellular Biology. 33, 15, p. 2976-2987 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Sheppard, K. E., Cullinane, C. M., Hannan, K. M., Wall, M., Chan, J. C., Barber, F., Foo, J., Cameron, D., Neilsen, A., Ng, P., Ellul, J., Kleinschmidt, M., Kinross, K. M., Bowtell, D. D. L., Christensen, J. G., Hicks, R., Johnstone, R. W., McArthur, G. A., Hannan, R. D., Phillips, W. A. & 1 others, Pearson, R. B., 2013, In : European Journal of Cancer. 49, 18, p. 3936 - 3944 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

Hannan, R. D., Drygin, D. & Pearson, R. B., 2013, In : Expert Opinion on Therapeutic Targets. 17, 8, p. 873 - 878 6 p.

Research output: Contribution to journalEditorialResearchpeer-review

Open Access

The mTORC1 inhibitor everolimus prevents and treats Emu-Myc lymphoma by restoring oncogene-induced senescence

Wall, M., Poortinga, G., Stanley, K. L., Lindemann, R. K., Bots, M., Chan, C. J. C., Bywater, M., Kinross, K. M., Astle, M. V., Waldeck, K. L., Hannan, K. M., Shortt, J., Smyth, M. J., Lowe, S. W., Hannan, R. D., Pearson, R. B., Johnstone, R. W. & McArthur, G. A., 2013, In : Cancer Discovery. 3, 1, p. 82 - 95 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Astle, M., Hannan, K., Ng, P., Lee, R., George, A., Hsu, A., Haupt, Y., Hannan, R. & Pearson, R., 2012, In : Oncogene. 31, 15, p. 1949 - 1962 14 p.

Research output: Contribution to journalArticleResearchpeer-review

An activating {Pik3ca} mutation coupled with {Pten} loss is sufficient to initiate ovarian tumorigenesis in mice

Kinross, K. M., Montgomery, K. G., Kleinschmidt, M., Waring, P., Ivetac, I., Tikoo, A., Saad, M., Hare, L. M., Roh, V., Mantamadiotis, T., Sheppard, K. E., Ryland, G. L., Campbell, I. G., Gorringe, K. L., Christensen, J. G., Cullinane, C. M., Hicks, R. J., Pearson, R. B., Johnstone, R. W., McArthur, G. A. & 1 others, Phillips, W., 2012, In : Journal of Clinical Investigation. 122, 2, p. 553 - 557 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

Layton, M. J., Saad, M., Church, N., Pearson, R. B., Mitchell, C. A. & Phillips, W. A., 2012, In : BMC Biochemistry. 13, 1, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

Bywater, M. J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C. M., Wall, M., Cluse, L. A., Drygin, D., Anderes, K., Huser, N., Proffitt, C., Bliesath, J., Haddach, M., Schwaebe, M. K., Ryckman, D. M., Rice, W. G., Schmitt, C., Lowe, S. W., Johnstone, R. W. & 3 others, Pearson, R. B., McArthur, G. A. & Hannan, R. D., 2012, In : Cancer Cell. 22, 1, p. 51 - 65 15 p.

Research output: Contribution to journalArticleResearchpeer-review

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

Cowin, P. A., George, J., Fereday, S., Loehrer, E., Van Loo, P., Cullinane, C. M., Etemadmoghadam, D., Ftouni, S., Galletta, L., Anglesio, M. S., Hendley, J., Bowes, L., Sheppard, K. E., Christie, E. L., Pearson, R. B., Harnett, P. R., Heinzelmann-Schwarz, V., Friedlander, M., McNally, O. M., Quinn, M. & 3 others, Campbell, P., DeFazio, A. & Bowtell, D. D. L., 15 Aug 2012, In : Cancer Research. 72, 16, p. 4060-4073 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Targeting cancer with PI3K pathway inhibitors: Who to aim at?

Kinross, K. M., Sheppard, K. E., Pearson, R. B. & Phillips, W. A., 1 Aug 2012, In : Translational Cancer Research. 1, 2, p. 119-121 3 p.

Research output: Contribution to journalArticleOtherpeer-review