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Research Output 1995 2019

2019

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Jiang, S. H., Athanasopoulos, V., Ellyard, J. I., Chuah, A., Cappello, J., Cook, A., Prabhu, S. B., Cardenas, J., Gu, J., Stanley, M., Roco, J. A., Papa, I., Yabas, M., Walters, G. D., Burgio, G., McKeon, K., Byers, J. M., Burrin, C., Enders, A., Miosge, L. A. & 21 others, Canete, P. F., Jelusic, M., Tasic, V., Lungu, A. C., Alexander, S. I., Kitching, A. R., Fulcher, D. A., Shen, N., Arsov, T., Gatenby, P. A., Babon, J. J., Mallon, D. F., de Lucas Collantes, C., Stone, E. A., Wu, P., Field, M. A., Andrews, T. D., Cho, E., Pascual, V., Cook, M. C. & Vinuesa, C. G., 1 Dec 2019, In : Nature Communications. 10, 1, 12 p., 2201.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis

Odobasic, D., Ruth, A. J., Oudin, V., Kitching, A. R. & Holdsworth, S. R., 1 Mar 2019, In : Nephrology Dialysis Transplantation. 34, 3, p. 429-441 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, R., Nel, H. J., Talekar, M., Liu, X., Ooi, J. D., Huynh, M., Hadjigol, S., Robson, K. J., Ting, Y. T., Cole, S., Cochlin, K., Hitchcock, S., Zeng, B., Yekollu, S., Boks, M., Goh, N., Roberts, H., Rossjohn, J., Reid, H. H., Boyd, B. J. & 7 others, Malaviya, R., Shealy, D. J., Baker, D. G., Madakamutil, L., Richard Kitching, A., O’Sullivan, B. J. & Thomas, R., 19 Sep 2019, In : JCI Insight. 4, 18, 21 p., e126025.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Platelet retention in inflamed glomeruli occurs via selective prolongation of interactions with immune cells

Finsterbusch, M., Norman, M. U., Hall, P., Kitching, A. R. & Hickey, M. J., 1 Feb 2019, In : Kidney International. 95, 2, p. 363-374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Standardized Outcomes in Nephrology—Glomerular Disease (SONG-GD): establishing a core outcome set for trials in patients with glomerular disease

Carter, S. A., Lightstone, L., Cattran, D., Bagga, A., Barbour, S. J., Barratt, J., Boletis, J., Caster, D., Coppo, R., Fervenza, F. C., Floege, J., Hladunewich, M., Hogan, J. J., Lafayette, R., Kitching, A. R., Malvar, A., Radhakrishnan, J., Rovin, B. H., Zhang, H., Gutman, T. & 17 others, Howell, M., Logeman, C., Shen, J. I., Teixeira-Pinto, A., Alexander, S. I., Cho, Y., Craig, J. C., Harris, D., Johnson, D. W., Kerr, P. G., Ryan, J., Viecelli, A. K., Wang, A. Y. M., Wilkie, M., Scholes-Robertson, N., Tong, A. & for the SONG-GD Initiative, 1 Jun 2019, In : Kidney International. 95, 6, p. 1280-1283 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

The renal draining lymph nodes in acute inflammatory kidney disease

Kitching, A. R. & Holdsworth, S. R., 1 Feb 2019, In : Kidney International. 95, 2, p. 254-256 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2018
2 Citations (Scopus)

Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus

Vincent, F. B., Slavin, L., Hoi, A. Y., Kitching, A. R., Mackay, F., Harris, J., Kandane-Rathnayake, R. & Morand, E. F., 1 Jan 2018, In : Lupus Science and Medicine. 5, 1, 10 p., e000277.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CD8+ cells and glomerular crescent formation: Outside-in as well as inside-out

Kitching, A. R. & Alikhan, M. A., 1 Aug 2018, In : Journal of Clinical Investigation. 128, 8, p. 3231-3233 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Chimeric antigen receptor T (CAR T) cells: another cancer therapy with potential applications in kidney disease and transplantation?

Kitching, A. R. & Jaw, J., 1 Jul 2018, In : Kidney International. 94, 1, p. 4-6 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

11 Citations (Scopus)

Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes

Westhorpe, C. L. V., Ursula Norman, M., Hall, P., Snelgrove, S. L., Finsterbusch, M., Li, A., Lo, C., Tan, Z. H., Li, S., Nilsson, S. K., Kitching, A. R. & Hickey, M. J., 1 Dec 2018, In : Nature Communications. 9, 1, 14 p., 747.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Formyl peptide receptor activation inhibits the expansion of effector T cells and synovial fibroblasts and attenuates joint injury in models of rheumatoid arthritis

Odobasic, D., Jia, Y., Kao, W., Fan, H., Wei, X., Gu, R., Ngo, D., Richard Kitching, A., Holdsworth, S. R., Morand, E. F. & Yang, Y. H., 1 Aug 2018, In : International Immunopharmacology. 61, p. 140-149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Goodpasture's autoimmune disease — A collagen IV disorder

Pedchenko, V., Kitching, A. R. & Hudson, B. G., 1 Oct 2018, In : Matrix Biology. 71-72, p. 240-249 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

4 Citations (Scopus)

HLA and kidney disease: from associations to mechanisms

Robson, K. J., Ooi, J. D., Holdsworth, S. R., Rossjohn, J. & Kitching, A. R., 1 Oct 2018, In : Nature Reviews Nephrology. 14, 10, p. 636-655 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Immune-mediated kidney disease in 2017: Progress in mechanisms and therapy for immunological kidney disease

Holdsworth, S. R. & Kitching, A. R., 1 Feb 2018, In : Nature Reviews Nephrology. 14, 2, p. 76-78 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2 Citations (Scopus)

Inflammasomes in the Kidney

Hutton, H., Alikhan, M. & Kitching, R., 1 Jan 2018, Inflammasomes: Clinical and Therapeutic Implications. Cordero, M. & Alcocer-Gomez, E. (eds.). Cham, Switzerland: Springer, p. 177-210 34 p. (Experientia Supplementum; vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

9 Citations (Scopus)

Regulatory T cells in renal disease

Alikhan, M. A., Huynh, M., Kitching, A. R. & Ooi, J. D., 1 Jan 2018, In : Clinical and Translational Immunology. 7, 1, 14 p., e1004.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File
1 Citation (Scopus)

Renal dendritic cells: The long and winding road

Richard Kitching, A. & Ooi, J. D., 1 Jan 2018, In : Journal of the American Society of Nephrology. 29, 1, p. 4-7 4 p.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)
Open Access
File
1 Citation (Scopus)

Urinary B-cell-activating factor of the tumour necrosis factor family (BAFF) in systemic lupus erythematosus

Vincent, FB., Kandane-Rathnayake, R., Hoi, AY., Slavin, L., Godsell, JD., Kitching, AR., Harris, J., Nelson, C. L., Jenkins, A. J., Chrysostomou, A., Hibbs, ML., Kerr, PG., Rischmueller, M., Mackay, F. & Morand, EF., 1 Nov 2018, In : Lupus. 27, 13, p. 2029-2040 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
17 Citations (Scopus)

Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury

Snelgrove, S. L. L., Lo, C., Hall, P., Lo, C. Y. Y., Alikhan, M. A. A., Coates, T. T., Holdsworth, S. R. R., Hickey, M. J. J. & Kitching, R. R., May 2017, In : Transplantation. 101, 5, p. 1013-1024 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing

Hutton, H. L., Holdsworth, S. R. & Kitching, A. R., 1 Sep 2017, In : Seminars in Nephrology. 37, 5, p. 418-435 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)

CD8+ T cells effect glomerular injury in experimental anti-myeloperoxidase GN

Chang, J., Eggenhuizen, P., O'Sullivan, K. M., Alikhan, M. A., Holdsworth, S. R., Ooi, J. D. & Kitching, A. R., 1 Jan 2017, In : Journal of the American Society of Nephrology. 28, 1, p. 47-55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Chyluria: When is proteinuria ‘not proteinuria’?

Teo, S., LePage, A., Kitching, A. R. & Johnstone, L., 1 Oct 2017, In : Journal of Paediatrics and Child Health. 53, 10, p. 1015-1017 3 p.

Research output: Contribution to journalArticleOtherpeer-review

58 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Epstein-Barr virus encephalitis in solid organ transplantation

Lau, J. S. Y., Low, Z. M., Abbott, I., Shochet, L., Kanellis, J., Kitching, A. R. & Korman, T. M., 1 Jul 2017, In : New Microbiologica. 40, 3, p. 212-217 6 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Imaging Leukocyte Responses in the Kidney

Finsterbusch, M., Kitching, A. R. & Hickey, M. J., Mar 2017, In : Transplantation. 101, 3, p. 506-516 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2 Citations (Scopus)

Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis

Ghali, J. R., Alikhan, M. A., Holdsworth, S. R. & Kitching, A. R., Jan 2017, In : Immunology. 150, 1, p. 100-114 15 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis

Ghali, J. R., O'Sullivan, K. M., Eggenhuizen, P. J., Holdsworth, S. R. & Kitching, A. R., Mar 2017, In : Nephron. 135, 3, p. 207-223 17 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

In Vivo Imaging of Inflamed Glomeruli Reveals Dynamics of Neutrophil Extracellular Trap Formation in Glomerular Capillaries

Westhorpe, C. L. V., Bayard, J. E., O'Sullivan, K. M., Hall, P., Cheng, Q., Kitching, A. R. & Hickey, M. J., 1 Feb 2017, In : American Journal of Pathology. 187, 2, p. 318-331 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenic role for γδ T cells in autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Fujita, T., Ooi, J. D., Alikhan, M. A., Dick, J., Shim, R., Odobasic, D., O'Sullivan, K. M., Kitching, A. R. & Holdsworth, S. R., 1 Nov 2017, In : Journal of Immunology. 199, 9, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
29 Citations (Scopus)

Biologics for the treatment of autoimmune renal diseases

Holdsworth, S. R., Gan, P. Y. & Kitching, A. R., 1 Apr 2016, In : Nature Reviews Nephrology. 12, 4, p. 217-231 15 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Endogenous toll-like receptor 9 regulates AKI by promoting regulatory T cell recruitment

Alikhan, M., Summers, S. A., Gan, P. Y., Chan, A., Khouri, M., Ooi, J., Ghali, J., Odobasic, D., Hickey, M. J., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 706 - 714 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Erratum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus (Nature Medicine (2013) 19 (107-112))

Devi, S., Li, A., Westhorpe, C. L. V., Lo, C. Y., Abeynaike, L. D., Snelgrove, S. L., Hall, P., Ooi, J. D., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 6 Apr 2016, In : Nature Medicine. 22, 4, p. 446 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

From bench to pet shop to bedside? The environment and immune function in mice

Kitching, R. & Ooi, J., 1 Dec 2016, In : Kidney International. 90, 6, p. 1142-1143 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

6 Citations (Scopus)

Mast cell stabilization ameliorates autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., O'Sullivan, K. M., Ooi, J. D., Alikhan, M. A., Odobasic, D., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 1 May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1321 - 1333 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Myeloperoxidase peptide-based nasal tolerance in experimental ANCA-associated GN

Gan, P. Y., Tan, D. S. Y., Ooi, J., Alikhan, M., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Neutrophil-mediated regulation of innate and adaptive immunity: The role of myeloperoxidase

Odobasic, D., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of Immunology Research. 2016, p. 1 - 11 11 p., 2349817.

Research output: Contribution to journalArticleOtherpeer-review

36 Citations (Scopus)

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus

Finsterbusch, M., Hall, P. H., Li, A., Devi, S., Westhorpe, C. L., Kitching, A. R. & Hickey, M. J., 30 Aug 2016, In : Proceedings of the National Academy of Sciences. 113, 35, p. 172 - 181 9 p., E5.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Regulatory T cells in immune mediated renal disease

Ghali, J., Wang, Y. M., Holdsworth, S. R. & Kitching, A. R., 2016, In : Nephrology. 21, 2, p. 86 - 96 11 p.

Research output: Contribution to journalArticleOtherpeer-review

56 Citations (Scopus)

The NLRP3 inflammasome in kidney disease and autoimmunity

Hutton, H. L., Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2016, In : Nephrology. 21, 9, p. 736 - 744 9 p.

Research output: Contribution to journalArticleOtherpeer-review

The players: Cells involved in glomerular disease

Kitching, A. R. & Hutton, H. L., 7 Sep 2016, In : Clinical Journal of the American Society of Nephrology. 11, 9, p. 1664-1674 11 p.

Research output: Contribution to journalArticleOtherpeer-review

2015
33 Citations (Scopus)

CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages

Engel, D. R., Krause, T. A., Snelgrove, S. L., Thiebes, S., Hickey, M. J., Boor, P., Kitching, A. R. & Kurts, C., 2015, In : Journal of Immunology. 194, 4, p. 1628 - 1638 11 p.

Research output: Contribution to journalArticleResearchpeer-review

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis

Ghali, J., O'Sullivan, K., Eggenhuizen, P. J., Holdsworth, S. R. & Kitching, A. R., 2015, In : PLoS ONE. 10, 4, 17 p., e0123118.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis

Gan, P. Y., Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2015, In : Current Pharmaceutical Design. 21, 18, p. 2380 - 2390 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis

Ooi, J., Li, M., Kourkoutzelos, K., Yagita, H., Azuma, M., Holdsworth, S. R. & Kitching, A. R., 2015, In : Nephrology. 20, 12, p. 892 - 898 7 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis

O'Sullivan, K., Lo, C. Y-W., Summers, S. A., Elgass, K., McMillan, P., Longano, A., Ford, S. L., Gan, P. Y., Kerr, P. G., Kitching, A. R. & Holdsworth, S. R., 2015, In : Kidney International. 88, 5, p. 1030 - 1046 17 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Suppression of autoimmunity and renal disease in pristane-induced lupus by myeloperoxidase

Odobasic, D., Muljadi, R. C. M., O'Sullivan, K., Kettle, A. J., Dickerhof, N., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 2015, In : Arthritis and Rheumatology. 67, 7, p. 1868 - 1880 13 p.

Research output: Contribution to journalArticleResearchpeer-review