19982019
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Research Output 1998 2019

2019

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Deora, G. S., Qin, C. X., Vecchio, E. A., Debono, A. J., Priebbenow, D. L., Brady, R. M., Beveridge, J., Teguh, S. C., Deo, M., May, L. T., Krippner, G., Ritchie, R. H. & Baell, J. B., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5242-5248 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo

Qin, C. X., Finlayson, S. B., Al-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 2 May 2018, In : Scientific Reports. 8, 1, p. 7185-7185 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H. & Wong, C. H. Y., 22 Oct 2018, In : Journal of Neuroinflammation. 15, 1, 13 p., 293.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Are targeted therapies for diabetic cardiomyopathy on the horizon?

Tate, M., Grieve, D. J. & Ritchie, R. H., 1 May 2017, In : Clinical Science. 131, 10, p. 897-915 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice in Vivo

Qin, C. X., Finlayson, S. B., Ai-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16615.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Qin, C. X., Sleaby, R., Davidoff, A. J., Bell, J. R., De Blasio, M. J., Delbridge, L. M., Chatham, J. C. & Ritchie, R. H., 1 Feb 2017, In : Pharmacological Research. 116, p. 45-56 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat

Tate, M., Deo, M., Cao, A. H., Hood, S. G., Huynh, K., Kiriazis, H., Du, X-J., Julius, T. L., Figtree, G. A., Dusting, G. J., Kaye, D. M. & Ritchie, R. H., 2017, In : Diabetes and Vascular Disease Research. 14, 5, p. 423-433 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy

Ritchie, R. H., Zerenturk, E. J., Prakoso, D. & Calkin, A. C., 1 May 2017, In : Journal of Molecular Endocrinology. 58, 4, p. R225-R240 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury

Chin, K. Y., Qin, C., May, L., Ritchie, R. H. & Woodman, O. L., 1 Jan 2017, In : Current Drug Targets. 18, 15, p. 1689-1711 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Prakoso, D., De Blasio, M. J., Qin, C., Rosli, S., Kiriazis, H., Qian, H., Du, X-J., Weeks, K. L., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., 7 Jun 2017, In : Clinical Science. 131, 12, p. 1345-1360 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Ng, H. H., Leo, C. H., Prakoso, D., Prakoso, D., Qin, C., Ritchie, R. H. & Parry, L. J., 9 Jan 2017, In : Scientific Reports. 7, 15 p., 39604 .

Research output: Contribution to journalArticleResearchpeer-review

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In : Nature Communications. 8, 13 p., 14232.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

Bubb, K., Kok, C., Tang, O., Rasko, N. B., Birgisdottir, A. B., Hansen, T. S., Ritchie, R., Bhindi, R., Reisman, S. A., Meyer, C., Ward, K., Karimi Galougahi, K. & Figtree, G. A., 1 Jul 2017, In : Free Radical Biology and Medicine. 108, p. 585-594 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Sharma, A., Rizky, L., Stefanovic, N., Tate, M., Ritchie, R. H., Ward, K. W. & de Haan, J. B., 3 Mar 2017, In : Cardiovascular Diabetology. 16, 1, 13 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

Tare, M., Kalidindi, R. S. R., Bubb, K. J., Parkington, H. C., Boon, W-M., Li, X., Sobey, C. G., Drummond, G. R., Ritchie, R. H. & Kemp-Harper, B. K., Apr 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 397-408 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo

Chin, K. Y., Michel, L., Qin, C. X., Cao, N., Woodman, O. L. & Ritchie, R. H., 1 Feb 2016, In : Pharmacological Research. 104, p. 165-175 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Kemp-Harper, B. K., Horowitz, J. D. & Ritchie, R. H., 1 Sep 2016, In : Drugs. 76, 14, p. 1337-1348 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Qin, C. H., Yang, Y. H., May, L. T., Gao, X-M., Stewart, A. G., Tu, Y., Woodman, O. L. & Ritchie, R. H., 2015, In : Pharmacology and Therapeutics. 148, p. 47 - 65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo

Cao, N., Wong, Y. G., Rosli, S., Kiriazis, H., Huynh, K., Qin, C. H., Du, X-J., Kemp-Harper, B. K. & Ritchie, R. H., 2015, In : Circulation: Heart Failure. 8, 3, p. 572 - 581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice

Bowden, M. A., Tesch, G. H., Julius, T. L., Rosli, S., Love, J. E. & Ritchie, R. H., 2015, In : Obesity. 23, 6, p. 1166 - 1177 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110alpha) signaling

De Blasio, M. J., Huynh, K. N. N., Qin, C. H., Rosli, S., Kiriazis, H., Ayer, A., Cemerlang, N., Stocker, R., Du, X-J., McMullen, J. R. & Ritchie, R. H., 2015, In : Free Radical Biology and Medicine. 87, (Art. No:12407), p. 137 - 147 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

Huynh, K., Bernardo, B. C., McMullen, J. R. & Ritchie, R. H., 2014, In : Pharmacology and Therapeutics. 142, 3, p. 375 - 415 41 p.

Research output: Contribution to journalArticleResearchpeer-review

Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

Fender, A. C., Pavic, G., Drummond, G. R., Dusting, G. J. & Ritchie, R. H., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 10, p. 1001 - 1007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO

Irvine, J. C., Cao, N., Gossain, S., Alexander, A. E., Love, J. E., Qin, C., Horowitz, J. D., Harper, B. K. & Ritchie, R. H., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 3, p. 365 - 377 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1{2-26}

Qin, C., Buxton, K. D., Pepe, S., Cao, A., Venardos, K. M., Love, J. E., Kaye, D. M., Yang, Y. H., Morand, E. F. & Ritchie, R. H., 2013, In : British Journal of Pharmacology. 168, 1, p. 238 - 252 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R. & Ritchie, R. H., 2013, In : Free Radical Biology and Medicine. 60, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness

Dautov, R., Ngo, D., Licari, G., Liu, S., Sverdlov, A. L., Ritchie, R. H., Harper, B. K., Horowitz, J. D. & Chirkov, Y. Y., 2013, In : Nitric Oxide-Biology and Chemistry. 35, p. 72 - 78 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Coenzyme Q{10} attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Jandeleit-Dahm, K. A. M., Forbes, J., McMullen, J. R. & Ritchie, R. H., 2012, In : Diabetologia. 55, 5, p. 1544 - 1553 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

Ritchie, R. H., Love, J. E., Huynh, K., Bernardo, B. C., Henstridge, D. C., Kiriazis, H., Tham, Y. K., Sapra, G., Qin, C., Cemerlang, N., Boey, E. J. H., Jandeleit-Dahm, K., Du, X. J. & McMullen, J. R., Dec 2012, In : Diabetologia. 55, 12, p. 3369-3381 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness

Mellor, K. M., Wendt, I. R., Ritchie, R. H. & Delbridge, L. MD., 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 4, p. H964 - H972 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation

Lin, E., Irvine, J. C., Cao, A. H., Alexander, A. E., Love, J. E., Patel, R., McMullen, J. R., Kaye, D. M., Kemp-Harper, B. K. & Ritchie, R. H., 2012, In : PLoS ONE. 7, 4, 11 p., e34892.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy

Irvine, J. C., Ganthavee, V., Love, J. E., Alexander, A. E., Horowitz, J. D., Stasch, J-P., Kemp-Harper, B. K. & Ritchie, R. H., 2012, In : PLoS ONE. 7, 11, 11 p., e44481.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

Sourris, K. C., Harcourt, B. E., Tang, P., Morley, A., Huynh, K., Penfold, S. A., Coughlan, M. T., Cooper, M. E., Nguyen, T-V., Ritchie, R. H. & Forbes, J. M., 2012, In : Free Radical Biology and Medicine. 52, 3, p. 716 - 723 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy

Smith, N. J., Chan, H-W., Qian, H., Bourne, A. M., Hannan, K. M., Warner, F. J., Ritchie, R. H., Pearson, R. B., Hannan, R. D. & Thomas, W. G., May 2011, In : Hypertension. 57, 5, p. 973-980 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Fructose modulates cardiomyocyte excitation-contraction coupling and Ca{2+} handling in vitro

Mellor, K. M., Bell, J. R., Wendt, I. R., Davidoff, A. J., Ritchie, R. H. & Delbridge, L. MD., 2011, In : PLoS ONE. 6, 9, 8 p., e25204.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

Mellor, K. M., Bell, J. R., Young, M., Ritchie, R. & Delbridge, L. M. D., Jun 2011, In : Journal of Molecular and Cellular Cardiology. 50, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial oxidative stress contributes to transgenic beta{2}-adrenoceptor activation-induced cardiomyopathy and heart failure

Xu, Q., Dalic, A., Fang, L., Kiriazis, H., Ritchie, R. H., Sim, K., Gao, X-M., Drummond, G. R., Sarwar, M., Zhang, Y-Y., Dart, A. M. & Du, X-J., 2011, In : British Journal of Pharmacology. 162, 5, p. 1012 - 1028 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl (HNO) as a vasoprotective signaling molecule

Bullen, M. L., Miller, A. A., Andrews, K., Irvine, J. C., Ritchie, R. H., Sobey, C. G. & Kemp-Harper, B. K., 2011, In : Antioxidants and Redox Signaling. 14, p. 1675 - 1686 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO. and beyond

Ritchie, R. H., Irvine, J. C., Rosenkranz, A. C., Patel, R., Wendt, I. R., Horowitz, J. D. & Kemp, B. K., 2009, In : Pharmacology and Therapeutics. 124, 3, p. 279 - 300 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Reduced L-arginine transport contributes to the pathogenesis of myocardial ischemia-reperfusion injury

Venardos, K., Zatta, A., Marshall, T., Ritchie, R. & Kaye, D., 2009, In : Journal of Cellular Biochemistry. 108, 1, p. 156 - 168 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Nitroxyl (HNO): the Cinderella of the nitric oxide story

Irvine, J. C., Ritchie, R. H., Favaloro, J. L., Andrews, K. L., Widdop, R. E. & Kemp-Harper, B. K., 2008, In : Trends in Pharmacological Sciences. 29, 12, p. 601 - 608 8 p.

Research output: Contribution to journalArticleResearchpeer-review