1994 …2022

Research output per year

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Research Output

2020

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart (Cardiovascular Drugs and Therapy, (2019), 33, 6, (669-674), 10.1007/s10557-019-06914-9)

Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T. & Ritchie, R. H., 1 Jan 2020, (Accepted/In press) In : Cardiovascular Drugs and Therapy. 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights

Leo, C. H., Ng, H. H., Marshall, S. A., Jelinic, M., Rupasinghe, T., Qin, C., Roessner, U., Ritchie, R. H., Tare, M. & Parry, L. J., Jan 2020, In : British Journal of Pharmacology. 177, 1, p. 217-233 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2019

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Characterising an Alternative Murine Model of Diabetic Cardiomyopathy

Tate, M., Prakoso, D., Willis, A. M., Peng, C., Deo, M., Qin, C. X., Walsh, J. L., Nash, D. M., Cohen, C. D., Rofe, A. K., Sharma, A., Kiriazis, H., Donner, D. G., De Haan, J. B., Watson, A. M. D., De Blasio, M. J. & Ritchie, R. H., 14 Nov 2019, In : Frontiers in Physiology. 10, 15 p., 1395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modified redox signaling in vasculature after chronic infusion of the insulin receptor antagonist, S961

Bubb, K. J., Ritchie, R. H. & Figtree, G. A., 1 Feb 2019, In : Microcirculation. 26, 2, 10 p., e12501.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

Senchenkova, E. Y., Ansari, J., Becker, F., Vital, S. A., Al-Yafeai, Z., Sparkenbaugh, E. M., Pawlinski, R., Stokes, K. Y., Carroll, J. L., Dragoi, A. M., Qin, C. X., Ritchie, R. H., Sun, H., Cuellar-Saenz, H. H., Rubinstein, M. R., Han, Y. W., Orr, A. W., Perretti, M., Granger, D. N. & Gavins, F. N. E., 23 Jul 2019, In : Circulation. 140, 4, p. 319-335 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Deora, G. S., Qin, C. X., Vecchio, E. A., Debono, A. J., Priebbenow, D. L., Brady, R. M., Beveridge, J., Teguh, S. C., Deo, M., May, L. T., Krippner, G., Ritchie, R. H. & Baell, J. B., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5242-5248 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Tate, M., Higgins, G., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garz, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. & Ritchie, R. H., Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 669-674 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo

Qin, C. X., Finlayson, S. B., Al-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 2 May 2018, In : Scientific Reports. 8, 1, p. 7185-7185 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
Open Access
File
1 Citation (Scopus)

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chandramouli, C., Reichelt, M. E., Curl, C. L., Varma, U., Bienvenu, L. A., Koutsifeli, P., Raaijmakers, A. J. A., De Blasio, M. J., Qin, C. X., Jenkins, A. J., Ritchie, R. H., Mellor, K. M. & Delbridge, L. M. D., 1 Dec 2018, In : Scientific Reports. 8, 1, 13 p., 2346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H. & Wong, C. H. Y., 22 Oct 2018, In : Journal of Neuroinflammation. 15, 1, 13 p., 293.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Generation of MicroRNA-34 sponges and tough decoys for the heart: Developments and challenges

Bernardo, B. C., Gregorevic, P., Ritchie, R. H. & McMullen, J. R., 21 Sep 2018, In : Frontiers in Pharmacology. 9, SEP, 10 p., 1090.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Implications of Underlying Mechanisms for the Recognition and Management of Diabetic Cardiomyopathy

Marwick, T. H., Ritchie, R., Shaw, J. E. & Kaye, D., 23 Jan 2018, In : Journal of the American College of Cardiology. 71, 3, p. 339-351 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
51 Citations (Scopus)

Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: Therapeutic implications

Sharma, A., Tate, M., Mathew, G., Vince, J. E., Ritchie, R. H. & De Haan, J. B., 20 Feb 2018, In : Frontiers in Physiology. 9, FEB, 15 p., 114.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
41 Citations (Scopus)

Relaxin as a therapeutic target for the cardiovascular complications of diabetes

Ng, H. H., Leo, C. H., Parry, L. J. & Ritchie, R. H., 15 May 2018, In : Frontiers in Pharmacology. 9, MAY, 10 p., 501.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation

Spallotta, F., Cencioni, C., Atlante, S., Garella, D., Cocco, M., Mori, M., Mastrocola, R., Kuenne, C., Guenther, S., Nanni, S., Azzimato, V., Zukunft, S., Kornberger, A., Sürün, D., Schnütgen, F., Von Melchner, H., Di Stilo, A., Aragno, M., Braspenning, M., Van Criekinge, W. & 13 others, De Blasio, M. J., Ritchie, R. H., Zaccagnini, G., Martelli, F., Farsetti, A., Fleming, I., Braun, T., Beiras-Fernandez, A., Botta, B., Collino, M., Bertinaria, M., Zeiher, A. M. & Gaetano, C., 5 Jan 2018, In : Circulation Research. 122, 1, p. 31-46 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)
2017

Are targeted therapies for diabetic cardiomyopathy on the horizon?

Tate, M., Grieve, D. J. & Ritchie, R. H., 1 May 2017, In : Clinical Science. 131, 10, p. 897-915 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice in Vivo

Qin, C. X., Finlayson, S. B., Ai-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16615.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Qin, C. X., Sleaby, R., Davidoff, A. J., Bell, J. R., De Blasio, M. J., Delbridge, L. M., Chatham, J. C. & Ritchie, R. H., 1 Feb 2017, In : Pharmacological Research. 116, p. 45-56 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat

Tate, M., Deo, M., Cao, A. H., Hood, S. G., Huynh, K., Kiriazis, H., Du, X-J., Julius, T. L., Figtree, G. A., Dusting, G. J., Kaye, D. M. & Ritchie, R. H., 2017, In : Diabetes and Vascular Disease Research. 14, 5, p. 423-433 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy

Ritchie, R. H., Zerenturk, E. J., Prakoso, D. & Calkin, A. C., 1 May 2017, In : Journal of Molecular Endocrinology. 58, 4, p. R225-R240 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury

Chin, K. Y., Qin, C., May, L., Ritchie, R. H. & Woodman, O. L., 1 Jan 2017, In : Current Drug Targets. 18, 15, p. 1689-1711 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Prakoso, D., De Blasio, M. J., Qin, C., Rosli, S., Kiriazis, H., Qian, H., Du, X-J., Weeks, K. L., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., 7 Jun 2017, In : Clinical Science. 131, 12, p. 1345-1360 16 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Ng, H. H., Leo, C. H., Prakoso, D., Qin, C., Ritchie, R. H. & Parry, L. J., 9 Jan 2017, In : Scientific Reports. 7, 15 p., 39604 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In : Nature Communications. 8, 13 p., 14232.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

Bubb, K., Kok, C., Tang, O., Rasko, N. B., Birgisdottir, A. B., Hansen, T. S., Ritchie, R., Bhindi, R., Reisman, S. A., Meyer, C., Ward, K., Karimi Galougahi, K. & Figtree, G. A., 1 Jul 2017, In : Free Radical Biology and Medicine. 108, p. 585-594 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Sharma, A., Rizky, L., Stefanovic, N., Tate, M., Ritchie, R. H., Ward, K. W. & de Haan, J. B., 3 Mar 2017, In : Cardiovascular Diabetology. 16, 1, 13 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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31 Citations (Scopus)

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

32 Citations (Scopus)
11 Citations (Scopus)

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

Tare, M., Kalidindi, R. S. R., Bubb, K. J., Parkington, H. C., Boon, W-M., Li, X., Sobey, C. G., Drummond, G. R., Ritchie, R. H. & Kemp-Harper, B. K., Apr 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 397-408 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2016

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Diabetic cardiomyopathy: The case for a role of fructose in disease etiology

Delbridge, L. M. D., Benson, V. L., Ritchie, R. H. & Mellor, K. M., 1 Dec 2016, In : Diabetes. 65, 12, p. 3521-3528 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo

Chin, K. Y., Michel, L., Qin, C. X., Cao, N., Woodman, O. L. & Ritchie, R. H., 1 Feb 2016, In : Pharmacological Research. 104, p. 165-175 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Kemp-Harper, B. K., Horowitz, J. D. & Ritchie, R. H., 1 Sep 2016, In : Drugs. 76, 14, p. 1337-1348 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2015

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Qin, C. H., Yang, Y. H., May, L. T., Gao, X-M., Stewart, A. G., Tu, Y., Woodman, O. L. & Ritchie, R. H., 2015, In : Pharmacology and Therapeutics. 148, p. 47 - 65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo

Cao, N., Wong, Y. G., Rosli, S., Kiriazis, H., Huynh, K., Qin, C. H., Du, X-J., Kemp-Harper, B. K. & Ritchie, R. H., 2015, In : Circulation: Heart Failure. 8, 3, p. 572 - 581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice

Bowden, M. A., Tesch, G. H., Julius, T. L., Rosli, S., Love, J. E. & Ritchie, R. H., 2015, In : Obesity. 23, 6, p. 1166 - 1177 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110alpha) signaling

De Blasio, M. J., Huynh, K. N. N., Qin, C. H., Rosli, S., Kiriazis, H., Ayer, A., Cemerlang, N., Stocker, R., Du, X-J., McMullen, J. R. & Ritchie, R. H., 2015, In : Free Radical Biology and Medicine. 87, (Art. No:12407), p. 137 - 147 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2014

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

Huynh, K., Bernardo, B. C., McMullen, J. R. & Ritchie, R. H., 2014, In : Pharmacology and Therapeutics. 142, 3, p. 375 - 415 41 p.

Research output: Contribution to journalArticleResearchpeer-review

231 Citations (Scopus)
16 Citations (Scopus)

Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

Fender, A. C., Pavic, G., Drummond, G. R., Dusting, G. J. & Ritchie, R. H., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 10, p. 1001 - 1007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
8 Citations (Scopus)

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO

Irvine, J. C., Cao, N., Gossain, S., Alexander, A. E., Love, J. E., Qin, C., Horowitz, J. D., Harper, B. K. & Ritchie, R. H., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 3, p. 365 - 377 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function

Ritchie, R. H., Leo, C. H., Qin, C., Stephenson, E. J., Bowden, M. A., Buxton, K. D., Lessard, S. J., Rivas, D. A., Koch, L. G., Britton, S. L., Hawley, J. A. & Woodman, O. L., 11 Mar 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 5

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Myocardial insulin resistance, metabolic stress and autophagy in diabetes

Mellor, K. M., Bell, J. R., Ritchie, R. H. & Delbridge, L. M., 1 Jan 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 1, p. 56-61 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1{2-26}

Qin, C., Buxton, K. D., Pepe, S., Cao, A., Venardos, K. M., Love, J. E., Kaye, D. M., Yang, Y. H., Morand, E. F. & Ritchie, R. H., 2013, In : British Journal of Pharmacology. 168, 1, p. 238 - 252 15 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R. & Ritchie, R. H., 2013, In : Free Radical Biology and Medicine. 60, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness

Dautov, R., Ngo, D., Licari, G., Liu, S., Sverdlov, A. L., Ritchie, R. H., Harper, B. K., Horowitz, J. D. & Chirkov, Y. Y., 2013, In : Nitric Oxide-Biology and Chemistry. 35, p. 72 - 78 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)