Projects per year
Personal profile
Biography
Professor Ritchie is the Theme Leader of the Drug Discovery Biology Theme in the Monash Institute of Pharmaceutical Sciences (MIPS), and holds an NHMRC Senior Research Fellowship. Professor Ritchie is internationally-recognised for her contributions to cardiac pharmacology. Her translationally-focused research objective is the identification of new treatment strategies for arresting the progression of heart failure, particularly in the context of diabetes and myocardial infarction. Professor Ritchie’s PhD focused on predictors of myocardial function in vivo in patients with ischaemic heart disease (University of Adelaide 1990–94), including development of the first quantitative model of the force-interval relationship in human myocardium. Her postdoctoral training — Wayne State University 1995–97, USA and the Florey Institute 1997–2002 — preceded her recruitment to the Baker Institute in late 2002. She has numerous relevant preclinical in vivo models of diabetic (T1D, T2D), ischaemic, and other cardiomyopathies in her laboratory.
The research achievements of Professor Ritchie to date include almost 100 career publications and continuous peer-reviewed funding since 1999 (comprising support from NHMRC, Diabetes Australia and the Heart Foundation). Her contributions to cardiac pharmacology have been recognised by the 2012 Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Achievement Award, the 2013 Diabetes Australia Millenium-Type 1 Diabetes Award, and election as a Fellow of the American Heart Association in 2013. Her international profile in her chosen field has been further recognised by numerous prestigious speaking invitations, including multiple World Congresses, including Cardiology, Diabetes, Pharmacology, and the International Society for Heart Research, as well as the American Heart Association and the British Pharmacology Society.
Achievements
- NHMRC Level A Senior Research Fellowship (2014–18)
- American Heart Association International Fellow (2013– )
- NHMRC Senior Research Fellowship Level A (2008)
- NHMRC Biomedical Career Development Award (2002)
- Foundation for High Blood Pressure Research Fellowship (2000)
Awards
- Diabetes Australia Research Trust Millennium Award, Type 1 diabetes (2013)
- ASCEPT Achievement Award for services to Australasian pharmacology and to scientific discipline/policy over the last 10 years (2012)
- Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) New Investigator Award (1998)
Research interests
Professor Ritchie leads the Heart Failure Pharmacology laboratory at Monash Institute of Pharmceutical Sciences. Click here to access the laboratory's homepage.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cardiology, Ph.D., University of Adelaide
Award Date: 10 Oct 1994
Clinical and Experimental Pharmacology, B.Sc. (Hons)., University of Adelaide
… → 1989
External positions
Co-Director of Drug Discovery and Translation Flagship, Australian Cardiovascular Alliance
2019 → …
Adjunct Professor, Baker Heart and Diabetes Institute
2019 → …
Adjunct Professor, School of Life Sciences, La Trobe University
2018 → …
Member, Management Round Table, Baker Heart and Diabetes Institute
2017 → 2019
Adjunct Professor, Dept of Pharmacology & Therapeutics, University of Melbourne
2017 → …
Research area keywords
- cardiac pharmacology
- new treatment strategies
- predictors of myocardial function
- ischaemic heart disease
- cardiac myocytes
- diabetic complications
- hypertrophy
Network
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RESOLVING INFLAMMATION TO TREAT DIABETIC VASCULAR REMODELLING
Qin, C. H., Wright, K., Ritchie, R. & Woodman, O. L.
Diabetes Australia, Monash University – Internal Department Contribution
1/06/22 → 31/05/23
Project: Research
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Characterisation of a preclinical mouse model of diabetic cardiomyopathy ready for translational investigations
10/03/23 → 9/03/25
Project: Research
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Endothelial Cells: an Underappreciated Therapeutic Target in HFpEF
Ritchie, R., Figtree, G. A., May, L. & Qin, C. H.
1/01/23 → 31/12/24
Project: Research
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ASHRA: Australian Stroke and Heart Research Accelerator (ASHRA)
Nicholls, S., Kovacic, J. C., Zoungas, S., Neal, B. C., Chow, C., Figtree, G., CV Campbell, B., Maple-Brown, L. J., Brown, A., Hayward, C., Hill, A., Hool, L. C., Currie, P., Rodgers, A., Arnott, C., Wu, J. H. Y., Kritharides, L., Ugander, M., Chiang, J., M Davis, S., Donnan, G. A., Yan, B., Barr, E. L. M., Breen, J., Barclay, J., Brown, H., Correa, M., Wu, C., Butters, J., Glass, P., Ritchie, R., Vandenburg, J., Patel, A., Semsarian, C., Martino, M., Laranjo, L., Thiagalingam, A., Sivagangabalan, G., Fox, K., Rice, H., Ali, M., Francisco, J., Dawidowska, I. & Greenway, A.
10/01/22 → 15/02/26
Project: Research
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Therapeutic Targeting to Protect the Diabetic Heart
Ritchie, R., Murphy, M. P. & De Blasio, M.
1/01/20 → 31/12/23
Project: Research
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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Velagic, A., Li, M., Deo, M., Li, J. C., Kiriazis, H., Donner, D. G., Anderson, D., De Blasio, M. J., Woodman, O. L., Kemp-Harper, B. K., Qin, C. X. & Ritchie, R. H., Feb 2023, In: American Journal of Physiology - Heart and Circulatory Physiology. 324, 2, p. H241-H257 17 p.Research output: Contribution to journal › Article › Research › peer-review
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Endothelium-dependent relaxation is impaired in Schlager hypertensive (BPH/2J) mice by region-specific mechanisms in conductance and resistance arteries
Jelinic, M., Jackson, K. L., O'Sullivan, K., Singh, J., Giddy, T., Deo, M., Parry, L. J., Ritchie, R. H., Woodman, O. L., Head, G. A., Leo, C. H. & Qin, C. X., 1 May 2023, In: Life Sciences. 320, 15 p., 121542.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice
Leo, C. H., Ou, J. L. M., Ong, E. S., Qin, C. X., Ritchie, R. H., Parry, L. J. & Ng, H. H., Jun 2023, In: Biomedicine & Pharmacotherapy. 162, 9 p., 114578.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Advancing cardiovascular translational research
Ritchie, R. H., Xu, S. & Zacchigna, S., Nov 2022, In: Trends in Pharmacological Sciences. 43, 11, p. 888-890 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance
Velagic, A., Li, J. C., Qin, C. X., Li, M., Deo, M., Marshall, S. A., Anderson, D., Woodman, O. L., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., Aug 2022, In: British Journal of Pharmacology. 179, 16, p. 4117-4135 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)