Projects per year
Personal profile
Biography
Dr Rebecca Lim was awarded her PhD from the University of Western Australia. She currently leads a dynamic research group at The Ritchie Centre, where she is mentored by and works closely with, Prof Euan Wallace, OAM. Dr Lim is presently a Chief Investigator on four NHandMRC project grants. She is also an investigator on two clinical trials at Monash Health.
The core research of Dr Lim's lab is in the area of stem cell biology and regenerative medicine. Her research team is focused on uncovering the regenerative potential of amnion derived stem-like cells while concurrently pursuing clinical translation of her findings. In recent years, her team has uncovered key immunological events that are critical to the success of amnion cell mediated lung repair in the settings of adult and neonatal lung disease. More recently her team has shown that amnion cells trigger endogenous repair processes by activating the adult stem cell niche and recruiting distal progenitor sites to the area of injury. She collaborates widely and looks to apply amnion cells across a variety of acute and chronic conditions in an effort to understand their potential and limitations.
Supervision interests
Accepting postgraduate students for research projects on endogenous stem/progenitor cell response, development of regenerative medicine-based novel therapeutics for urgent unmet needs and industry-supported collaborative research.
Research interests
Regenerative medicine, stem cell biology, cancer stem cells, extracellular vesicles, therapeutics development, bronchopulmonary dysplasia, liver cirrhosis, stroke, chronic inflammation, lung fibrosis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine and Pharmacology, PhD, Uncovering the effects of interferon alpha and interferon gamma on liver progenitor cells in chronic viral hepatitis, University of Western Australia
Award Date: 1 Jun 2007
External positions
Scientific Advisory Board, CCRM (Australia)
Mar 2018 → …
Adjunct Assistant Professor, Chinese University of Hong Kong
2017 → …
Board of Directors, Meluha Capital Sdn Bhd
2016 → …
Scientific Advisor, Hygieia Therapeutics Sdn Bhd
2014 → …
Research area keywords
- stem cell biology
- chronic inflammation
- Perinatal
- Regenerative medicine
- clinical translation
- Cell therapies
- clinical trials
- good manufacturing practices
- Industry Specialisation
- cell manufacturing
- cancer stem cells
- Extracellular vesicles
- fibrosis
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Locally administered extracellular vesicles for perianal fistulising Crohn's disease
Moore, G. (Primary Chief Investigator (PCI)), Keung, C. (Chief Investigator (CI)), Lim, R. (Chief Investigator (CI)), Sievert, W. (Chief Investigator (CI)) & Nguyen, T. C. (Chief Investigator (CI))
1/06/21 → 28/02/26
Project: Research
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ARC Training Centre for Cell and Tissue Engineering Technologies
Meagher, L. (Primary Chief Investigator (PCI)), Bray, L. J. (Chief Investigator (CI)), Voelcker, N. (Chief Investigator (CI)), Risbridger, G. (Chief Investigator (CI)), Hutmacher, D. W. (Chief Investigator (CI)), Batra, J. (Chief Investigator (CI)), Dargaville, T. (Chief Investigator (CI)), Elnathan, R. (Chief Investigator (CI)), Saifzadeh, S. (Chief Investigator (CI)), Heng, T. (Chief Investigator (CI)), Aguilar, M. (Chief Investigator (CI)), Lim, R. (Partner Investigator (PI)), Klein, T. J. (Chief Investigator (CI)), Fisher, A. (Partner Investigator (PI)), McGovern, J. (Chief Investigator (CI)), Dislakis, V. (Partner Investigator (PI)), McLellan, A. (Partner Investigator (PI)), Dulleck, U. (Chief Investigator (CI)), Steck, R. (Chief Investigator (CI)), Scott, W. (Partner Investigator (PI)), Corrie, S. (Chief Investigator (CI)), Thissen, H. (Partner Investigator (PI)), Cameron, N. (Chief Investigator (CI)), Haupt, L. (Chief Investigator (CI)), Werner, C. (Partner Investigator (PI)), Levett, P. (Partner Investigator (PI)), Whyte, S. (Chief Investigator (CI)), Forsythe, J. (Chief Investigator (CI)), Smith, N. (Partner Investigator (PI)), Frith, J. (Chief Investigator (CI)), Hicks, C. (Partner Investigator (PI)), Rackham, O. J. L. (Partner Investigator (PI)), Sohal, A. (Chief Investigator (CI)), Polo, J. (Chief Investigator (CI)), May, M. (Partner Investigator (PI)), Reimers, N. (Partner Investigator (PI)), Toh, Y.-C. (Chief Investigator (CI)), McKee, J. (Partner Investigator (PI)), Adams, M. (Chief Investigator (CI)), Obschonka, M. (Partner Investigator (PI)), Subramaniam, N. (Chief Investigator (CI)), Yambem, S. D. (Chief Investigator (CI)), Russell-Bennett, R. (Chief Investigator (CI)), Bertram, J. (Chief Investigator (CI)), Schierjott, R. (Partner Investigator (PI)), Hollands, J. (Partner Investigator (PI)), Currie, P. (Chief Investigator (CI)), Ball, G. (Partner Investigator (PI)), Trapani, J. A. (Partner Investigator (PI)), Cadarso Busto, V. (Chief Investigator (CI)), Loessner, D. (Chief Investigator (CI)), Ecker, R. (Partner Investigator (PI)), Boyd, R. L. (Partner Investigator (PI)) & Lim, J. (Partner Investigator (PI))
ARC - Australian Research Council, PolVax Pty Ltd, Cartherics Pty Ltd, TissueGUARD GmbH, Peter MacCallum Cancer Centre, TissueGnostics GmbH
13/01/21 → 30/11/27
Project: Research
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A novel exosome therapy for perianal fistulas occurring in Crohn’s Disease patients
Lim, R. (Primary Chief Investigator (PCI)), Moore, G. (Chief Investigator (CI)), Keung, C. (Chief Investigator (CI)), Sievert, W. (Chief Investigator (CI)) & Chan, S. (Chief Investigator (CI))
1/06/23 → 31/03/25
Project: Research
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Organ perfusion for transplant mechanism using cell-based regenerative products
Lim, R. (Primary Chief Investigator (PCI)), Fisher, A. (Partner Investigator (PI)), Scott, W. (Chief Investigator (CI)), Meagher, L. (Chief Investigator (CI)) & Ruka, D. (Project Manager)
Newcastle University (United Kingdom)
1/09/21 → 1/06/25
Project: Research
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Delivering a novel cell free therapy to improve stroke outcomes
Broughton, B. (Primary Chief Investigator (PCI)), Lim, R. (Chief Investigator (CI)) & Sobey, C. G. (Chief Investigator (CI))
National Heart Foundation of Australia
1/01/21 → 31/12/22
Project: Research
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Human Amniotic Epithelial Cell Transplantation is Safe and Well Tolerated in Patients with Compensated Cirrhosis: A First-in-Human Trial
Lim, R., Hodge, A., Warner, S., Moore, G. T., Correia, J., Krause, M., McDonald, H., Chan, S. T., Goonetilleke, M., Lyon, S. M. & Sievert, W., Jun 2024, In: Stem Cells Translational Medicine. 13, 6, p. 522-531 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., M˜y, G. M., Mohanty, S., Möller, A., Nieuwland, R. & Ochiya, T. & 53 others, , Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.Research output: Contribution to journal › Article › Research › peer-review
Open Access2068 Citations (Scopus) -
Stem Cell Derived Extracellular Vesicle Therapy for Multiple Sclerosis, A Systematic Review and Meta-Analysis of Preclinical Studies
Barabadi, M., Paton, M. C. B., Kumar, N., Lim, R. & Payne, N. L., May 2024, In: Stem Cells Translational Medicine. 13, 5, p. 436-447 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Citations (Scopus) -
Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT) (Frontiers in Neuroscience, (2023), 17, (1153231), 10.3389/fnins.2023.1153231)
Phan, T. G., Lim, R., Krause, M., Chan, S. T., McDonald, H., Gan, P. Y., Zhang, S. R., Barreto Arce, L. J., Vuong, J., Thirugnanachandran, T., Clissold, B., Ly, J., Singhal, S., Hervet, M. V., Kim, H. A., Drummond, G. R., Wallace, E. M., Ma, H. & Sobey, C. G., 2023, In: Frontiers in Neuroscience. 17, 1 p., 1237920.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Local fistula injection of allogeneic human amnion epithelial cells is safe and well tolerated in patients with refractory complex perianal Crohn's disease: a phase I open label study with long-term follow up
Keung, C., Nguyen, T. C., Lim, R., Gerstenmaier, A., Sievert, W. & Moore, G. T., Dec 2023, In: EBioMedicine. 98, 11 p., 104879.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus)
Prizes
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Hugh Rogers Fellowship - Boston Melbourne Sisters Association
Lim, R. (Recipient), 2013
Prize: Competitive Fellowships
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International Society for Cell Therapies
Lim, R. (Recipient), 26 May 2018
Prize: Prize (including medals and awards)
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Cytotherapy (Journal)
Lim, R. (Editorial board member)
1 Jan 2021Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Society for Cellular Therapy (External organisation)
Lim, R. (Member)
1 Nov 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Stem Cell Research & Therapy (Journal)
Lim, R. (Associate editor)
1 Oct 2019Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Society of Extracellular Vesicles (External organisation)
Lim, R. (Member)
1 Dec 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Centre for Commercialisation of Regenerative Medicine (AU) (External organisation)
Lim, R. (Member)
19 Jun 2018 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board