Projects per year
Personal profile
Biography
Dr Rebecca Lim was awarded her PhD from the University of Western Australia. She currently leads a dynamic research group at The Ritchie Centre, where she is mentored by and works closely with, Prof Euan Wallace, OAM. Dr Lim is presently a Chief Investigator on four NHandMRC project grants. She is also an investigator on two clinical trials at Monash Health.
The core research of Dr Lim's lab is in the area of stem cell biology and regenerative medicine. Her research team is focused on uncovering the regenerative potential of amnion derived stem-like cells while concurrently pursuing clinical translation of her findings. In recent years, her team has uncovered key immunological events that are critical to the success of amnion cell mediated lung repair in the settings of adult and neonatal lung disease. More recently her team has shown that amnion cells trigger endogenous repair processes by activating the adult stem cell niche and recruiting distal progenitor sites to the area of injury. She collaborates widely and looks to apply amnion cells across a variety of acute and chronic conditions in an effort to understand their potential and limitations.
Supervision interests
Accepting postgraduate students for research projects on endogenous stem/progenitor cell response, development of regenerative medicine-based novel therapeutics for urgent unmet needs and industry-supported collaborative research.
Research interests
Regenerative medicine, stem cell biology, cancer stem cells, extracellular vesicles, therapeutics development, bronchopulmonary dysplasia, liver cirrhosis, stroke, chronic inflammation, lung fibrosis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine and Pharmacology, PhD, Uncovering the effects of interferon alpha and interferon gamma on liver progenitor cells in chronic viral hepatitis, University of Western Australia
Award Date: 1 Jun 2007
External positions
Scientific Advisory Board, CCRM (Australia)
Mar 2018 → …
Adjunct Assistant Professor, Chinese University of Hong Kong
2017 → …
Board of Directors, Meluha Capital Sdn Bhd
2016 → …
Scientific Advisor, Hygieia Therapeutics
2014 → …
Research area keywords
- stem cell biology
- chronic inflammation
- Perinatal
- Regenerative medicine
- clinical translation
- Cell therapies
- clinical trials
- good manufacturing practices
- Industry Specialisation
- cell manufacturing
- cancer stem cells
- Extracellular vesicles
- fibrosis
Collaborations and top research areas from the last five years
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A novel exosome therapy for perianal fistulas occurring in Crohn’s Disease patients
Lim, R., Moore, G., Keung, C., Sievert, W. & Chan, S.
1/06/23 → 31/03/25
Project: Research
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Organ perfusion for transplant mechanism using cell-based regenerative products
Lim, R., Fisher, A., Scott, W., Meagher, L. & Ruka, D.
Newcastle University (United Kingdom)
1/09/21 → 1/06/25
Project: Research
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Locally administered extracellular vesicles for perianal fistulising Crohn's disease
Moore, G., Keung, C., Lim, R., Sievert, W. & Nguyen, T. C.
1/06/21 → 28/02/26
Project: Research
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ARC Training Centre for Cell and Tissue Engineering Technologies
Meagher, L., Bray, L., Voelcker, N., Risbridger, G., Hutmacher, D. W., Batra, J., Dargaville, T., Elnathan, R., Saifzadeh, S., Heng, T., Aguilar, M., Lim, R., Klein, T. J., Fisher, A., McGovern, J., Dislakis, V., McLellan, A., Dulleck, U., Steck, R., Scott, W., Corrie, S., Thissen, H., Cameron, N., Haupt, L. M., Werner, C., Levett, P., Whyte, S., Forsythe, J., Smith, N., Frith, J., Hicks, C., Rackham, O. J. L., Sohal, A., Polo, J., May, M., Reimers, N., Toh, Y., McKee, J., Adams, M., Obschonka, M., Subramaniam, N., Yambem, S. D., Russell-Bennett, R., Bertram, J., Schierjott, R., Hollands, J., Currie, P., Ball, G., Trapani, J. A., Cadarso Busto, V., Loessner, D., Ecker, R., Boyd, R. L. & Lim, J.
Australian Research Council (ARC), PolVax Pty Ltd, Cartherics Pty Ltd, TissueGUARD GmbH, Peter MacCallum Cancer Centre, TissueGnostics GmbH
13/01/21 → 30/11/27
Project: Research
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Delivering a novel cell free therapy to improve stroke outcomes
Broughton, B., Lim, R. & Sobey, C. G.
National Heart Foundation of Australia
1/01/21 → 31/12/22
Project: Research
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Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)
Phan, T. G., Lim, R., Chan, S. T., McDonald, H., Gan, P. Y., Zhang, S. R., Barreto Arce, L. J., Vuong, J., Thirugnanachandran, T., Clissold, B., Ly, J., Singhal, S., Hervet, M. V., Kim, H. A., Drummond, G. R., Wallace, E. M., Ma, H. & Sobey, C. G., 2023, In: Frontiers in Neuroscience. 17, 10 p., 1153231.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Substrate mechanical properties bias MSC paracrine activity and therapeutic potential
Vilar, A., Hodgson-Garms, M., Kusuma, G. D., Donderwinkel, I., Carthew, J., Tan, J. L., Lim, R. & Frith, J. E., 15 Sept 2023, In: Acta Biomaterialia. 168, p. 144-158 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia
Zhu, D., Krause, M., Yawno, T., Kusuma, G. D., Schwab, R., Barabadi, M., Maleken, A. S., Chan, S. T., Hunt, R., Greening, D., Wallace, E. M. & Lim, R., Dec 2022, In: Stem Cell Research & Therapy. 13, 1, 24 p., 196.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies
Kusuma, G. D., Li, A., Zhu, D., McDonald, H., Inocencio, I. M., Chambers, D. C., Sinclair, K., Fang, H., Greening, D. W., Frith, J. E. & Lim, R., 14 Feb 2022, In: Frontiers in Cell and Developmental Biology. 10, p. 1-17 17 p., 819726.Research output: Contribution to journal › Article › Research › peer-review
Open Access41 Citations (Scopus) -
Fourier-Transform Infra-Red Microspectroscopy Can Accurately Diagnose Colitis and Assess Severity of Inflammation
Keung, C., Heraud, P., Kuk, N., Lim, R., Sievert, W., Moore, G. & Wood, B., 1 Mar 2022, In: International Journal of Molecular Sciences. 23, 5, 19 p., 2849.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Prizes
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Hugh Rogers Fellowship - Boston Melbourne Sisters Association
Lim, Rebecca (Recipient), 2013
Prize: Competitive Fellowships
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International Society for Cell Therapies
Lim, Rebecca (Recipient), 26 May 2018
Prize: Prize (including medals and awards)
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Cytotherapy (Journal)
Rebecca Lim (Editorial board member)
1 Jan 2021Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Society for Cellular Therapy (External organisation)
Rebecca Lim (Member)
1 Nov 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Stem Cell Research & Therapy (Journal)
Rebecca Lim (Associate editor)
1 Oct 2019Activity: Publication peer-review and editorial work types › Editorial responsibility
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International Society of Extracellular Vesicles (External organisation)
Rebecca Lim (Member)
1 Dec 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Centre for Commercialisation of Regenerative Medicine (AU) (External organisation)
Rebecca Lim (Member)
19 Jun 2018 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board