1971 …2024

Research output per year

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Article
2001

Designed peptide analogues of the potassium channel blocker ShK toxin

Lanigan, M. D., Pennington, M. W., Lefievre, Y., Rauer, H. & Norton, R. S., 25 Dec 2001, In : Biochemistry. 40, 51, p. 15528-15537 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

The Val-210-I1e pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrPC

Thompson, A. J., Barnham, K. J., Norton, R. S. & Barrow, C. J., 12 Jan 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1544, 1-2, p. 242-254 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2000

Backbone dynamics measurements on leukemia inhibitory factor, a rigid four-helical bundle cytokine

Yao, S., Smith, D. K., Hinds, M. G., Zhang, J. G., Nicola, N. A. & Norton, R. S., 2000, In : Protein Science. 9, 4, p. 671-682 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Peptide self-association in aqueous trifluoroethanol monitored by pulsed field gradient NMR diffusion measurements

Yao, S., Howlett, G. J. & Norton, R. S., 2000, In : Journal of Biomolecular NMR. 16, 2, p. 109-119 11 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca2+-activated over voltage-gated K+ channels

Rauer, H., Lanigan, M. D., Pennington, M. W., Aiyar, J., Ghanshani, S., Cahalan, M. D., Norton, R. S. & George Chandy, K., 14 Jan 2000, In : Journal of Biological Chemistry. 275, 2, p. 1201-1208 8 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis- Trans isomerism

Pallaghy, P. K., He, W., Jimenez, E. C., Olivera, B. M. & Norton, R. S., 24 Oct 2000, In : Biochemistry. 39, 42, p. 12845-12852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

The cyclic contryphan motif CPxXPXC, a robust scaffold potentially useful as an ω mimic

Pallaghy, P. K. & Norton, R. S., Sep 2000, In : Biopolymers. 54, 3, p. 173-179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The single mutation Phe173 → Ala induces a molten globule-like state in murine interleukin-6

Matthews, J. M., Norton, R. S., Hammacher, A. & Simpson, R. J., 29 Feb 2000, In : Biochemistry. 39, 8, p. 1942-1950 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
1999

Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: Relationship to biological activity

Barnham, K. J., Catalfamo, F., Pallaghy, P. K., Howlett, G. J. & Norton, R. S., 16 Nov 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1435, 1-2, p. 127-137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Polypeptide ω-conotoxin GVIA as a basis for new analgesic and neuroprotective agents

Norton, R. S., Pallaghy, P. K., Baell, J. B., Wright, C. E., Lew, M. J. & Angus, J. A., 1999, In : Drug Development Research. 46, 3-4, p. 206-218 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Refined solution structure of ω-conotoxin GVIA: Implications for calcium channel binding

Pallaghy, P. K. & Norton, R. S., 1999, In : Journal of Peptide Research. 53, 3, p. 343-351 9 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin

Pennington, M. W., Lanigan, M. D., Kalman, K., Mahnir, V. M., Rauer, H., McVaugh, C. T., Behm, D., Donaldson, D., Chandy, K. G., Kem, W. R. & Norton, R. S., 2 Nov 1999, In : Biochemistry. 38, 44, p. 14549-14558 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Role of disulfide bridges in the folding, structure and biological activity of ω-conotoxin GVIA

Flinn, J. P., Pallaghy, P. K., Lew, M. J., Murphy, R., Angus, J. A. & Norton, R. S., 14 Sep 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1434, 1, p. 177-190 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Roles of key functional groups in ω-conotoxin GVIA: Synthesis, structure and functional assay of selected peptide analogues

Flinn, J. P., Pallaghy, P. K., Michael J, L., Murphy, R., Angus, J. A. & Norton, R. S., 1 Jun 1999, In : European Journal of Biochemistry. 262, 2, p. 447-455 9 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

Hinds, M. G., Norton, R. S., Vaux, D. L. & Day, C. L., 1999, In : Nature Structural Biology. 6, 7, p. 648-651 4 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing d-tryptophan: Comparison with protein loops

Pallaghy, P. K., Melnikova, A. P., Jimenez, E. C., Olivera, B. M. & Norton, R. S., 31 Aug 1999, In : Biochemistry. 38, 35, p. 11553-11559 7 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
1998

Assignment of 1H and 15N resonances of murine Tec SH3 domain

Pursglove, S. E., Mulhern, T. D., Hinds, M. G., Norton, R. S. & Booker, G. W., 1998, In : Journal of Biomolecular NMR. 12, 3, p. 461-462 2 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Helical structure of polypeptides from the C-terminal half of HIV-1 VPR

Yao, S., Azad, A. A., Macreadie, I. G. & Norton, R. S., 1998, In : Protein and Peptide Letters. 5, 3, p. 127-134 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Improved Estimation of Protein Rotational Correlation Times from 15N Relaxation Measurements

Yao, S., Hinds, M. G. & Norton, R. S., 1998, In : Journal of Magnetic Resonance. 131, 2, p. 347-350 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

Tudor, J. E., Pennington, M. W. & Norton, R. S., 15 Jan 1998, In : European Journal of Biochemistry. 251, 1-2, p. 133-141 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor

Barnham, K. J., Torres, A. M., Alewood, D., Alewood, P. F., Domagala, T., Nice, E. C. & Norton, R. S., 1998, In : Protein Science. 7, 8, p. 1738-1749 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Shk-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

Kalman, K., Pennington, M. W., Lanigan, M. D., Nguyen, A., Rauer, H., Mahnir, V., Paschetto, K., Kem, W. R., Grissmer, S., Gutman, G. A., Christian, E. P., Cahalan, M. D., Norton, R. S. & Chandy, K. G., 4 Dec 1998, In : Journal of Biological Chemistry. 273, 49, p. 32697-32707 11 p.

Research output: Contribution to journalArticleResearchpeer-review

204 Citations (Scopus)

Solution structure of leukemia inhibitory factor

Hinds, M. G., Maurer, T., Zhang, J. G., Nicola, N. A. & Norton, R. S., 29 May 1998, In : Journal of Biological Chemistry. 273, 22, p. 13738-13745 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Solution structure of peptides from HIV-1 Vpr protein that cause membrane permeabilization and growth arrest

Yao, S., Torres, A. M., Azad, A. A., Macreadie, I. G. & Norton, R. S., 1998, In : Journal of Peptide Science. 4, 7, p. 426-435 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The cystine knot structure of ion channel toxins and related polypeptides

Norton, R. S. & Pallaghy, P. K., Nov 1998, In : Toxicon. 36, 11, p. 1573-1583 11 p.

Research output: Contribution to journalArticleResearchpeer-review

244 Citations (Scopus)
1997

NMR Spectroscopy of Peptides and Proteins: Practical Considerations

Hinds, M. G. & Norton, R. S., 1997, In : Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology. 7, 3, p. 315-331 17 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Resonance assignments, secondary structure and topology of leukaemia inhibitory factor in solution

Hinds, M. G., Maurer, T., Zhang, J. G., Nicola, N. A. & Norton, R. S., 1997, In : Journal of Biomolecular NMR. 9, 2, p. 113-126 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Roles of histidine 31 and tryptophan 34 in the structure, self- association, and folding of murine interleukin-6

Matthews, J. M., Ward, L. D., Hammacher, A., Norton, R. S. & Simpson, R. J., 20 May 1997, In : Biochemistry. 36, 20, p. 6187-6196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Solution structure of a polypeptide from the N terminus of the HIV protein Nef

Barnham, K. J., Monks, S. A., Hinds, M. G., Azad, A. A. & Norton, R. S., 20 May 1997, In : Biochemistry. 36, 20, p. 5970-5980 11 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus

Pallaghy, P. K., Alewood, D., Alewood, P. F. & Norton, R. S., 15 Dec 1997, In : FEBS Letters. 419, 2-3, p. 191-196 6 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Structure-function relationships of ω-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine- substituted analogues

Lew, M. J., Flinn, J. P., Pallaghy, P. K., Murphy, R., Whorlow, S. L., Wright, C. E., Norton, R. S. & Angus, J. A., 2 May 1997, In : Journal of Biological Chemistry. 272, 18, p. 12014-12023 10 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: A helical hairpin cross-linked by disulphide bonding

Barnham, K. J., Dyke, T. R., Kem, W. R. & Norton, R. S., 23 May 1997, In : Journal of Molecular Biology. 268, 5, p. 886-902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
1996

Preparation and characterization of a biologically active spin-labeled sea anemone toxin

Monks, S. A., Norton, R. S., Curtain, C. C. & Berliner, L. J., 1996, In : Journal of Protein Chemistry. 15, 5, p. 427-434 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Solution structure of human neuropeptide Y

Monks, S. A., Karagianis, G., Howlett, G. J. & Norton, R. S., 1996, In : Journal of Biomolecular NMR. 8, 4, p. 379-390 12 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

Tudor, J. E., Pallaghy, P. K., Pennington, M. W. & Norton, R. S., 1996, In : Nature Structural Biology. 3, 4, p. 317-320 4 p.

Research output: Contribution to journalArticleResearchpeer-review

142 Citations (Scopus)

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

Dyke, T. R., Duggan, B. M., Pennington, M. W., Byrnes, M. E., Kem, W. R. & Norton, R. S., 4 Jan 1996, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1292, 1, p. 31-38 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
1995

Chemical modification of cationic groups in the polypeptide cardiac stimulant anthopleurin-A

Gould, A. R. & Norton, R. S., 1995, In : Toxicon. 33, 2, p. 187-199 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

NMR studies of the solution properties of recombinant murine interleukin-6

Morton, C. J., Bai, H., Hammacher, A., Norton, R. S., Simpson, R. J. & Mabbutt, B. C., 12 Jun 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1249, 2, p. 189-203 15 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41

Kortt, A. A., Guthrie, R. E., Hinds, M. G., Power, B. E., Ivancic, N., Caldwell, J. B., Gruen, L. C., Norton, R. S. & Hudson, P. J., Apr 1995, In : Journal of Protein Chemistry. 14, 3, p. 167-178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Solution structure of a polypeptide containing four heptad repeat units from a merozoite surface antigen of Plasmodium falciparum

Mulhern, T. D., Norton, R. S., Howlett, G. J., Reid, G. E., Simpson, R. J., McColl, D. J., Anders, R. F. & Mulhern, T. D., 1995, In : Biochemistry. 34, 11, p. 3479-3491 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Solution structure of human insulin-like growthfactor II. Relationship to receptor and binding protein interactions

Torres, A. M., Forbes, B. E., Aplin, S. E., Wallace, J. C., Francise, G. L. & Norton, R. S., 1995, In : Journal of Molecular Biology. 248, 2, p. 385-401 17 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A

Monks, S. A., Pallaghy, P. K., Scanlon, M. J. & Norton, R. S., 1995, In : Structure. 3, 8, p. 791-803 13 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Three-Dimensional Structure in Solution of the Polypeptide Cardiac Stimulant Anthopleurin-A

Pallaghy, P. K., Scanlon, M. J., Monks, S. A. & Norton, R. S., 1995, In : Biochemistry. 34, 11, p. 3782-3794 13 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)
1994

A common structural motif incorporating a cystine knot and a triple‐stranded β‐sheet in toxic and inhibitory polypeptides

Pallaghy, P. K., Norton, R. S., Nielsen, K. J. & Craik, D. J., 1994, In : Protein Science. 3, 10, p. 1833-1839 7 p.

Research output: Contribution to journalArticleResearchpeer-review

422 Citations (Scopus)

Homology modelling and 1H NMR studies of human leukaemia inhibitory factor

Smith, D. K., Treutlein, H. R., Maurer, T., Owczarek, C. M., Layton, M. J., Nicola, N. A. & Norton, R. S., 22 Aug 1994, In : FEBS Letters. 350, 2-3, p. 275-280 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Limited proteolysis study of structure-function relationships in Sh I, a polypeptide neurotoxin from a sea anemone

Monks, S. A., Gould, A. R., Lumley, P. E., Alewood, P. F., Kem, W. R., Goss, N. H. & Norton, R. S., 20 Jul 1994, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1207, 1, p. 93-101 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Multiple conformations of the sea anemone polypeptide anthopleurin‐A in solution

Scanlon, M. J. & Norton, R. S., 1994, In : Protein Science. 3, 7, p. 1121-1124 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

NMR studies of a murine-human chimera of leukaemia inhibitory factor (LIF). Comparison with human LIF

Maurer, T., Smith, D. K., Owczarek, C. M., Layton, M. J., Zhang, J. G., Nicola, N. A. & Norton, R. S., 1994, In : Growth Factors. 11, 4, p. 271-276 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Solution structure of synthetic peptides corresponding to the C‐terminal helix of interleukin‐6

MORTON, C. J., SIMPSON, R. J. & NORTON, R. S., 1994, In : European Journal of Biochemistry. 219, 1-2, p. 97-107 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Synthesis of the cardiac inotropic polypeptide anthopleurin‐A

PENNINGTON, MICHAEL. W., ZADENBERG, INNA., BYRNES, MICHAEL. E., NORTON, RAYMOND. S. & KEM, WILLIAM. R., 1994, In : International Journal of Peptide and Protein Research. 43, 5, p. 463-470 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)