1971 …2024

Research output per year

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Article
2007

Merozoite surface protein 2 of Plasmodium falciparum: Expression, structure, dynamics, and fibril formation of the conserved N-terminal domain

Low, A., Chandrashekaran, I. R., Adda, C. G., Yao, S., Sabo, J. K., Zhang, X., Soetopo, A., Anders, R. F. & Norton, R. S., Sep 2007, In : Biopolymers. 87, 1, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue

Sabo, J. K., Keizer, D. W., Feng, Z. P., Casey, J. L., Parisi, K., Coley, A. M., Foley, M. & Norton, R. S., Jan 2007, In : Infection and Immunity. 75, 1, p. 61-73 13 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Corzo, G., Sabo, J. K., Bosmans, F., Billen, B., Villegas, E., Tytgat, J. & Norton, R. S., 16 Feb 2007, In : Journal of Biological Chemistry. 282, 7, p. 4643-4652 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Structural Insights into the Interaction of Insulin-like Growth Factor 2 with IGF2R Domain 11

Williams, C., Rezgui, D., Prince, S. N., Zaccheo, O. J., Foulstone, E. J., Forbes, B. E., Norton, R. S., Crosby, J., Hassan, A. B. & Crump, M. P., 11 Sep 2007, In : Structure. 15, 9, p. 1065-1078 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Structure/function characterization of μ-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels

Zhang, M. M., Green, B. R., Catlin, P., Fiedler, B., Azam, L., Chadwick, A., Terlau, H., McArthur, J. R., French, R. J., Gulyas, J., Rivier, J. E., Smith, B. J., Norton, R. S., Olivera, B. M., Yoshikami, D. & Bulaj, G., 19 Oct 2007, In : Journal of Biological Chemistry. 282, 42, p. 30699-30706 8 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Structure and sodium channel activity of an excitatory I 1-superfamily conotoxin

Buczek, O., Wei, D., Babon, J. J., Yang, X., Fiedler, B., Chen, P., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 4 Sep 2007, In : Biochemistry. 46, 35, p. 9929-9940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

Chandrashekaran, I. R., Yao, S., Wang, C. C., Bansal, P. S., Alewood, P. F., Forbes, B., Wallace, J. C., Bach, L. A. & Norton, R. S., 2007, In : Biochemistry. 46, 11, p. 3065 - 3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2006

Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes

Feng, Z. P., Zhang, X., Han, P., Arora, N., Anders, R. F. & Norton, R. S., Dec 2006, In : Molecular and Biochemical Parasitology. 150, 2, p. 256-267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

Conotoxins down under

Norton, R. S. & Olivera, B. M., 1 Dec 2006, In : Toxicon. 48, 7, p. 780-798 19 p.

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops

Yao, S., Liu, M. S., Masters, S. L., Zhang, J. G., Babon, J. J., Nicola, N. A., Nicholson, S. E. & Norton, R. S., Dec 2006, In : Protein Science. 15, 12, p. 2761-2772 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Predicting disordered regions in proteins based on decision trees of reduced amino acid composition

Han, P., Zhang, X., Norton, R. S. & Feng, Z. P., Nov 2006, In : Journal of Computational Biology. 13, 9, p. 1579-1590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)

Kuang, Z., Yao, S., Keizer, D. W., Wang, C. C., Bach, L. A., Forbes, B., Wallace, J. C. & Norton, R. S., 2006, In : Journal of Molecular Biology. 364, 4, p. 690 - 704 15 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II

Drechsler, A., Potrich, C., Jennifer, J., Frisanco, M., Guella, G., Serra, M. D., Anderluh, G., Separovic, F. & Norton, R., 2006, In : Biochemistry. 45, 6, p. 1818 - 1828 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

Masters, S., Yao, S., Willson, T., Zhang, J-G., Palmer, K., Smith, B., Babon, J., Nicola, N., Norton, R. & Nicholson, S., 2006, In : Nature Structural & Molecular Biology. 13, 1, p. 77 - 84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability

Babon, J., McManus, E., Yao, S., De Souza, D. P., Mielke, L., Sprigg, N., Willson, T., Hilton, D., Nicola, N., Baca, M., Nicholson, S. & Norton, R., 2006, In : Molecular Cell. 22, p. 205 - 216 12 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)
2005

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

Lauth, X., Babon, J., Stannard, J., Singh, S., Nizet, V., Carlberg, J., Ostland, V., Pennington, M., Norton, R. & Westerman, M., 2005, In : Journal of Biological Chemistry. 280, 10, p. 9272 - 9282 11 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1

Harris, K., Casey, J., Coley, A., Masciantonio, R., Sabo, J. K., Keizer, D., Lee, E., McMahon, A., Norton, R., Anders, R. & Foley, M., 2005, In : Infection and Immunity. 73, 10, p. 6981 - 6989 9 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

IGF-binding proteins - The pieces are falling into place

Bach, L. A., Headey, S. & Norton, R. S., 2005, In : Trends in Endocrinology & Metabolism. 16, 5, p. 228 - 234 7 p.

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance

Carrick, F., Hinds, M., McNeil, K., Wallace, J., Forbes, B. & Norton, R., 2005, In : Journal of Molecular Endocrinology. 34, p. 685 - 698 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: 19F NMR studies

Anderluh, G., Razpotnik, A., Podlesek, Z., Macek, P., Separovic, F. & Norton, R., 2005, In : Journal of Molecular Biology. 347, 1, p. 27 - 39 13 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2) [4]

Yao, S., Masters, S., Zhang, J-G., Palmer, K., Nicola, N., Babon, J., Nicholson, S. & Norton, R., 2005, In : Journal of Biomolecular NMR. 31, p. 69 - 70 2 p.

Research output: Contribution to journalArticleOtherpeer-review

14 Citations (Scopus)

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

Bulaj, G., West, P., Garrett, J., Watkins, M., Zhang, M-M., Norton, R., Smith, B., Yoshikami, D. & Olivera, B., 2005, In : Biochemistry. 44, 19, p. 7259 - 7265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

Babon, J., Yao, S., De Souza, D. P., Harrison, C., Fabri, L., Liepinsh, E., Scrofani, S., Baca, M. & Norton, R., 2005, In : FEBS Journal. 272, 23, p. 6120 - 6130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

Denley, A., Wang, C., McNeil, K., Walenkamp, M., Duyvenvoorde, H., Wit, J., Wallace, J., Norton, R., Karperien, M. & Forbes, B., 2005, In : The Journal of Clinical Endocrinology and Metabolism. 19, 3, p. 711 - 721 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1

Feng, Z-P., Keizer, D., Stevenson, R., Yao, S., Babon, J., Murphy, V., Anders, R. & Norton, R., 2005, In : Journal of Molecular Biology. 350, 4, p. 641 - 656 16 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2004

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling

Fairlie, W., Uboldi, A., McCoubrie, J., Wang, C., Lee, E., Yao, S., De Souza, D. P., Mifsud, S., Metcalf, D., Nicola, N., Norton, R. & Baca, M., 2004, In : Journal of Biological Chemistry. 279, 3, p. 2125 - 2134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions

Headey, S., Keizer, D. W., Yao, S., Wallace, J. C., Bach, L. A. & Norton, R. S., 2004, In : FEBS Letters. 568, 1-3, p. 19 - 22 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Biological activity and ferric ion binding of fragments of glycine-extended gastrin

He, H., Shehan, P., Barnham, K., Norton, R., Shulkes, A. & Baldwin, G., 2004, In : Biochemistry. 43, 37, p. 11853 - 11861 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding

Headey, S., Leeding, K. S., Norton, R. & Bach, L. A., 2004, In : Journal of Molecular Endocrinology. 33, 2, p. 377 - 386 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

C-terminal domain of insulin-like growth factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding

Yao, S., Headey, S., Keizer, D. W., Bach, L. A. & Norton, R. S., 2004, In : Biochemistry. 43, 35, p. 11187 - 11195 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

Headey, S., Keizer, D. W., Yao, S., Brasier, G., Kantharidis, P., Bach, L. A. & Norton, R. S., 2004, In : Molecular Endocrinology. 18, 11, p. 2740 - 2750 11 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)
2003

A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin

Pannequin, J., Kovac, S., Tantiongco, J-P., Norton, R., Shulkes, A., Barnham, K. & Baldwin, G., 2003, In : Journal of Biological Chemistry. 279, 4, p. 2453 - 2460 8 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Effects of the eukaryotic pore-forming cytolysin equinatoxin II on lipid membranes and the role of sphingomyelin

Bonev, B. B., Lam, Y. H., Anderluh, G., Watts, A., Norton, R. S. & Separovict, F., 1 Apr 2003, In : Biophysical Journal. 84, 4, p. 2382-2392 11 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA

Keizer, D. W., West, P. J., Lee, E. F., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 21 Nov 2003, In : Journal of Biological Chemistry. 278, 47, p. 46805-46813 9 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

Barnham, K. J., McKinstry, W. J., Multhaup, G., Galatis, D., Morton, C. J., Curtain, C. C., Williamson, N. A., White, A. R., Hinds, M. G., Norton, R. S., Beyreuther, K., Masters, C. L., Parker, M. W. & Cappai, R., 2003, In : Journal of Biological Chemistry. 278, 19, p. 17401 - 17407 7 p.

Research output: Contribution to journalArticleResearchpeer-review

220 Citations (Scopus)

Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion

Keizer, D. W., Miles, L. A., Li, F., Nair, M., Anders, R. F., Coley, A. M., Foley, M. & Norton, R. S., 26 Aug 2003, In : Biochemistry. 42, 33, p. 9915-9923 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Synthesis and Characterization of δ-Atracotoxin-Ar1a, the Lethal Neurotoxin from Venom of the Sydney Funnel-Web Spider (Atrax robustus)

Alewood, D., Birinyi-Strachan, L. C., Pallaghy, P. K., Norton, R. S., Nicholson, G. M. & Alewood, P. F., 11 Nov 2003, In : Biochemistry. 42, 44, p. 12933-12940 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2002

Design and synthesis of type-III mimetics of ShK toxin

Baell, J. B., Harvey, A. J. & Norton, R. S., 1 Apr 2002, In : Journal of Computer-Aided Molecular Design. 16, 4, p. 245-262 18 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin

Pannequin, J., Barnham, K. J., Hollande, F., Shulkes, A., Norton, R. S. & Baldwin, G. S., 13 Dec 2002, In : Journal of Biological Chemistry. 277, 50, p. 48602-48609 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore - Vestibule region of the voltage-gated potassium channel, Kv1.3

Lanigan, M. D., Kalman, K., Lefievre, Y., Pennington, M. W., Chandy, K. G. & Norton, R. S., 8 Oct 2002, In : Biochemistry. 41, 40, p. 11963-11971 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II: Implications for pore formation

Hinds, M. G., Zhang, W., Anderluh, G., Hansen, P. E. & Norton, R. S., 2002, In : Journal of Molecular Biology. 315, 5, p. 1219-1229 11 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges

Yao, S., Smith-White, M. A., Potter, E. K. & Norton, R. S., 23 May 2002, In : Journal of Medicinal Chemistry. 45, 11, p. 2310-2318 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structure and activity of D-Pro14 melittin

Hewish, D. R., Barnham, K. J., Werkmeister, J. A., Kirkpatrick, A., Bartone, N., Liu, S. T., Norton, R. S., Curtain, C. & Rivett, D. E., 2002, In : Journal of Protein Chemistry. 21, 4, p. 243-253 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif

Miles, L. A., Dy, C. Y., Nielsen, J., Barnham, K. J., Hinds, M. G., Olivera, B. M., Bulaj, G. & Norton, R. S., 8 Nov 2002, In : Journal of Biological Chemistry. 277, 45, p. 43033-43040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)

Nair, M., Hinds, M. G., Coley, A. M., Hodder, A. N., Foley, M., Anders, R. F. & Norton, R. S., 2002, In : Journal of Molecular Biology. 322, 4, p. 741-753 13 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)
2001

A helical capping motif in ShK toxin and its role in helix stabilization

Lanigan, M. D., Tudor, J. E., Pennington, M. W. & Norton, R. S., 2001, In : Biopolymers. 58, 4, p. 422-436 15 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Alzheimer's disease amyloid- binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

Curtain, C. C., Ali, F., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Masters, C. L., Bush, A. I. & Barnham, K. J., 2001, In : Journal of Biological Chemistry. 276, 23, p. 20466 - 20473 8 p.

Research output: Contribution to journalArticleResearchpeer-review

543 Citations (Scopus)

Antiviral Activity and Structural Characteristics of the Nonglycosylated Central Subdomain of Human Respiratory Syncytial Virus Attachment (G) Glycoprotein

Gorman, J. J., McKimm-Breschkin, J. L., Norton, R. S. & Barnham, K. J., 19 Oct 2001, In : Journal of Biological Chemistry. 276, 42, p. 38988-38994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator

Corzo, G., Escoubas, P., Villegas, E., Barnham, K. J., He, W., Norton, R. S. & Nakajima, T., 1 Oct 2001, In : Biochemical Journal. 359, 1, p. 35-45 11 p.

Research output: Contribution to journalArticleResearchpeer-review

135 Citations (Scopus)

Design and synthesis of type-III mimetics of ω-conotoxin GVIA

Baell, J. B., Forsyth, S. A., Gable, R. W., Norton, R. S. & Mulder, R. J., 2001, In : Journal of Computer-Aided Molecular Design. 15, 12, p. 1119-1136 18 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)