1971 …2024

Research output per year

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Article
2012

Role of the helical structure of the N-terminal region of plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interaction

Zhang, X., Adda, C. G., Low, A., Zhang, J., Zhang, W., Sun, H., Tu, X., Anders, R. F. & Norton, R. S., 2012, In : Biochemistry. 51, 7, p. 1380 - 1387 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S. & Nicola, N. A., 2012, In : Immunity. 36, 2, p. 239 - 250 12 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Feng, Z-P., Chandrashekaran, I. R., Low, A., Speed, T. P., Nicholson, S. E. & Norton, R. S., 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 3, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2011

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

Robinson, M., Donnelly, S., Hutchinson, A., To, J., Taylor, N., Norton, R., Perugini, M. & Dalton, J., 2011, In : PLoS Pathogens. 7, 5, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
80 Citations (Scopus)

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Beeton, C., Pennington, M. & Norton, R., 2011, In : Inflammation & Allergy - Drug Targets. 10, 5, p. 313 - 321 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Apical membrane antigen 1 as an anti-malarial drug target

MacRaild, C., Anders, R., Foley, M. & Norton, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 16, p. 2039 - 2047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I., Adda, C., MacRaild, C., Anders, R. & Norton, R., 2011, In : Archives of Biochemistry and Biophysics. 513, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D (1)H-(15)N heteronuclear correlation spectra acquired with band-selective pulses

Yao, S., Hinds, M., Murphy, J. & Norton, R., 2011, In : Journal of Magnetic Resonance. 211, 2, p. 243 - 247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Lactam-stabilized helical analogues of the analgesic mu-conotoxin KIIIA

Khoo, K., Wilson, M., Smith, B., Zhang, M-M., Gulyas, J., Yoshikami, D., Rivier, J., Bulaj, G. & Norton, R., 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7558 - 7566 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution

Yao, S., Young, I., Norton, R. & Murphy, J., 2011, In : Biochemistry. 50, 13, p. 2464 - 2477 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues

Lee, E., Yao, S., Sabo, J., Fairlie, W., Stevenson, R., Harris, K., Anders, R., Foley, M. & Norton, R., 2011, In : Biopolymers. 95, 5 (SI), p. 354 - 364 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Peroxidase catalysed cross-Linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima

Mai, K., Smith, N., Feng, Z-P., Katrib, M., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., Norton, R. & Belli, S., 2011, In : International Journal for Parasitology. 41, 11, p. 1157 - 1164 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

TLR regulation of SPSB1 controls inducible nitric oxide synthase induction

Lewis, R., Kolesnik, T., Kuang, Z., D'Cruz, A., Blewitt, M., Masters, S., Low, A., Willson, T., Norton, R. & Nicholson, S., 2011, In : Journal of Immunology. 187, 7, p. 3798 - 3805 8 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)
2010

1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity

Yao, S., Murphy, J., Low, A. & Norton, R., 2010, In : Biomolecular NMR Assignments. 4, 1, p. 73 - 77 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Identification of key residues involved in fibril formation by the conserved N-terminal region of plasmodium falciparum merozoite surface protein 2 (MSP2)

Yang, X., Adda, C. G., MacRaild, C. A., Low, A., Zhang, X., Zeng, W., Jackson, D. C., Anders, R. F. & Norton, R. S., 2010, In : Biochimie. 92, 10, p. 1287 - 1295 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Inhibition by flavonoids of amyloid-like fibril formation by plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I. R., Adda, C. G., MacRaild, C. A., Anders, R. F. & Norton, R. S., 2010, In : Biochemistry. 49, 28, p. 5899 - 5908 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites

Richard, D., MacRaild, C. A., Riglar, D. T., Chan, J-A., Foley, M., Baum, J., Ralph, S. A., Norton, R. S. & Cowman, A. F., 2010, In : Journal of Biological Chemistry. 285, 19, p. 14815 - 14822 8 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)

mu-Conotoxins as leads in the development of new analgesics

Norton, R. S., 2010, In : Molecules. 15, 4, p. 2825 - 2844 20 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Potassium channel gating: Not an open and shut case

Norton, R. S. & Gulbis, J. M., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7623 - 7624 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Potassium channel modulation by a toxin domain in matrix metalloprotease 23

Rangaraju, S., Khoo, K. K., Feng, Z-P., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Pham, C., Calabresi, P., Pennington, M. W., Norton, R. S. & Chandy, K. G., 2010, In : Journal of Biological Chemistry. 285, 12, p. 9124 - 9136 13 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Recombinant protein vaccines against the asexual blood-stages of Plasmodium falciparum

Anders, R. F., Adda, C. G., Foley, M. & Norton, R. S., 1 Jan 2010, In : Human Vaccines. 6, 1, p. 39 - 53 15 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Solid-state NMR and simulation studies of equinatoxin II N-terminus interaction with lipid bilayers

Lam, Y., Hung, A., Norton, R. S., Separovic, F. & Watts, A., 2010, In : Proteins: Structure, Function, and Bioinformatics. 78, 4, p. 858 - 872 15 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Solid-state NMR study of membrane interactions of the pore-forming cytolysin, equinatoxin II

Drechsler, A., Anderluh, G., Norton, R. S. & Separovic, F., 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 2, p. 244 - 251 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structural basis for par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

Filippakopoulos, P., Low, A., Sharpe, T. D., Uppenberg, J., Yao, S., Kuang, Z., Savitsky, P., Lewis, R. S., Nicholson, S. E., Norton, R. S. & Bullock, A. N., 2010, In : Journal of Molecular Biology. 401, 3, p. 389 - 402 14 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Kuang, Z., Lewis, R. S., Curtis, J. M., Zhan, Y., Saunders, B. M., Babon, J. J., Kolesnik, T. B., Low, A., Masters, S. L., Willson, T. A., Kedzierski, L., Yao, S., Handman, E., Norton, R. S. & Nicholson, S. E., 2010, In : Journal of Cell Biology. 190, 1, p. 129 - 141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)
2009

Effect of lipid on the conformation of the N-terminal region of equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Drechsler, A., Miles, A. J., Norton, R. S., Wallace, B. A. & Separovic, F., Jan 2009, In : European Biophysics Journal. 39, 1, p. 121-127 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

Pennington, M. W., Beeton, C., Galea, C., Smith, B. J., Chi, V., Monaghan, K. P., Garcia, A., Rangaraju, S., Giuffrida, A., Plank, D. K., Crossley, G., Nugent, D., Khaytin, I., LeFievre, Y., Peshenko, I., Dixon, C., Chauhan, S., Orzel, A., Inoue, T., Hu, X. & 3 others, Moore, R. V., Norton, R. S. & Chandy, K. G., 2009, In : Molecular Pharmacology. 75, 4, p. 762 - 773 12 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Insulin-like growth factor-I (IGF-I): Solution properties and NMR chemical shift assignments near physiological pH

Kuang, Z., Yao, S., McNeil, K. A., Forbes, B. E., Wallace, J. C. & Norton, R. S., 2009, In : Growth Hormone and IGF Research. 19, 3, p. 226 - 231 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Large-scale prediction of long disordered regions in proteins using random forests

Han, P., Zhang, X., Norton, R. S. & Feng, Z-P., 9 Jan 2009, In : BMC Bioinformatics. 10, 8.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

Harris, K. S., Casey, J. L., Coley, A. M., Karas, J., Sabo, J. K., Tan, Y. Y., Dolezal, O., Norton, R. S., Hughes, A. B., Scanlon, D. & Foley, M., 2009, In : Journal of Biological Chemistry. 284, 14, p. 9361 - 9371 11 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding

Kuang, Z., Yao, S., Xu, Y., Lewis, R. S., Low, A., Masters, S. L., Willson, T. A., Kolesnik, T. B., Nicholson, S. E., Garrett, T. PJ. & Norton, R. S., 2009, In : Journal of Molecular Biology. 386, 3, p. 662 - 674 13 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an a-conotoxin containing a nonreducible cystine analogue

MacRaild, C. A., Illesinghe, J., Van Lierop, B. J., Townsend, A. L., Chebib, M., Livett, B. G., Robinson, A. J. & Norton, R. S., 2009, In : Journal of Medicinal Chemistry. 52, 3, p. 755 - 762 8 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Structure of the analgesic u-conotoxin KIIIA and effects on the structure and function of disulfide deletion

Khoo, K. K., Feng, Z-P., Smith, B. J., Zhang, M., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 2009, In : Biochemistry. 48, 6, p. 1210 - 1219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Structures of sea anemone toxins

Norton, R. S., 2009, In : Toxicon : official journal of the International Society on Toxinology. 54, 8, p. 1075 - 1088 14 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

The SOCS box encodes a hierarchy of affinities for cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression

Babon, J. J., Sabo, J. K., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2009, In : Journal of Molecular Biology. 387, 1, p. 162 - 174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)
2008

a-RgIA, a novel conotoxin that blocks the a9a10 nAChR: Structure and identification of key receptor-binding residues

Ellison, M., Feng, Z-P., Park, A. J., Zhang, X., Olivera, B. M., McIntosh, J. M. & Norton, R. S., 2008, In : Journal of Molecular Biology. 377, 4, p. 1216 - 1227 12 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Coarse-grained dynamics of the receiver domain of NtrC: Fluctuations, correlations and implications for allosteric cooperativity

Liu, M. S., Todd, B. D., Yao, S., Feng, Z. P., Norton, R. S. & Sadus, R. J., Oct 2008, In : Proteins: Structure, Function and Genetics. 73, 1, p. 218-227 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Peptides targeting voltage-gated calcium channels

Norton, R. S. & McDonough, S. I., 2008, In : Current Pharmaceutical Design. 14, 24, p. 2480 - 2491 12 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Protein effective rotational correlation times from translational self-diffusion coefficients measured by PFG-NMR

Yao, S., Babon, J. J. & Norton, R. S., Aug 2008, In : Biophysical Chemistry. 136, 2-3, p. 145-151 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2

Zhang, X., Perugini, M. A., Yao, S., Adda, C. G., Murphy, V. J., Low, A., Anders, R. F. & Norton, R. S., 2008, In : Journal of Molecular Biology. 379, 1, p. 105 - 121 17 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7

Fiedler, B., Zhang, M. M., Buczek, O., Azam, L., Bulaj, G., Norton, R. S., Olivera, B. M. & Yoshikami, D., 15 Jun 2008, In : Biochemical Pharmacology. 75, 12, p. 2334-2344 11 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Structure, dynamics, and selectivity of the sodium channel blocker u-conotoxin SIIIA

Yao, S., Zhang, M., Yoshikami, D., Azam, L., Olivera, B. M., Bulaj, G. & Norton, R. S., 2008, In : Biochemistry. 47, 41, p. 10940 - 10949 10 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

Beeton, C., Smith, B. J., Sabo, J. K., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Chandy, G. K., Pennington, M. W. & Norton, R. S., 2008, In : Journal of Biological Chemistry. 283, 2, p. 988 - 997 10 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Miles, A. J., Drechsler, A., Kristan, K., Anderluh, G., Norton, R. S., Wallace, B. A. & Separovic, F., Oct 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2091-2096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2008, In : Journal of Molecular Biology. 381, 4, p. 928 - 940 13 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Tyrosine modification enhances metal-ion binding

Baldwin, G. S., Bailey, M. F., Shehan, B. P., Sims, I. & Norton, R. S., 15 Nov 2008, In : Biochemical Journal. 416, 1, p. 77-84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2007

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

Yang, X., Adda, C. G., Keizer, D. W., Murphy, V. J., Rizkalla, M. M., Perugini, M. A., Jackson, D. C., Anders, R. F. & Norton, R. S., Dec 2007, In : Journal of Peptide Science. 13, 12, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Conotoxins Containing Nonnatural Backbone Spacers: Cladistic-Based Design, Chemical Synthesis, and Improved Analgesic Activity

Green, B. R., Catlin, P., Zhang, M. M., Fiedler, B., Bayudan, W., Morrison, A., Norton, RS. S., Smith, B. J., Yoshikami, D., Olivera, B. M. & Bulaj, G., 20 Apr 2007, In : Chemistry and Biology. 14, 4, p. 399-407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding

Kuang, Z., Yao, S., McNeil, K. A., Thompson, J. A., Bach, L. A., Forbes, B. E., Wallace, J. C. & Norton, R. S., 2007, In : Biochemistry. 46, 48, p. 13720 - 13732 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)