1971 …2024

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2015

Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2

MacRaild, C. A., Zachrdla, M., Andrew, D. W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J. S., Beeson, J. G., Anders, R. F. & Norton, R. S., 2015, In : PLoS ONE. 10, 3, 18 p., e0119899.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Pennington, M. W., Chang, S. J., Chauhan, S., Huq, R., Tajhya, R. B., Chhabra, S., Norton, R. S. & Beeton, C., 2015, In : Marine Drugs. 13, 1, p. 529 - 542 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Robinson, S., Safavi-Hemami, H., Raghuraman, S. C., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In : Journal of Proteomics. 114, p. 38 - 47 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Enhancing the buccal mucosal delivery of peptide and protein therapeutics

Caon, T., Jin, L., Simoes, M. O. C., Norton, R. S. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 1, p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3

Chang, S. C., Huq, R., Chhabra, S., Beeton, C., Pennington, M. W., Smith, B. J. & Norton, R. S., 2015, In : FEBS Journal. 282, 12, p. 2247-2259 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743 - 1748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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70 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

De Almeida Vilela Morales, R., MacRaild, C. A., Seow, J. T-J., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R. F., Christ, D., McGowan, S. & Norton, R. S., 2015, In : Scientific Reports. 5, 10 p., 10103 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R. S. & Chill, J. H., 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15130-15137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 1 Oct 2014, In : MedChemComm. 5, 10, p. 1500-1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Activation of Src family tyrosine kinases by ferric ions

Baldwin, G. S., Lio, D. S. S., Ferrand, A., Catimel, B., Shehan, B. P., Norton, R. S. & Cheng, H. C., Mar 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 3, p. 487-496 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

Kuyucak, S. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1645 - 1658 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Conformational flexibility in the binding surface of the potassium channel blocker ShK

Sher, I., Chang, S. J., Li, Y., Chhabra, S., Palmer III, A. G., Norton, R. S. & Chill, J., 2014, In : ChemBioChem. 15, 16, p. 2402 - 2410 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Conotoxin gene superfamilies

Robinson, S. & Norton, R. S., 2014, In : Marine Drugs. 12, 12, p. 6058 - 6101 44 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
71 Citations (Scopus)

Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B. J., Robinson, S., Kompella, S. N., Hung, A., Callaghan, B., Adams, D. J., Robinson, A. J. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9933 - 9944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
67 Citations (Scopus)

Domain structure and function of matrix metalloprotease 23 (MMP23): Role in potassium channel trafficking

Galea, C., Nguyen, H. M., Chandy, G. K., Smith, B. J. & Norton, R. S., 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1191 - 1210 20 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

Chhabra, S., Chang, S. J., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W. & 2 others, Norton, R. S. & Chandy, G. K., 2014, In : The FASEB Journal. 28, p. 3952 - 3964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Ge, X., MacRaild, C. A., Devine, S., Debono, C., Wang, G., Scammells, P. J., Scanlon, M., Anders, R. F., Foley, M. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6419 - 6427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

RASP: Rapid and robust backbone chemical shift assignments from protein structure

MacRaild, C. A. & Norton, R. S., 2014, In : Journal of Biomolecular NMR. 58, 3, p. 155 - 163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2013

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)

A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

10 Citations (Scopus)

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening

Lim, S. S., Debono, C., MacRaild, C. A., Chandrashekaran, I. R., Dolezal, O., Anders, R. F., Simpson, J. S., Scanlon, M., Devine, S., Scammells, P. J. & Norton, R. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1530 - 1536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA(B) receptors

Van Lierop, B. J., Robinson, S., Kompella, S. N., Belgi, A., McArthur, J. R., Hung, A., MacRaild, C. A., Adams, D. J., Norton, R. S. & Robinson, A. J., 2013, In : ACS Chemical Biology. 8, 8, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

Nguyen, H. M., Galea, C., Schmunk, G., Smith, B. J., Edwards, R. A., Norton, R. S. & Chandy, K. G., 2013, In : Journal of Biological Chemistry. 288, 9, p. 6451 - 6464 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Mammalian neuronal sodium channel blocker u-conotoxin BuIIIB has a structured N-terminus that influences potency

Kuang, Z., Zhang, M-M., Gupta, K., Gajewiak, J., Gulyas, J., Balaram, P., Rivier, J. E., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2013, In : ACS Chemical Biology. 8, 6, p. 1344 - 1351 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S., 2013, In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

D'Cruz, A., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : Protein Science. 22, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Suppressor of cytokine signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1

Linossi, E. M., Chandrashekaran, I. R., Kolesnik, T. B., Murphy, J. M., Webb, A. I., Willson, T. A., Kedzierski, L., Bullock, A. N., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : PLoS ONE. 8, 8, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)
2012

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Pennington, M. W., Rashid, M. H., Tajhya, R. B., Beeton, C., Kuyucak, S. & Norton, R. S., 2012, In : FEBS Letters. 586, 22, p. 3996 - 4001 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Ye, M., Khoo, K. K., Xu, S., Zhou, M., Boonyalai, N., Chi, C., Galea, C., Wang, C. & Norton, R. S., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14973 - 14983 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2

Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J. G., Norton, R. S. & Anders, R., 2012, In : Infection and Immunity. 80, 12, p. 4177 - 4185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Chi, V., Pennington, M. W., Norton, R. S., Tarcha, E. J., Londono, L. M., Sims-Fahey, B., Upadhyay, S. K., Lakey, J. T., Iadonato, S., Wulff, H., Beeton, C. & Chandy, K. G., 2012, In : Toxicon : official journal of the International Society on Toxinology. 59, 4, p. 529 - 546 18 p.

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)

Distinct disulfide isomers of u-conotoxins KIIIA and KIIIB block voltage-gated sodium channels

Khoo, K. K., Gupta, K., Green, B. R., Zhang, M-M., Watkins, M., Olivera, B. M., Balaram, P., Yoshikami, D., Bulaj, G. & Norton, R. S., 2012, In : Biochemistry. 51, 49, p. 9826 - 9835 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Chang, S. C., Galea, C., Leung, E. W. W., Tajhya, R. B., Beeton, C., Pennington, M. W. & Norton, R. S., 2012, In : Toxicon : official journal of the International Society on Toxinology. 60, 5, p. 840 - 850 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain

Galea, C., Mobli, M., McNeil, K. A., Mulhern, T. D., Wallace, J. C., King, G. F., Forbes, B. & Norton, R. S., 2012, In : Biochimie. 94, 3, p. 608 - 616 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Insulin-like growth factor binding proteins: a structural perspective

Forbes, B., McCarthy, P. & Norton, R. S., 2012, In : Frontiers in Endocrinology. 3, 38, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
101 Citations (Scopus)

Lipid interactions of the malaria antigen merozoite surface protein 2

MacRaild, C. A., Pedersen, M. O., Anders, R. F. & Norton, R. S., 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2572 - 2578 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)