1971 …2024

Research output per year

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13C N.M.R. spin-lattice relaxation time measurements determining the major tautomer of 1-methylisoguanosine in solution

Norton, R. S., Gregson, R. P. & Quinn, R. J., 1980, In : Journal of the Chemical Society, Chemical Communications. 8, p. 339-341 3 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

13C NMR-study of flexibilide, an anti-inflammatory agent from a soft cora

Norton, R. S. & Kazlauskas, R., Mar 1980, In : Experientia. 36, 3, p. 276-278 3 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

13C NMR-study of osmoregulatory metabolites in the marine mollusc Tapes watlingi

Norton, R. S. & de Rome, P., May 1980, In : Experientia. 36, 5, p. 522-524 3 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

13C nuclear magnetic resonance study of biosynthesis of glucosylglycerol by a cyanobacterium under osmotic stress

Mackay, M. A. & Norton, R. S., 1987, In : Journal of General Microbiology. 133, 6, p. 1535-1542 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity

Yao, S., Murphy, J., Low, A. & Norton, R., 2010, In : Biomolecular NMR Assignments. 4, 1, p. 73 - 77 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

1H-n.M.R. Study of the solution properties and secondary structure of neurotoxin III from the sea anemone Anemonia sulcata

Norton, R. S., Cross, K., Braach-Maksvytis, V. & Wachter, E., 15 Jul 1993, In : Biochemical Journal. 293, 2, p. 545-551 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

1H‐NMR study of neurotoxin B‐IV from the marine worm Cerebratulus lacteus Solution properties, sequence‐specific resonance assignments, secondary structure and global fold

HANSEN, P. E., KEM, W. R., BIEBER, A. L. & NORTON, R. S., 1992, In : European Journal of Biochemistry. 210, 1, p. 231-240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

1H NMR Study of the Solution Properties of the Polypeptide Neurotoxin I from the Sea Anemone Stichodactyla helianthus

Norton, R. S., Cossins, A. I. & Kem, W. R., 1989, In : Biochemistry. 28, 4, p. 1820-1826 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

1H Nuclear Magnetic Resonance Spectroscopic Study of the Polypeptide Toxin I from Anemonia sulcata

Gooley, P. R., Norton, R. S. & Beress, L., 1984, In : Biochemistry. 23, 10, p. 2144-2152 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver

Norton, R. S., 1985, In : European Journal of Drug Metabolism and Pharmacokinetics. 10, 3, p. 253 - 260 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

31P Nuclear‐Magnetic‐Resonance Studies of Energy Metabolism in Tissue from the Marine Invertebrate Tapes watlingi

BARROW, K. D., JAMIESON, D. D. & NORTON, R. S., 1980, In : European Journal of Biochemistry. 103, 2, p. 289-297 9 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

31P nuclear magnetic resonance studies of the fermentation of glucose to ethanol by Zymomonas mobilis

Barrow, K. D., Collins, J. G. & Norton, R. S., 1984, In : Journal of Biological Chemistry. 259, 9, p. 5711-5716 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

A 31P nuclear magnetic resonance study of Crithidia luciliae

Grote, R., Edwards, M. R., Norton, R. S. & O'Sullivan, W. J., 1990, In : Molecular and Biochemical Parasitology. 42, 1, p. 109-117 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes

Feng, Z. P., Zhang, X., Han, P., Arora, N., Anders, R. F. & Norton, R. S., Dec 2006, In : Molecular and Biochemical Parasitology. 150, 2, p. 256-267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

A common structural motif incorporating a cystine knot and a triple‐stranded β‐sheet in toxic and inhibitory polypeptides

Pallaghy, P. K., Norton, R. S., Nielsen, K. J. & Craik, D. J., 1994, In : Protein Science. 3, 10, p. 1833-1839 7 p.

Research output: Contribution to journalArticleResearchpeer-review

422 Citations (Scopus)

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 1 Oct 2014, In : MedChemComm. 5, 10, p. 1500-1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Pennington, M. W., Rashid, M. H., Tajhya, R. B., Beeton, C., Kuyucak, S. & Norton, R. S., 2012, In : FEBS Letters. 586, 22, p. 3996 - 4001 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Activation of Src family tyrosine kinases by ferric ions

Baldwin, G. S., Lio, D. S. S., Ferrand, A., Catimel, B., Shehan, B. P., Norton, R. S. & Cheng, H. C., Mar 2014, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1844, 3, p. 487-496 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

Robinson, M., Donnelly, S., Hutchinson, A., To, J., Taylor, N., Norton, R., Perugini, M. & Dalton, J., 2011, In : PLoS Pathogens. 7, 5, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
80 Citations (Scopus)

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling

Fairlie, W., Uboldi, A., McCoubrie, J., Wang, C., Lee, E., Yao, S., De Souza, D. P., Mifsud, S., Metcalf, D., Nicola, N., Norton, R. & Baca, M., 2004, In : Journal of Biological Chemistry. 279, 3, p. 2125 - 2134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

A helical capping motif in ShK toxin and its role in helix stabilization

Lanigan, M. D., Tudor, J. E., Pennington, M. W. & Norton, R. S., 2001, In : Biopolymers. 58, 4, p. 422-436 15 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Ye, M., Khoo, K. K., Xu, S., Zhou, M., Boonyalai, N., Chi, C., Galea, C., Wang, C. & Norton, R. S., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14973 - 14983 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Alzheimer's disease amyloid- binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

Curtain, C. C., Ali, F., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Masters, C. L., Bush, A. I. & Barnham, K. J., 2001, In : Journal of Biological Chemistry. 276, 23, p. 20466 - 20473 8 p.

Research output: Contribution to journalArticleResearchpeer-review

543 Citations (Scopus)

Amide proton exchange rates in cardioactive sea anemone polypeptides.

Torda, A. E. & Norton, R. S., Sep 1987, In : Biochemistry International. 15, 3, p. 659-666 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural & Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Beeton, C., Pennington, M. & Norton, R., 2011, In : Inflammation & Allergy - Drug Targets. 10, 5, p. 313 - 321 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin

Pannequin, J., Kovac, S., Tantiongco, J-P., Norton, R., Shulkes, A., Barnham, K. & Baldwin, G., 2003, In : Journal of Biological Chemistry. 279, 4, p. 2453 - 2460 8 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2

Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J. G., Norton, R. S. & Anders, R., 2012, In : Infection and Immunity. 80, 12, p. 4177 - 4185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Anti-Infective Peptides to Enhance the Host Innate Response: Design, Development and Delivery

Norton, R. S., 2018, In : Protein and Peptide Letters. 25, 12, p. 1101-1107 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

Rodriguez, A., Pedersen, M., Villegas, E., Rivas-Santiago, B., Villegas-Moreno, J., Amero, C., Norton, R. S. & Corzo, G., Jan 2020, In : Proteins: Structure, Function, and Bioinformatics. 88, 1, p. 175-186 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antiviral Activity and Structural Characteristics of the Nonglycosylated Central Subdomain of Human Respiratory Syncytial Virus Attachment (G) Glycoprotein

Gorman, J. J., McKimm-Breschkin, J. L., Norton, R. S. & Barnham, K. J., 19 Oct 2001, In : Journal of Biological Chemistry. 276, 42, p. 38988-38994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

Yang, X., Adda, C. G., Keizer, D. W., Murphy, V. J., Rizkalla, M. M., Perugini, M. A., Jackson, D. C., Anders, R. F. & Norton, R. S., Dec 2007, In : Journal of Peptide Science. 13, 12, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Apical membrane antigen 1 as an anti-malarial drug target

MacRaild, C., Anders, R., Foley, M. & Norton, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 16, p. 2039 - 2047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
37 Citations (Scopus)

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

a-RgIA, a novel conotoxin that blocks the a9a10 nAChR: Structure and identification of key receptor-binding residues

Ellison, M., Feng, Z-P., Park, A. J., Zhang, X., Olivera, B. M., McIntosh, J. M. & Norton, R. S., 2008, In : Journal of Molecular Biology. 377, 4, p. 1216 - 1227 12 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Assignment of 1H and 15N resonances of murine Tec SH3 domain

Pursglove, S. E., Mulhern, T. D., Hinds, M. G., Norton, R. S. & Booker, G. W., 1998, In : Journal of Biomolecular NMR. 12, 3, p. 461-462 2 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Assignment of aromatic resonances in the 1H nuclear magnetic resonance spectra of cardioactive polypeptides from sea anemones

Gooley, P. R., Blunt, J. W., Beress, L., Norton, T. R. & Norton, R. S., 1986, In : Journal of Biological Chemistry. 261, 4, p. 1536-1538 3 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Backbone dynamics measurements on leukemia inhibitory factor, a rigid four-helical bundle cytokine

Yao, S., Smith, D. K., Hinds, M. G., Zhang, J. G., Nicola, N. A. & Norton, R. S., 2000, In : Protein Science. 9, 4, p. 671-682 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Backbone folding of the polypeptide cardiac stimulant anthopleurin-A determined by nuclear magnetic resonance, distance geometry and molecular dynamics

Torda, A. E., Mabbutt, B. C., van Gunsteren, W. F. & Norton, R. S., 7 Nov 1988, In : FEBS Letters. 239, 2, p. 266-270 5 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

Lauth, X., Babon, J., Stannard, J., Singh, S., Nizet, V., Carlberg, J., Ostland, V., Pennington, M., Norton, R. & Westerman, M., 2005, In : Journal of Biological Chemistry. 280, 10, p. 9272 - 9282 11 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)