Raymond Norton

Professor

1971 …2024

Research output per year

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Research Output

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Article
2020

Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

Rodriguez, A., Pedersen, M., Villegas, E., Rivas-Santiago, B., Villegas-Moreno, J., Amero, C., Norton, R. S. & Corzo, G., Jan 2020, In : Proteins: Structure, Function, and Bioinformatics. 88, 1, p. 175-186 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Tentacle Transcriptomes of the Speckled Anemone (Actiniaria: Actiniidae: Oulactis sp.): Venom-Related Components and Their Domain Structure

Mitchell, M. L., Tonkin-Hill, G. Q., Morales, R. A. V., Purcell, A. W., Papenfuss, A. T. & Norton, R. S., 24 Jan 2020, (Accepted/In press) In : Marine Biotechnology. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2019

Conformational exchange in the potassium channel blocker ShK

Iwakawa, N., Baxter, N. J., Wai, D. C. C., Fowler, N. J., Morales, R. A. V., Sugase, K., Norton, R. S. & Williamson, M. P., 17 Dec 2019, In : Scientific Reports. 9, 1, 8 p., 19307.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Evolution of cnidarian trans-defensins: Sequence, structure and exploration of chemical space

Mitchell, M. L., Shafee, T., Papenfuss, A. T. & Norton, R. S., 1 Jul 2019, In : Proteins: Structure, Function and Bioinformatics. 87, 7, p. 551-560 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Akter, M., Drinkwater, N., Devine, S. M., Drew, S. C., Krishnarjuna, B., Debono, C. O., Wang, G., Scanlon, M. J., Scammells, P. J., McGowan, S., MacRaild, C. A. & Norton, R. S., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 603-612 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of merozoite surface protein 2 with lipid membranes

Lu, C., Zheng, X., Zhang, W., Zhao, H., MacRaild, C. A., Norton, R. S., Zhuang, Y., Wang, J. & Zhang, X., Feb 2019, In : FEBS Letters. 593, 3, p. 288-295 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Mapping the chemical and sequence space of the ShKT superfamily

Shafee, T., Mitchell, M. L. & Norton, R. S., 1 Jul 2019, In : Toxicon. 165, p. 95-102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Modulation of the aggregation of an amyloidogenic sequence by flanking-disordered region in the intrinsically disordered antigen merozoite surface protein 2

Zhang, W., Zhang, J., MacRaild, C. A., Norton, R. S., Anders, R. F. & Zhang, X., 2019, In : European Biophysics Journal. 48, 1, p. 99-110 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Elnahriry, K. A., Wai, D. C. C., Krishnarjuna, B., Badawy, N. N., Chittoor, B., MacRaild, C. A., Williams-Noonan, B. J., Surm, J. M., Chalmers, D. K., Zhang, A. H., Peigneur, S., Mobli, M., Tytgat, J., Prentis, P. & Norton, R. S., 1 Oct 2019, In : Toxicon. 168, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The Single Disulfide-Directed β-Hairpin Fold: Role of Disulfide Bond in Folding and Effect of an Additional Disulfide Bond on Stability

Chittoor, B., Krishnarjuna, B., Morales, R. A. V. & Norton, R. S., 15 Nov 2019, (Accepted/In press) In : Australian Journal of Chemistry. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 22, p. 8745-8759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2018

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Anti-Infective Peptides to Enhance the Host Innate Response: Design, Development and Delivery

Norton, R. S., 2018, In : Protein and Peptide Letters. 25, 12, p. 1101-1107 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Characterisation of peptide interactions that regulate PKCε activation

Chandrashekaran, I. R., Norton, R. S. & Schmitz-Peiffer, C., 1 Jan 2018, In : FEBS Letters. 592, 2, p. 179-189 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp.

Sunanda, P., Krishnarjuna, B., Peigneur, S., Mitchell, M. L., Estrada, R., Villegas-Moreno, J., Pennington, M. W., Tytgat, J. & Norton, R. S., 1 Jul 2018, In : Peptide Science. 110, 4, 10 p., e24073.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Peptide therapeutics from venom: Current status and potential

Pennington, M. W., Czerwinski, A. & Norton, R. S., 1 Jun 2018, In : Bioorganic and Medicinal Chemistry. 26, 10, p. 2738-2758 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
46 Citations (Scopus)

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6 –A11 bond

Ong, S. C., Belgi, A., Van Lierop, B., Delaine, C., Andrikopoulos, S., MacRaild, C. A., Norton, R. S., Haworth, N. L., Robinson, A. J. & Forbes, B. E., 27 Jul 2018, In : Journal of Biological Chemistry. 293, 30, p. 11928-11943 16 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., Jan 2018, In : Peptides. 99, p. 169–178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Krishnarjuna, B., Villegas-Moreno, J., Mitchell, M. L., Csoti, A., Peigneur, S., Amero, C., Pennington, M. W., Tytgat, J., Panyi, G. & Norton, R. S., 1 Aug 2018, In : Toxicon. 150, p. 50-59 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope

Krishnarjuna, B., Sugiki, T., Morales, R. A. V., Seow, J., Fujiwara, T., Wilde, K. L., Norton, R. S. & MacRaild, C. A., 1 Dec 2018, In : Communications Biology. 1, 1, p. 1-10 10 p., 58.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
2017

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Bergmann, R., Kubeil, M., Zarschler, K., Chhabra, S., Tajhya, R. B., Beeton, C., Pennington, M. W., Bachmann, M. H., Norton, R. S. & Stephan, H., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 3756.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2

Das, S. C., Morales, R. A. V., Seow, J., Krishnarjuna, B., Dissanayake, R., Anders, R. F., Macraild, C. A. & Norton, R. S., 2017, In : FEBS Journal. 284, 16, p. 649–2662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Molecular insights into the interaction between the SPRY domain-containing SOCS box protein SPSB2 and peptides based on the binding motif from iNOS

Leung, E., Mulcair, M., Yap, S., Nicholson, S. E., Scanlon, M. & Norton, R., 2017, In : Australian Journal of Chemistry. 70, 2, p. 191-200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Tanner, M. R., Tajhya, R. B., Huq, R., Gehrmann, E. J., Rodarte, K. E., Atik, M. A., Norton, R. S., Pennington, M. W. & Beeton, C., 1 Jul 2017, In : Clinical Immunology. 180, p. 45-57 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Reinvestigation of the biological activity of D-allo-ShK protein

Dang, B., Chhabra, S., Pennington, M. W., Norton, R. S. & Kent, S. B. H., 2017, In : Journal of Biological Chemistry. 292, 30, p. 12599-12605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)
2016

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Neutron reflection study of the interaction of the eukaryotic pore-forming actinoporin equinatoxin II with lipid membranes reveals intermediate states in pore formation

Wacklin, H. P., Bremec, B. B., Moulin, M., Rojko, N., Haertlein, M., Forsyth, T., Anderluh, G. & Norton, R., 1 Apr 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 4, p. 640-652 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases

Jin, L., Zhou, Q. T., Chan, H-K., Larson, I. C., Pennington, M. W., Morales, R. A. V., Boyd, B. J., Norton, R. S. & Nicolazzo, J. A., 1 Feb 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 650-656 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Krishnarjuna, B., Lim, S. S., Devine, S. M., Debono, C. O., Lam, R., Chandrashekaran, I. R., Jaipuria, G., Yagi, H., Atreya, H. S., Scanlon, M. J., MacRaild, C. A., Scammells, P. J. & Norton, R. S., 1 Jun 2016, In : Journal of Molecular Recognition. 29, 6, p. 281-291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Stereoselective synthesis and structural elucidation of dicarba peptides

Gleeson, E. C., Wang, Z. J., Robinson, S. D., Chhabra, S., MacRaild, C. A., Jackson, W. R., Norton, R. S. & Robinson, A. J., 2016, In : Chemical Communications. 52, 24, p. 4446-4449 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

Krishnarjuna, B., Andrew, D., MacRaild, C. A., Morales, R. A. V., Beeson, J. G., Anders, R. F., Richards, J. S. & Norton, R. S., 11 Feb 2016, In : Scientific Reports. 6, 12 p., 20613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Structural basis for the inhibition of voltage-gated sodium channels by conotoxin μO§-GVIIJ

Green, B. R., Gajewiak, J., Chhabra, S., Skalicky, J. J., Zhang, M. M., Rivier, J. E., Bulaj, G., Olivera, B. M., Yoshikami, D. & Norton, R., 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 7205-7220 16 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The ways and means of fragment-based drug design

Doak, B. C., Norton, R. S. & Scanlon, M. J., 1 Nov 2016, In : Pharmacology and Therapeutics. 167, p. 28-37 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2015

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

Jin, L., Boyd, B. J., White, P. J., Pennington, M. W., Norton, R. S. & Nicolazzo, J., 2015, In : Journal of Controlled Release. 199, p. 37 - 44 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2

MacRaild, C. A., Zachrdla, M., Andrew, D. W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J. S., Beeson, J. G., Anders, R. F. & Norton, R. S., 2015, In : PLoS ONE. 10, 3, 18 p., e0119899.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)