Raymond Norton

Professor

1971 …2024
If you made any changes in Pure these will be visible here soon.

Research Output 1971 2019

Article
242 Citations (Scopus)

The cystine knot structure of ion channel toxins and related polypeptides

Norton, R. S. & Pallaghy, P. K., Nov 1998, In : Toxicon. 36, 11, p. 1573-1583 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

Beeton, C., Smith, B. J., Sabo, J. K., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Chandy, G. K., Pennington, M. W. & Norton, R. S., 2008, In : Journal of Biological Chemistry. 283, 2, p. 988 - 997 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Miles, A. J., Drechsler, A., Kristan, K., Anderluh, G., Norton, R. S., Wallace, B. A. & Separovic, F., Oct 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2091-2096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Feng, Z-P., Chandrashekaran, I. R., Low, A., Speed, T. P., Nicholson, S. E. & Norton, R. S., 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 3, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

Chandrashekaran, I. R., Yao, S., Wang, C. C., Bansal, P. S., Alewood, P. F., Forbes, B., Wallace, J. C., Bach, L. A. & Norton, R. S., 2007, In : Biochemistry. 46, 11, p. 3065 - 3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The physical state of osmoregulatory solutes in unicellular algae. A natural-abundance carbon-13 nuclear-magnetic-resonance relaxation study.

Norton, R. S., MacKay, M. A. & Borowitzka, L. J., 1982, In : The Biochemical journal. 202, 3, p. 699-706 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Thermodenaturation of bovine β-lactoglobulin. Kinetics and the introduction of β-structure

Sawyer, W. H., Norton, R. S., Nichol, L. W. & McKenzie, G. H., 25 Jul 1971, In : BBA - Protein Structure. 243, 1, p. 19-30 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The single mutation Phe173 → Ala induces a molten globule-like state in murine interleukin-6

Matthews, J. M., Norton, R. S., Hammacher, A. & Simpson, R. J., 29 Feb 2000, In : Biochemistry. 39, 8, p. 1942-1950 9 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2008, In : Journal of Molecular Biology. 381, 4, p. 928 - 940 13 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

The SOCS box encodes a hierarchy of affinities for cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression

Babon, J. J., Sabo, J. K., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2009, In : Journal of Molecular Biology. 387, 1, p. 162 - 174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Kuang, Z., Lewis, R. S., Curtis, J. M., Zhan, Y., Saunders, B. M., Babon, J. J., Kolesnik, T. B., Low, A., Masters, S. L., Willson, T. A., Kedzierski, L., Yao, S., Handman, E., Norton, R. S. & Nicholson, S. E., 2010, In : Journal of Cell Biology. 190, 1, p. 129 - 141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

Masters, S., Yao, S., Willson, T., Zhang, J-G., Palmer, K., Smith, B., Babon, J., Nicola, N., Norton, R. & Nicholson, S., 2006, In : Nature Structural and Molecular Biology. 13, 1, p. 77 - 84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability

Babon, J., McManus, E., Yao, S., De Souza, D. P., Mielke, L., Sprigg, N., Willson, T., Hilton, D., Nicola, N., Baca, M., Nicholson, S. & Norton, R., 2006, In : Molecular Cell. 22, p. 205 - 216 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 22, p. 8745-8759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

The Val-210-I1e pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrPC

Thompson, A. J., Barnham, K. J., Norton, R. S. & Barrow, C. J., 12 Jan 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1544, 1-2, p. 242-254 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The ways and means of fragment-based drug design

Doak, B. C., Norton, R. S. & Scanlon, M. J., 1 Nov 2016, In : Pharmacology and Therapeutics. 167, p. 28-37 10 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Three-Dimensional Structure in Solution of Neurotoxin III from the Sea Anemone Anemonia sulcata

Manoleras, N. & Norton, R. S., 1 Sep 1994, In : Biochemistry. 33, 37, p. 11051-11061 11 p.

Research output: Contribution to journalArticleResearchpeer-review

131 Citations (Scopus)

Three-dimensional structure in solution of the calcium channel blocker ω-conotoxin

Pallaghy, P. K., Duggan, B. M., Pennington, M. W. & Norton, R. S., 20 Nov 1993, In : Journal of Molecular Biology. 234, 2, p. 405-420 16 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Three-Dimensional Structure in Solution of the Polypeptide Cardiac Stimulant Anthopleurin-A

Pallaghy, P. K., Scanlon, M. J., Monks, S. A. & Norton, R. S., 1995, In : Biochemistry. 34, 11, p. 3782-3794 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Three new polyhalogenated monoterpenes from Plocamium species

Norton, R. S., Warren, R. G. & Wells, R. J., 1977, In : Tetrahedron Letters. 18, 44, p. 3905-3908 4 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

TLR regulation of SPSB1 controls inducible nitric oxide synthase induction

Lewis, R., Kolesnik, T., Kuang, Z., D'Cruz, A., Blewitt, M., Masters, S., Low, A., Willson, T., Norton, R. & Nicholson, S., 2011, In : Journal of Immunology. 187, 7, p. 3798 - 3805 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope

Krishnarjuna, B., Sugiki, T., Morales, R. A. V., Seow, J., Fujiwara, T., Wilde, K. L., Norton, R. S. & MacRaild, C. A., 1 Dec 2018, In : Communications Biology. 1, 1, p. 1-10 10 p., 58.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

Tyrosine modification enhances metal-ion binding

Baldwin, G. S., Bailey, M. F., Shehan, B. P., Sims, I. & Norton, R. S., 15 Nov 2008, In : Biochemical Journal. 416, 1, p. 77-84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Use of 13C spin-lattice relaxation measurements to determine the structure of a tetrabromo diphenyl ether from the sponge Dysidea herbacea

Norton, R. S. & Wells, R. J., 1980, In : Tetrahedron Letters. 21, 39, p. 3801-3804 4 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Chapter (Book)
5 Citations (Scopus)

Case Study 2: transforming a toxin into a therapeutic: the sea anemone potassium channel blocker ShK toxin for treatment of autoimmune diseases

Norton, R., Pennington, M. W. & Beeton, C., 2015, Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. King, G. F. (ed.). Cambridge UK: The Royal Society of Chemistry, Vol. 2015-January. p. 255-274 20 p. (RSC Drug Discovery Series; no. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Peptide toxin structure and function by NMR

Norton, R. S., 13 Jun 2018, Modern Magnetic Resonance. Webb, G. A. (ed.). Cham Switzerland: Springer, p. 2018-2097 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

12 Citations (Scopus)

Role of Disulfide Bonds in Peptide and Protein Conformation

Khoo, K. & Norton, R. S., 2011, Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides. Hughes, A. B. (ed.). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 5. p. 395-417 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

File
3 Citations (Scopus)

Sea anemone peptides

Norton, R. S., 2013, Handbook of Biologically Active Peptides. Kastin, A. J. (ed.). Second Edition ed. San Diego CA USA: Elsevier, p. 430 - 436 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

5 Citations (Scopus)

Sea Anemone Venom Peptides

Norton, R. S., 2006, Handbook of Biologically Active Peptides. Academic Press, p. 363-367 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Structure and Activity of N-Methylated Peptides

Norton, R., 28 Nov 2011, Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides. Hughes, A. B. (ed.). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 5. p. 155-166 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

File
Comment / Debate

Corrigendum to “Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK” [Peptides 99 (2018) 169–178](S0196978117303054)(10.1016/j.peptides.2017.10.001)

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., 1 Mar 2018, In : Peptides. 101, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum: Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels (Biochemistry (May 17, 2005) 44, 19 (7259-7265))

Bulaj, G., West, P. J., Garrett, J. E., Watkins, M., Zhang, M. M., Norton, R. S., Smith, B. J., Yoshikami, D. & Olivera, B. M., 7 Mar 2006, In : Biochemistry. 45, 9, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum: Roles of key functional groups in ω-conotoxin GVIA. Synthesis, structure and functional assay of selected peptide analogues (European Journal of Biochemistry (1999) 262 (447-455))

Flinn, J. P., Pallaghy, P. K., Lew, M. J., Murphy, R., Angus, J. A. & Norton, R. S., 15 Aug 1999, In : European Journal of Biochemistry. 264, 1, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum: Structure and sodium channel activity of an excitatory I 1-superfamily conotoxin (Biochemistry (2007) 46, 35, (9929-9940))

Buczek, O., Wei, D., Babon, J. J., Yang, X., Fiedler, B., Chen, P., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 6 Nov 2007, In : Biochemistry. 46, 44, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum: Design and synthesis of type-III mimetics of ω-conotoxin GVIA (Journal of Computer-Aided Molecular Design (2001) vol. 15 (1119-1136))

Baell, J. B., Forsyth, S. A., Gable, R. W., Norton, R. S. & Mulder, R. J., 1 Apr 2002, In : Journal of Computer-Aided Molecular Design. 16, 4, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Conference Paper
1 Citation (Scopus)

Reducing overfitting in predicting intrinsically unstructured proteins

Han, P., Zhang, X., Norton, R. S. & Feng, Z., 2007, Advances in Knowledge Discovery and Data Mining - 11th Pacific-Asia Conference, PAKDD 2007, Proceedings. Vol. 4426 LNAI. p. 515-522 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4426 LNAI).

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Editorial
1 Citation (Scopus)

Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2–6, 2018

Battle, A. R., Norton, R. S., Böcking, T., Noji, H., Kim, K. K. & Nagayama, K., 1 Jun 2019, In : Biophysical Reviews. 11, 3, p. 245-247 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)

FraGment-Based Drug Discovery

Norton, R. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1463-1464 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

8 Citations (Scopus)

Interactions of disulfide-deficient selenocysteine analogs of u-conotoxin BuIIIB with the a-subunit of the voltage-gated sodium channel subtype 1.3

Green, B. R., Zhang, M., Chhabra, S., Robinson, S., Wilson, M. J., Redding, A., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2014, In : FEBS Journal. 281, 13, p. 2885 - 2898 14 p.

Research output: Contribution to journalEditorialResearchpeer-review

Toxinology in Australia-Pioneers to Frontiers

Norton, R. S. & Winkel, K. D., 1 Dec 2006, In : Toxicon. 48, 7, 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

9 Citations (Scopus)

Venoms to the rescue: Insights into the evolutionary biology of venoms are leading to therapeutic advances

Holford, M., Daly, M., King, G. F. & Norton, R. S., 31 Aug 2018, In : Science. 361, 6405, p. 842-844 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Letter
5 Citations (Scopus)

1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6)

Headey, S., Yao, S., Parker, N. J., Kantharidis, P., Bach, L. A. & Norton, R., 2003, In : Journal of Biomolecular NMR. 25, 3, p. 251 - 252 2 p.

Research output: Contribution to journalLetterOther

6 Citations (Scopus)

Assignment of 1H, 13C and 15N resonances of domain III of the ectodomain of apical membrane antigen 1 from Plasmodium falciparum [5]

Nair, M., Hodder, A. N., Hinds, M. G., Anders, R. F. & Norton, R. S., 2001, In : Journal of Biomolecular NMR. 19, 1, p. 85-86 2 p.

Research output: Contribution to journalLetterOtherpeer-review

9 Citations (Scopus)

Letter to the editor: Sequence-specific resonance assignments of the potent cytolysin equinatoxin II [2]

Zhang, W., Hinds, M. G., Anderluh, G., Hansen, P. E. & Norton, R. S., 2000, In : Journal of Biomolecular NMR. 18, 3, p. 281-282 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Studies of muscle metabolism in the marine bivalve mollusc tapes watlingi

Barrow, K. D., Jamieson, D. & Norton, R. S., 1980, In : Journal of the Malacological Society of Australia. 4, 4, 1 p.

Research output: Contribution to journalLetterOtherpeer-review