Raymond Norton

Professor

1971 …2024
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Research Output 1971 2019

39 Citations (Scopus)

Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II

Drechsler, A., Potrich, C., Jennifer, J., Frisanco, M., Guella, G., Serra, M. D., Anderluh, G., Separovic, F. & Norton, R., 2006, In : Biochemistry. 45, 6, p. 1818 - 1828 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Structure and function of peptide and protein toxins from marine organisms

Norton, R. S., 1998, In : Journal of Toxicology - Toxin Reviews. 17, 2, p. 99-130 32 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

52 Citations (Scopus)

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

D'Cruz, A., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : Protein Science. 22, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1

Feng, Z-P., Keizer, D., Stevenson, R., Yao, S., Babon, J., Murphy, V., Anders, R. & Norton, R., 2005, In : Journal of Molecular Biology. 350, 4, p. 641 - 656 16 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Structure and sodium channel activity of an excitatory I 1-superfamily conotoxin

Buczek, O., Wei, D., Babon, J. J., Yang, X., Fiedler, B., Chen, P., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 4 Sep 2007, In : Biochemistry. 46, 35, p. 9929-9940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

196 Citations (Scopus)

Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel

Norton, R. S., 1991, In : Toxicon. 29, 9, p. 1051-1084 34 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Structure determination from the spin–lattice relaxation behaviour of quaternary carbons. Effects of deuterium substitution

Norton, R. S., 1981, In : Organic Magnetic Resonance. 17, 1, p. 37-40 4 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Structure‐function relationships in the polypeptide cardiac stimulant, anthopleurin‐A: Effects of limited proteolysis by trypsin

GOULD, A. R., MABBUTT, B. C. & NORTON, R. S., 1990, In : European Journal of Biochemistry. 189, 1, p. 145-153 9 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Structure-function relationships of ω-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine- substituted analogues

Lew, M. J., Flinn, J. P., Pallaghy, P. K., Murphy, R., Whorlow, S. L., Wright, C. E., Norton, R. S. & Angus, J. A., 2 May 1997, In : Journal of Biological Chemistry. 272, 18, p. 12014-12023 10 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca2+-activated over voltage-gated K+ channels

Rauer, H., Lanigan, M. D., Pennington, M. W., Aiyar, J., Ghanshani, S., Cahalan, M. D., Norton, R. S. & George Chandy, K., 14 Jan 2000, In : Journal of Biological Chemistry. 275, 2, p. 1201-1208 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif

Miles, L. A., Dy, C. Y., Nielsen, J., Barnham, K. J., Hinds, M. G., Olivera, B. M., Bulaj, G. & Norton, R. S., 8 Nov 2002, In : Journal of Biological Chemistry. 277, 45, p. 43033-43040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)

Nair, M., Hinds, M. G., Coley, A. M., Hodder, A. N., Foley, M., Anders, R. F. & Norton, R. S., 2002, In : Journal of Molecular Biology. 322, 4, p. 741-753 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: A helical hairpin cross-linked by disulphide bonding

Barnham, K. J., Dyke, T. R., Kem, W. R. & Norton, R. S., 23 May 1997, In : Journal of Molecular Biology. 268, 5, p. 886-902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

220 Citations (Scopus)

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

Barnham, K. J., McKinstry, W. J., Multhaup, G., Galatis, D., Morton, C. J., Curtain, C. C., Williamson, N. A., White, A. R., Hinds, M. G., Norton, R. S., Beyreuther, K., Masters, C. L., Parker, M. W. & Cappai, R., 2003, In : Journal of Biological Chemistry. 278, 19, p. 17401 - 17407 7 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Structure of the analgesic u-conotoxin KIIIA and effects on the structure and function of disulfide deletion

Khoo, K. K., Feng, Z-P., Smith, B. J., Zhang, M., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 2009, In : Biochemistry. 48, 6, p. 1210 - 1219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion

Keizer, D. W., Miles, L. A., Li, F., Nair, M., Anders, R. F., Coley, A. M., Foley, M. & Norton, R. S., 26 Aug 2003, In : Biochemistry. 42, 33, p. 9915-9923 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Structures of sea anemone toxins

Norton, R. S., 2009, In : Toxicon : official journal of the International Society on Toxinology. 54, 8, p. 1075 - 1088 14 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis- Trans isomerism

Pallaghy, P. K., He, W., Jimenez, E. C., Olivera, B. M. & Norton, R. S., 24 Oct 2000, In : Biochemistry. 39, 42, p. 12845-12852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Studies of chemical modifications of proteins by carbon 13 nuclear magnetic resonance spectroscopy. Reaction of hen egg white lysozyme with iodine

Norton, R. S. & Allerhand, A., 1976, In : Journal of Biological Chemistry. 251, 21, p. 6522-6528 7 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Studies of Individual Carbon Sites of Azurin from Pseudomonas aeruginosa by Natural-Abundance Carbon-13 Nuclear Magnetic Resonance Spectroscopy

Ugurbil, K., Norton, R. S., Allerhand, A. & Bersohn, R., 1 Mar 1977, In : Biochemistry. 16, 5, p. 886-894 9 p.

Research output: Contribution to journalArticleResearchpeer-review

142 Citations (Scopus)

Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Relaxation behavior

Oldfield, E., Norton, R. S. & Allerhand, A., 1975, In : Journal of Biological Chemistry. 250, 16, p. 6368-6380 13 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Strategies for assignments

Oldfield, E., Norton, R. S. & Allerhand, A., 1975, In : Journal of Biological Chemistry. 250, 16, p. 6381-6402 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Studies of muscle metabolism in the marine bivalve mollusc tapes watlingi

Barrow, K. D., Jamieson, D. & Norton, R. S., 1980, In : Journal of the Malacological Society of Australia. 4, 4, 1 p.

Research output: Contribution to journalLetterOtherpeer-review

77 Citations (Scopus)

Studies of Proteins in Solution by Natural-Abundance Carbon-13 Nuclear Magnetic Resonance. Spectral Resolution and Relaxation Behavior at High Magnetic Field Strengths

Norton, R. S., Clouse, A. O., Addleman, R. & Allerh, A., 1977, In : Journal of the American Chemical Society. 99, 1, p. 79-83 5 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S. & Nicola, N. A., 2012, In : Immunity. 36, 2, p. 239 - 250 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Suppressor of cytokine signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1

Linossi, E. M., Chandrashekaran, I. R., Kolesnik, T. B., Murphy, J. M., Webb, A. I., Willson, T. A., Kedzierski, L., Bullock, A. N., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : PLoS ONE. 8, 8, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Krishnarjuna, B., Villegas-Moreno, J., Mitchell, M. L., Csoti, A., Peigneur, S., Amero, C., Pennington, M. W., Tytgat, J., Panyi, G. & Norton, R. S., 1 Aug 2018, In : Toxicon. 150, p. 50-59 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Synthesis and Characterization of δ-Atracotoxin-Ar1a, the Lethal Neurotoxin from Venom of the Sydney Funnel-Web Spider (Atrax robustus)

Alewood, D., Birinyi-Strachan, L. C., Pallaghy, P. K., Norton, R. S., Nicholson, G. M. & Alewood, P. F., 11 Nov 2003, In : Biochemistry. 42, 44, p. 12933-12940 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

Dyke, T. R., Duggan, B. M., Pennington, M. W., Byrnes, M. E., Kem, W. R. & Norton, R. S., 4 Jan 1996, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1292, 1, p. 31-38 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Synthesis of the cardiac inotropic polypeptide anthopleurin‐A

PENNINGTON, MICHAEL. W., ZADENBERG, INNA., BYRNES, MICHAEL. E., NORTON, RAYMOND. S. & KEM, WILLIAM. R., 1994, In : International Journal of Peptide and Protein Research. 43, 5, p. 463-470 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Tenebrosin-A, a new cardiostimulant protein from the Australian sea anemone Actinia tenebrosa

Thomson, M., Moritz, R. L., Simpson, R. J. & Norton, R. S., 1987, In : Biochemistry International. 15, 4, p. 711-718 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The application of nuclear magnetic resonance spectroscopy to parasite metabolism

O'Sullivan, W. J., Edwards, M. R. & Norton, R. S., 1989, In : Parasitology Today. 5, 3, p. 79-82 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The cyclic contryphan motif CPxXPXC, a robust scaffold potentially useful as an ω mimic

Pallaghy, P. K. & Norton, R. S., Sep 2000, In : Biopolymers. 54, 3, p. 173-179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

242 Citations (Scopus)

The cystine knot structure of ion channel toxins and related polypeptides

Norton, R. S. & Pallaghy, P. K., Nov 1998, In : Toxicon. 36, 11, p. 1573-1583 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

Beeton, C., Smith, B. J., Sabo, J. K., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Chandy, G. K., Pennington, M. W. & Norton, R. S., 2008, In : Journal of Biological Chemistry. 283, 2, p. 988 - 997 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Miles, A. J., Drechsler, A., Kristan, K., Anderluh, G., Norton, R. S., Wallace, B. A. & Separovic, F., Oct 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2091-2096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Feng, Z-P., Chandrashekaran, I. R., Low, A., Speed, T. P., Nicholson, S. E. & Norton, R. S., 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 3, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

Chandrashekaran, I. R., Yao, S., Wang, C. C., Bansal, P. S., Alewood, P. F., Forbes, B., Wallace, J. C., Bach, L. A. & Norton, R. S., 2007, In : Biochemistry. 46, 11, p. 3065 - 3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The physical state of osmoregulatory solutes in unicellular algae. A natural-abundance carbon-13 nuclear-magnetic-resonance relaxation study.

Norton, R. S., MacKay, M. A. & Borowitzka, L. J., 1982, In : The Biochemical journal. 202, 3, p. 699-706 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Thermodenaturation of bovine β-lactoglobulin. Kinetics and the introduction of β-structure

Sawyer, W. H., Norton, R. S., Nichol, L. W. & McKenzie, G. H., 25 Jul 1971, In : BBA - Protein Structure. 243, 1, p. 19-30 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The single mutation Phe173 → Ala induces a molten globule-like state in murine interleukin-6

Matthews, J. M., Norton, R. S., Hammacher, A. & Simpson, R. J., 29 Feb 2000, In : Biochemistry. 39, 8, p. 1942-1950 9 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2008, In : Journal of Molecular Biology. 381, 4, p. 928 - 940 13 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

The SOCS box encodes a hierarchy of affinities for cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression

Babon, J. J., Sabo, J. K., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2009, In : Journal of Molecular Biology. 387, 1, p. 162 - 174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Kuang, Z., Lewis, R. S., Curtis, J. M., Zhan, Y., Saunders, B. M., Babon, J. J., Kolesnik, T. B., Low, A., Masters, S. L., Willson, T. A., Kedzierski, L., Yao, S., Handman, E., Norton, R. S. & Nicholson, S. E., 2010, In : Journal of Cell Biology. 190, 1, p. 129 - 141 13 p.

Research output: Contribution to journalArticleResearchpeer-review