Raymond Norton

Professor

1971 …2021
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Research Output 1971 2019

2004

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

Norton, R. S., Pennington, M. W. & Wulff, H., 2004, In : Current Medicinal Chemistry. 11, 23, p. 3041-3052 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2003

1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6)

Headey, S., Yao, S., Parker, N. J., Kantharidis, P., Bach, L. A. & Norton, R., 2003, In : Journal of Biomolecular NMR. 25, 3, p. 251 - 252 2 p.

Research output: Contribution to journalLetterOther

A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin

Pannequin, J., Kovac, S., Tantiongco, J-P., Norton, R., Shulkes, A., Barnham, K. & Baldwin, G., 2003, In : Journal of Biological Chemistry. 279, 4, p. 2453 - 2460 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of the eukaryotic pore-forming cytolysin equinatoxin II on lipid membranes and the role of sphingomyelin

Bonev, B. B., Lam, Y. H., Anderluh, G., Watts, A., Norton, R. S. & Separovict, F., 1 Apr 2003, In : Biophysical Journal. 84, 4, p. 2382-2392 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA

Keizer, D. W., West, P. J., Lee, E. F., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 21 Nov 2003, In : Journal of Biological Chemistry. 278, 47, p. 46805-46813 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

Barnham, K. J., McKinstry, W. J., Multhaup, G., Galatis, D., Morton, C. J., Curtain, C. C., Williamson, N. A., White, A. R., Hinds, M. G., Norton, R. S., Beyreuther, K., Masters, C. L., Parker, M. W. & Cappai, R., 2003, In : Journal of Biological Chemistry. 278, 19, p. 17401 - 17407 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion

Keizer, D. W., Miles, L. A., Li, F., Nair, M., Anders, R. F., Coley, A. M., Foley, M. & Norton, R. S., 26 Aug 2003, In : Biochemistry. 42, 33, p. 9915-9923 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and Characterization of δ-Atracotoxin-Ar1a, the Lethal Neurotoxin from Venom of the Sydney Funnel-Web Spider (Atrax robustus)

Alewood, D., Birinyi-Strachan, L. C., Pallaghy, P. K., Norton, R. S., Nicholson, G. M. & Alewood, P. F., 11 Nov 2003, In : Biochemistry. 42, 44, p. 12933-12940 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Design and synthesis of type-III mimetics of ShK toxin

Baell, J. B., Harvey, A. J. & Norton, R. S., 1 Apr 2002, In : Journal of Computer-Aided Molecular Design. 16, 4, p. 245-262 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Design and synthesis of type-III mimetics of ω-conotoxin GVIA (Journal of Computer-Aided Molecular Design (2001) vol. 15 (1119-1136))

Baell, J. B., Forsyth, S. A., Gable, R. W., Norton, R. S. & Mulder, R. J., 1 Apr 2002, In : Journal of Computer-Aided Molecular Design. 16, 4, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin

Pannequin, J., Barnham, K. J., Hollande, F., Shulkes, A., Norton, R. S. & Baldwin, G. S., 13 Dec 2002, In : Journal of Biological Chemistry. 277, 50, p. 48602-48609 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore - Vestibule region of the voltage-gated potassium channel, Kv1.3

Lanigan, M. D., Kalman, K., Lefievre, Y., Pennington, M. W., Chandy, K. G. & Norton, R. S., 8 Oct 2002, In : Biochemistry. 41, 40, p. 11963-11971 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II: Implications for pore formation

Hinds, M. G., Zhang, W., Anderluh, G., Hansen, P. E. & Norton, R. S., 2002, In : Journal of Molecular Biology. 315, 5, p. 1219-1229 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges

Yao, S., Smith-White, M. A., Potter, E. K. & Norton, R. S., 23 May 2002, In : Journal of Medicinal Chemistry. 45, 11, p. 2310-2318 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of D-Pro14 melittin

Hewish, D. R., Barnham, K. J., Werkmeister, J. A., Kirkpatrick, A., Bartone, N., Liu, S. T., Norton, R. S., Curtain, C. & Rivett, D. E., 2002, In : Journal of Protein Chemistry. 21, 4, p. 243-253 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif

Miles, L. A., Dy, C. Y., Nielsen, J., Barnham, K. J., Hinds, M. G., Olivera, B. M., Bulaj, G. & Norton, R. S., 8 Nov 2002, In : Journal of Biological Chemistry. 277, 45, p. 43033-43040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)

Nair, M., Hinds, M. G., Coley, A. M., Hodder, A. N., Foley, M., Anders, R. F. & Norton, R. S., 2002, In : Journal of Molecular Biology. 322, 4, p. 741-753 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

A helical capping motif in ShK toxin and its role in helix stabilization

Lanigan, M. D., Tudor, J. E., Pennington, M. W. & Norton, R. S., 2001, In : Biopolymers. 58, 4, p. 422-436 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer's disease amyloid- binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

Curtain, C. C., Ali, F., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Masters, C. L., Bush, A. I. & Barnham, K. J., 2001, In : Journal of Biological Chemistry. 276, 23, p. 20466 - 20473 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Antiviral Activity and Structural Characteristics of the Nonglycosylated Central Subdomain of Human Respiratory Syncytial Virus Attachment (G) Glycoprotein

Gorman, J. J., McKimm-Breschkin, J. L., Norton, R. S. & Barnham, K. J., 19 Oct 2001, In : Journal of Biological Chemistry. 276, 42, p. 38988-38994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Assignment of 1H, 13C and 15N resonances of domain III of the ectodomain of apical membrane antigen 1 from Plasmodium falciparum [5]

Nair, M., Hodder, A. N., Hinds, M. G., Anders, R. F. & Norton, R. S., 2001, In : Journal of Biomolecular NMR. 19, 1, p. 85-86 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator

Corzo, G., Escoubas, P., Villegas, E., Barnham, K. J., He, W., Norton, R. S. & Nakajima, T., 1 Oct 2001, In : Biochemical Journal. 359, 1, p. 35-45 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and synthesis of type-III mimetics of ω-conotoxin GVIA

Baell, J. B., Forsyth, S. A., Gable, R. W., Norton, R. S. & Mulder, R. J., 2001, In : Journal of Computer-Aided Molecular Design. 15, 12, p. 1119-1136 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Designed peptide analogues of the potassium channel blocker ShK toxin

Lanigan, M. D., Pennington, M. W., Lefievre, Y., Rauer, H. & Norton, R. S., 25 Dec 2001, In : Biochemistry. 40, 51, p. 15528-15537 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Potassium channels in T lymphocytes: Toxins to therapeutic immunosuppressants

George Chandy, K., Cahalan, M., Pennington, M., Norton, R. S., Wulff, H. & Gutman, G. A., 2001, In : Toxicon. 39, 9, p. 1269-1276 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Val-210-I1e pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrPC

Thompson, A. J., Barnham, K. J., Norton, R. S. & Barrow, C. J., 12 Jan 2001, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1544, 1-2, p. 242-254 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Backbone dynamics measurements on leukemia inhibitory factor, a rigid four-helical bundle cytokine

Yao, S., Smith, D. K., Hinds, M. G., Zhang, J. G., Nicola, N. A. & Norton, R. S., 2000, In : Protein Science. 9, 4, p. 671-682 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Letter to the editor: Sequence-specific resonance assignments of the potent cytolysin equinatoxin II [2]

Zhang, W., Hinds, M. G., Anderluh, G., Hansen, P. E. & Norton, R. S., 2000, In : Journal of Biomolecular NMR. 18, 3, p. 281-282 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Peptide self-association in aqueous trifluoroethanol monitored by pulsed field gradient NMR diffusion measurements

Yao, S., Howlett, G. J. & Norton, R. S., 2000, In : Journal of Biomolecular NMR. 16, 2, p. 109-119 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca2+-activated over voltage-gated K+ channels

Rauer, H., Lanigan, M. D., Pennington, M. W., Aiyar, J., Ghanshani, S., Cahalan, M. D., Norton, R. S. & George Chandy, K., 14 Jan 2000, In : Journal of Biological Chemistry. 275, 2, p. 1201-1208 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis- Trans isomerism

Pallaghy, P. K., He, W., Jimenez, E. C., Olivera, B. M. & Norton, R. S., 24 Oct 2000, In : Biochemistry. 39, 42, p. 12845-12852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The cyclic contryphan motif CPxXPXC, a robust scaffold potentially useful as an ω mimic

Pallaghy, P. K. & Norton, R. S., Sep 2000, In : Biopolymers. 54, 3, p. 173-179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The single mutation Phe173 → Ala induces a molten globule-like state in murine interleukin-6

Matthews, J. M., Norton, R. S., Hammacher, A. & Simpson, R. J., 29 Feb 2000, In : Biochemistry. 39, 8, p. 1942-1950 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

1H NMR study of robustoxin, the lethal neurotoxin from the funnel web spider Atrax robustus

Temple, M. D., Hinds, M. G., Sheumack, D. D., Howden, M. E. H. & Norton, R. S., Mar 1999, In : Toxicon. 37, 3, p. 485-506 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Erratum: Roles of key functional groups in ω-conotoxin GVIA. Synthesis, structure and functional assay of selected peptide analogues (European Journal of Biochemistry (1999) 262 (447-455))

Flinn, J. P., Pallaghy, P. K., Lew, M. J., Murphy, R., Angus, J. A. & Norton, R. S., 15 Aug 1999, In : European Journal of Biochemistry. 264, 1, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: Relationship to biological activity

Barnham, K. J., Catalfamo, F., Pallaghy, P. K., Howlett, G. J. & Norton, R. S., 16 Nov 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1435, 1-2, p. 127-137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Polypeptide ω-conotoxin GVIA as a basis for new analgesic and neuroprotective agents

Norton, R. S., Pallaghy, P. K., Baell, J. B., Wright, C. E., Lew, M. J. & Angus, J. A., 1999, In : Drug Development Research. 46, 3-4, p. 206-218 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Refined solution structure of ω-conotoxin GVIA: Implications for calcium channel binding

Pallaghy, P. K. & Norton, R. S., 1999, In : Journal of Peptide Research. 53, 3, p. 343-351 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin

Pennington, M. W., Lanigan, M. D., Kalman, K., Mahnir, V. M., Rauer, H., McVaugh, C. T., Behm, D., Donaldson, D., Chandy, K. G., Kem, W. R. & Norton, R. S., 2 Nov 1999, In : Biochemistry. 38, 44, p. 14549-14558 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of disulfide bridges in the folding, structure and biological activity of ω-conotoxin GVIA

Flinn, J. P., Pallaghy, P. K., Lew, M. J., Murphy, R., Angus, J. A. & Norton, R. S., 14 Sep 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1434, 1, p. 177-190 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Roles of key functional groups in ω-conotoxin GVIA: Synthesis, structure and functional assay of selected peptide analogues

Flinn, J. P., Pallaghy, P. K., Michael J, L., Murphy, R., Angus, J. A. & Norton, R. S., 1 Jun 1999, In : European Journal of Biochemistry. 262, 2, p. 447-455 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Sea anemone toxins as templates for the design of immunosuppressant drugs

Kem, W. R., Pennington, M. W. & Norton, R. S., 1999, In : Perspectives in Drug Discovery and Design. 15-16, p. 111-129 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

Hinds, M. G., Norton, R. S., Vaux, D. L. & Day, C. L., 1999, In : Nature Structural Biology. 6, 7, p. 648-651 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing d-tryptophan: Comparison with protein loops

Pallaghy, P. K., Melnikova, A. P., Jimenez, E. C., Olivera, B. M. & Norton, R. S., 31 Aug 1999, In : Biochemistry. 38, 35, p. 11553-11559 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Assignment of 1H and 15N resonances of murine Tec SH3 domain

Pursglove, S. E., Mulhern, T. D., Hinds, M. G., Norton, R. S. & Booker, G. W., 1998, In : Journal of Biomolecular NMR. 12, 3, p. 461-462 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Helical structure of polypeptides from the C-terminal half of HIV-1 VPR

Yao, S., Azad, A. A., Macreadie, I. G. & Norton, R. S., 1998, In : Protein and Peptide Letters. 5, 3, p. 127-134 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Improved Estimation of Protein Rotational Correlation Times from 15N Relaxation Measurements

Yao, S., Hinds, M. G. & Norton, R. S., 1998, In : Journal of Magnetic Resonance. 131, 2, p. 347-350 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

Tudor, J. E., Pennington, M. W. & Norton, R. S., 15 Jan 1998, In : European Journal of Biochemistry. 251, 1-2, p. 133-141 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor

Barnham, K. J., Torres, A. M., Alewood, D., Alewood, P. F., Domagala, T., Nice, E. C. & Norton, R. S., 1998, In : Protein Science. 7, 8, p. 1738-1749 12 p.

Research output: Contribution to journalArticleResearchpeer-review