Raymond Norton

Professor

1971 …2021
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Research Output 1971 2019

2008

Coarse-grained dynamics of the receiver domain of NtrC: Fluctuations, correlations and implications for allosteric cooperativity

Liu, M. S., Todd, B. D., Yao, S., Feng, Z. P., Norton, R. S. & Sadus, R. J., Oct 2008, In : Proteins: Structure, Function and Genetics. 73, 1, p. 218-227 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptides targeting voltage-gated calcium channels

Norton, R. S. & McDonough, S. I., 2008, In : Current Pharmaceutical Design. 14, 24, p. 2480 - 2491 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein effective rotational correlation times from translational self-diffusion coefficients measured by PFG-NMR

Yao, S., Babon, J. J. & Norton, R. S., Aug 2008, In : Biophysical Chemistry. 136, 2-3, p. 145-151 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2

Zhang, X., Perugini, M. A., Yao, S., Adda, C. G., Murphy, V. J., Low, A., Anders, R. F. & Norton, R. S., 2008, In : Journal of Molecular Biology. 379, 1, p. 105 - 121 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7

Fiedler, B., Zhang, M. M., Buczek, O., Azam, L., Bulaj, G., Norton, R. S., Olivera, B. M. & Yoshikami, D., 15 Jun 2008, In : Biochemical Pharmacology. 75, 12, p. 2334-2344 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure, dynamics, and selectivity of the sodium channel blocker u-conotoxin SIIIA

Yao, S., Zhang, M., Yoshikami, D., Azam, L., Olivera, B. M., Bulaj, G. & Norton, R. S., 2008, In : Biochemistry. 47, 41, p. 10940 - 10949 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

Beeton, C., Smith, B. J., Sabo, J. K., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Chandy, G. K., Pennington, M. W. & Norton, R. S., 2008, In : Journal of Biological Chemistry. 283, 2, p. 988 - 997 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Miles, A. J., Drechsler, A., Kristan, K., Anderluh, G., Norton, R. S., Wallace, B. A. & Separovic, F., Oct 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 10, p. 2091-2096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2008, In : Journal of Molecular Biology. 381, 4, p. 928 - 940 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Tyrosine modification enhances metal-ion binding

Baldwin, G. S., Bailey, M. F., Shehan, B. P., Sims, I. & Norton, R. S., 15 Nov 2008, In : Biochemical Journal. 416, 1, p. 77-84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils

Yang, X., Adda, C. G., Keizer, D. W., Murphy, V. J., Rizkalla, M. M., Perugini, M. A., Jackson, D. C., Anders, R. F. & Norton, R. S., Dec 2007, In : Journal of Peptide Science. 13, 12, p. 839-848 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Conotoxins Containing Nonnatural Backbone Spacers: Cladistic-Based Design, Chemical Synthesis, and Improved Analgesic Activity

Green, B. R., Catlin, P., Zhang, M. M., Fiedler, B., Bayudan, W., Morrison, A., Norton, RS. S., Smith, B. J., Yoshikami, D., Olivera, B. M. & Bulaj, G., 20 Apr 2007, In : Chemistry and Biology. 14, 4, p. 399-407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding

Kuang, Z., Yao, S., McNeil, K. A., Thompson, J. A., Bach, L. A., Forbes, B. E., Wallace, J. C. & Norton, R. S., 2007, In : Biochemistry. 46, 48, p. 13720 - 13732 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Structure and sodium channel activity of an excitatory I 1-superfamily conotoxin (Biochemistry (2007) 46, 35, (9929-9940))

Buczek, O., Wei, D., Babon, J. J., Yang, X., Fiedler, B., Chen, P., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 6 Nov 2007, In : Biochemistry. 46, 44, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Merozoite surface protein 2 of Plasmodium falciparum: Expression, structure, dynamics, and fibril formation of the conserved N-terminal domain

Low, A., Chandrashekaran, I. R., Adda, C. G., Yao, S., Sabo, J. K., Zhang, X., Soetopo, A., Anders, R. F. & Norton, R. S., Sep 2007, In : Biopolymers. 87, 1, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue

Sabo, J. K., Keizer, D. W., Feng, Z. P., Casey, J. L., Parisi, K., Coley, A. M., Foley, M. & Norton, R. S., Jan 2007, In : Infection and Immunity. 75, 1, p. 61-73 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Reducing overfitting in predicting intrinsically unstructured proteins

Han, P., Zhang, X., Norton, R. S. & Feng, Z., 2007, Advances in Knowledge Discovery and Data Mining - 11th Pacific-Asia Conference, PAKDD 2007, Proceedings. Vol. 4426 LNAI. p. 515-522 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4426 LNAI).

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Corzo, G., Sabo, J. K., Bosmans, F., Billen, B., Villegas, E., Tytgat, J. & Norton, R. S., 16 Feb 2007, In : Journal of Biological Chemistry. 282, 7, p. 4643-4652 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Insights into the Interaction of Insulin-like Growth Factor 2 with IGF2R Domain 11

Williams, C., Rezgui, D., Prince, S. N., Zaccheo, O. J., Foulstone, E. J., Forbes, B. E., Norton, R. S., Crosby, J., Hassan, A. B. & Crump, M. P., 11 Sep 2007, In : Structure. 15, 9, p. 1065-1078 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure/function characterization of μ-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels

Zhang, M. M., Green, B. R., Catlin, P., Fiedler, B., Azam, L., Chadwick, A., Terlau, H., McArthur, J. R., French, R. J., Gulyas, J., Rivier, J. E., Smith, B. J., Norton, R. S., Olivera, B. M., Yoshikami, D. & Bulaj, G., 19 Oct 2007, In : Journal of Biological Chemistry. 282, 42, p. 30699-30706 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and sodium channel activity of an excitatory I 1-superfamily conotoxin

Buczek, O., Wei, D., Babon, J. J., Yang, X., Fiedler, B., Chen, P., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 4 Sep 2007, In : Biochemistry. 46, 35, p. 9929-9940 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

Chandrashekaran, I. R., Yao, S., Wang, C. C., Bansal, P. S., Alewood, P. F., Forbes, B., Wallace, J. C., Bach, L. A. & Norton, R. S., 2007, In : Biochemistry. 46, 11, p. 3065 - 3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes

Feng, Z. P., Zhang, X., Han, P., Arora, N., Anders, R. F. & Norton, R. S., Dec 2006, In : Molecular and Biochemical Parasitology. 150, 2, p. 256-267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Conotoxins down under

Norton, R. S. & Olivera, B. M., 1 Dec 2006, In : Toxicon. 48, 7, p. 780-798 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops

Yao, S., Liu, M. S., Masters, S. L., Zhang, J. G., Babon, J. J., Nicola, N. A., Nicholson, S. E. & Norton, R. S., Dec 2006, In : Protein Science. 15, 12, p. 2761-2772 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels (Biochemistry (May 17, 2005) 44, 19 (7259-7265))

Bulaj, G., West, P. J., Garrett, J. E., Watkins, M., Zhang, M. M., Norton, R. S., Smith, B. J., Yoshikami, D. & Olivera, B. M., 7 Mar 2006, In : Biochemistry. 45, 9, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Predicting disordered regions in proteins based on decision trees of reduced amino acid composition

Han, P., Zhang, X., Norton, R. S. & Feng, Z. P., Nov 2006, In : Journal of Computational Biology. 13, 9, p. 1579-1590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Predicting disordered regions in proteins based on decision trees of reduced amino acid composition

Han, P., Zhang, X., Norton, R. S. & Feng, Z. P., Dec 2006, In : Journal of Computational Biology. 13, 10, p. 1723-1734 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Sea Anemone Venom Peptides

Norton, R. S., 2006, Handbook of Biologically Active Peptides. Academic Press, p. 363-367 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)

Kuang, Z., Yao, S., Keizer, D. W., Wang, C. C., Bach, L. A., Forbes, B., Wallace, J. C. & Norton, R. S., 2006, In : Journal of Molecular Biology. 364, 4, p. 690 - 704 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II

Drechsler, A., Potrich, C., Jennifer, J., Frisanco, M., Guella, G., Serra, M. D., Anderluh, G., Separovic, F. & Norton, R., 2006, In : Biochemistry. 45, 6, p. 1818 - 1828 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

Masters, S., Yao, S., Willson, T., Zhang, J-G., Palmer, K., Smith, B., Babon, J., Nicola, N., Norton, R. & Nicholson, S., 2006, In : Nature Structural and Molecular Biology. 13, 1, p. 77 - 84 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability

Babon, J., McManus, E., Yao, S., De Souza, D. P., Mielke, L., Sprigg, N., Willson, T., Hilton, D., Nicola, N., Baca, M., Nicholson, S. & Norton, R., 2006, In : Molecular Cell. 22, p. 205 - 216 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Toxinology in Australia-Pioneers to Frontiers

Norton, R. S. & Winkel, K. D., 1 Dec 2006, In : Toxicon. 48, 7, 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

2005

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

Lauth, X., Babon, J., Stannard, J., Singh, S., Nizet, V., Carlberg, J., Ostland, V., Pennington, M., Norton, R. & Westerman, M., 2005, In : Journal of Biological Chemistry. 280, 10, p. 9272 - 9282 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1

Harris, K., Casey, J., Coley, A., Masciantonio, R., Sabo, J. K., Keizer, D., Lee, E., McMahon, A., Norton, R., Anders, R. & Foley, M., 2005, In : Infection and Immunity. 73, 10, p. 6981 - 6989 9 p.

Research output: Contribution to journalArticleResearchpeer-review

IGF-binding proteins - The pieces are falling into place

Bach, L. A., Headey, S. & Norton, R. S., 2005, In : Trends in Endocrinology and Metabolism. 16, 5, p. 228 - 234 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance

Carrick, F., Hinds, M., McNeil, K., Wallace, J., Forbes, B. & Norton, R., 2005, In : Journal of Molecular Endocrinology. 34, p. 685 - 698 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: 19F NMR studies

Anderluh, G., Razpotnik, A., Podlesek, Z., Macek, P., Separovic, F. & Norton, R., 2005, In : Journal of Molecular Biology. 347, 1, p. 27 - 39 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2) [4]

Yao, S., Masters, S., Zhang, J-G., Palmer, K., Nicola, N., Babon, J., Nicholson, S. & Norton, R., 2005, In : Journal of Biomolecular NMR. 31, p. 69 - 70 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

Bulaj, G., West, P., Garrett, J., Watkins, M., Zhang, M-M., Norton, R., Smith, B., Yoshikami, D. & Olivera, B., 2005, In : Biochemistry. 44, 19, p. 7259 - 7265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

Babon, J., Yao, S., De Souza, D. P., Harrison, C., Fabri, L., Liepinsh, E., Scrofani, S., Baca, M. & Norton, R., 2005, In : FEBS Journal. 272, 23, p. 6120 - 6130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

Denley, A., Wang, C., McNeil, K., Walenkamp, M., Duyvenvoorde, H., Wit, J., Wallace, J., Norton, R., Karperien, M. & Forbes, B., 2005, In : Journal of Clinical Endocrinology and Metabolism. 19, 3, p. 711 - 721 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1

Feng, Z-P., Keizer, D., Stevenson, R., Yao, S., Babon, J., Murphy, V., Anders, R. & Norton, R., 2005, In : Journal of Molecular Biology. 350, 4, p. 641 - 656 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling

Fairlie, W., Uboldi, A., McCoubrie, J., Wang, C., Lee, E., Yao, S., De Souza, D. P., Mifsud, S., Metcalf, D., Nicola, N., Norton, R. & Baca, M., 2004, In : Journal of Biological Chemistry. 279, 3, p. 2125 - 2134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions

Headey, S., Keizer, D. W., Yao, S., Wallace, J. C., Bach, L. A. & Norton, R. S., 2004, In : FEBS Letters. 568, 1-3, p. 19 - 22 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Biological activity and ferric ion binding of fragments of glycine-extended gastrin

He, H., Shehan, P., Barnham, K., Norton, R., Shulkes, A. & Baldwin, G., 2004, In : Biochemistry. 43, 37, p. 11853 - 11861 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding

Headey, S., Leeding, K. S., Norton, R. & Bach, L. A., 2004, In : Journal of Molecular Endocrinology. 33, 2, p. 377 - 386 10 p.

Research output: Contribution to journalArticleResearchpeer-review

C-terminal domain of insulin-like growth factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding

Yao, S., Headey, S., Keizer, D. W., Bach, L. A. & Norton, R. S., 2004, In : Biochemistry. 43, 35, p. 11187 - 11195 9 p.

Research output: Contribution to journalArticleResearchpeer-review

C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

Headey, S., Keizer, D. W., Yao, S., Brasier, G., Kantharidis, P., Bach, L. A. & Norton, R. S., 2004, In : Molecular Endocrinology. 18, 11, p. 2740 - 2750 11 p.

Research output: Contribution to journalArticleResearchpeer-review