Raymond Norton

Professor

1971 …2021
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Research Output 1971 2019

2012

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Pennington, M. W., Rashid, M. H., Tajhya, R. B., Beeton, C., Kuyucak, S. & Norton, R. S., 2012, In : FEBS Letters. 586, 22, p. 3996 - 4001 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Ye, M., Khoo, K. K., Xu, S., Zhou, M., Boonyalai, N., Chi, C., Galea, C., Wang, C. & Norton, R. S., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14973 - 14983 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2

Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J. G., Norton, R. S. & Anders, R., 2012, In : Infection and Immunity. 80, 12, p. 4177 - 4185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Chi, V., Pennington, M. W., Norton, R. S., Tarcha, E. J., Londono, L. M., Sims-Fahey, B., Upadhyay, S. K., Lakey, J. T., Iadonato, S., Wulff, H., Beeton, C. & Chandy, K. G., 2012, In : Toxicon : official journal of the International Society on Toxinology. 59, 4, p. 529 - 546 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct disulfide isomers of u-conotoxins KIIIA and KIIIB block voltage-gated sodium channels

Khoo, K. K., Gupta, K., Green, B. R., Zhang, M-M., Watkins, M., Olivera, B. M., Balaram, P., Yoshikami, D., Bulaj, G. & Norton, R. S., 2012, In : Biochemistry. 51, 49, p. 9826 - 9835 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Chang, S. C., Galea, C., Leung, E. W. W., Tajhya, R. B., Beeton, C., Pennington, M. W. & Norton, R. S., 2012, In : Toxicon : official journal of the International Society on Toxinology. 60, 5, p. 840 - 850 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain

Galea, C., Mobli, M., McNeil, K. A., Mulhern, T. D., Wallace, J. C., King, G. F., Forbes, B. & Norton, R. S., 2012, In : Biochimie. 94, 3, p. 608 - 616 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-like growth factor binding proteins: a structural perspective

Forbes, B., McCarthy, P. & Norton, R. S., 2012, In : Frontiers in Endocrinology. 3, 38, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Lipid interactions of the malaria antigen merozoite surface protein 2

MacRaild, C. A., Pedersen, M. O., Anders, R. F. & Norton, R. S., 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2572 - 2578 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of the helical structure of the N-terminal region of plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interaction

Zhang, X., Adda, C. G., Low, A., Zhang, J., Zhang, W., Sun, H., Tu, X., Anders, R. F. & Norton, R. S., 2012, In : Biochemistry. 51, 7, p. 1380 - 1387 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S. & Nicola, N. A., 2012, In : Immunity. 36, 2, p. 239 - 250 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Feng, Z-P., Chandrashekaran, I. R., Low, A., Speed, T. P., Nicholson, S. E. & Norton, R. S., 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 3, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

Robinson, M., Donnelly, S., Hutchinson, A., To, J., Taylor, N., Norton, R., Perugini, M. & Dalton, J., 2011, In : PLoS Pathogens. 7, 5, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Beeton, C., Pennington, M. & Norton, R., 2011, In : Inflammation & Allergy - Drug Targets. 10, 5, p. 313 - 321 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Apical membrane antigen 1 as an anti-malarial drug target

MacRaild, C., Anders, R., Foley, M. & Norton, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 16, p. 2039 - 2047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I., Adda, C., MacRaild, C., Anders, R. & Norton, R., 2011, In : Archives of Biochemistry and Biophysics. 513, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D (1)H-(15)N heteronuclear correlation spectra acquired with band-selective pulses

Yao, S., Hinds, M., Murphy, J. & Norton, R., 2011, In : Journal of Magnetic Resonance. 211, 2, p. 243 - 247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Lactam-stabilized helical analogues of the analgesic mu-conotoxin KIIIA

Khoo, K., Wilson, M., Smith, B., Zhang, M-M., Gulyas, J., Yoshikami, D., Rivier, J., Bulaj, G. & Norton, R., 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7558 - 7566 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution

Yao, S., Young, I., Norton, R. & Murphy, J., 2011, In : Biochemistry. 50, 13, p. 2464 - 2477 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues

Lee, E., Yao, S., Sabo, J., Fairlie, W., Stevenson, R., Harris, K., Anders, R., Foley, M. & Norton, R., 2011, In : Biopolymers. 95, 5 (SI), p. 354 - 364 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Peroxidase catalysed cross-Linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima

Mai, K., Smith, N., Feng, Z-P., Katrib, M., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., Norton, R. & Belli, S., 2011, In : International Journal for Parasitology. 41, 11, p. 1157 - 1164 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Redefining the SPRY/B30.2 domain and investigating its binding specificities

D'Cruz, A., Young, H. (ed.), Linossi, E., Tan, S-L. (ed.), Babon, J., Norton, R., Nicola, N. & Nicholson, S., 2011, p. 64 - 64. 1 p.

Research output: Contribution to conferenceAbstractOther

Role of Disulfide Bonds in Peptide and Protein Conformation

Khoo, K. & Norton, R. S., 2011, Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides. Hughes, A. B. (ed.). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 5. p. 395-417 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

File

Structure and Activity of N-Methylated Peptides

Norton, R., 28 Nov 2011, Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides. Hughes, A. B. (ed.). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 5. p. 155-166 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

File

TLR regulation of SPSB1 controls inducible nitric oxide synthase induction

Lewis, R., Kolesnik, T., Kuang, Z., D'Cruz, A., Blewitt, M., Masters, S., Low, A., Willson, T., Norton, R. & Nicholson, S., 2011, In : Journal of Immunology. 187, 7, p. 3798 - 3805 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity

Yao, S., Murphy, J., Low, A. & Norton, R., 2010, In : Biomolecular NMR Assignments. 4, 1, p. 73 - 77 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of key residues involved in fibril formation by the conserved N-terminal region of plasmodium falciparum merozoite surface protein 2 (MSP2)

Yang, X., Adda, C. G., MacRaild, C. A., Low, A., Zhang, X., Zeng, W., Jackson, D. C., Anders, R. F. & Norton, R. S., 2010, In : Biochimie. 92, 10, p. 1287 - 1295 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition by flavonoids of amyloid-like fibril formation by plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I. R., Adda, C. G., MacRaild, C. A., Anders, R. F. & Norton, R. S., 2010, In : Biochemistry. 49, 28, p. 5899 - 5908 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites

Richard, D., MacRaild, C. A., Riglar, D. T., Chan, J-A., Foley, M., Baum, J., Ralph, S. A., Norton, R. S. & Cowman, A. F., 2010, In : Journal of Biological Chemistry. 285, 19, p. 14815 - 14822 8 p.

Research output: Contribution to journalArticleResearchpeer-review

mu-Conotoxins as leads in the development of new analgesics

Norton, R. S., 2010, In : Molecules. 15, 4, p. 2825 - 2844 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Potassium channel gating: Not an open and shut case

Norton, R. S. & Gulbis, J. M., 2010, In : Proceedings of the National Academy of Sciences. 107, 17, p. 7623 - 7624 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Potassium channel modulation by a toxin domain in matrix metalloprotease 23

Rangaraju, S., Khoo, K. K., Feng, Z-P., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Pham, C., Calabresi, P., Pennington, M. W., Norton, R. S. & Chandy, K. G., 2010, In : Journal of Biological Chemistry. 285, 12, p. 9124 - 9136 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Recombinant protein vaccines against the asexual blood-stages of Plasmodium falciparum

Anders, R. F., Adda, C. G., Foley, M. & Norton, R. S., 1 Jan 2010, In : Human Vaccines. 6, 1, p. 39 - 53 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Solid-state NMR and simulation studies of equinatoxin II N-terminus interaction with lipid bilayers

Lam, Y., Hung, A., Norton, R. S., Separovic, F. & Watts, A., 2010, In : Proteins: Structure, Function, and Bioinformatics. 78, 4, p. 858 - 872 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Solid-state NMR study of membrane interactions of the pore-forming cytolysin, equinatoxin II

Drechsler, A., Anderluh, G., Norton, R. S. & Separovic, F., 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 2, p. 244 - 251 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

Filippakopoulos, P., Low, A., Sharpe, T. D., Uppenberg, J., Yao, S., Kuang, Z., Savitsky, P., Lewis, R. S., Nicholson, S. E., Norton, R. S. & Bullock, A. N., 2010, In : Journal of Molecular Biology. 401, 3, p. 389 - 402 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Kuang, Z., Lewis, R. S., Curtis, J. M., Zhan, Y., Saunders, B. M., Babon, J. J., Kolesnik, T. B., Low, A., Masters, S. L., Willson, T. A., Kedzierski, L., Yao, S., Handman, E., Norton, R. S. & Nicholson, S. E., 2010, In : Journal of Cell Biology. 190, 1, p. 129 - 141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Effect of lipid on the conformation of the N-terminal region of equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Drechsler, A., Miles, A. J., Norton, R. S., Wallace, B. A. & Separovic, F., Jan 2009, In : European Biophysics Journal. 39, 1, p. 121-127 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

Pennington, M. W., Beeton, C., Galea, C., Smith, B. J., Chi, V., Monaghan, K. P., Garcia, A., Rangaraju, S., Giuffrida, A., Plank, D. K., Crossley, G., Nugent, D., Khaytin, I., LeFievre, Y., Peshenko, I., Dixon, C., Chauhan, S., Orzel, A., Inoue, T., Hu, X. & 3 othersMoore, R. V., Norton, R. S. & Chandy, K. G., 2009, In : Molecular Pharmacology. 75, 4, p. 762 - 773 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-like growth factor-I (IGF-I): Solution properties and NMR chemical shift assignments near physiological pH

Kuang, Z., Yao, S., McNeil, K. A., Forbes, B. E., Wallace, J. C. & Norton, R. S., 2009, In : Growth Hormone and IGF Research. 19, 3, p. 226 - 231 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Large-scale prediction of long disordered regions in proteins using random forests

Han, P., Zhang, X., Norton, R. S. & Feng, Z-P., 9 Jan 2009, In : BMC Bioinformatics. 10, 8.

Research output: Contribution to journalArticleResearchpeer-review

Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

Harris, K. S., Casey, J. L., Coley, A. M., Karas, J., Sabo, J. K., Tan, Y. Y., Dolezal, O., Norton, R. S., Hughes, A. B., Scanlon, D. & Foley, M., 2009, In : Journal of Biological Chemistry. 284, 14, p. 9361 - 9371 11 p.

Research output: Contribution to journalArticleResearchpeer-review

SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding

Kuang, Z., Yao, S., Xu, Y., Lewis, R. S., Low, A., Masters, S. L., Willson, T. A., Kolesnik, T. B., Nicholson, S. E., Garrett, T. PJ. & Norton, R. S., 2009, In : Journal of Molecular Biology. 386, 3, p. 662 - 674 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an a-conotoxin containing a nonreducible cystine analogue

MacRaild, C. A., Illesinghe, J., Van Lierop, B. J., Townsend, A. L., Chebib, M., Livett, B. G., Robinson, A. J. & Norton, R. S., 2009, In : Journal of Medicinal Chemistry. 52, 3, p. 755 - 762 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the analgesic u-conotoxin KIIIA and effects on the structure and function of disulfide deletion

Khoo, K. K., Feng, Z-P., Smith, B. J., Zhang, M., Yoshikami, D., Olivera, B. M., Bulaj, G. & Norton, R. S., 2009, In : Biochemistry. 48, 6, p. 1210 - 1219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structures of sea anemone toxins

Norton, R. S., 2009, In : Toxicon : official journal of the International Society on Toxinology. 54, 8, p. 1075 - 1088 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The SOCS box encodes a hierarchy of affinities for cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression

Babon, J. J., Sabo, J. K., Zhang, J-G., Nicola, N. A. & Norton, R. S., 2009, In : Journal of Molecular Biology. 387, 1, p. 162 - 174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms

Fry, B. G., Roelants, K., Champagne, D. E., Scheib, H., Tyndall, J. D. A., King, G. F., Nevalainen, T. J., Norman, J. A., Lewis, R. J., Norton, R. S., Renjifo, C. & Rodríguez De La Vega, R. C., Sep 2009, In : Annual Review of Genomics and Human Genetics. 10, p. 483-511 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2008

a-RgIA, a novel conotoxin that blocks the a9a10 nAChR: Structure and identification of key receptor-binding residues

Ellison, M., Feng, Z-P., Park, A. J., Zhang, X., Olivera, B. M., McIntosh, J. M. & Norton, R. S., 2008, In : Journal of Molecular Biology. 377, 4, p. 1216 - 1227 12 p.

Research output: Contribution to journalArticleResearchpeer-review