1971 …2020

Research output per year

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Research Output

2016

Applications of 19F-NMR in fragment-based drug discovery

Norton, R. S., Leung, E. W. W., Chandrashekaran, I. R. & MacRaild, C. A., 1 Jul 2016, In : Molecules. 21, 7, 13 p., 860.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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36 Citations (Scopus)

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Immunology: Channelling potassium to fight cancer

Chandy, K. G. & Norton, R. S., 14 Sep 2016, In : Nature. 537, 7621, p. 497-499 3 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

11 Citations (Scopus)

Neutron reflection study of the interaction of the eukaryotic pore-forming actinoporin equinatoxin II with lipid membranes reveals intermediate states in pore formation

Wacklin, H. P., Bremec, B. B., Moulin, M., Rojko, N., Haertlein, M., Forsyth, T., Anderluh, G. & Norton, R., 1 Apr 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 4, p. 640-652 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases

Jin, L., Zhou, Q. T., Chan, H-K., Larson, I. C., Pennington, M. W., Morales, R. A. V., Boyd, B. J., Norton, R. S. & Nicolazzo, J. A., 1 Feb 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 650-656 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Krishnarjuna, B., Lim, S. S., Devine, S. M., Debono, C. O., Lam, R., Chandrashekaran, I. R., Jaipuria, G., Yagi, H., Atreya, H. S., Scanlon, M. J., MacRaild, C. A., Scammells, P. J. & Norton, R. S., 1 Jun 2016, In : Journal of Molecular Recognition. 29, 6, p. 281-291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Stereoselective synthesis and structural elucidation of dicarba peptides

Gleeson, E. C., Wang, Z. J., Robinson, S. D., Chhabra, S., MacRaild, C. A., Jackson, W. R., Norton, R. S. & Robinson, A. J., 2016, In : Chemical Communications. 52, 24, p. 4446-4449 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

Krishnarjuna, B., Andrew, D., MacRaild, C. A., Morales, R. A. V., Beeson, J. G., Anders, R. F., Richards, J. S. & Norton, R. S., 11 Feb 2016, In : Scientific Reports. 6, 12 p., 20613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Structural basis for the inhibition of voltage-gated sodium channels by conotoxin μO§-GVIIJ

Green, B. R., Gajewiak, J., Chhabra, S., Skalicky, J. J., Zhang, M. M., Rivier, J. E., Bulaj, G., Olivera, B. M., Yoshikami, D. & Norton, R., 25 Mar 2016, In : The Journal of Biological Chemistry. 291, 13, p. 7205-7220 16 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The ways and means of fragment-based drug design

Doak, B. C., Norton, R. S. & Scanlon, M. J., 1 Nov 2016, In : Pharmacology and Therapeutics. 167, p. 28-37 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2015

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

Jin, L., Boyd, B. J., White, P. J., Pennington, M. W., Norton, R. S. & Nicolazzo, J., 2015, In : Journal of Controlled Release. 199, p. 37 - 44 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Case Study 2: transforming a toxin into a therapeutic: the sea anemone potassium channel blocker ShK toxin for treatment of autoimmune diseases

Norton, R., Pennington, M. W. & Beeton, C., 2015, Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. King, G. F. (ed.). Cambridge UK: The Royal Society of Chemistry, Vol. 2015-January. p. 255-274 20 p. (RSC Drug Discovery Series; no. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

6 Citations (Scopus)

Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2

MacRaild, C. A., Zachrdla, M., Andrew, D. W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J. S., Beeson, J. G., Anders, R. F. & Norton, R. S., 2015, In : PLoS ONE. 10, 3, 18 p., e0119899.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Pennington, M. W., Chang, S. J., Chauhan, S., Huq, R., Tajhya, R. B., Chhabra, S., Norton, R. S. & Beeton, C., 2015, In : Marine Drugs. 13, 1, p. 529 - 542 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Robinson, S., Safavi-Hemami, H., Raghuraman, S. C., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In : Journal of Proteomics. 114, p. 38 - 47 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Enhancing the buccal mucosal delivery of peptide and protein therapeutics

Caon, T., Jin, L., Simoes, M. O. C., Norton, R. S. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 1, p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3

Chang, S. C., Huq, R., Chhabra, S., Beeton, C., Pennington, M. W., Smith, B. J. & Norton, R. S., 2015, In : FEBS Journal. 282, 12, p. 2247-2259 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743 - 1748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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72 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : The Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

De Almeida Vilela Morales, R., MacRaild, C. A., Seow, J. T-J., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R. F., Christ, D., McGowan, S. & Norton, R. S., 2015, In : Scientific Reports. 5, 10 p., 10103 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R. S. & Chill, J. H., 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15130-15137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 1 Oct 2014, In : MedChemComm. 5, 10, p. 1500-1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Activation of Src family tyrosine kinases by ferric ions

Baldwin, G. S., Lio, D. S. S., Ferrand, A., Catimel, B., Shehan, B. P., Norton, R. S. & Cheng, H. C., Mar 2014, In : BBA Proteins and Proteomics. 1844, 3, p. 487-496 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

Kuyucak, S. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1645 - 1658 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Conformational flexibility in the binding surface of the potassium channel blocker ShK

Sher, I., Chang, S. J., Li, Y., Chhabra, S., Palmer III, A. G., Norton, R. S. & Chill, J., 2014, In : ChemBioChem. 15, 16, p. 2402 - 2410 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Conotoxin gene superfamilies

Robinson, S. & Norton, R. S., 2014, In : Marine Drugs. 12, 12, p. 6058 - 6101 44 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
73 Citations (Scopus)

Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B. J., Robinson, S., Kompella, S. N., Hung, A., Callaghan, B., Adams, D. J., Robinson, A. J. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9933 - 9944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
68 Citations (Scopus)

Domain structure and function of matrix metalloprotease 23 (MMP23): Role in potassium channel trafficking

Galea, C., Nguyen, H. M., Chandy, G. K., Smith, B. J. & Norton, R. S., 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1191 - 1210 20 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Interactions of disulfide-deficient selenocysteine analogs of u-conotoxin BuIIIB with the a-subunit of the voltage-gated sodium channel subtype 1.3

Green, B. R., Zhang, M., Chhabra, S., Robinson, S., Wilson, M. J., Redding, A., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2014, In : FEBS Journal. 281, 13, p. 2885 - 2898 14 p.

Research output: Contribution to journalEditorialResearchpeer-review

9 Citations (Scopus)

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

Chhabra, S., Chang, S. J., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W. & 2 others, Norton, R. S. & Chandy, G. K., 2014, In : The FASEB Journal. 28, p. 3952 - 3964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Ge, X., MacRaild, C. A., Devine, S., Debono, C., Wang, G., Scammells, P. J., Scanlon, M., Anders, R. F., Foley, M. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6419 - 6427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

RASP: Rapid and robust backbone chemical shift assignments from protein structure

MacRaild, C. A. & Norton, R. S., 2014, In : Journal of Biomolecular NMR. 58, 3, p. 155 - 163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2013

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)

A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)