1971 …2020

Research output per year

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Research Output

2020

Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

Rodriguez, A., Pedersen, M., Villegas, E., Rivas-Santiago, B., Villegas-Moreno, J., Amero, C., Norton, R. S. & Corzo, G., Jan 2020, In : Proteins: Structure, Function, and Bioinformatics. 88, 1, p. 175-186 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterising functional venom profiles of anthozoans and medusozoans within their ecological context

Ashwood, L. M., Norton, R. S., Undheim, E. A. B., Hurwood, D. A. & Prentis, P. J., 9 Dec 2020, In : Marine Drugs. 18, 4, 19 p., 202.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by the Campylobacter jejuni Chemoreceptor Tlp3

Khan, M. F., Machuca, M. A., Rahman, M. M., Koç, C., Norton, R. S., Smith, B. J. & Roujeinikova, A., 11 May 2020, In : Biomolecules. 10, 5, 26 p., 744.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Tentacle Transcriptomes of the Speckled Anemone (Actiniaria: Actiniidae: Oulactis sp.): Venom-Related Components and Their Domain Structure

Mitchell, M. L., Tonkin-Hill, G. Q., Morales, R. A. V., Purcell, A. W., Papenfuss, A. T. & Norton, R. S., Apr 2020, In : Marine Biotechnology. 22, p. 207-219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Single Disulfide-Directed β-Hairpin Fold: Role of Disulfide Bond in Folding and Effect of an Additional Disulfide Bond on Stability

Chittoor, B., Krishnarjuna, B., Morales, R. A. V. & Norton, R. S., Apr 2020, In : Australian Journal of Chemistry. 73, 4, p. 312-320 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Conformational exchange in the potassium channel blocker ShK

Iwakawa, N., Baxter, N. J., Wai, D. C. C., Fowler, N. J., Morales, R. A. V., Sugase, K., Norton, R. S. & Williamson, M. P., 17 Dec 2019, In : Scientific Reports. 9, 1, 8 p., 19307.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2–6, 2018

Battle, A. R., Norton, R. S., Böcking, T., Noji, H., Kim, K. K. & Nagayama, K., 1 Jun 2019, In : Biophysical Reviews. 11, 3, p. 245-247 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

1 Citation (Scopus)

Evolution of cnidarian trans-defensins: Sequence, structure and exploration of chemical space

Mitchell, M. L., Shafee, T., Papenfuss, A. T. & Norton, R. S., 1 Jul 2019, In : Proteins: Structure, Function and Bioinformatics. 87, 7, p. 551-560 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Akter, M., Drinkwater, N., Devine, S. M., Drew, S. C., Krishnarjuna, B., Debono, C. O., Wang, G., Scanlon, M. J., Scammells, P. J., McGowan, S., MacRaild, C. A. & Norton, R. S., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 603-612 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of merozoite surface protein 2 with lipid membranes

Lu, C., Zheng, X., Zhang, W., Zhao, H., MacRaild, C. A., Norton, R. S., Zhuang, Y., Wang, J. & Zhang, X., Feb 2019, In : FEBS Letters. 593, 3, p. 288-295 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mapping the chemical and sequence space of the ShKT superfamily

Shafee, T., Mitchell, M. L. & Norton, R. S., 1 Jul 2019, In : Toxicon. 165, p. 95-102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Modulation of the aggregation of an amyloidogenic sequence by flanking-disordered region in the intrinsically disordered antigen merozoite surface protein 2

Zhang, W., Zhang, J., MacRaild, C. A., Norton, R. S., Anders, R. F. & Zhang, X., 2019, In : European Biophysics Journal. 48, 1, p. 99-110 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Elnahriry, K. A., Wai, D. C. C., Krishnarjuna, B., Badawy, N. N., Chittoor, B., MacRaild, C. A., Williams-Noonan, B. J., Surm, J. M., Chalmers, D. K., Zhang, A. H., Peigneur, S., Mobli, M., Tytgat, J., Prentis, P. & Norton, R. S., 1 Oct 2019, In : Toxicon. 168, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 1 Jan 2019, In : The Journal of Biological Chemistry. 294, 22, p. 8745-8759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2018

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Anti-Infective Peptides to Enhance the Host Innate Response: Design, Development and Delivery

Norton, R. S., 2018, In : Protein and Peptide Letters. 25, 12, p. 1101-1107 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterisation of peptide interactions that regulate PKCε activation

Chandrashekaran, I. R., Norton, R. S. & Schmitz-Peiffer, C., 1 Jan 2018, In : FEBS Letters. 592, 2, p. 179-189 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Corrigendum to “Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK” [Peptides 99 (2018) 169–178](S0196978117303054)(10.1016/j.peptides.2017.10.001)

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., 1 Mar 2018, In : Peptides. 101, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Disordered epitopes as peptide vaccines

MacRaild, C. A., Seow, J., Das, S. C. & Norton, R. S., May 2018, In : Peptide Science. 110, 3, 11 p., e24067.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp.

Sunanda, P., Krishnarjuna, B., Peigneur, S., Mitchell, M. L., Estrada, R., Villegas-Moreno, J., Pennington, M. W., Tytgat, J. & Norton, R. S., 1 Jul 2018, In : Peptide Science. 110, 4, 10 p., e24073.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Peptide therapeutics from venom: Current status and potential

Pennington, M. W., Czerwinski, A. & Norton, R. S., 1 Jun 2018, In : Bioorganic & Medicinal Chemistry. 26, 10, p. 2738-2758 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
61 Citations (Scopus)

Peptide toxin structure and function by NMR

Norton, R. S., 13 Jun 2018, Modern Magnetic Resonance. Webb, G. A. (ed.). Cham Switzerland: Springer, p. 2018-2097 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6 –A11 bond

Ong, S. C., Belgi, A., Van Lierop, B., Delaine, C., Andrikopoulos, S., MacRaild, C. A., Norton, R. S., Haworth, N. L., Robinson, A. J. & Forbes, B. E., 27 Jul 2018, In : The Journal of Biological Chemistry. 293, 30, p. 11928-11943 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Sea anemones: Quiet achievers in the field of peptide toxins

Prentis, P. J., Pavasovic, A. & Norton, R. S., 8 Jan 2018, In : Toxins. 10, 1, 15 p., 36.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
35 Citations (Scopus)

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., Jan 2018, In : Peptides. 99, p. 169–178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Krishnarjuna, B., Villegas-Moreno, J., Mitchell, M. L., Csoti, A., Peigneur, S., Amero, C., Pennington, M. W., Tytgat, J., Panyi, G. & Norton, R. S., 1 Aug 2018, In : Toxicon. 150, p. 50-59 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope

Krishnarjuna, B., Sugiki, T., Morales, R. A. V., Seow, J., Fujiwara, T., Wilde, K. L., Norton, R. S. & MacRaild, C. A., 1 Dec 2018, In : Communications Biology. 1, 1, p. 1-10 10 p., 58.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Venoms to the rescue: Insights into the evolutionary biology of venoms are leading to therapeutic advances

Holford, M., Daly, M., King, G. F. & Norton, R. S., 31 Aug 2018, In : Science. 361, 6405, p. 842-844 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

13 Citations (Scopus)
2017

Antimalarial drug discovery targeting apical membrane antigen 1

Devine, S. M., MacRaild, C. A., Norton, R. S. & Scammells, P. J., 2017, In : MedChemComm. 8, 1, p. 13-20 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Bergmann, R., Kubeil, M., Zarschler, K., Chhabra, S., Tajhya, R. B., Beeton, C., Pennington, M. W., Bachmann, M. H., Norton, R. S. & Stephan, H., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 3756.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Enhancing the therapeutic potential of peptide toxins

Norton, R. S., 3 Jun 2017, In : Expert Opinion on Drug Discovery. 12, 6, p. 611-623 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2

Das, S. C., Morales, R. A. V., Seow, J., Krishnarjuna, B., Dissanayake, R., Anders, R. F., Macraild, C. A. & Norton, R. S., 2017, In : FEBS Journal. 284, 16, p. 649–2662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Molecular insights into the interaction between the SPRY domain-containing SOCS box protein SPSB2 and peptides based on the binding motif from iNOS

Leung, E., Mulcair, M., Yap, S., Nicholson, S. E., Scanlon, M. & Norton, R., 2017, In : Australian Journal of Chemistry. 70, 2, p. 191-200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease

Chandy, G. K. & Norton, R. S., 1 Jun 2017, In : Current Opinion in Chemical Biology. 38, p. 97-107 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Tanner, M. R., Tajhya, R. B., Huq, R., Gehrmann, E. J., Rodarte, K. E., Atik, M. A., Norton, R. S., Pennington, M. W. & Beeton, C., 1 Jul 2017, In : Clinical Immunology. 180, p. 45-57 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Reinvestigation of the biological activity of D-allo-ShK protein

Dang, B., Chhabra, S., Pennington, M. W., Norton, R. S. & Kent, S. B. H., 2017, In : The Journal of Biological Chemistry. 292, 30, p. 12599-12605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2016

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural & Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Applications of 19F-NMR in fragment-based drug discovery

Norton, R. S., Leung, E. W. W., Chandrashekaran, I. R. & MacRaild, C. A., 1 Jul 2016, In : Molecules. 21, 7, 13 p., 860.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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35 Citations (Scopus)