Personal profile
Biography
Professor Ray Norton holds a personal chair at the Monash Institute of Pharmaceutical Sciences, Melbourne, Australia. He obtained his PhD in chemistry from the Australian National University and undertook postdoctoral studies in the US before returning to Australia as a QEII Fellow at the Roche Research Institute of Marine Pharmacology in Sydney. His lab at Monash employs a range of biophysical approaches, including NMR, SPR, ITC and X-ray crystallography, as well as molecular modelling and design, in studies of peptides and proteins from venomous organisms. One of the venom-derived peptides he works with has completed Phase 1 clinical trial for autoimmune diseases and another is the basis for development of ultra-rapid acting insulins that are currently undergoing preclinical evaluation. He is also designing small cyclic peptides that show promise as anti-infective agents with a novel mechanism of action. In addition, his lab applies a combination of structure-based and fragment-based drug discovery programs to protein targets in the areas of infectious and parasitic diseases, graft rejection and metabolic diseases. Ray Norton has published over 380 articles, received numerous national awards, and is an inventor on more than 10 patents. His h-factor is 67 and his papers have been cited > 17,400 times (Google Scholar). He leads a group of more than 15 researchers and has been successful in attracting funding from NHMRC, ARC, Wellcome, Diabetes Australia and NIH. He was recently elected a Fellow of the International Society of Magnetic Resonance. He is Chair of the Council of the International Conference on Magnetic Resonance in Biological Systems (ICMRBS) and a member of the Council of the International Society on Toxinology.
Monash teaching commitment
Bachelor of Pharmaceutical Science teaching
- BPS3231 - Advanced Experimental Spectroscopy
- PSC3131 - Analysis of Drug Receptor Interactions
- PSC3432 - Medicinal Chemistry Research Project
- PSC1041 - Scientific Discoveries
Education/Academic qualification
Chemistry, PhD, Australian National University (ANU)
Biochemistry, BSc (Honours), University of Melbourne
Research area keywords
- Peptide Drugs
- Peptide toxins
- Proteins
- Ion channels
- Auto-immunity
- Innate Immunity
- Malaria
- NMR spectroscopy and biochemistry
- Biophysics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 14 Life Below Water
Collaborations and top research areas from the last five years
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EPTIC: EPTIC: Engineered peptides to target ion channels
Panyi, G. (Primary Chief Investigator (PCI)), Norton, R. (Chief Investigator (CI)), Wai, D. (Chief Investigator (CI)), Nicolazzo, J. (Chief Investigator (CI)), Herzig, V. (Chief Investigator (CI)), Szabó, I. (Chief Investigator (CI)), Varga, Z. (Chief Investigator (CI)), Papp, F. (Chief Investigator (CI)), Szanto, T. G. (Chief Investigator (CI)), Hajdu, P. (Chief Investigator (CI)), Zakany, F. (Chief Investigator (CI)), Naseem, M. U. (Chief Investigator (CI)) & Shakeel, K. (Chief Investigator (CI))
6/01/26 → 31/12/27
Project: Research
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Developing potent and brain-permeable peptide therapeutics for AD
Wai, D. (Primary Chief Investigator (PCI)), Norton, R. (Associate Investigator (AI)) & Nicolazzo, J. (Associate Investigator (AI))
1/03/22 → 1/12/23
Project: Research
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IC18.12 Cytiva SPR method development for Fragment-Based Design
Scanlon, M. (Primary Chief Investigator (PCI)), Norton, R. (Chief Investigator (CI)) & O'Meara, T. (Partner Investigator (PI))
16/09/21 → 16/09/25
Project: Research
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IC18.1 Expression of membrane proteins using Tetrahymena
Scanlon, M. (Primary Chief Investigator (PCI)) & Norton, R. (Chief Investigator (CI))
ARC - Australian Research Council
17/10/19 → 21/07/24
Project: Research
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New aminobenzimidazole antimalarial agents with a novel mechanism of action
Creek, D. (Primary Chief Investigator (PCI)), Scammells, P. (Chief Investigator (CI)), Ralph, S. A. (Chief Investigator (CI)), Norton, R. (Chief Investigator (CI)) & Devine, S. (Chief Investigator (CI))
1/01/19 → 31/12/21
Project: Research
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Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2/RACK2 with protein kinase Cε and cargo proteins
Olushola-Siedoks, A. A., Small, L., Fincham, K. J., Wai, D. C. C., Monteiro, D., Conway, J. R. W., Cadell, A., Parker, B. J., Croucher, D. R., Schmitz-Peiffer, C. & Norton, R. S., Jan 2026, In: BBA Molecular Cell Research. 1873, 1, 16 p., 120071.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A comparative analysis of toxin gene families across diverse sea anemone species
Smith, H. L., Broszczak, D. A., van der Burg, C. A., Surm, J. M., Liggins, L., Norton, R. S. & Prentis, P. J., Jun 2025, In: Toxicon: X. 26, 15 p., 100217.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Structure and functional studies of Avt1, a novel peptide from the sea anemone Aulactinia veratra
Albar, R. A., Smith, H. L., Sanches, K., Wai, D. C. C., Naseem, M. U., Szanto, T. G., Panyi, G., Prentis, P. J. & Norton, R. S., 1 Jan 2025, In: BBA Proteins and Proteomics. 1873, 1, 12 p., 141050.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Toxicon and Toxicon: X - Editorial transitions and future directions in 2025
Norton, R. S. & Tambourgi, D. V., Jun 2025, In: Toxicon. 260, 2 p., 108347.Research output: Contribution to journal › Letter › Other › peer-review
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Toxicon and Toxicon: X - Editorial transitions and future directions in 2025
Norton, R. S. & Tambourgi, D. V., Jun 2025, In: Toxicon: X. 26, 2 p., 100223.Research output: Contribution to journal › Letter › Other › peer-review
Open Access