Projects per year
Personal profile
Biography
Professor Ray Norton holds a personal chair at the Monash Institute of Pharmaceutical Sciences, Melbourne, Australia. He obtained his PhD in chemistry from the Australian National University and undertook postdoctoral studies in the US before returning to Australia as a QEII Fellow at the Roche Research Institute of Marine Pharmacology in Sydney. His lab at Monash employs a range of biophysical approaches, including NMR, SPR, ITC and X-ray crystallography, as well as molecular modelling and design, in studies of peptides and proteins from venomous organisms. One of the venom-derived peptides he works with has completed Phase 1 clinical trial for autoimmune diseases and another is the basis for development of ultra-rapid acting insulins that are currently undergoing preclinical evaluation. He is also designing small cyclic peptides that show promise as anti-infective agents with a novel mechanism of action. In addition, his lab applies a combination of structure-based and fragment-based drug discovery programs to protein targets in the areas of infectious and parasitic diseases, graft rejection and metabolic diseases. Ray Norton has published over 380 articles, received numerous national awards, and is an inventor on more than 10 patents. His h-factor is 67 and his papers have been cited > 17,400 times (Google Scholar). He leads a group of more than 15 researchers and has been successful in attracting funding from NHMRC, ARC, Wellcome, Diabetes Australia and NIH. He was recently elected a Fellow of the International Society of Magnetic Resonance. He is Chair of the Council of the International Conference on Magnetic Resonance in Biological Systems (ICMRBS) and a member of the Council of the International Society on Toxinology.
Monash teaching commitment
Bachelor of Pharmaceutical Science teaching
- BPS3231 - Advanced Experimental Spectroscopy
- PSC3131 - Analysis of Drug Receptor Interactions
- PSC3432 - Medicinal Chemistry Research Project
- PSC1041 - Scientific Discoveries
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Chemistry, PhD, Australian National University (ANU)
Biochemistry, BSc (Honours), University of Melbourne
Research area keywords
- Peptide Drugs
- Peptide toxins
- Proteins
- Ion channels
- Auto-immunity
- Innate Immunity
- Malaria
- NMR spectroscopy and biochemistry
- Biophysics
Collaborations and top research areas from the last five years
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Developing potent and brain-permeable peptide therapeutics for AD
Wai, D., Norton, R. & Nicolazzo, J.
1/03/22 → 1/12/23
Project: Research
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IC18.12 Cytiva SPR method development for Fragment-Based Design
Scanlon, M., Norton, R. & O'Meara, T.
16/09/21 → 16/09/25
Project: Research
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IC18.1 Expression of membrane proteins using Tetrahymena
Australian Research Council (ARC)
17/10/19 → 21/07/24
Project: Research
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New aminobenzimidazole antimalarial agents with a novel mechanism of action
Creek, D., Scammells, P., Ralph, S. A., Norton, R. & Devine, S.
1/01/19 → 31/12/21
Project: Research
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Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases
23/10/18 → 23/10/19
Project: Research
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Acontia, a Specialised Defensive Structure, Has Low Venom Complexity in Calliactis polypus
Smith, H. L., Prentis, P. J., Bryan, S. E., Norton, R. S. & Broszczak, D. A., Mar 2023, In: Toxins. 15, 3, 14 p., 218.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins
Krishnarjuna, B., Sunanda, P., Seow, J., Tae, H. S., Robinson, S. D., Belgi, A., Robinson, A. J., Safavi-Hemami, H., Adams, D. J. & Norton, R. S., Feb 2023, In: Marine Drugs. 21, 2, 15 p., 81.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family
Ashwood, L. M., Elnahriry, K. A., Stewart, Z. K., Shafee, T., Naseem, M. U., Szanto, T. G., van der Burg, C. A., Smith, H. L., Surm, J. M., Undheim, E. A. B., Madio, B., Hamilton, B. R., Guo, S., Wai, D. C. C., Coyne, V. L., Phillips, M. J., Dudley, K. J., Hurwood, D. A., Panyi, G., King, G. F., & 3 others , 24 May 2023, In: BMC Biology. 21, 1, 25 p., 121.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics
Sanches, K., Prypoten, V., Chandy, K. G., Chalmers, D. K. & Norton, R. S., 4 May 2023, In: Journal of Chemical Information and Modeling. 63, 10, p. 3043–3053 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Peripheral Administration of the Kv1.3-Blocking Peptide HsTX1[R14A] Improves Cognitive Performance in Senescence Accelerated SAMP8 Mice
Pan, Y., Kagawa, Y., Sun, J., Lucas, D. S. D., Takechi, R., Mamo, J. C. L., Wai, D. C. C., Norton, R. S., Jin, L. & Nicolazzo, J. A., 24 May 2023, (Accepted/In press) In: Neurotherapeutics. 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access