• Wellington Road, 26 Innovation Walk

    3800 Monash

    Australia

Accepting PhD Students

PhD projects

Speech processing in altered brain conditions Traumatic brain injury models and brain processing of sensory input

1983 …2020

Research output per year

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Personal profile

Biography

Sensory information and the brain

Professor Ramesh Rajan's research is predicated on the over-riding hypothesis that a huge part of our internal lives and our interactions with the world are guided by our senses, by what we hear, see, touch, smell, taste and our other senses.

Using this overarching theme, he studies sensory processing in the brain to understand how brain disorders affect the way in which we receive and process information about the world, to shape and guide our internal lives and our responses to the world and how the many cognitive, motor, memory and emotional deficits in brain disorders may flow from disordered sensory processing that distorts our world view and our interactions with self and others. 

He studies models of traumatic brain injury and the processing of sensory information, as well as how brain alterations in conditions like Huntington's Disease, Multiple Sclerosis, Autism Spectrum Disorders, and Parkinson's Disease, affect the ability to understand our most powerful communication tool, namely speech, in noisy backgrounds.

'Our world is noisy and crowded and operating in it requires us to extract information of interest from competing, but uninformative or unnecessary, information. For example, when you listen to speech, people are often talking in the background. When you look around a messy room, you're able to identify the book or toy you're interested in. I'm interested in how we pick up what's of interest and discard what's not, from all the information that bombards us. This isn't just a case of what we hear but also a case of how the brain selects what to attend to and what to suppress, and how the brain uses its memory and experience to guide that selection and the perception.'

 

Ramesh is also trying to understand how traumatic brain injury impacts on our ability to process sensory information.

'In some forms of traumatic brain injury, using CAT scans or MRIs doesn't identify any visible damage and so it's hard to find what's going wrong. Yet these people have cognitive deficits, memory loss, movement disorders, etc. We've found a new set of effects in how they process sensory information, which impacts on producing the appropriate response. When we produce a response, we have to take in the information that's coming, such as catching a ball that's coming towards you. The parts of the brain that control movement and learning produce the wrong responses - not necessarily because there's something wrong with them, but because they're getting the wrong information as to what to do.'

Research area keywords

  • Traumatic brain injury
  • Speech processing
  • Cortex

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Projects

Research Output

A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na+, K+, Mg2 +, Ca2 +, Cl) Within Brain Tissue

Hartnell, D., Andrews, W., Smith, N., Jiang, H., McAllum, E., Rajan, R., Colbourne, F., Fitzgerald, M., Lam, V., Takechi, R., Pushie, M. J., Kelly, M. E. & Hackett, M. J., 22 Jan 2020, In : Frontiers in Neuroscience. 13, 8 p., 1415.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Characterization of Ionic and Lipid Gradients within Corpus Callosum White Matter after Diffuse Traumatic Brain Injury in the Rat

Hartnell, D., Gillespie-Jones, K., Ciornei, C., Hollings, A., Thomas, A., Harrild, E., Reinhardt, J., Paterson, D. J., Alwis, D., Rajan, R. & Hackett, M. J., 5 Feb 2020, In : ACS Chemical Neuroscience. 11, 3, p. 248-257 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitory neuronal changes following a mixed diffuse-focal model of traumatic brain injury

Carron, S. F., Sun, M., Shultz, S. R. & Rajan, R., 1 Feb 2020, In : The Journal of Comparative Neurology. 528, 2, p. 175-198 24 p.

Research output: Contribution to journalArticleResearchpeer-review

A mathematical approach to correlating objective spectro-temporal features of non-linguistic sounds with their subjective perceptions in humans

Burns, T. & Rajan, R., 31 Jul 2019, In : Frontiers in Neuroscience. 13, 14 p., 794.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Distributed representation of vocalization pitch in marmoset primary auditory cortex

Zhu, S., Allitt, B., Samuel, A., Lui, L., Rosa, M. G. P. & Rajan, R., Jan 2019, In : European Journal of Neuroscience. 49, 2, p. 179-198 20 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Activities

  • 1 Online content/ delivery

Monash teaching commitment

Ramesh Rajan (Speaker)

1997

Activity: Other Teaching Engagements and non-HDR SupervisionsOnline content/ delivery